Hürthle cell neoplasm - Revision history

Michael: /* Adenoma versus carcinoma */

2016-02-17T14:04:47Z

Adenoma versus carcinoma

← Older revision		Revision as of 14:04, 17 February 2016
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	**Adenomas usu. <3 cm.		**Adenomas usu. <3 cm.
	Definite for carcinoma:<ref name=pmid9697901/>		Definite for carcinoma:<ref name=pmid9697901/>
	*Lymphovascular invasion.		*[[Lymphovascular invasion]].
	*Capsular invasion.		*Capsular invasion.

Michael at 05:21, 13 January 2016

2016-01-13T05:21:57Z

← Older revision		Revision as of 05:21, 13 January 2016
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			[[Image:Hurthle cell carcinoma -- very high mag.jpg\|thumb\|right\|300px\|Micrograph showing a (metastatic) Hürthle cell carcinoma. [[H&E stain]].]]
	'''Hürthle cell neoplasm''' is a rare tumour of the [[thyroid gland]] that can have a benign or malignant behaviour. They are generally considered a subset of [[follicular neoplasm]],<ref name=pmid26530486>{{Cite journal \| last1 = Wei \| first1 = S. \| last2 = LiVolsi \| first2 = VA. \| last3 = Montone \| first3 = KT. \| last4 = Morrissette \| first4 = JJ. \| last5 = Baloch \| first5 = ZW. \| title = PTEN and TP53 Mutations in Oncocytic Follicular Carcinoma. \| journal = Endocr Pathol \| volume = 26 \| issue = 4 \| pages = 365-9 \| month = Dec \| year = 2015 \| doi = 10.1007/s12022-015-9403-6 \| PMID = 26530486 }}</ref><ref name=pmid24753500>{{Cite journal \| last1 = Ustun \| first1 = B. \| last2 = Chhieng \| first2 = D. \| last3 = Van Dyke \| first3 = A. \| last4 = Carling \| first4 = T. \| last5 = Holt \| first5 = E. \| last6 = Udelsman \| first6 = R. \| last7 = Adeniran \| first7 = AJ. \| title = Risk stratification in follicular neoplasm: a cytological assessment using the modified Bethesda classification. \| journal = Cancer Cytopathol \| volume = 122 \| issue = 7 \| pages = 536-45 \| month = Jul \| year = 2014 \| doi = 10.1002/cncy.21425 \| PMID = 24753500 }}</ref> which includes [[follicular thyroid carcinoma]] and [[follicular thyroid adenoma]].		'''Hürthle cell neoplasm''' is a rare tumour of the [[thyroid gland]] that can have a benign or malignant behaviour. They are generally considered a subset of [[follicular neoplasm]],<ref name=pmid26530486>{{Cite journal \| last1 = Wei \| first1 = S. \| last2 = LiVolsi \| first2 = VA. \| last3 = Montone \| first3 = KT. \| last4 = Morrissette \| first4 = JJ. \| last5 = Baloch \| first5 = ZW. \| title = PTEN and TP53 Mutations in Oncocytic Follicular Carcinoma. \| journal = Endocr Pathol \| volume = 26 \| issue = 4 \| pages = 365-9 \| month = Dec \| year = 2015 \| doi = 10.1007/s12022-015-9403-6 \| PMID = 26530486 }}</ref><ref name=pmid24753500>{{Cite journal \| last1 = Ustun \| first1 = B. \| last2 = Chhieng \| first2 = D. \| last3 = Van Dyke \| first3 = A. \| last4 = Carling \| first4 = T. \| last5 = Holt \| first5 = E. \| last6 = Udelsman \| first6 = R. \| last7 = Adeniran \| first7 = AJ. \| title = Risk stratification in follicular neoplasm: a cytological assessment using the modified Bethesda classification. \| journal = Cancer Cytopathol \| volume = 122 \| issue = 7 \| pages = 536-45 \| month = Jul \| year = 2014 \| doi = 10.1002/cncy.21425 \| PMID = 24753500 }}</ref> which includes [[follicular thyroid carcinoma]] and [[follicular thyroid adenoma]].

