Hemangioblastoma - Revision history

Michael at 13:57, 19 March 2025

2025-03-19T13:57:30Z

← Older revision		Revision as of 13:57, 19 March 2025
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	*[[Von Hippel-Lindau disease]].		*[[Von Hippel-Lindau disease]].
	*[[Neuropathology tumours]].		*[[Neuropathology tumours]].
			*[[Hemangioblastoma of the kidney]].

	==References==		==References==

Jensflorian: update + pictures

2015-05-22T07:48:29Z

update + pictures

← Older revision		Revision as of 07:48, 22 May 2015
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image = ~~Cerebellar_hemangioblastoma_high_mag~~.jpg		\| Image = Hemangioblastoma Histology HE.jpg
	\| Width =		\| Width =
	\| Caption = Cerebellar hemangioblastoma.		\| Caption = Cerebellar hemangioblastoma.
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	==General==		==General==
	*Usually ''cerebellar''.		*Usually ''cerebellar''.
			**occassionally brainstem or spinal cord. Supratentorial tumors are exceptionally rare.
			*Typically in adults.<ref>{{Cite journal \| last1 = Kassardjian \| first1 = CD. \| last2 = Macdonald \| first2 = RL. \| last3 = Munoz \| first3 = DG. \| title = Hemangioblastomas in the elderly: epidemiology and clinical characteristics. \| journal = J Clin Neurosci \| volume = 21 \| issue = 7 \| pages = 1205-8 \| month = Jul \| year = 2014 \| doi = 10.1016/j.jocn.2013.10.023 \| PMID = 24629394 }}</ref>
	*Associated with [[von Hippel-Lindau syndrome]].		*Associated with [[von Hippel-Lindau syndrome]].
	*WHO grade I.<ref>URL: [http://www.expertconsultbook.com/expertconsult/ob/book.do?method=display&type=bookPage&decorator=none&eid=4-u1.0-B978-1-4160-4580-9..00019-8--sc0155&isbn=978-1-4160-4580-9 http://www.expertconsultbook.com/expertconsult/ob/book.do?method=display&type=bookPage&decorator=none&eid=4-u1.0-B978-1-4160-4580-9..00019-8--sc0155&isbn=978-1-4160-4580-9]. Accessed on: 9 December 2010.</ref>		*Symptomatic when CSF flow is impaired.
			*WHO grade I (ICD-O: 9161/1).<ref>URL: [http://www.expertconsultbook.com/expertconsult/ob/book.do?method=display&type=bookPage&decorator=none&eid=4-u1.0-B978-1-4160-4580-9..00019-8--sc0155&isbn=978-1-4160-4580-9 http://www.expertconsultbook.com/expertconsult/ob/book.do?method=display&type=bookPage&decorator=none&eid=4-u1.0-B978-1-4160-4580-9..00019-8--sc0155&isbn=978-1-4160-4580-9]. Accessed on: 9 December 2010.</ref>

			==Macroscopy==
			*Red to yellow nodules, highly vascularized.
			*75% are cystic tumors.
			**Peripheral solid portion.


	==Microscopic==		==Microscopic==
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	**Hyperchromatic nuclei.		**Hyperchromatic nuclei.
	**Vacuolar cytoplasm.		**Vacuolar cytoplasm.
			*Occassionally extensive sclerosis.

			Note:
			*Based on the stromal content, some classify the tumors as "cellular" and "reticular".<ref>{{Cite journal \| last1 = Hasselblatt \| first1 = M. \| last2 = Jeibmann \| first2 = A. \| last3 = Gerss \| first3 = J. \| last4 = Behrens \| first4 = C. \| last5 = Rama \| first5 = B. \| last6 = Wassmann \| first6 = H. \| last7 = Paulus \| first7 = W. \| title = Cellular and reticular variants of haemangioblastoma revisited: a clinicopathologic study of 88 cases. \| journal = Neuropathol Appl Neurobiol \| volume = 31 \| issue = 6 \| pages = 618-22 \| month = Dec \| year = 2005 \| doi = 10.1111/j.1365-2990.2005.00669.x \| PMID = 16281910 }}</ref>


	DDx:		DDx:
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	Image:Cerebellar_hemangioblastoma_high_mag.jpg \| Hemangioblastoma - high mag. (WC)		Image:Cerebellar_hemangioblastoma_high_mag.jpg \| Hemangioblastoma - high mag. (WC)
	Image:Hemangioblastoma_-_nse_-_intermed_mag.jpg \| Hemangioblastoma - NSE - intermed. mag. (WC)		Image:Hemangioblastoma_-_nse_-_intermed_mag.jpg \| Hemangioblastoma - NSE - intermed. mag. (WC)
			File:Hemangioblastoma - nse - high mag.jpg \| Hemangioblastoma - NSE - high mag. (WC)
			File:Hemangioblastoma Histology CD31.jpg \| Hemangioblastoma - CD31. (WC/marvin101)
			File:Hippel Lindau.gif \| Hemangioblastomas in Hippel-Lindau disease (PlosONE).
	</gallery>		</gallery>
	www:		www:
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	*NSE +ve (nucleus + cytoplasm).		*NSE +ve (nucleus + cytoplasm).
	**RCC typically -ve.		**RCC typically -ve.
			*CK -ve.

