Human papillomavirus - Revision history

Michael at 15:35, 9 December 2021

2021-12-09T15:35:40Z

← Older revision		Revision as of 15:35, 9 December 2021
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	===Images===		===Images===
	<gallery>		<gallery>
	Image: High grade squamous intraepithelial lesion - 2 - p16 -- high mag.jpg \| Block positive p16 staining in HSIL. (WC)		Image: High grade squamous intraepithelial lesion - 2 - p16 -- high mag.jpg \| Block positive p16 staining in [[HSIL]]. (WC)
			Image:Consistent with HPV-associated SCC - p16 -- intermed mag.jpg \| c/w [[Human papillomavirus-associated head and neck squamous cell carcinoma\|HPV-assoc. SCC]] - p16 - intermed. mag. (WC/Nephron)
			Image:Consistent with HPV-associated SCC - p16 -- high mag.jpg \| c/w HPV-assoc. SCC - p16 - high mag. (WC/Nephron)
	</gallery>		</gallery>

Michael at 15:33, 9 December 2021

2021-12-09T15:33:38Z

← Older revision		Revision as of 15:33, 9 December 2021
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	[[Image:High grade squamous intraepithelial lesion - 2 - p16 -- high mag.jpg\|thumb\|Micrograph showing block positive [[p16]] immunostaining in [[high-grade squamous intraepithelial lesion]] of the cervix. (WC)]]		[[Image:High grade squamous intraepithelial lesion - 2 - p16 -- high mag.jpg\|thumb\|Micrograph showing block positive [[p16]] immunostaining in [[high-grade squamous intraepithelial lesion]] of the cervix. ''p16'' is commonly used as a surrogate marker for human papillomavirus (HPV). (WC)]]
	'''Human papillomavirus''', abbreviated '''HPV''', is virus implicated in a large number of [[cancer]]s.		'''Human papillomavirus''', abbreviated '''HPV''', is virus implicated in a large number of [[cancer]]s.

Michael at 15:32, 9 December 2021

2021-12-09T15:32:04Z

← Older revision		Revision as of 15:32, 9 December 2021
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	[[Image:High grade squamous intraepithelial lesion - 2 - p16 -- high mag.jpg\|Micrograph showing block positive [[p16]] immunostaining in [[high-grade squamous intraepithelial lesion]] of the cervix. (WC)]]		[[Image:High grade squamous intraepithelial lesion - 2 - p16 -- high mag.jpg\|thumb\|Micrograph showing block positive [[p16]] immunostaining in [[high-grade squamous intraepithelial lesion]] of the cervix. (WC)]]
	'''Human papillomavirus''', abbreviated '''HPV''', is virus implicated in a large number of [[cancer]]s.		'''Human papillomavirus''', abbreviated '''HPV''', is virus implicated in a large number of [[cancer]]s.

Michael at 15:31, 9 December 2021

2021-12-09T15:31:52Z

← Older revision		Revision as of 15:31, 9 December 2021
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			[[Image:High grade squamous intraepithelial lesion - 2 - p16 -- high mag.jpg\|Micrograph showing block positive [[p16]] immunostaining in [[high-grade squamous intraepithelial lesion]] of the cervix. (WC)]]
	'''Human papillomavirus''', abbreviated '''HPV''', is virus implicated in a large number of [[cancer]]s.		'''Human papillomavirus''', abbreviated '''HPV''', is virus implicated in a large number of [[cancer]]s.

Michael: /* IHC */

2021-12-09T15:18:51Z

IHC

← Older revision		Revision as of 15:18, 9 December 2021
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	==IHC==		==IHC==
	*[[p16]] +ve -- stains most cells infected by HPV.		*[[p16]] +ve -- stains most cells infected by HPV.


			===Images===
			<gallery>
			Image: High grade squamous intraepithelial lesion - 2 - p16 -- high mag.jpg \| Block positive p16 staining in HSIL. (WC)
			</gallery>

	==See also==		==See also==

Michael: /* IHC */

2021-12-09T15:17:56Z

IHC

← Older revision		Revision as of 15:17, 9 December 2021
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	==IHC==		==IHC==
	*p16 +ve -- stains most cells infected by HPV.		*[[p16]] +ve -- stains most cells infected by HPV.

	==See also==		==See also==

Michael: /* Microscopic */

2021-12-09T15:17:46Z

Microscopic

← Older revision		Revision as of 15:17, 9 December 2021
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	*** Central location - nucleus should be smack in the middle of the cell.		*** Central location - nucleus should be smack in the middle of the cell.

	Images:		===Images===
	*[http://commons.wikimedia.org/w/index.php?title=File:Low-grade_squamous_intraepithelial_lesion.jpg LSIL (WC)].		<gallery>
	*[http://commons.wikimedia.org/wiki/File:Low-grade_sil_and_endocx.jpg LSIL & endocervix (WC)].		Image:Low-grade_squamous_intraepithelial_lesion.jpg \| LSIL (WC).
			Image:Low-grade_sil_and_endocx.jpg \| LSIL & endocervix (WC).
			</gallery>

	==IHC==		==IHC==

Michael: Removed redirect to Viruses#Human papillomavirus

2021-12-09T15:16:02Z

Removed redirect to Viruses#Human papillomavirus

← Older revision		Revision as of 15:16, 9 December 2021
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	#~~redirect~~ [[Viruses~~#Human_papillomavirus~~]]		'''Human papillomavirus''', abbreviated '''HPV''', is virus implicated in a large number of [[cancer]]s.

			==General==
			*Sexually transmitted.

			Note:
			*Some tests can be done on formalin-fixed, paraffin-embedded tissue.<ref name=pmid21128780>{{Cite journal \| last1 = Black \| first1 = CC. \| last2 = Bentley \| first2 = HA. \| last3 = Davis \| first3 = TH. \| last4 = Tsongalis \| first4 = GJ. \| title = Use of a linear array for the detection of human papillomavirus genotypes in head and neck cancer. \| journal = Arch Pathol Lab Med \| volume = 134 \| issue = 12 \| pages = 1813-7 \| month = Dec \| year = 2010 \| doi = 10.1043/2009-0592-OAR.1 \| PMID = 21128780 }}</ref>

			===Associated pathology===
			*Benign:
			**[[Verruca vulgaris]].
			**[[Condyloma acuminatum]].
			**[[Esophagus#Human_papilloma_virus_esophagitis\|HPV esophagitis]].
			*Malignant:
			*#[[Uterine cervix\|Cervical cancer]] and precursors ([[LSIL]], [[HSIL]]).
			*#Anal cancer and precursors ([[Anus#Anal_intraepithelial_neoplasia\|AIN]]).<ref name=pmid21616117>{{Cite journal \| last1 = Borget \| first1 = I. \| last2 = Abramowitz \| first2 = L. \| last3 = Mathevet \| first3 = P. \| title = Economic burden of HPV-related cancers in France. \| journal = Vaccine \| volume = 29 \| issue = 32 \| pages = 5245-9 \| month = Jul \| year = 2011 \| doi = 10.1016/j.vaccine.2011.05.018 \| PMID = 21616117 }}</ref>
			*#[[Vulva\|Vulvar cancer]].<ref name=pmid21616117/>
			*#[[Vagina\|Vaginal cancer]].<ref name=pmid21616117/>
			*#[[Penis\|Penile cancer]].<ref name=pmid21616117/>
			*#[[HPV-associated head and neck squamous cell carcinoma]] - oropharynx (specifically - tonsils, base of tongue).
			*#[[Human papillomavirus-related multiphenotypic sinonasal carcinoma]] (previously known as ''HPV-related carcinoma with adenoid cystic-like features'').
			**Possibly esophageal carcinoma<ref name=pmid21130683>{{Cite journal \| last1 = Zhang \| first1 = QY. \| last2 = Zhang \| first2 = DH. \| last3 = Shen \| first3 = ZY. \| last4 = Xu \| first4 = LY. \| last5 = Li \| first5 = EM. \| last6 = Au \| first6 = WW. \| title = Infection and integration of human papillomavirus in esophageal carcinoma. \| journal = Int J Hyg Environ Health \| volume = 214 \| issue = 2 \| pages = 156-61 \| month = Mar \| year = 2011 \| doi = 10.1016/j.ijheh.2010.11.001 \| PMID = 21130683 }}</ref> - disputed.<ref name=pmid21169053>{{Cite journal \| last1 = Iyer \| first1 = A. \| last2 = Rajendran \| first2 = V. \| last3 = Adamson \| first3 = CS. \| last4 = Peng \| first4 = Z. \| last5 = Cooper \| first5 = K. \| last6 = Evans \| first6 = MF. \| title = Human papillomavirus is detectable in Barrett's esophagus and esophageal carcinoma but is unlikely to be of any etiologic significance. \| journal = J Clin Virol \| volume = 50 \| issue = 3 \| pages = 205-8 \| month = Mar \| year = 2011 \| doi = 10.1016/j.jcv.2010.11.015 \| PMID = 21169053 }}</ref>

			===Oncocytic types===
			Known as "high risk" types; this grouping includes:<ref name=pmid22312235>{{Cite journal \| last1 = Ntova \| first1 = CK. \| last2 = Kottaridi \| first2 = C. \| last3 = Chranioti \| first3 = A. \| last4 = Spathis \| first4 = A. \| last5 = Kassanos \| first5 = D. \| last6 = Paraskevaidis \| first6 = E. \| last7 = Karakitsos \| first7 = P. \| title = Genetic Variability and Phylogeny of High Risk HPV Type 16, 18, 31, 33 and 45 L1 Gene in Greek Women. \| journal = Int J Mol Sci \| volume = 13 \| issue = 1 \| pages = 1-17 \| month = \| year = 2012 \| doi = 10.3390/ijms13010001 \| PMID = 22312235 }}</ref>
			*HPV 18 - predominantly adenocarcinoma.<ref name=pmid15551313>{{Cite journal \| last1 = De Boer \| first1 = MA. \| last2 = Peters \| first2 = LA. \| last3 = Aziz \| first3 = MF. \| last4 = Siregar \| first4 = B. \| last5 = Cornain \| first5 = S. \| last6 = Vrede \| first6 = MA. \| last7 = Jordanova \| first7 = ES. \| last8 = Fleuren \| first8 = GJ. \| title = Human papillomavirus type 18 variants: histopathology and E6/E7 polymorphisms in three countries. \| journal = Int J Cancer \| volume = 114 \| issue = 3 \| pages = 422-5 \| month = Apr \| year = 2005 \| doi = 10.1002/ijc.20727 \| PMID = 15551313 }}</ref>
			**'''Eigh'''teen = '''a'''denocarcinoma.
			*HPV 16 - predominantly squamous cell carcinoma.<ref name=pmid15551313/>
			**'''S'''ixteen = '''s'''quamous.
			*HPV 31.
			*HPV 33.
			*HPV 45.

			===Oncogenesis===
			Quick & dirty explanation of pathogenesis:<ref name=pmid12445661>{{Cite journal \| last1 = Münger \| first1 = K. \| last2 = Howley \| first2 = PM. \| title = Human papillomavirus immortalization and transformation functions. \| journal = Virus Res \| volume = 89 \| issue = 2 \| pages = 213-28 \| month = Nov \| year = 2002 \| doi = \| PMID = 12445661 }}</ref><ref name=Ref_PCPBoD8_169>{{Ref PCPBoD8\|169}}</ref>
			*Virus integrates into host genome.
			**This is accompanied by loss of ''viral gene E2'' (which suppresses function of E6 & E7).
			*''Viral gene E6'' dysregulates ''p53''.
			*''Viral gene E7'' dysregulates ''RB''.

			===Vaccine===
			Recombinant vaccine (Gardasil, Silgard) - covers:<ref name=pmid21942919>{{Cite journal \| last1 = McCormack \| first1 = PL. \| last2 = Joura \| first2 = EA. \| title = Spotlight on Quadrivalent Human Papillomavirus(Types 6, 11, 16, 18) Recombinant Vaccine(Gardasil®) in the Prevention of PremalignantGenital Lesions, Genital Cancer, and Genital Warts in Women†. \| journal = BioDrugs \| volume = 25 \| issue = 5 \| pages = 339-43 \| month = Oct \| year = 2011 \| doi = 10.2165/11205060-000000000-00000 \| PMID = 21942919 }}</ref>
			*HPV 6.
			*HPV 11.
			*HPV 16.
			*HPV 18.

			==Microscopic==
			Features:
			*Koilocytes:
			** Perinuclear clearing.
			** Nuclear changes.
			*** Size similar (or larger) to those in the basal layer of the epithelium.
			*** Nuclear enlargement should be evident on low power, i.e. 25x.
			*** Central location - nucleus should be smack in the middle of the cell.

			Images:
			*[http://commons.wikimedia.org/w/index.php?title=File:Low-grade_squamous_intraepithelial_lesion.jpg LSIL (WC)].
			*[http://commons.wikimedia.org/wiki/File:Low-grade_sil_and_endocx.jpg LSIL & endocervix (WC)].

			==IHC==
			*p16 +ve -- stains most cells infected by HPV.

			==See also==
			*[[Virus]].
			*[[Viruses and cancer]].

			==References==
			{{Reflist\|2}}

	[[Category:Viruses]]		[[Category:Viruses]]

Michael: redirect

2011-11-27T18:39:09Z

redirect

New page

#redirect [[Viruses#Human_papillomavirus]]

[[Category:Viruses]]