Granular cell tumour - Revision history

Michael at 19:21, 24 April 2024

2024-04-24T19:21:24Z

← Older revision		Revision as of 19:21, 24 April 2024
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	==General==		==General==
			*A nerve shealth tumour.<ref name=pmid22668577>{{cite journal \|authors=Izquierdo F, Suárez-Vilela D, Honrado E \|title=Perineurial cells in granular cell tumors and neoplasms with perineural invasion: an immunohistochemical study \|journal=Am J Dermatopathol \|volume=34 \|issue=8 \|pages=800–9 \|date=December 2012 \|pmid=22668577 \|doi=10.1097/DAD.0b013e31824ba93b \|url=}}</ref>
	*Rare.		*Rare.
	*Usually benign.		*Usually benign.

Michael at 18:52, 22 April 2024

2024-04-22T18:52:14Z

← Older revision		Revision as of 18:52, 22 April 2024
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	*Vimentin +ve (membranous).		*Vimentin +ve (membranous).
	*Calretinin +ve (90-95%).<ref name=pmid12579997>{{Cite journal \| last1 = Fine \| first1 = SW. \| last2 = Li \| first2 = M. \| title = Expression of calretinin and the alpha-subunit of inhibin in granular cell tumors. \| journal = Am J Clin Pathol \| volume = 119 \| issue = 2 \| pages = 259-64 \| month = Feb \| year = 2003 \| doi = 10.1309/GRH4-JWX6-J9J7-QQTA \| PMID = 12579997 }}</ref>		*Calretinin +ve (90-95%).<ref name=pmid12579997>{{Cite journal \| last1 = Fine \| first1 = SW. \| last2 = Li \| first2 = M. \| title = Expression of calretinin and the alpha-subunit of inhibin in granular cell tumors. \| journal = Am J Clin Pathol \| volume = 119 \| issue = 2 \| pages = 259-64 \| month = Feb \| year = 2003 \| doi = 10.1309/GRH4-JWX6-J9J7-QQTA \| PMID = 12579997 }}</ref>
			*SOX10 +ve (11 of 11 cases).<ref name=pmid37026754>{{cite journal \|authors=Malik F, Bernieh A, Saad AG \|title=Esophageal Granular Cell Tumor in Children: A Clinicopathologic Study of 11 Cases and Review of the Literature \|journal=Am J Clin Pathol \|volume=160 \|issue=1 \|pages=106–112 \|date=July 2023 \|pmid=37026754 \|doi=10.1093/ajcp/aqad025 \|url=}}</ref>

	===Images===		===Images===

Michael: /* Microscopic */

2019-03-19T01:56:05Z

Microscopic

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	***Size: 1-3 micrometers.		***Size: 1-3 micrometers.
	***Poorly demarcated (on light microscopy).		***Poorly demarcated (on light microscopy).
	*Nested architecture.		**Poorly defined cellular borders.
			*Nested architecture or syncytial growth pattern.
	*+/-Pustulo-ovoid bodies (focal eosinophilic granules surrounded by a clear halo).<ref name=pmid22760808>{{Cite journal \| last1 = Fernandes \| first1 = BF. \| last2 = Belfort Neto \| first2 = R. \| last3 = Odashiro \| first3 = AN. \| last4 = Pereira \| first4 = PR. \| last5 = Burnier \| first5 = MN. \| title = Clinical and histopathological features of orbital granular cell tumor: case report. \| journal = Arq Bras Oftalmol \| volume = 75 \| issue = 2 \| pages = 137-9 \| month = \| year = \| doi = \| PMID = 22760808 }}</ref>		*+/-Pustulo-ovoid bodies (focal eosinophilic granules surrounded by a clear halo).<ref name=pmid22760808>{{Cite journal \| last1 = Fernandes \| first1 = BF. \| last2 = Belfort Neto \| first2 = R. \| last3 = Odashiro \| first3 = AN. \| last4 = Pereira \| first4 = PR. \| last5 = Burnier \| first5 = MN. \| title = Clinical and histopathological features of orbital granular cell tumor: case report. \| journal = Arq Bras Oftalmol \| volume = 75 \| issue = 2 \| pages = 137-9 \| month = \| year = \| doi = \| PMID = 22760808 }}</ref>
	*+/-Pseudoepitheliomatous hyperplasia.		*+/-Pseudoepitheliomatous hyperplasia.

Michael: /* Special stains */

2019-03-19T01:54:10Z

Special stains

← Older revision		Revision as of 01:54, 19 March 2019
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	==Special stains==		==Special stains==
	*PAS +ve.		*PAS +ve.
			*PASD +ve (pustulo-ovoid bodies).