	==See also==		==See also==

Michael at 02:30, 22 December 2013

2013-12-22T02:30:22Z

← Older revision		Revision as of 02:30, 22 December 2013
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	\| Micro = vascular tumour with large polygonal stromal cells with hyperchromatic nuclei and vacuolar cytoplasm		\| Micro = vascular tumour with large polygonal stromal cells with hyperchromatic nuclei and vacuolar cytoplasm
	\| Subtypes =		\| Subtypes =
	\| LMDDx = metastatic [[~~cell~~ cell renal cell carcinoma]]		\| LMDDx = metastatic [[clear cell renal cell carcinoma]]
	\| Stains =		\| Stains =
	\| IHC = alpha-inhibin +ve, NSE +ve, EMA -ve		\| IHC = alpha-inhibin +ve, NSE +ve, EMA -ve

Michael: split-out

2013-12-22T02:30:02Z

split-out

← Older revision		Revision as of 02:30, 22 December 2013
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Cerebellar_hemangioblastoma_high_mag.jpg
			\| Width =
			\| Caption = Cerebellar hemangioblastoma.
			\| Synonyms =
			\| Micro = vascular tumour with large polygonal stromal cells with hyperchromatic nuclei and vacuolar cytoplasm
			\| Subtypes =
			\| LMDDx = metastatic [[cell cell renal cell carcinoma]]
			\| Stains =
			\| IHC = alpha-inhibin +ve, NSE +ve, EMA -ve
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = brain - usu. [[cerebellum]]
			\| Assdx =
			\| Syndromes = [[von Hippel-Lindau disease]]
			\| Clinicalhx =
			\| Signs =
			\| Symptoms =
			\| Prevalence =
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = good (WHO grade I)
			\| Other =
			\| ClinDDx =
			\| Tx =
			}}
	'''Hemangioblastoma''' is a low grade [[brain tumour]] tumour typically found the [[cerebellum]].		'''Hemangioblastoma''' is a low grade [[brain tumour]] tumour typically found the [[cerebellum]].

Michael: more

2013-12-22T02:26:46Z

← Older revision		Revision as of 02:26, 22 December 2013
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	~~#redirect~~ [[Neuropathology tumours~~#Hemangioblastoma~~]]		'''Hemangioblastoma''' is a low grade [[brain tumour]] tumour typically found the [[cerebellum]].

			==General==
			*Usually ''cerebellar''.
			*Associated with [[von Hippel-Lindau syndrome]].
			*WHO grade I.<ref>URL: [http://www.expertconsultbook.com/expertconsult/ob/book.do?method=display&type=bookPage&decorator=none&eid=4-u1.0-B978-1-4160-4580-9..00019-8--sc0155&isbn=978-1-4160-4580-9 http://www.expertconsultbook.com/expertconsult/ob/book.do?method=display&type=bookPage&decorator=none&eid=4-u1.0-B978-1-4160-4580-9..00019-8--sc0155&isbn=978-1-4160-4580-9]. Accessed on: 9 December 2010.</ref>

			==Microscopic==
			Features:<ref>URL: [http://emedicine.medscape.com/article/340994-media http://emedicine.medscape.com/article/340994-media]. Accessed on: 23 June 2010.</ref>
			*Vascular.
			*Polygonal stromal cells with:
			**Hyperchromatic nuclei.
			**Vacuolar cytoplasm.

			DDx:
			*Metastatic [[clear cell renal cell carcinoma]].

			===Images===
			<gallery>
			Image:Cerebellar_hemangioblastoma_intermed_mag.jpg \| Hemangioblastoma - intermed. mag. (WC)
			Image:Cerebellar_hemangioblastoma_high_mag.jpg \| Hemangioblastoma - high mag. (WC)
			Image:Hemangioblastoma_-_nse_-_intermed_mag.jpg \| Hemangioblastoma - NSE - intermed. mag. (WC)
			</gallery>
			www:
			*[http://path.upmc.edu/cases/case342.html Hemangioblastoma - several images (upmc.edu)].

			==IHC==
			Features:<ref>URL: [http://www.nature.com/modpathol/journal/v18/n6/full/3800351a.html http://www.nature.com/modpathol/journal/v18/n6/full/3800351a.html]. Accessed on: 9 December 2010.</ref>
			*Alpha-inhibin +ve (cytoplasm).
			*EMA -ve.
			**RCC typically +ve.
			*NSE +ve (nucleus + cytoplasm).
			**RCC typically -ve.

			==See also==
			*[[Von Hippel-Lindau disease]].
			*[[Neuropathology tumours]].

			==References==
			{{Reflist\|2}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Neuropathology tumours]]

Michael: redirect

2011-10-18T04:03:50Z

redirect

New page

#redirect [[Neuropathology tumours#Hemangioblastoma]]

[[Category:Diagnosis]]