Granuloma annulare - Revision history

Michael: tweak

2022-10-06T12:26:53Z

tweak

← Older revision		Revision as of 12:26, 6 October 2022
Line 14:		Line 14:
	\| Gross = usu. arms and hands, papules		\| Gross = usu. arms and hands, papules
	\| Grossing =		\| Grossing =
	\| Site = [[skin]]		\| Site = [[skin]] - esp. antecubital fossae
	\| Assdx =		\| Assdx =
	\| Syndromes =		\| Syndromes =
Line 33:		Line 33:
	*Benign and self-limited condition.		*Benign and self-limited condition.
	*Etiology unknown - may be assoc. with trauma.<ref name=Ref_Derm51>{{Ref Derm\|51}}</ref>		*Etiology unknown - may be assoc. with trauma.<ref name=Ref_Derm51>{{Ref Derm\|51}}</ref>
			**Associations: trauma, infections, diabetes mellitus, dyslipidemia, thyroid disease, malignancy, medications.<ref name=pmid32941717>{{cite journal \|authors=Fox JD, Aramin H, Ghiam N, Freedman JB, Romanelli P \|title=Secukinumab-associated localized granuloma annulare (SAGA): a case report and review of the literature \|journal=Dermatol Online J \|volume=26 \|issue=8 \|pages= \|date=August 2020 \|pmid=32941717 \|doi= \|url=}}</ref>
	*A deep GA can mimic a [[rheumatoid nodule]]; may be called a ''pseudorheumatoid nodule''.<ref>{{Cite journal \| last1 = Barzilai \| first1 = A. \| last2 = Huszar \| first2 = M. \| last3 = Shpiro \| first3 = D. \| last4 = Nass \| first4 = D. \| last5 = Trau \| first5 = H. \| title = Pseudorheumatoid nodules in adults: a juxta-articular form of nodular granuloma annulare. \| journal = Am J Dermatopathol \| volume = 27 \| issue = 1 \| pages = 1-5 \| month = Feb \| year = 2005 \| doi = \| PMID = 15677968 }}</ref>		*A deep GA can mimic a [[rheumatoid nodule]]; may be called a ''pseudorheumatoid nodule''.<ref>{{Cite journal \| last1 = Barzilai \| first1 = A. \| last2 = Huszar \| first2 = M. \| last3 = Shpiro \| first3 = D. \| last4 = Nass \| first4 = D. \| last5 = Trau \| first5 = H. \| title = Pseudorheumatoid nodules in adults: a juxta-articular form of nodular granuloma annulare. \| journal = Am J Dermatopathol \| volume = 27 \| issue = 1 \| pages = 1-5 \| month = Feb \| year = 2005 \| doi = \| PMID = 15677968 }}</ref>

Line 42:		Line 43:
	Image:Granuloma_annulare.jpg \| Granuloma annulare. (WC)		Image:Granuloma_annulare.jpg \| Granuloma annulare. (WC)
	</gallery>		</gallery>

			==Gross==
			*Antecubital fossae.<ref name=pmid32941717/>

	==Microscopic==		==Microscopic==

Michael: /* References */

2015-02-15T07:08:20Z

References

← Older revision		Revision as of 07:08, 15 February 2015
Line 116:		Line 116:

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Dermatopathology]]

Michael: rm spaces

2014-06-24T17:10:05Z

rm spaces

← Older revision		Revision as of 17:10, 24 June 2014
Line 28:		Line 28:
	\| ClinDDx =		\| ClinDDx =
	}}		}}


	'''Granuloma annulare''' is relatively uncommon problem in [[dermatopathology]].		'''Granuloma annulare''' is relatively uncommon problem in [[dermatopathology]].

Michael: /* Microscopic */

2013-12-07T03:28:05Z

Microscopic

← Older revision		Revision as of 03:28, 7 December 2013
Line 64:		Line 64:
	*[[Rheumatoid nodule]] - has fibrin in the core of the granuloma (instead of mucin), multinucleated macrophages more common.<ref name=Ref_Derm52-3>{{Ref Derm\|52-3}}</ref>		*[[Rheumatoid nodule]] - has fibrin in the core of the granuloma (instead of mucin), multinucleated macrophages more common.<ref name=Ref_Derm52-3>{{Ref Derm\|52-3}}</ref>
	*[[Epithelioid sarcoma]] - esp. if the lesion appears to be mid-to-deep dermis.		*[[Epithelioid sarcoma]] - esp. if the lesion appears to be mid-to-deep dermis.
			*Tattoo reaction (granuloma annulare-like) - case report.<ref>{{Cite journal \| last1 = Bagwan \| first1 = IN. \| last2 = Walker \| first2 = M. \| last3 = Theaker \| first3 = JM. \| title = Granuloma annulare-like tattoo reaction. \| journal = J Cutan Pathol \| volume = 34 \| issue = 10 \| pages = 804-5 \| month = Oct \| year = 2007 \| doi = 10.1111/j.1600-0560.2006.00666.x \| PMID = 17880589 }}</ref>

