Hairy cell leukemia - Revision history

Michael: vauthors

2021-03-25T17:22:27Z

vauthors

← Older revision		Revision as of 17:22, 25 March 2021
Line 43:		Line 43:
	*Annexin A1 +ve (only useful in heavy bone marrow infiltration as it is also positive in T-cells and granulopoietic cells)		*Annexin A1 +ve (only useful in heavy bone marrow infiltration as it is also positive in T-cells and granulopoietic cells)
	*TRAP - tartrate-resistant acid phosphatase (historically histochemically, now immunohistochemically)		*TRAP - tartrate-resistant acid phosphatase (historically histochemically, now immunohistochemically)
	*[[HBME1]]<ref name=pmid24092261>{{cite journal \|~~vauthors~~=Krenács L, Tóth-Lipták J, Demeter J, Piukovics K, Borbényi Z, Gogolák P, Sári E, Bagdi E \|title=Monoclonal antibody HBME-1 reacts with a minor subset of B cells with villous surface and can be useful in the diagnosis of hairy cell leukemia and other indolent lymphoproliferations of villous B lymphocytes \|journal=Virchows Arch. \|volume=463 \|issue=6 \|pages=787–94 \|date=December 2013 \|pmid=24092261 \|doi=10.1007/s00428-013-1490-5 \|url=}}</ref>		*[[HBME1]]<ref name=pmid24092261>{{cite journal \|authors=Krenács L, Tóth-Lipták J, Demeter J, Piukovics K, Borbényi Z, Gogolák P, Sári E, Bagdi E \|title=Monoclonal antibody HBME-1 reacts with a minor subset of B cells with villous surface and can be useful in the diagnosis of hairy cell leukemia and other indolent lymphoproliferations of villous B lymphocytes \|journal=Virchows Arch. \|volume=463 \|issue=6 \|pages=787–94 \|date=December 2013 \|pmid=24092261 \|doi=10.1007/s00428-013-1490-5 \|url=}}</ref>
	*BRAF V600E mutation-specific antibody		*BRAF V600E mutation-specific antibody
	*CD5 -ve.		*CD5 -ve.

Mark: other IHC

2020-08-02T20:38:45Z

other IHC

← Older revision		Revision as of 20:38, 2 August 2020
Line 42:		Line 42:
	*CD20 +ve, CD11c+ve, CD25 +ve, CD103 +ve, CD123 +ve, cyclin D1 +ve, DBA44 +ve		*CD20 +ve, CD11c+ve, CD25 +ve, CD103 +ve, CD123 +ve, cyclin D1 +ve, DBA44 +ve
	*Annexin A1 +ve (only useful in heavy bone marrow infiltration as it is also positive in T-cells and granulopoietic cells)		*Annexin A1 +ve (only useful in heavy bone marrow infiltration as it is also positive in T-cells and granulopoietic cells)
			*TRAP - tartrate-resistant acid phosphatase (historically histochemically, now immunohistochemically)
			*[[HBME1]]<ref name=pmid24092261>{{cite journal \|vauthors=Krenács L, Tóth-Lipták J, Demeter J, Piukovics K, Borbényi Z, Gogolák P, Sári E, Bagdi E \|title=Monoclonal antibody HBME-1 reacts with a minor subset of B cells with villous surface and can be useful in the diagnosis of hairy cell leukemia and other indolent lymphoproliferations of villous B lymphocytes \|journal=Virchows Arch. \|volume=463 \|issue=6 \|pages=787–94 \|date=December 2013 \|pmid=24092261 \|doi=10.1007/s00428-013-1490-5 \|url=}}</ref>
	*BRAF V600E mutation-specific antibody		*BRAF V600E mutation-specific antibody
	*CD5 -ve.		*CD5 -ve.

Michael: tweak format

2018-06-17T18:26:00Z

tweak format

← Older revision		Revision as of 18:26, 17 June 2018
Line 10:		Line 10:
	*Good prognosis (with treatment), though (likely) not curable.		*Good prognosis (with treatment), though (likely) not curable.

	===Gross===		==Gross==
	Features:<ref name=Ref_PCPBoD8_326>{{Ref PCPBoD8\|326}}</ref>		Features:<ref name=Ref_PCPBoD8_326>{{Ref PCPBoD8\|326}}</ref>
	*Huge beefy red [[spleen]].		*Huge beefy red [[spleen]].
	**Red as white pulp obliterated.		**Red as white pulp obliterated.

	===Microscopic===		==Microscopic==
	Features:<ref>URL: [http://emedicine.medscape.com/article/200580-diagnosis http://emedicine.medscape.com/article/200580-diagnosis]. Accessed on: 18 August 2010.</ref>		Features:<ref>URL: [http://emedicine.medscape.com/article/200580-diagnosis http://emedicine.medscape.com/article/200580-diagnosis]. Accessed on: 18 August 2010.</ref>
	*Small cells (10-20 micrometers) with "Fried egg"-like appearance:		*Small cells (10-20 micrometers) with "Fried egg"-like appearance:
Line 26:		Line 26:
	*[[Hepatosplenic T-cell lymphoma]].		*[[Hepatosplenic T-cell lymphoma]].

	====Images====		===Images===
	<gallery>		<gallery>
	Image:Hairy_cell_leukemia.jpg \| HCL - blood film. (WC)		Image:Hairy_cell_leukemia.jpg \| HCL - blood film. (WC)
Line 38:		Line 38:
	*[http://webpathology.com/image.asp?case=380&n=3 HCL in the spleen (webpathology.com)].		*[http://webpathology.com/image.asp?case=380&n=3 HCL in the spleen (webpathology.com)].

	===IHC===		==IHC==
	Features:<ref>URL: [http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022&rendertype=table&id=A34029 http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022&rendertype=table&id=A34029]. Accessed on: 20 August 2010.</ref>		Features:<ref>URL: [http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022&rendertype=table&id=A34029 http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022&rendertype=table&id=A34029]. Accessed on: 20 August 2010.</ref>
	*CD20 +ve, CD11c+ve, CD25 +ve, CD103 +ve, CD123 +ve, cyclin D1 +ve, DBA44 +ve		*CD20 +ve, CD11c+ve, CD25 +ve, CD103 +ve, CD123 +ve, cyclin D1 +ve, DBA44 +ve
Line 48:		Line 48:
	*CD19 +ve, CD11c +ve, FMC7 +ve.		*CD19 +ve, CD11c +ve, FMC7 +ve.

	===References===		==See also==
			*[[Small cell lymphomas]].

			==References==
	{{Reflist}}		{{Reflist}}

	[[Category: Haematopathology]]		[[Category: Haematopathology]]

Mark: BRAF and references

2018-06-16T21:12:07Z

BRAF and references

← Older revision		Revision as of 21:12, 16 June 2018
Line 1:		Line 1:
	[[File:Bone marrow infiltration by hairy cell leukaemia.jpg\|thumb\|High power magnification of a bone marrow trephine showing infiltration by hairy cell leukaemia.]]		[[File:Bone marrow infiltration by hairy cell leukaemia.jpg\|thumb\|High power magnification of a bone marrow trephine showing infiltration by hairy cell leukaemia.]]
	Indolent B-cell neoplasm, abbreviated ''HCL''. Named for the appearances on peripheral blood smears.		Indolent B-cell neoplasm, abbreviated ''HCL''. Named for the appearances on peripheral blood smears. The vast majority (>95%) harbour the BRAF V600E mutation.<ref name=pmid25992240>{{Cite journal \| last1 = Ahmadzadeh \| first1 = A. \| last2 = Shahrabi \| first2 = S. \| last3 = Jaseb \| first3 = K. \| last4 = Norozi \| first4 = F. \| last5 = Shahjahani \| first5 = M. \| last6 = Vosoughi \| first6 = T. \| last7 = Hajizamani \| first7 = S. \| last8 = Saki \| first8 = N. \| title = BRAF Mutation in Hairy Cell Leukemia. \| journal = Oncol Rev \| volume = 8 \| issue = 2 \| pages = 253 \| month = Sep \| year = 2014 \| doi = 10.4081/oncol.2014.253 \| PMID = 25992240 }}</ref> Mutations in other parts of the BRAF gene are described, but rare.<ref name=pmid24433452>{{Cite journal \| last1 = Tschernitz \| first1 = S. \| last2 = Flossbach \| first2 = L. \| last3 = Bonengel \| first3 = M. \| last4 = Roth \| first4 = S. \| last5 = Rosenwald \| first5 = A. \| last6 = Geissinger \| first6 = E. \| title = Alternative BRAF mutations in BRAF V600E-negative hairy cell leukaemias. \| journal = Br J Haematol \| volume = 165 \| issue = 4 \| pages = 529-33 \| month = May \| year = 2014 \| doi = 10.1111/bjh.12735 \| PMID = 24433452 }}</ref>

	*Due to the ~~biology~~, ''dry taps'' ~~are common~~.<ref name=pmid22499303>{{Cite journal \| last1 = Galani \| first1 = KS. \| last2 = Subramanian \| first2 = PG. \| last3 = Gadage \| first3 = VS. \| last4 = Rahman \| first4 = K. \| last5 = Ashok Kumar \| first5 = MS. \| last6 = Shinde \| first6 = S. \| last7 = Mahadik \| first7 = S. \| last8 = Ansari \| first8 = R. \| last9 = Sengar \| first9 = M. \| title = Clinico-pathological profile of Hairy cell leukemia: critical insights gained at a tertiary care cancer hospital. \| journal = Indian J Pathol Microbiol \| volume = 55 \| issue = 1 \| pages = 61-5 \| month = \| year = \| doi = 10.4103/0377-4929.94858 \| PMID = 22499303 }}</ref>		In the bone marrow, they are associated with heavy reticulin fibrosis, commonly resulting in ''dry taps''.<ref name=pmid22499303>{{Cite journal \| last1 = Galani \| first1 = KS. \| last2 = Subramanian \| first2 = PG. \| last3 = Gadage \| first3 = VS. \| last4 = Rahman \| first4 = K. \| last5 = Ashok Kumar \| first5 = MS. \| last6 = Shinde \| first6 = S. \| last7 = Mahadik \| first7 = S. \| last8 = Ansari \| first8 = R. \| last9 = Sengar \| first9 = M. \| title = Clinico-pathological profile of Hairy cell leukemia: critical insights gained at a tertiary care cancer hospital. \| journal = Indian J Pathol Microbiol \| volume = 55 \| issue = 1 \| pages = 61-5 \| month = \| year = \| doi = 10.4103/0377-4929.94858 \| PMID = 22499303 }}</ref>

	Clinical:<ref>URL: [http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022 http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022]. Accessed on: 20 August 2010.</ref>		Clinical:<ref>URL: [http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022 http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022]. Accessed on: 20 August 2010.</ref>
Line 41:		Line 41:
	Features:<ref>URL: [http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022&rendertype=table&id=A34029 http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022&rendertype=table&id=A34029]. Accessed on: 20 August 2010.</ref>		Features:<ref>URL: [http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022&rendertype=table&id=A34029 http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022&rendertype=table&id=A34029]. Accessed on: 20 August 2010.</ref>
	*CD20 +ve, CD11c+ve, CD25 +ve, CD103 +ve, CD123 +ve, cyclin D1 +ve, DBA44 +ve		*CD20 +ve, CD11c+ve, CD25 +ve, CD103 +ve, CD123 +ve, cyclin D1 +ve, DBA44 +ve
			*Annexin A1 +ve (only useful in heavy bone marrow infiltration as it is also positive in T-cells and granulopoietic cells)
			*BRAF V600E mutation-specific antibody
	*CD5 -ve.		*CD5 -ve.

	Flow cytometry:		Flow cytometry:
	*CD19 +ve, CD11c +ve, FMC7 +ve.		*CD19 +ve, CD11c +ve, FMC7 +ve.

			===References===
			{{Reflist}}

			[[Category: Haematopathology]]

Mark: expand IHC panel

2018-06-16T20:56:48Z

expand IHC panel

← Older revision		Revision as of 20:56, 16 June 2018
Line 1:		Line 1:
	~~#redirect~~ [[~~Small_cell_lymphomas#Hairy_cell_leukemia~~]]		[[File:Bone marrow infiltration by hairy cell leukaemia.jpg\|thumb\|High power magnification of a bone marrow trephine showing infiltration by hairy cell leukaemia.]]
			Indolent B-cell neoplasm, abbreviated ''HCL''. Named for the appearances on peripheral blood smears.

	[[~~Category~~:~~Diagnosis~~]]		*Due to the biology, ''dry taps'' are common.<ref name=pmid22499303>{{Cite journal \| last1 = Galani \| first1 = KS. \| last2 = Subramanian \| first2 = PG. \| last3 = Gadage \| first3 = VS. \| last4 = Rahman \| first4 = K. \| last5 = Ashok Kumar \| first5 = MS. \| last6 = Shinde \| first6 = S. \| last7 = Mahadik \| first7 = S. \| last8 = Ansari \| first8 = R. \| last9 = Sengar \| first9 = M. \| title = Clinico-pathological profile of Hairy cell leukemia: critical insights gained at a tertiary care cancer hospital. \| journal = Indian J Pathol Microbiol \| volume = 55 \| issue = 1 \| pages = 61-5 \| month = \| year = \| doi = 10.4103/0377-4929.94858 \| PMID = 22499303 }}</ref>

			Clinical:<ref>URL: [http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022 http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022]. Accessed on: 20 August 2010.</ref>
			*Pancytopenia. Monocytopenia common in earlier disease.
			*Splenic enlargement.
			*No lymphadenopathy.
			*Good prognosis (with treatment), though (likely) not curable.

			===Gross===
			Features:<ref name=Ref_PCPBoD8_326>{{Ref PCPBoD8\|326}}</ref>
			*Huge beefy red [[spleen]].
			**Red as white pulp obliterated.

			===Microscopic===
			Features:<ref>URL: [http://emedicine.medscape.com/article/200580-diagnosis http://emedicine.medscape.com/article/200580-diagnosis]. Accessed on: 18 August 2010.</ref>
			*Small cells (10-20 micrometers) with "Fried egg"-like appearance:
			**Well-demarcated fuzzy cell borders,
			**Clear/whispy cytoplasm and,
			**Central round nucleus.
			***Peri-nuclear clearing ("water-clear rim"<ref>URL: [http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022 http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022]. Accessed on: 20 August 2010.</ref>) -- '''key feature'''.

			DDx:
			*[[Hepatosplenic T-cell lymphoma]].

			====Images====
			<gallery>
			Image:Hairy_cell_leukemia.jpg \| HCL - blood film. (WC)
			Image:Hairy cell leukemia - high mag.jpg \| HCL - high mag. (WC)
			Image:Hairy_cell_leukemia_-_very_high_mag.jpg \| HCL - very high mag. (WC)
			</gallery>
			www:
			*[http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022&rendertype=figure&id=A34027 HCL - bone marrow (nlm.nih.gov)] from [http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022 Holland-Frei Cancer Medicine (nlm.nih.gov)].
			*[http://path.upmc.edu/cases/case240.html HCL - several images (upmc.edu)].
			*[http://path.upmc.edu/cases/case691.html HCL - another case with several images (upmc.edu)].
			*[http://webpathology.com/image.asp?case=380&n=3 HCL in the spleen (webpathology.com)].

			===IHC===
			Features:<ref>URL: [http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022&rendertype=table&id=A34029 http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022&rendertype=table&id=A34029]. Accessed on: 20 August 2010.</ref>
			*CD20 +ve, CD11c+ve, CD25 +ve, CD103 +ve, CD123 +ve, cyclin D1 +ve, DBA44 +ve
			*CD5 -ve.

			Flow cytometry:
			*CD19 +ve, CD11c +ve, FMC7 +ve.

Michael: +cat.

2011-10-18T04:26:53Z

+cat.

← Older revision		Revision as of 04:26, 18 October 2011
Line 1:		Line 1:
	#redirect [[Small_cell_lymphomas#Hairy_cell_leukemia]]		#redirect [[Small_cell_lymphomas#Hairy_cell_leukemia]]

			[[Category:Diagnosis]]

Michael: redirect

2010-09-02T05:17:26Z

redirect

New page

#redirect [[Small_cell_lymphomas#Hairy_cell_leukemia]]