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	*Medullary thyroid carcinoma oncocytic variant.		*Medullary thyroid carcinoma oncocytic variant.
	*Others.		*Others.

			===Images===
			<gallery>
			Image: Hurthle cell carcinoma -- intermed mag.jpg \| HCC - intermed. mag. (WC)
			Image: Hurthle cell carcinoma -- high mag.jpg \| HCC - high mag. (WC)
			Image: Hurthle cell carcinoma -- very high mag.jpg \| HCC - very high mag. (WC)
			Image: Hurthle cell carcinoma - atl -- very high mag.jpg \| HCC - very high mag. (WC)
			</gallery>

	==IHC==		==IHC==

Michael: /* See also */

2015-12-21T18:09:33Z

Michael at 18:09, 21 December 2015

2015-12-21T18:09:14Z

← Older revision		Revision as of 18:09, 21 December 2015
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	'''Hürthle cell neoplasm''' is a rare tumour of the [[thyroid gland]] that can have a benign or malignant behaviour.		'''Hürthle cell neoplasm''' is a rare tumour of the [[thyroid gland]] that can have a benign or malignant behaviour. They are generally considered a subset of [[follicular neoplasm]],<ref name=pmid26530486>{{Cite journal \| last1 = Wei \| first1 = S. \| last2 = LiVolsi \| first2 = VA. \| last3 = Montone \| first3 = KT. \| last4 = Morrissette \| first4 = JJ. \| last5 = Baloch \| first5 = ZW. \| title = PTEN and TP53 Mutations in Oncocytic Follicular Carcinoma. \| journal = Endocr Pathol \| volume = 26 \| issue = 4 \| pages = 365-9 \| month = Dec \| year = 2015 \| doi = 10.1007/s12022-015-9403-6 \| PMID = 26530486 }}</ref><ref name=pmid24753500>{{Cite journal \| last1 = Ustun \| first1 = B. \| last2 = Chhieng \| first2 = D. \| last3 = Van Dyke \| first3 = A. \| last4 = Carling \| first4 = T. \| last5 = Holt \| first5 = E. \| last6 = Udelsman \| first6 = R. \| last7 = Adeniran \| first7 = AJ. \| title = Risk stratification in follicular neoplasm: a cytological assessment using the modified Bethesda classification. \| journal = Cancer Cytopathol \| volume = 122 \| issue = 7 \| pages = 536-45 \| month = Jul \| year = 2014 \| doi = 10.1002/cncy.21425 \| PMID = 24753500 }}</ref> which includes [[follicular thyroid carcinoma]] and [[follicular thyroid adenoma]].

	It may be referred to as ''[[oncocytic neoplasm]]''. They are generally considered a subset of [[follicular neoplasm]],<ref name=pmid26530486>{{Cite journal \| last1 = Wei \| first1 = S. \| last2 = LiVolsi \| first2 = VA. \| last3 = Montone \| first3 = KT. \| last4 = Morrissette \| first4 = JJ. \| last5 = Baloch \| first5 = ZW. \| title = PTEN and TP53 Mutations in Oncocytic Follicular Carcinoma. \| journal = Endocr Pathol \| volume = 26 \| issue = 4 \| pages = 365-9 \| month = Dec \| year = 2015 \| doi = 10.1007/s12022-015-9403-6 \| PMID = 26530486 }}</ref><ref name=pmid24753500>{{Cite journal \| last1 = Ustun \| first1 = B. \| last2 = Chhieng \| first2 = D. \| last3 = Van Dyke \| first3 = A. \| last4 = Carling \| first4 = T. \| last5 = Holt \| first5 = E. \| last6 = Udelsman \| first6 = R. \| last7 = Adeniran \| first7 = AJ. \| title = Risk stratification in follicular neoplasm: a cytological assessment using the modified Bethesda classification. \| journal = Cancer Cytopathol \| volume = 122 \| issue = 7 \| pages = 536-45 \| month = Jul \| year = 2014 \| doi = 10.1002/cncy.21425 \| PMID = 24753500 }}</ref> which includes [[follicular thyroid carcinoma]] and [[follicular thyroid adenoma]].		It may be referred to as ''[[oncocytic neoplasm]]''.

	'''Hürthle cell carcinoma''' and '''Hürthle cell adenoma''' redirect to here.		'''Hürthle cell carcinoma''' and '''Hürthle cell adenoma''' redirect to here.

Michael at 18:08, 21 December 2015

2015-12-21T18:08:20Z

← Older revision		Revision as of 18:08, 21 December 2015
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	'''Hürthle cell neoplasm''' is a rare tumour of the [[thyroid gland]] that can have a benign or malignant behaviour.		'''Hürthle cell neoplasm''' is a rare tumour of the [[thyroid gland]] that can have a benign or malignant behaviour.

	It may be referred to as ''[[oncocytic neoplasm]]''.		It may be referred to as ''[[oncocytic neoplasm]]''. They are generally considered a subset of [[follicular neoplasm]],<ref name=pmid26530486>{{Cite journal \| last1 = Wei \| first1 = S. \| last2 = LiVolsi \| first2 = VA. \| last3 = Montone \| first3 = KT. \| last4 = Morrissette \| first4 = JJ. \| last5 = Baloch \| first5 = ZW. \| title = PTEN and TP53 Mutations in Oncocytic Follicular Carcinoma. \| journal = Endocr Pathol \| volume = 26 \| issue = 4 \| pages = 365-9 \| month = Dec \| year = 2015 \| doi = 10.1007/s12022-015-9403-6 \| PMID = 26530486 }}</ref><ref name=pmid24753500>{{Cite journal \| last1 = Ustun \| first1 = B. \| last2 = Chhieng \| first2 = D. \| last3 = Van Dyke \| first3 = A. \| last4 = Carling \| first4 = T. \| last5 = Holt \| first5 = E. \| last6 = Udelsman \| first6 = R. \| last7 = Adeniran \| first7 = AJ. \| title = Risk stratification in follicular neoplasm: a cytological assessment using the modified Bethesda classification. \| journal = Cancer Cytopathol \| volume = 122 \| issue = 7 \| pages = 536-45 \| month = Jul \| year = 2014 \| doi = 10.1002/cncy.21425 \| PMID = 24753500 }}</ref> which includes [[follicular thyroid carcinoma]] and [[follicular thyroid adenoma]].

	'''Hürthle cell carcinoma''' and '''Hürthle cell adenoma''' redirect to here.		'''Hürthle cell carcinoma''' and '''Hürthle cell adenoma''' redirect to here.

	==General==		==General==
	*Incidence: uncommon.		*Incidence: uncommon.

Michael: /* Risk of malignancy by tumour size */

2015-12-18T22:13:29Z

Risk of malignancy by tumour size

← Older revision		Revision as of 22:13, 18 December 2015
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	====Risk of malignancy by tumour size====		====Risk of malignancy by tumour size====
	Risk of malignancy by size:<ref name=pmid9563543>{{Cite journal \| last1 = Chen \| first1 = H. \| last2 = Nicol \| first2 = TL. \| last3 = Zeiger \| first3 = MA. \| last4 = Dooley \| first4 = WC. \| last5 = Ladenson \| first5 = PW. \| last6 = Cooper \| first6 = DS. \| last7 = Ringel \| first7 = M. \| last8 = Parkerson \| first8 = S. \| last9 = Allo \| first9 = M. \| title = Hürthle cell neoplasms of the thyroid: are there factors predictive of malignancy? \| journal = Ann Surg \| volume = 227 \| issue = 4 \| pages = 542-6 \| month = Apr \| year = 1998 \| doi = \| PMID = 9563543 }}</ref>		Risk of malignancy by size - based on a series of 57 cases:<ref name=pmid9563543>{{Cite journal \| last1 = Chen \| first1 = H. \| last2 = Nicol \| first2 = TL. \| last3 = Zeiger \| first3 = MA. \| last4 = Dooley \| first4 = WC. \| last5 = Ladenson \| first5 = PW. \| last6 = Cooper \| first6 = DS. \| last7 = Ringel \| first7 = M. \| last8 = Parkerson \| first8 = S. \| last9 = Allo \| first9 = M. \| title = Hürthle cell neoplasms of the thyroid: are there factors predictive of malignancy? \| journal = Ann Surg \| volume = 227 \| issue = 4 \| pages = 542-6 \| month = Apr \| year = 1998 \| doi = \| PMID = 9563543 }}</ref>
	{\| class="wikitable sortable"		{\| class="wikitable sortable"
	!Size		!Size