	===Images===		===Images===

Michael at 16:29, 28 November 2013

2013-11-28T16:29:29Z

← Older revision		Revision as of 16:29, 28 November 2013
Line 35:		Line 35:
	*Benign and self-limited condition.		*Benign and self-limited condition.
	*Etiology unknown - may be assoc. with trauma.<ref name=Ref_Derm51>{{Ref Derm\|51}}</ref>		*Etiology unknown - may be assoc. with trauma.<ref name=Ref_Derm51>{{Ref Derm\|51}}</ref>
			*A deep GA can mimic a [[rheumatoid nodule]]; may be called a ''pseudorheumatoid nodule''.<ref>{{Cite journal \| last1 = Barzilai \| first1 = A. \| last2 = Huszar \| first2 = M. \| last3 = Shpiro \| first3 = D. \| last4 = Nass \| first4 = D. \| last5 = Trau \| first5 = H. \| title = Pseudorheumatoid nodules in adults: a juxta-articular form of nodular granuloma annulare. \| journal = Am J Dermatopathol \| volume = 27 \| issue = 1 \| pages = 1-5 \| month = Feb \| year = 2005 \| doi = \| PMID = 15677968 }}</ref>

	==Gross==		==Gross==

Michael: /* IHC */

2013-11-28T15:57:28Z

IHC

← Older revision		Revision as of 15:57, 28 November 2013
Line 81:		Line 81:
	==IHC==		==IHC==
	*CD68 +ve.		*CD68 +ve.
	*Factor XIIIa +ve<ref name=pmid16132226>{{Cite journal \| last1 = Töröcsik \| first1 = D. \| last2 = Bárdos \| first2 = H. \| last3 = Nagy \| first3 = L. \| last4 = Adány \| first4 = R. \| title = Identification of factor XIII-A as a marker of alternative macrophage activation. \| journal = Cell Mol Life Sci \| volume = 62 \| issue = 18 \| pages = 2132-9 \| month = Sep \| year = 2005 \| doi = 10.1007/s00018-005-5242-9 \| PMID = 16132226 }}</ref> - nuclear.<ref name=pmid11372678>{{Cite journal \| last1 = Adány \| first1 = R. \| last2 = Bárdos \| first2 = H. \| last3 = Antal \| first3 = M. \| last4 = Módis \| first4 = L. \| last5 = Sárváry \| first5 = A. \| last6 = Szücs \| first6 = S. \| last7 = Balogh \| first7 = I. \| title = Factor XIII of blood coagulation as a nuclear crosslinking enzyme. \| journal = Thromb Haemost \| volume = 85 \| issue = 5 \| pages = 845-51 \| month = May \| year = 2001 \| doi = \| PMID = 11372678 }}</ref>		*Factor XIIIa +ve<ref name=pmid16132226>{{Cite journal \| last1 = Töröcsik \| first1 = D. \| last2 = Bárdos \| first2 = H. \| last3 = Nagy \| first3 = L. \| last4 = Adány \| first4 = R. \| title = Identification of factor XIII-A as a marker of alternative macrophage activation. \| journal = Cell Mol Life Sci \| volume = 62 \| issue = 18 \| pages = 2132-9 \| month = Sep \| year = 2005 \| doi = 10.1007/s00018-005-5242-9 \| PMID = 16132226 }}</ref> -- nuclear.<ref name=pmid11372678>{{Cite journal \| last1 = Adány \| first1 = R. \| last2 = Bárdos \| first2 = H. \| last3 = Antal \| first3 = M. \| last4 = Módis \| first4 = L. \| last5 = Sárváry \| first5 = A. \| last6 = Szücs \| first6 = S. \| last7 = Balogh \| first7 = I. \| title = Factor XIII of blood coagulation as a nuclear crosslinking enzyme. \| journal = Thromb Haemost \| volume = 85 \| issue = 5 \| pages = 845-51 \| month = May \| year = 2001 \| doi = \| PMID = 11372678 }}</ref>

	Note:		Note:

Michael: /* Stains */

2013-11-28T15:57:04Z

Stains

← Older revision		Revision as of 15:57, 28 November 2013
Line 78:		Line 78:
	Image:		Image:
	*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861218/figure/F7/ Granuloma annulare (nih.gov)].<ref name=pmid20523767>{{Cite journal \| last1 = Yun \| first1 = JH. \| last2 = Lee \| first2 = JY. \| last3 = Kim \| first3 = MK. \| last4 = Seo \| first4 = YJ. \| last5 = Kim \| first5 = MH. \| last6 = Cho \| first6 = KH. \| last7 = Kim \| first7 = MB. \| last8 = Lee \| first8 = WS. \| last9 = Lee \| first9 = KH. \| title = Clinical and pathological features of generalized granuloma annulare with their correlation: a retrospective multicenter study in Korea. \| journal = Ann Dermatol \| volume = 21 \| issue = 2 \| pages = 113-9 \| month = May \| year = 2009 \| doi = 10.5021/ad.2009.21.2.113 \| PMID = 20523767 \| PMC = 2861218 }}</ref>		*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861218/figure/F7/ Granuloma annulare (nih.gov)].<ref name=pmid20523767>{{Cite journal \| last1 = Yun \| first1 = JH. \| last2 = Lee \| first2 = JY. \| last3 = Kim \| first3 = MK. \| last4 = Seo \| first4 = YJ. \| last5 = Kim \| first5 = MH. \| last6 = Cho \| first6 = KH. \| last7 = Kim \| first7 = MB. \| last8 = Lee \| first8 = WS. \| last9 = Lee \| first9 = KH. \| title = Clinical and pathological features of generalized granuloma annulare with their correlation: a retrospective multicenter study in Korea. \| journal = Ann Dermatol \| volume = 21 \| issue = 2 \| pages = 113-9 \| month = May \| year = 2009 \| doi = 10.5021/ad.2009.21.2.113 \| PMID = 20523767 \| PMC = 2861218 }}</ref>

			==IHC==
			*CD68 +ve.
			*Factor XIIIa +ve<ref name=pmid16132226>{{Cite journal \| last1 = Töröcsik \| first1 = D. \| last2 = Bárdos \| first2 = H. \| last3 = Nagy \| first3 = L. \| last4 = Adány \| first4 = R. \| title = Identification of factor XIII-A as a marker of alternative macrophage activation. \| journal = Cell Mol Life Sci \| volume = 62 \| issue = 18 \| pages = 2132-9 \| month = Sep \| year = 2005 \| doi = 10.1007/s00018-005-5242-9 \| PMID = 16132226 }}</ref> - nuclear.<ref name=pmid11372678>{{Cite journal \| last1 = Adány \| first1 = R. \| last2 = Bárdos \| first2 = H. \| last3 = Antal \| first3 = M. \| last4 = Módis \| first4 = L. \| last5 = Sárváry \| first5 = A. \| last6 = Szücs \| first6 = S. \| last7 = Balogh \| first7 = I. \| title = Factor XIII of blood coagulation as a nuclear crosslinking enzyme. \| journal = Thromb Haemost \| volume = 85 \| issue = 5 \| pages = 845-51 \| month = May \| year = 2001 \| doi = \| PMID = 11372678 }}</ref>

			Note:
			*Not routinely used.

	==Sign out==		==Sign out==

Michael: /* Micro */

2013-08-07T08:21:07Z

Micro

← Older revision		Revision as of 08:21, 7 August 2013
Line 97:		Line 97:

	===Micro===		===Micro===
	The sections show superficial palisading granuloma with cores of necrobiotic collagen and ~~scant~~ mucin. ~~No plasma~~ cells are apparent.		The sections show hair bearing skin with superficial palisading granuloma with cores of necrobiotic collagen and mucin. Plasma cells are not apparent in association with the lesion.

	The overlying epidermis ~~is unremarkable~~.		The overlying epidermis matures normally to the surface and has no basal atypia.

	==See also==		==See also==

Michael: /* Sign out */ +micro

2013-08-06T17:14:41Z

Sign out: +micro

← Older revision		Revision as of 17:14, 6 August 2013
Line 95:		Line 95:
	however, plasma cells are not apparent. The differential diagnosis is rheumatoid nodule.		however, plasma cells are not apparent. The differential diagnosis is rheumatoid nodule.
	</pre>		</pre>

			===Micro===
			The sections show superficial palisading granuloma with cores of necrobiotic collagen and scant mucin. No plasma cells are apparent.

			The overlying epidermis is unremarkable.

	==See also==		==See also==

Michael: /* Sign out */

2013-08-06T17:12:02Z

Sign out

← Older revision		Revision as of 17:12, 6 August 2013
Line 80:		Line 80:

	==Sign out==		==Sign out==
			<pre>
			SKIN LESION, UPPER BACK, PUNCH BIOPSY:
			- SUPERFICIAL PALISADING GRANULOMAS WITH CORES OF NECROBIOTIC COLLAGEN, AND SCANT
			MUCIN; CONSISTENT WITH GRANULOMA ANNULARE.
			</pre>

	<pre>		<pre>
	Skin lesion, left elbow, excision:		Skin lesion, left elbow, excision: