Hemophagocytic syndrome - Revision history

Michael at 00:50, 16 July 2015

2015-07-16T00:50:33Z

← Older revision		Revision as of 00:50, 16 July 2015
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	\| Symptoms =		\| Symptoms =
	\| Prevalence = rare		\| Prevalence = rare
	\| Bloodwork = +/-EBV serology, +/-HIV serology		\| Bloodwork = +/-EBV serology (secondary form), +/-HIV serology (secondary form)
	\| Rads =		\| Rads =
	\| Endoscopy =		\| Endoscopy =

2015-07-16T00:49:59Z

tweak

← Older revision		Revision as of 00:49, 16 July 2015
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	\| Symptoms =		\| Symptoms =
	\| Prevalence = rare		\| Prevalence = rare
	\| Bloodwork = +/-EBV serology		\| Bloodwork = +/-EBV serology, +/-HIV serology
	\| Rads =		\| Rads =
	\| Endoscopy =		\| Endoscopy =

2015-07-14T06:04:40Z

← Older revision		Revision as of 06:04, 14 July 2015
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	\| Synonyms =		\| Synonyms =
	\| Micro = macrophages containing erythrocytes (red blood cells), leukocytes, platelets		\| Micro = macrophages containing erythrocytes (red blood cells), leukocytes, platelets
	\| Subtypes = primary, secondary		\| Subtypes = primary, secondary
	\| LMDDx = overlapping cells, [[emperipolesis]]		\| LMDDx = overlapping cells, [[emperipolesis]]
	\| Stains =		\| Stains =

2015-07-14T06:02:51Z

← Older revision		Revision as of 06:02, 14 July 2015
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	\| Symptoms =		\| Symptoms =
	\| Prevalence = rare		\| Prevalence = rare
	\| Bloodwork =		\| Bloodwork = +/-EBV serology
	\| Rads =		\| Rads =
	\| Endoscopy =		\| Endoscopy =
	\| Prognosis = dependent on underlying cause		\| Prognosis = dependent on underlying cause
	\| Other =		\| Other =
	\| ClinDDx =		\| ClinDDx = malignancy
	\| Tx =		\| Tx = dependent on underlying cause
	}}		}}
	'''Hemophagocytic syndrome''', also known as '''hemophagocytic lymphohistiocytosis''', is a rare condition often associated with viral infections.		'''Hemophagocytic syndrome''', also known as '''hemophagocytic lymphohistiocytosis''', is a rare condition often associated with viral infections.

2015-07-14T06:00:47Z

← Older revision		Revision as of 06:00, 14 July 2015
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	\| IHC =		\| IHC =
	\| EM =		\| EM =
	\| Molecular = ~~primary form:~~ FHL1 mutation or FHL2 mutation~~; autosomal recessive~~		\| Molecular = FHL1 mutation or FHL2 mutation in primary form
	\| IF =		\| IF =
	\| Gross =		\| Gross =
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	\| Assdx = only in ''secondary'' form (EBV infection, malignancy, rheumatologic disease)		\| Assdx = only in ''secondary'' form (EBV infection, malignancy, rheumatologic disease)
	\| Syndromes =		\| Syndromes =
	\| Clinicalhx = +/-consanguinity for ''primary'' form		\| Clinicalhx = +/-consanguinity for ''primary'' form (autosomal recessive)
	\| Signs = fever, [[splenomegaly]], jaundice		\| Signs = fever, [[splenomegaly]], jaundice
	\| Symptoms =		\| Symptoms =

2015-07-14T05:59:25Z

← Older revision		Revision as of 05:59, 14 July 2015
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	\| IHC =		\| IHC =
	\| EM =		\| EM =
	\| Molecular =		\| Molecular = primary form: FHL1 mutation or FHL2 mutation; autosomal recessive
	\| IF =		\| IF =
	\| Gross =		\| Gross =
	\| Grossing =		\| Grossing =
	\| Site = [[lymph nodes]], [[liver]], [[spleen]], [[bone marrow]], others		\| Site = [[lymph nodes]], [[liver]], [[spleen]], [[bone marrow]], others
	\| Assdx = only in ''secondary'' (EBV infection, malignancy, rheumatologic disease)		\| Assdx = only in ''secondary'' form (EBV infection, malignancy, rheumatologic disease)
	\| Syndromes =		\| Syndromes =
	\| Clinicalhx = +/-consanguinity for ''primary''		\| Clinicalhx = +/-consanguinity for ''primary'' form
	\| Signs = fever, [[splenomegaly]], jaundice		\| Signs = fever, [[splenomegaly]], jaundice
	\| Symptoms =		\| Symptoms =

