Graft-versus-host disease - Revision history

Michael: /* Microscopic (intestine) */

2021-02-11T19:03:19Z

Microscopic (intestine)

← Older revision		Revision as of 19:03, 11 February 2021
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	Notes:		Notes:
	*Neutrophils may be present.		*Neutrophils may be present.

			DDx:
			*Drug effect (mycophenolate mofetil) - cannot be distinguished from GVHD.

	====Grading<ref name=pmid20953169/>====		====Grading<ref name=pmid20953169/>====

Mark: gastric images

2018-09-30T16:29:12Z

gastric images

← Older revision		Revision as of 16:29, 30 September 2018
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	Clinical:		Clinical:
	*May present as diarrhea.		*May present as diarrhea.
	*Main DDx (clinical): infection.		*Main DDx (clinical): infection and certain drugs, especially mycophenolate

	==Microscopic==		==Microscopic==
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	Notes:		Notes:
	*Neutrophils ~~should not~~ be present.		*Neutrophils may be present.

	====Grading<ref name=pmid20953169/>====		====Grading<ref name=pmid20953169/>====
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	===Images===		===Images===
	<gallery>		<gallery>
			Image: apoptotic gastropathy intermed mag.jpg \| Consistent with gastric GvHD (need to exclude mycophenolate as an alternative cause) - intermed mag. (WC)
			Image: apoptotic gastropathy high mag.jpg \| Consistent with gastric GvHD - high mag. (WC)
	Image: Colonic graft-versus-host disease (high magnification).jpg \| Colonic GvHD - high mag. (WC)		Image: Colonic graft-versus-host disease (high magnification).jpg \| Colonic GvHD - high mag. (WC)
	Image: Skin graft versus host disease high mag 1.jpg \| Skin GvHD - high mag. (WC)		Image: Skin graft versus host disease high mag 1.jpg \| Skin GvHD - high mag. (WC)

Mark: skin images

2018-09-30T15:57:08Z

skin images

← Older revision		Revision as of 15:57, 30 September 2018
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	<gallery>		<gallery>
	Image: Colonic graft-versus-host disease (high magnification).jpg \| Colonic GvHD - high mag. (WC)		Image: Colonic graft-versus-host disease (high magnification).jpg \| Colonic GvHD - high mag. (WC)
			Image: Skin graft versus host disease high mag 1.jpg \| Skin GvHD - high mag. (WC)
			Image: Skin graft versus host disease high mag 1.jpg \| Skin GvHD - high mag. (WC)
	</gallery>		</gallery>

Mark: photomicrograph

2018-09-23T16:10:59Z

photomicrograph

← Older revision		Revision as of 16:10, 23 September 2018
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	Notes:		Notes:
	*Neutrophils should not be present.		*Neutrophils should not be present.

	~~Images:~~
	*[https://www.nature.com/articles/modpathol2010163/figures/1 GVHD grade 1-4 (nature.com)].<ref name=pmid20953169/>

	====Grading<ref name=pmid20953169/>====		====Grading<ref name=pmid20953169/>====
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	===Microscopic (liver)===		===Microscopic (liver)===
	:See: ''[[Vanishing bile duct syndrome]]''.		:See: ''[[Vanishing bile duct syndrome]]''.

			===Images===
			<gallery>
			Image: Colonic graft-versus-host disease (high magnification).jpg \| Colonic GvHD - high mag. (WC)
			</gallery>

			*[https://www.nature.com/articles/modpathol2010163/figures/1 GVHD grade 1-4 (nature.com)].<ref name=pmid20953169/>

	==See also==		==See also==

Michael: fix image ref

2018-06-20T14:58:36Z

fix image ref

← Older revision		Revision as of 14:58, 20 June 2018
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	Images:		Images:
			*[https://www.nature.com/articles/modpathol2010163/figures/1 GVHD grade 1-4 (nature.com)].<ref name=pmid20953169/>

	====Grading<ref name=pmid20953169/>====		====Grading<ref name=pmid20953169/>====

Brigitte: /* Microscopic (intestine) */

2018-06-20T13:50:58Z

Microscopic (intestine)

← Older revision		Revision as of 13:50, 20 June 2018
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	Images:		Images:
	*[http://www.nature.com/modpathol/journal/v24/n1/fig_tab/modpathol2010163f1.html#figure-title GVHD grade 1-4 (nature.com)].

	====Grading<ref name=pmid20953169/>====		====Grading<ref name=pmid20953169/>====

Michael at 19:18, 11 April 2014

2014-04-11T19:18:45Z

← Older revision		Revision as of 19:18, 11 April 2014
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	'''Graft-versus-host disease''', abbreviated as '''GVHD''', is a rare thingy seen mostly in tertiary care centres. It is a complication of [[hematopoietic stem cell transplantation]].		'''Graft-versus-host disease''', abbreviated as '''GVHD''', is a rare thingy seen mostly in tertiary care centres. It is a complication of [[hematopoietic stem cell transplantation]].