	==IHC==		==IHC==

Michael: /* Microscopic */

2019-03-19T01:22:41Z

Microscopic

← Older revision		Revision as of 01:22, 19 March 2019
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	***Poorly demarcated (on light microscopy).		***Poorly demarcated (on light microscopy).
	*Nested architecture.		*Nested architecture.
			*+/-Pustulo-ovoid bodies (focal eosinophilic granules surrounded by a clear halo).<ref name=pmid22760808>{{Cite journal \| last1 = Fernandes \| first1 = BF. \| last2 = Belfort Neto \| first2 = R. \| last3 = Odashiro \| first3 = AN. \| last4 = Pereira \| first4 = PR. \| last5 = Burnier \| first5 = MN. \| title = Clinical and histopathological features of orbital granular cell tumor: case report. \| journal = Arq Bras Oftalmol \| volume = 75 \| issue = 2 \| pages = 137-9 \| month = \| year = \| doi = \| PMID = 22760808 }}</ref>
	*+/-Pseudoepitheliomatous hyperplasia.		*+/-Pseudoepitheliomatous hyperplasia.
	**May mimic [[SCC]].		**May mimic [[SCC]].

Michael: /* Gross */

2015-07-22T16:16:51Z

Gross

← Older revision		Revision as of 16:16, 22 July 2015
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	*Granular cell tumour.		*Granular cell tumour.
	*[[Lipoma]].		*[[Lipoma]].
	*Xanthoma.		*[[Xanthoma]].

	==Microscopic==		==Microscopic==

Michael at 16:23, 24 June 2014

2014-06-24T16:23:41Z

← Older revision		Revision as of 16:23, 24 June 2014
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	\| Width =		\| Width =
	\| Caption = Granular cell tumour. [[H&E stain]].		\| Caption = Granular cell tumour. [[H&E stain]].
	\| Micro = cells with abundant eosinophilic granular cytoplasm (granules ~ 1-3 micrometers, poorly demarcated on LM), +/-[[pseudoepitheliomatous hyperplasia]]		\| Micro = cells (usually epithelioid) with (usually abundant) eosinophilic granular cytoplasm (granules ~ 1-3 micrometers, poorly demarcated on LM), +/-[[pseudoepitheliomatous hyperplasia]]
	\| Subtypes = benign (common), malignant (uncommon)		\| Subtypes = benign (common), malignant (uncommon)
	\| LMDDx = [[squamous cell carcinoma]], [[oncocytoma]], adjacent ulcer, [[xanthoma]], [[melanocytic nevus]] with neurotization		\| LMDDx = [[squamous cell carcinoma]], [[oncocytoma]], adjacent ulcer, [[xanthoma]], [[melanocytic nevus]] with neurotization

Michael: /* Sign out */

2014-06-24T16:21:46Z

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← Older revision		Revision as of 16:21, 24 June 2014
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	<pre>		<pre>
	SKIN LESION, NECK, EXCISION:		SKIN LESION, NECK, EXCISION:
	- ~~BENIGN~~ GRANULAR CELL TUMOUR, INCOMPLETELY EXCISED.		- GRANULAR CELL TUMOUR WITH BENIGN FEATURES, INCOMPLETELY EXCISED.

	COMMENT:		COMMENT:

Michael: /* Sign out */

2014-06-24T16:21:07Z

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← Older revision		Revision as of 16:21, 24 June 2014
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	NEGATIVE: HMB-45.		NEGATIVE: HMB-45.

	A conservative re-excision is ~~suggested~~.		A conservative re-excision is recommended.
	</pre>		</pre>

Michael: /* General */

2014-06-24T16:20:45Z

General

← Older revision		Revision as of 16:20, 24 June 2014
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	Treatment:		Treatment:
	*Complete excision.<ref>{{cite journal \|author=Toelen C, Goovaerts G, Huyghe M \|title=Granular cell tumor of the abdominal wall: case report and review of the literature \|journal=Acta Chir. Belg. \|volume=113 \|issue=5 \|pages=364–6 \|year=2013 \|pmid=24294803 \|doi= \|url=}}</ref><ref>{{cite journal \|author=Emesz M, Arlt EM, Krall EM, ''et al.'' \|title=[Granular cell tumors of the orbit : Diagnostics and therapeutic aspects exemplified by a case report.] \|journal=Ophthalmologe \|volume= \|issue= \|pages= \|year=2013 \|month=November \|pmid=24173669 \|doi=10.1007/s00347-013-2972-1 \|url=}}</ref>		*Complete excision.<ref>{{cite journal \|author=Toelen C, Goovaerts G, Huyghe M \|title=Granular cell tumor of the abdominal wall: case report and review of the literature \|journal=Acta Chir. Belg. \|volume=113 \|issue=5 \|pages=364–6 \|year=2013 \|pmid=24294803 \|doi= \|url=}}</ref><ref>{{cite journal \|author=Emesz M, Arlt EM, Krall EM, ''et al.'' \|title=[Granular cell tumors of the orbit : Diagnostics and therapeutic aspects exemplified by a case report.] \|journal=Ophthalmologe \|volume= \|issue= \|pages= \|year=2013 \|month=November \|pmid=24173669 \|doi=10.1007/s00347-013-2972-1 \|url=}}</ref>
			*Followup.<ref name=pmid24652564>{{cite journal \|author=Paksoy M, Eken M, Ayduran E, Altin G \|title=Two cases of granular cell tumors of the head and neck at different sites \|journal=Ear Nose Throat J \|volume=93 \|issue=3 \|pages=E15–7 \|year=2014 \|month=March \|pmid=24652564 \|doi= \|url=}}</ref>

	===Sites===		===Sites===