Hereditary leiomyomatosis and renal cell carcinoma syndrome - Revision history

Michael: /* General */

2025-11-10T18:53:40Z

General

← Older revision		Revision as of 18:53, 10 November 2025
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	*[[Hereditary leiomyomatosis and renal cell carcinoma syndrome-associated renal cell carcinoma]].		*[[Hereditary leiomyomatosis and renal cell carcinoma syndrome-associated renal cell carcinoma]].
	**Often aggressive and significant cause of mortality.<ref name=pmid24441663>{{Cite journal \| last1 = Chen \| first1 = YB. \| last2 = Brannon \| first2 = AR. \| last3 = Toubaji \| first3 = A. \| last4 = Dudas \| first4 = ME. \| last5 = Won \| first5 = HH. \| last6 = Al-Ahmadie \| first6 = HA. \| last7 = Fine \| first7 = SW. \| last8 = Gopalan \| first8 = A. \| last9 = Frizzell \| first9 = N. \| title = Hereditary leiomyomatosis and renal cell carcinoma syndrome-associated renal cancer: recognition of the syndrome by pathologic features and the utility of detecting aberrant succination by immunohistochemistry. \| journal = Am J Surg Pathol \| volume = 38 \| issue = 5 \| pages = 627-37 \| month = May \| year = 2014 \| doi = 10.1097/PAS.0000000000000163 \| PMID = 24441663 }}</ref>		**Often aggressive and significant cause of mortality.<ref name=pmid24441663>{{Cite journal \| last1 = Chen \| first1 = YB. \| last2 = Brannon \| first2 = AR. \| last3 = Toubaji \| first3 = A. \| last4 = Dudas \| first4 = ME. \| last5 = Won \| first5 = HH. \| last6 = Al-Ahmadie \| first6 = HA. \| last7 = Fine \| first7 = SW. \| last8 = Gopalan \| first8 = A. \| last9 = Frizzell \| first9 = N. \| title = Hereditary leiomyomatosis and renal cell carcinoma syndrome-associated renal cancer: recognition of the syndrome by pathologic features and the utility of detecting aberrant succination by immunohistochemistry. \| journal = Am J Surg Pathol \| volume = 38 \| issue = 5 \| pages = 627-37 \| month = May \| year = 2014 \| doi = 10.1097/PAS.0000000000000163 \| PMID = 24441663 }}</ref>
	*[[Paraganglioma]] or [[pheochromocytoma]].<ref name=~~pmid36773955~~>{{cite journal \|authors=Orrego JJ, Chorny JA \|title=Hereditary leiomyomatosis and renal cell cancer (HLRCC), pheochromocytoma (PCC)/paraganglioma (PGL) and germline fumarate hydratase (FH) variants \|journal=Endocrinol Diabetes Metab Case Rep \|volume=2024 \|issue=4 \|pages= \|date=October 2024 \|pmid=39705504 \|pmc=11737469 \|doi=10.1530/EDM-24-0073 \|url=}}</ref><ref name=pmid36773955>{{cite journal \|authors=Zavoshi S, Lu E, Boutros PC, Zhang L, Harari A, Hatchell KE, Nielsen SM, Esplin ED, Ouyang K, Nykamp K, Wilde B, Christofk H, Shuch B \|title=Fumarate Hydratase Variants and Their Association With Paraganglioma/Pheochromocytoma \|journal=Urology \|volume=176 \|issue= \|pages=106–114 \|date=June 2023 \|pmid=36773955 \|doi=10.1016/j.urology.2022.11.053 \|url=}}</ref>		*[[Paraganglioma]] or [[pheochromocytoma]].<ref name=pmid39705504>{{cite journal \|authors=Orrego JJ, Chorny JA \|title=Hereditary leiomyomatosis and renal cell cancer (HLRCC), pheochromocytoma (PCC)/paraganglioma (PGL) and germline fumarate hydratase (FH) variants \|journal=Endocrinol Diabetes Metab Case Rep \|volume=2024 \|issue=4 \|pages= \|date=October 2024 \|pmid=39705504 \|pmc=11737469 \|doi=10.1530/EDM-24-0073 \|url=}}</ref><ref name=pmid36773955>{{cite journal \|authors=Zavoshi S, Lu E, Boutros PC, Zhang L, Harari A, Hatchell KE, Nielsen SM, Esplin ED, Ouyang K, Nykamp K, Wilde B, Christofk H, Shuch B \|title=Fumarate Hydratase Variants and Their Association With Paraganglioma/Pheochromocytoma \|journal=Urology \|volume=176 \|issue= \|pages=106–114 \|date=June 2023 \|pmid=36773955 \|doi=10.1016/j.urology.2022.11.053 \|url=}}</ref>

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Michael: /* General */

2025-11-10T18:52:49Z

General

← Older revision		Revision as of 18:52, 10 November 2025
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	*[[Hereditary leiomyomatosis and renal cell carcinoma syndrome-associated renal cell carcinoma]].		*[[Hereditary leiomyomatosis and renal cell carcinoma syndrome-associated renal cell carcinoma]].
	**Often aggressive and significant cause of mortality.<ref name=pmid24441663>{{Cite journal \| last1 = Chen \| first1 = YB. \| last2 = Brannon \| first2 = AR. \| last3 = Toubaji \| first3 = A. \| last4 = Dudas \| first4 = ME. \| last5 = Won \| first5 = HH. \| last6 = Al-Ahmadie \| first6 = HA. \| last7 = Fine \| first7 = SW. \| last8 = Gopalan \| first8 = A. \| last9 = Frizzell \| first9 = N. \| title = Hereditary leiomyomatosis and renal cell carcinoma syndrome-associated renal cancer: recognition of the syndrome by pathologic features and the utility of detecting aberrant succination by immunohistochemistry. \| journal = Am J Surg Pathol \| volume = 38 \| issue = 5 \| pages = 627-37 \| month = May \| year = 2014 \| doi = 10.1097/PAS.0000000000000163 \| PMID = 24441663 }}</ref>		**Often aggressive and significant cause of mortality.<ref name=pmid24441663>{{Cite journal \| last1 = Chen \| first1 = YB. \| last2 = Brannon \| first2 = AR. \| last3 = Toubaji \| first3 = A. \| last4 = Dudas \| first4 = ME. \| last5 = Won \| first5 = HH. \| last6 = Al-Ahmadie \| first6 = HA. \| last7 = Fine \| first7 = SW. \| last8 = Gopalan \| first8 = A. \| last9 = Frizzell \| first9 = N. \| title = Hereditary leiomyomatosis and renal cell carcinoma syndrome-associated renal cancer: recognition of the syndrome by pathologic features and the utility of detecting aberrant succination by immunohistochemistry. \| journal = Am J Surg Pathol \| volume = 38 \| issue = 5 \| pages = 627-37 \| month = May \| year = 2014 \| doi = 10.1097/PAS.0000000000000163 \| PMID = 24441663 }}</ref>
			*[[Paraganglioma]] or [[pheochromocytoma]].<ref name=pmid36773955>{{cite journal \|authors=Orrego JJ, Chorny JA \|title=Hereditary leiomyomatosis and renal cell cancer (HLRCC), pheochromocytoma (PCC)/paraganglioma (PGL) and germline fumarate hydratase (FH) variants \|journal=Endocrinol Diabetes Metab Case Rep \|volume=2024 \|issue=4 \|pages= \|date=October 2024 \|pmid=39705504 \|pmc=11737469 \|doi=10.1530/EDM-24-0073 \|url=}}</ref><ref name=pmid36773955>{{cite journal \|authors=Zavoshi S, Lu E, Boutros PC, Zhang L, Harari A, Hatchell KE, Nielsen SM, Esplin ED, Ouyang K, Nykamp K, Wilde B, Christofk H, Shuch B \|title=Fumarate Hydratase Variants and Their Association With Paraganglioma/Pheochromocytoma \|journal=Urology \|volume=176 \|issue= \|pages=106–114 \|date=June 2023 \|pmid=36773955 \|doi=10.1016/j.urology.2022.11.053 \|url=}}</ref>

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Michael at 18:58, 24 March 2024

2024-03-24T18:58:40Z

← Older revision		Revision as of 18:58, 24 March 2024
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	Characteristics:		Characteristics:
	* [[~~Hereditary leiomyomatosis and renal cell carcinoma syndrome~~-~~associated~~ renal cell carcinoma]].		* [[Fumarate hydratase-deficient renal cell carcinoma]].
	* Benign [[leiomyoma]]s skin/[[uterine leiomyoma\|uterus]].		* Benign [[leiomyoma]]s skin/[[uterine leiomyoma\|uterus]].
	* Uterine [[leiomyosarcoma]].		* Uterine [[leiomyosarcoma]].

Michael: /* General */

2024-03-24T15:56:23Z

General

← Older revision		Revision as of 15:56, 24 March 2024
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	Note:		Note:
	*The RCC in the past was typically diagnosed as ''[[papillary renal cell carcinoma]]''.<ref name=Ref_WMSP290>{{Ref WMSP\|290}}</ref>		*The RCC in the past was typically diagnosed as ''[[papillary renal cell carcinoma]]''.<ref name=Ref_WMSP290>{{Ref WMSP\|290}}</ref>
			*Case reports describing an association with [[adrenal cortical carcinoma]].<ref>{{cite journal \|authors=Silverman E, Addasi N, Azzawi M, Duarte EM, Huang D, Swanson B, Ganti AK, Reiser G, Fingeret AL, Kotwal A \|title=Recurrent Cushing Syndrome From Metastatic Adrenocortical Carcinoma With Fumarate Hydratase Allelic Variant \|journal=AACE Clin Case Rep \|volume=8 \|issue=6 \|pages=259–263 \|date=2022 \|pmid=36447829 \|pmc=9701913 \|doi=10.1016/j.aace.2022.09.003 \|url=}}</ref>

	==See also==		==See also==

Michael: fix typo

2018-09-11T16:08:08Z

fix typo

← Older revision		Revision as of 16:08, 11 September 2018
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	#One of the following (pathologic) findings:		#One of the following (pathologic) findings:
	#*Multiple cutaneous leiomyoma where one was proven histologically.		#*Multiple cutaneous leiomyoma where one was proven histologically.
	#*One cutaneous leiomyoma in the context of a family history of ~~HRLCC~~.		#*One cutaneous leiomyoma in the context of a family history of HLRCC.
	#*RCC with a morphology suggestive of HRLCC syndrome-associated RCC.		#*RCC with a morphology suggestive of HRLCC syndrome-associated RCC.

Michael: /* General */

2017-11-15T06:48:04Z

General

← Older revision		Revision as of 06:48, 15 November 2017
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	*[[Leiomyoma]]s - high penetrance.		*[[Leiomyoma]]s - high penetrance.
	**Manifestation: skin rash.<ref name=pmid24999901>{{Cite journal \| last1 = Toon \| first1 = CW. \| last2 = Hasovits \| first2 = C. \| last3 = Paik \| first3 = J. \| last4 = Field \| first4 = M. \| last5 = Chou \| first5 = A. \| last6 = Hugh \| first6 = TJ. \| last7 = Pavlakis \| first7 = N. \| last8 = Gill \| first8 = AJ. \| title = Skin rash, a kidney mass and a family mystery dating back to World War II. \| journal = Med J Aust \| volume = 201 \| issue = 1 \| pages = 58-60 \| month = Jul \| year = 2014 \| doi = \| PMID = 24999901 }}</ref>		**Manifestation: skin rash.<ref name=pmid24999901>{{Cite journal \| last1 = Toon \| first1 = CW. \| last2 = Hasovits \| first2 = C. \| last3 = Paik \| first3 = J. \| last4 = Field \| first4 = M. \| last5 = Chou \| first5 = A. \| last6 = Hugh \| first6 = TJ. \| last7 = Pavlakis \| first7 = N. \| last8 = Gill \| first8 = AJ. \| title = Skin rash, a kidney mass and a family mystery dating back to World War II. \| journal = Med J Aust \| volume = 201 \| issue = 1 \| pages = 58-60 \| month = Jul \| year = 2014 \| doi = \| PMID = 24999901 }}</ref>
	**Involvement may be minimal or extensive.		**Involvement may be minimal or extensive.<ref name=pmid15937070/>
	*[[Hereditary leiomyomatosis and renal cell carcinoma syndrome-associated renal cell carcinoma]].		*[[Hereditary leiomyomatosis and renal cell carcinoma syndrome-associated renal cell carcinoma]].
	**Often aggressive and significant cause of mortality.<ref name=pmid24441663>{{Cite journal \| last1 = Chen \| first1 = YB. \| last2 = Brannon \| first2 = AR. \| last3 = Toubaji \| first3 = A. \| last4 = Dudas \| first4 = ME. \| last5 = Won \| first5 = HH. \| last6 = Al-Ahmadie \| first6 = HA. \| last7 = Fine \| first7 = SW. \| last8 = Gopalan \| first8 = A. \| last9 = Frizzell \| first9 = N. \| title = Hereditary leiomyomatosis and renal cell carcinoma syndrome-associated renal cancer: recognition of the syndrome by pathologic features and the utility of detecting aberrant succination by immunohistochemistry. \| journal = Am J Surg Pathol \| volume = 38 \| issue = 5 \| pages = 627-37 \| month = May \| year = 2014 \| doi = 10.1097/PAS.0000000000000163 \| PMID = 24441663 }}</ref>		**Often aggressive and significant cause of mortality.<ref name=pmid24441663>{{Cite journal \| last1 = Chen \| first1 = YB. \| last2 = Brannon \| first2 = AR. \| last3 = Toubaji \| first3 = A. \| last4 = Dudas \| first4 = ME. \| last5 = Won \| first5 = HH. \| last6 = Al-Ahmadie \| first6 = HA. \| last7 = Fine \| first7 = SW. \| last8 = Gopalan \| first8 = A. \| last9 = Frizzell \| first9 = N. \| title = Hereditary leiomyomatosis and renal cell carcinoma syndrome-associated renal cancer: recognition of the syndrome by pathologic features and the utility of detecting aberrant succination by immunohistochemistry. \| journal = Am J Surg Pathol \| volume = 38 \| issue = 5 \| pages = 627-37 \| month = May \| year = 2014 \| doi = 10.1097/PAS.0000000000000163 \| PMID = 24441663 }}</ref>

Michael: /* General */

2017-11-15T06:47:14Z

General

← Older revision		Revision as of 06:47, 15 November 2017
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	*[[Leiomyoma]]s - high penetrance.		*[[Leiomyoma]]s - high penetrance.
	**Manifestation: skin rash.<ref name=pmid24999901>{{Cite journal \| last1 = Toon \| first1 = CW. \| last2 = Hasovits \| first2 = C. \| last3 = Paik \| first3 = J. \| last4 = Field \| first4 = M. \| last5 = Chou \| first5 = A. \| last6 = Hugh \| first6 = TJ. \| last7 = Pavlakis \| first7 = N. \| last8 = Gill \| first8 = AJ. \| title = Skin rash, a kidney mass and a family mystery dating back to World War II. \| journal = Med J Aust \| volume = 201 \| issue = 1 \| pages = 58-60 \| month = Jul \| year = 2014 \| doi = \| PMID = 24999901 }}</ref>		**Manifestation: skin rash.<ref name=pmid24999901>{{Cite journal \| last1 = Toon \| first1 = CW. \| last2 = Hasovits \| first2 = C. \| last3 = Paik \| first3 = J. \| last4 = Field \| first4 = M. \| last5 = Chou \| first5 = A. \| last6 = Hugh \| first6 = TJ. \| last7 = Pavlakis \| first7 = N. \| last8 = Gill \| first8 = AJ. \| title = Skin rash, a kidney mass and a family mystery dating back to World War II. \| journal = Med J Aust \| volume = 201 \| issue = 1 \| pages = 58-60 \| month = Jul \| year = 2014 \| doi = \| PMID = 24999901 }}</ref>
	**Involvement may be minimal or extensive.~~<ref name=pmid16597677/>~~		**Involvement may be minimal or extensive.
	*[[Hereditary leiomyomatosis and renal cell carcinoma syndrome-associated renal cell carcinoma]].		*[[Hereditary leiomyomatosis and renal cell carcinoma syndrome-associated renal cell carcinoma]].
	**Often aggressive and significant cause of mortality.<ref name=pmid24441663>{{Cite journal \| last1 = Chen \| first1 = YB. \| last2 = Brannon \| first2 = AR. \| last3 = Toubaji \| first3 = A. \| last4 = Dudas \| first4 = ME. \| last5 = Won \| first5 = HH. \| last6 = Al-Ahmadie \| first6 = HA. \| last7 = Fine \| first7 = SW. \| last8 = Gopalan \| first8 = A. \| last9 = Frizzell \| first9 = N. \| title = Hereditary leiomyomatosis and renal cell carcinoma syndrome-associated renal cancer: recognition of the syndrome by pathologic features and the utility of detecting aberrant succination by immunohistochemistry. \| journal = Am J Surg Pathol \| volume = 38 \| issue = 5 \| pages = 627-37 \| month = May \| year = 2014 \| doi = 10.1097/PAS.0000000000000163 \| PMID = 24441663 }}</ref>		**Often aggressive and significant cause of mortality.<ref name=pmid24441663>{{Cite journal \| last1 = Chen \| first1 = YB. \| last2 = Brannon \| first2 = AR. \| last3 = Toubaji \| first3 = A. \| last4 = Dudas \| first4 = ME. \| last5 = Won \| first5 = HH. \| last6 = Al-Ahmadie \| first6 = HA. \| last7 = Fine \| first7 = SW. \| last8 = Gopalan \| first8 = A. \| last9 = Frizzell \| first9 = N. \| title = Hereditary leiomyomatosis and renal cell carcinoma syndrome-associated renal cancer: recognition of the syndrome by pathologic features and the utility of detecting aberrant succination by immunohistochemistry. \| journal = Am J Surg Pathol \| volume = 38 \| issue = 5 \| pages = 627-37 \| month = May \| year = 2014 \| doi = 10.1097/PAS.0000000000000163 \| PMID = 24441663 }}</ref>