	===General===		==General==
	*Complication of hematopoietic stem cell transplantation, i.e. bone marrow transplantation (BMT).		*Complication of hematopoietic stem cell transplantation, i.e. bone marrow transplantation (BMT).
	**Affects skin, liver (bile ducts), gastrointestinal tract.<ref name=pmid15792120>{{cite journal \|author=Niino D, Nakashima M, Kondo H, ''et al.'' \|title=Correlation of donor-derived keratinocytes and severity of graft-versus-host disease (GVHD) in epidermis \|journal=Pathol. Res. Pract. \|volume=200 \|issue=11-12 \|pages=775–81 \|year=2005 \|pmid=15792120 \|doi= \|url=}}</ref><ref>{{cite journal \|author=van Dijk AM, Kessler FL, Verdonck LF, ''et al.'' \|title=Primary human keratinocytes as targets in predicting acute graft-versus-host disease following HLA-identical bone marrow transplantation \|journal=Br. J. Haematol. \|volume=111 \|issue=3 \|pages=791–6 \|year=2000 \|month=December \|pmid=11122139 \|doi= \|url=}}</ref>		**Affects skin, liver (bile ducts), gastrointestinal tract.<ref name=pmid15792120>{{cite journal \|author=Niino D, Nakashima M, Kondo H, ''et al.'' \|title=Correlation of donor-derived keratinocytes and severity of graft-versus-host disease (GVHD) in epidermis \|journal=Pathol. Res. Pract. \|volume=200 \|issue=11-12 \|pages=775–81 \|year=2005 \|pmid=15792120 \|doi= \|url=}}</ref><ref>{{cite journal \|author=van Dijk AM, Kessler FL, Verdonck LF, ''et al.'' \|title=Primary human keratinocytes as targets in predicting acute graft-versus-host disease following HLA-identical bone marrow transplantation \|journal=Br. J. Haematol. \|volume=111 \|issue=3 \|pages=791–6 \|year=2000 \|month=December \|pmid=11122139 \|doi= \|url=}}</ref>
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	*Main DDx (clinical): infection.		*Main DDx (clinical): infection.

			==Microscopic==
	===Microscopic (skin)===		===Microscopic (skin)===
	Features:<ref name=stanford>{{cite web \|url=http://surgpathcriteria.stanford.edu/transplant/skinacutegvhd/printable.html \|title=Acute Graft versus Host Disease of the Skin \|last1= \|first1= \|last2= \|first2= \|date= \|work= \|publisher= \|accessdate=January 17, 2011}}</ref>		Features:<ref name=stanford>{{cite web \|url=http://surgpathcriteria.stanford.edu/transplant/skinacutegvhd/printable.html \|title=Acute Graft versus Host Disease of the Skin \|last1= \|first1= \|last2= \|first2= \|date= \|work= \|publisher= \|accessdate=January 17, 2011}}</ref>

Michael: /* Microscopic (liver) */

2011-11-25T02:28:40Z

Microscopic (liver)

← Older revision		Revision as of 02:28, 25 November 2011
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	===Microscopic (liver)===		===Microscopic (liver)===
	:See: ''[[~~vanishing~~ bile duct syndrome]]''.		:See: ''[[Vanishing bile duct syndrome]]''.

	==See also==		==See also==

Michael: /* Microscopic (intestine) */ +live

2011-11-25T02:28:20Z

Microscopic (intestine): +live

← Older revision		Revision as of 02:28, 25 November 2011
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	Notes:		Notes:
	*Low-grade rejection is a diagnosis that requires a careful examination, i.e. it is subtle.		*Low-grade rejection is a diagnosis that requires a careful examination, i.e. it is subtle.

			===Microscopic (liver)===
			:See: ''[[vanishing bile duct syndrome]]''.

	==See also==		==See also==

Michael: /* Microscopic (skin) */

2011-09-08T01:00:55Z

Microscopic (skin)

← Older revision		Revision as of 01:00, 8 September 2011
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	===Microscopic (skin)===		===Microscopic (skin)===
	Features:<ref name=stanford>{{cite web \|url=http://surgpathcriteria.stanford.edu/transplant/skinacutegvhd/printable.html \|title=Acute Graft versus Host Disease of the Skin \|last1= \|first1= \|last2= \|first2= \|date= \|work= \|publisher= \|accessdate=January 17, 2011}}</ref>		Features:<ref name=stanford>{{cite web \|url=http://surgpathcriteria.stanford.edu/transplant/skinacutegvhd/printable.html \|title=Acute Graft versus Host Disease of the Skin \|last1= \|first1= \|last2= \|first2= \|date= \|work= \|publisher= \|accessdate=January 17, 2011}}</ref>
	#Keratinocyte apoptosis.		#Keratinocyte [[apoptosis]].
	#*Intensely eosinophilic on [[H&E]].		#*Intensely eosinophilic on [[H&E]].
	#Epidermotropic lymphocytic infiltrate = lymphocytes in the epidermis.		#Epidermotropic lymphocytic infiltrate = lymphocytes in the epidermis.