Michael: /* Risk of malignancy by tumour size */

2015-12-18T22:12:29Z

Risk of malignancy by tumour size

← Older revision		Revision as of 22:12, 18 December 2015
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	====Risk of malignancy by tumour size====		====Risk of malignancy by tumour size====
	Risk of malignancy by size:<ref name=pmid9563543></ref>		Risk of malignancy by size:<ref name=pmid9563543>{{Cite journal \| last1 = Chen \| first1 = H. \| last2 = Nicol \| first2 = TL. \| last3 = Zeiger \| first3 = MA. \| last4 = Dooley \| first4 = WC. \| last5 = Ladenson \| first5 = PW. \| last6 = Cooper \| first6 = DS. \| last7 = Ringel \| first7 = M. \| last8 = Parkerson \| first8 = S. \| last9 = Allo \| first9 = M. \| title = Hürthle cell neoplasms of the thyroid: are there factors predictive of malignancy? \| journal = Ann Surg \| volume = 227 \| issue = 4 \| pages = 542-6 \| month = Apr \| year = 1998 \| doi = \| PMID = 9563543 }}</ref>
	{\| class="wikitable sortable"		{\| class="wikitable sortable"
	!Size		!Size

Michael: /* Risk of malignancy by tumour size */

2015-12-18T22:11:50Z

Risk of malignancy by tumour size

← Older revision		Revision as of 22:11, 18 December 2015
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	{\| class="wikitable sortable"		{\| class="wikitable sortable"
	!Size		!Size
	!Percentage malignant		!Percentage<br>malignant
	\|-		\|-
	\| <=1 cm		\| <=1 cm
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	\|-		\|-
	\| 1-4 cm		\| 1-4 cm
	\| 23% ~~malignant~~		\| 23%
	\|-		\|-
	\| >4 cm		\| >4 cm

Michael: /* Adenoma versus carcinoma */

2015-12-18T22:11:31Z

Adenoma versus carcinoma

← Older revision		Revision as of 22:11, 18 December 2015
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	Suggestive for carcinoma:<ref name=pmid9697901/>		Suggestive for carcinoma:<ref name=pmid9697901/>
	*Male.		*Male.
	*>4 cm		*>4 cm.
	**Adenomas usu. <3 cm.		**Adenomas usu. <3 cm.
	Definite for carcinoma:<ref name=pmid9697901/>		Definite for carcinoma:<ref name=pmid9697901/>
	*Lymphovascular invasion.		*Lymphovascular invasion.
	*Capsular invasion.		*Capsular invasion.

			====Risk of malignancy by tumour size====
			Risk of malignancy by size:<ref name=pmid9563543></ref>
			{\| class="wikitable sortable"
			!Size
			!Percentage malignant
			\|-
			\| <=1 cm
			\| 17%
			\|-
			\|-
			\| 1-4 cm
			\| 23% malignant
			\|-
			\| >4 cm
			\| 65%
			\|}

	==Gross==		==Gross==

Michael: /* Gross */

2015-12-15T04:56:44Z

Gross

← Older revision		Revision as of 04:56, 15 December 2015
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	*Capsular invasion.		*Capsular invasion.

	===Gross===		==Gross==
	*Yellow.		*Yellow.
	*Encapsulated.		*Encapsulated.

← Older revision		Revision as of 18:09, 21 December 2015
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	*[[Thyroid gland]].		*[[Thyroid gland]].
	*[[Oncocytoma]].		*[[Oncocytoma]].
			*[[Follicular neoplasm]].

	==References==		==References==