Michael: /* General */ fix ref

2017-11-15T06:45:52Z

General: fix ref

← Older revision		Revision as of 06:45, 15 November 2017
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	==General==		==General==
	*Autosomal dominant inheritance<ref name=pmid17895761>{{Cite journal \| last1 = Merino \| first1 = MJ. \| last2 = Torres-Cabala \| first2 = C. \| last3 = Pinto \| first3 = P. \| last4 = Linehan \| first4 = WM. \| title = The morphologic spectrum of kidney tumors in hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome. \| journal = Am J Surg Pathol \| volume = 31 \| issue = 10 \| pages = 1578-85 \| month = Oct \| year = 2007 \| doi = 10.1097/PAS.0b013e31804375b8 \| PMID = 17895761 }}</ref> with variable penetration.<ref name=pmid24309325>{{Cite journal \| last1 = Reyes \| first1 = C. \| last2 = Karamurzin \| first2 = Y. \| last3 = Frizzell \| first3 = N. \| last4 = Garg \| first4 = K. \| last5 = Nonaka \| first5 = D. \| last6 = Chen \| first6 = YB. \| last7 = Soslow \| first7 = RA. \| title = Uterine smooth muscle tumors with features suggesting fumarate hydratase aberration: detailed morphologic analysis and correlation with S-(2-succino)-cysteine immunohistochemistry. \| journal = Mod Pathol \| volume = 27 \| issue = 7 \| pages = 1020-7 \| month = Jul \| year = 2014 \| doi = 10.1038/modpathol.2013.215 \| PMID = 24309325 }}</ref>		*Autosomal dominant inheritance<ref name=pmid17895761>{{Cite journal \| last1 = Merino \| first1 = MJ. \| last2 = Torres-Cabala \| first2 = C. \| last3 = Pinto \| first3 = P. \| last4 = Linehan \| first4 = WM. \| title = The morphologic spectrum of kidney tumors in hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome. \| journal = Am J Surg Pathol \| volume = 31 \| issue = 10 \| pages = 1578-85 \| month = Oct \| year = 2007 \| doi = 10.1097/PAS.0b013e31804375b8 \| PMID = 17895761 }}</ref> with variable penetration.<ref name=pmid24309325>{{Cite journal \| last1 = Reyes \| first1 = C. \| last2 = Karamurzin \| first2 = Y. \| last3 = Frizzell \| first3 = N. \| last4 = Garg \| first4 = K. \| last5 = Nonaka \| first5 = D. \| last6 = Chen \| first6 = YB. \| last7 = Soslow \| first7 = RA. \| title = Uterine smooth muscle tumors with features suggesting fumarate hydratase aberration: detailed morphologic analysis and correlation with S-(2-succino)-cysteine immunohistochemistry. \| journal = Mod Pathol \| volume = 27 \| issue = 7 \| pages = 1020-7 \| month = Jul \| year = 2014 \| doi = 10.1038/modpathol.2013.215 \| PMID = 24309325 }}</ref>
	**In one series of 21 families: 62% had renal cancer, 76% had cutaneous leiomyomas and 100% had [[uterine leiomyoma]]s.<ref name=~~pmid16597677~~>{{Cite journal \| last1 = ~~Pithukpakorn~~ \| first1 = M. \| last2 = ~~Wei~~ \| first2 = MH. \| last3 = ~~Toure~~ \| first3 = O. \| last4 = ~~Steinbach~~ \| first4 = PJ. \| last5 = ~~Glenn~~ \| first5 = GM. \| last6 = ~~Zbar~~ \| first6 = B. \| last7 = ~~Linehan~~ \| first7 = WM. \| last8 = ~~Toro~~ \| first8 = JR. \| title = ~~Fumarate hydratase enzyme activity~~ in ~~lymphoblastoid cells~~ and ~~fibroblasts~~ of ~~individuals~~ in families with hereditary leiomyomatosis and renal cell cancer. \| journal = J Med Genet \| volume = 43 \| issue = 9 \| pages = ~~755~~-62 \| month = ~~Sep~~ \| year = 2006 \| doi = 10.1136/jmg.~~2006~~.~~041087~~ \| PMID = ~~16597677~~ }}</ref>		**In one series of 21 families: 62% had renal cancer, 76% had cutaneous leiomyomas and 100% had [[uterine leiomyoma]]s.<ref name=pmid15937070>{{Cite journal \| last1 = Wei \| first1 = MH. \| last2 = Toure \| first2 = O. \| last3 = Glenn \| first3 = GM. \| last4 = Pithukpakorn \| first4 = M. \| last5 = Neckers \| first5 = L. \| last6 = Stolle \| first6 = C. \| last7 = Choyke \| first7 = P. \| last8 = Grubb \| first8 = R. \| last9 = Middelton \| first9 = L. \| title = Novel mutations in FH and expansion of the spectrum of phenotypes expressed in families with hereditary leiomyomatosis and renal cell cancer. \| journal = J Med Genet \| volume = 43 \| issue = 1 \| pages = 18-27 \| month = Jan \| year = 2006 \| doi = 10.1136/jmg.2005.033506 \| PMID = 15937070 }}</ref>