2015-07-14T05:57:36Z

← Older revision		Revision as of 05:57, 14 July 2015
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	\| Assdx = only in ''secondary'' (EBV infection, malignancy, rheumatologic disease)		\| Assdx = only in ''secondary'' (EBV infection, malignancy, rheumatologic disease)
	\| Syndromes =		\| Syndromes =
	\| Clinicalhx =		\| Clinicalhx = +/-consanguinity for ''primary''
	\| Signs = fever, [[splenomegaly]], jaundice		\| Signs = fever, [[splenomegaly]], jaundice
	\| Symptoms =		\| Symptoms =

2015-07-14T05:56:12Z

tweak

← Older revision		Revision as of 05:56, 14 July 2015
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	\| Synonyms =		\| Synonyms =
	\| Micro = macrophages containing erythrocytes (red blood cells), leukocytes, platelets		\| Micro = macrophages containing erythrocytes (red blood cells), leukocytes, platelets
	\| Subtypes =		\| Subtypes = primary, secondary
	\| LMDDx = overlapping cells, [[emperipolesis]]		\| LMDDx = overlapping cells, [[emperipolesis]]
	\| Stains =		\| Stains =
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	\| Gross =		\| Gross =
	\| Grossing =		\| Grossing =
	\| Site =		\| Site = [[lymph nodes]], [[liver]], [[spleen]], [[bone marrow]], others
	\| Assdx =		\| Assdx = only in ''secondary'' (EBV infection, malignancy, rheumatologic disease)
	\| Syndromes =		\| Syndromes =
	\| Clinicalhx =		\| Clinicalhx =
	\| Signs =		\| Signs = fever, [[splenomegaly]], jaundice
	\| Symptoms =		\| Symptoms =
	\| Prevalence = rare		\| Prevalence = rare
	\| Bloodwork =		\| Bloodwork =

2015-07-14T05:52:18Z

Microscopic

← Older revision		Revision as of 05:52, 14 July 2015
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	DDx:		DDx:
	*Overlapping cells (red blood cells overlapping macrophages).		*Overlapping cells (red blood cells overlapping macrophages).
	*[[Emperipolesis]].		*[[Emperipolesis]] in the context of other pathology.

	===Images===		===Images===

2015-07-14T05:52:01Z

redirect

← Older revision		Revision as of 05:52, 14 July 2015
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Hemophagocytic_syndrome_-_cropped_-_very_high_mag.jpg
			\| Width =
			\| Caption = Micrograph showing phagocytosed RBCs in hemophagocytic syndrome. [[H&E stain]].
			\| Synonyms =
			\| Micro = macrophages containing erythrocytes (red blood cells), leukocytes, platelets
			\| Subtypes =
			\| LMDDx = overlapping cells, [[emperipolesis]]
			\| Stains =
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site =
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms =
			\| Prevalence = rare
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = dependent on underlying cause
			\| Other =
			\| ClinDDx =
			\| Tx =
			}}
	'''Hemophagocytic syndrome''', also known as '''hemophagocytic lymphohistiocytosis''', is a rare condition often associated with viral infections.		'''Hemophagocytic syndrome''', also known as '''hemophagocytic lymphohistiocytosis''', is a rare condition often associated with viral infections.

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	Features:<ref name=pmid11076718/>		Features:<ref name=pmid11076718/>
	*Macrophages with phagocytosed:		*Macrophages with phagocytosed:
	**~~Erythrocytes~~.		**[[Erythrocyte]]s.
	**Leukocytes.		**Leukocytes.
	**Platelets.		**Platelets.

			DDx:
			*Overlapping cells (red blood cells overlapping macrophages).
			*[[Emperipolesis]].

	===Images===		===Images===