	Features - clinical:		Features - clinical:

Michael: /* Formal criteria */

2017-11-15T06:11:06Z

Formal criteria

← Older revision		Revision as of 06:11, 15 November 2017
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	==Formal criteria==		==Formal criteria==
	The diagnosis of the HLRCC syndrome requires ~~that~~:<ref>{{Cite journal \| last1 = Adam \| first1 = MP. \| last2 = Ardinger \| first2 = HH. \| last3 = Pagon \| first3 = RA. \| last4 = Wallace \| first4 = SE. \| last5 = Bean \| first5 = LJH. \| last6 = Mefford \| first6 = HC. \| last7 = Stephens \| first7 = K. \| last8 = Amemiya \| first8 = A. \| last9 = Ledbetter \| first9 = N. \| title = Hereditary Leiomyomatosis and Renal Cell Cancer \| journal = \| volume = \| issue = \| pages = \| month = \| year = \| doi = \| PMID = 20301430 }}</ref>		The diagnosis of the HLRCC syndrome requires both #1 and #2:<ref>{{Cite journal \| last1 = Adam \| first1 = MP. \| last2 = Ardinger \| first2 = HH. \| last3 = Pagon \| first3 = RA. \| last4 = Wallace \| first4 = SE. \| last5 = Bean \| first5 = LJH. \| last6 = Mefford \| first6 = HC. \| last7 = Stephens \| first7 = K. \| last8 = Amemiya \| first8 = A. \| last9 = Ledbetter \| first9 = N. \| title = Hereditary Leiomyomatosis and Renal Cell Cancer \| journal = \| volume = \| issue = \| pages = \| month = \| year = \| doi = \| PMID = 20301430 }}</ref>
	#A pathogenic FH mutation is present by molecular testing.		#A pathogenic FH mutation is present by molecular testing.
	#One of the following (pathologic) findings:		#One of the following (pathologic) findings:

Michael: /* Formal criteria */

2017-11-15T06:10:50Z

Formal criteria

← Older revision		Revision as of 06:10, 15 November 2017
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	#*Multiple cutaneous leiomyoma where one was proven histologically.		#*Multiple cutaneous leiomyoma where one was proven histologically.
	#*One cutaneous leiomyoma in the context of a family history of HRLCC.		#*One cutaneous leiomyoma in the context of a family history of HRLCC.
	#*RCC with a morphology suggestive of HRLCC syndrome-associated RCC		#*RCC with a morphology suggestive of HRLCC syndrome-associated RCC.

	==General==		==General==