Giant cell tumour of bone - Revision history

Michael: more

2013-10-01T07:42:46Z

← Older revision		Revision as of 07:42, 1 October 2013
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	\| Syndromes =		\| Syndromes =
	\| Clinicalhx = usu. young adults (20-45 years old)		\| Clinicalhx = usu. young adults (20-45 years old)
	\| Signs =		\| Signs = +/-immobility
	\| Symptoms =		\| Symptoms = +/-pain
	\| Prevalence =		\| Prevalence = uncommon ~ 5% of primary bone tumours
	\| Bloodwork =		\| Bloodwork =
	\| Rads =		\| Rads =

Michael: /* See also */

2013-08-25T12:47:22Z

Michael at 12:44, 25 August 2013

2013-08-25T12:44:09Z

← Older revision		Revision as of 12:44, 25 August 2013
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	\| Gross =		\| Gross =
	\| Grossing =		\| Grossing =
	\| Site = [[bone]]		\| Site = [[bone]], epiphysis usually
	\| Assdx =		\| Assdx =
	\| Syndromes =		\| Syndromes =

Michael: tweak

2013-08-25T12:42:01Z

tweak

← Older revision		Revision as of 12:42, 25 August 2013
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	\| Assdx =		\| Assdx =
	\| Syndromes =		\| Syndromes =
	\| Clinicalhx =		\| Clinicalhx = usu. young adults (20-45 years old)
	\| Signs =		\| Signs =
	\| Symptoms =		\| Symptoms =

Michael: +infobox

2013-08-25T12:39:03Z

+infobox

← Older revision		Revision as of 12:39, 25 August 2013
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Giant_cell_tumour_of_bone_-_high_mag.jpg
			\| Width =
			\| Caption = Giant cell tumour of bone. [[H&E stain]].
			\| Micro = giant cells (usu. with >10 in the plane of section), mononuclear cells and small multinucleated cells with nuclei similar to those in the giant cells
			\| Subtypes =
			\| LMDDx = other [[giant cell lesions]]
			\| Stains =
			\| IHC = p63 +ve (patchy)
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[bone]]
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms =
			\| Prevalence =
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis =
			\| Other =
			\| ClinDDx =
			}}
	'''Giant cell tumour of bone''' is an uncommon [[bone]] tumour.		'''Giant cell tumour of bone''' is an uncommon [[bone]] tumour.

Michael: /* See also */

2013-08-25T12:33:41Z

Michael: split out

2013-08-25T12:32:03Z

split out

← Older revision		Revision as of 12:32, 25 August 2013
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	~~#redirect~~ [[Chondro-osseous tumours~~#Giant_cell_tumour_of_bone~~]]		'''Giant cell tumour of bone''' is an uncommon [[bone]] tumour.

			==General==
			Features:<ref name=Ref_WMSP648>{{Ref WMSP\|648}}</ref>
			*Approximately 5% of primary [[bone tumour]]s.
			*Typical age: 20-45 years.

			===Clinical===
			*Location: growth plate of long bones.<ref name=pmid11501745>{{Cite journal \| last1 = Wülling \| first1 = M. \| last2 = Engels \| first2 = C. \| last3 = Jesse \| first3 = N. \| last4 = Werner \| first4 = M. \| last5 = Delling \| first5 = G. \| last6 = Kaiser \| first6 = E. \| title = The nature of giant cell tumor of bone. \| journal = J Cancer Res Clin Oncol \| volume = 127 \| issue = 8 \| pages = 467-74 \| month = Aug \| year = 2001 \| doi = \| PMID = 11501745 }}</ref>
			**May present with joint pain, immobility.

			Note:
			*Several types of [[giant cell lesions\|giant cell tumours]] exist.

			==Microscopic==
			Features:<ref name=Ref_Klatt420>{{Ref Klatt\|420}}</ref>
			*Giant cells with a large number of nuclei (usu. >10 in the plane of section).
			**Usu. have [[prominent nucleoli]].
			*Mononuclear cells and small multinucleated cells with nuclei similar to those in the giant cells - '''key feature'''.
			*+/-Hemosiderin deposition - not common.<ref name=pmid1939753>{{Cite journal \| last1 = Aoki \| first1 = J. \| last2 = Moriya \| first2 = K. \| last3 = Yamashita \| first3 = K. \| last4 = Fujioka \| first4 = F. \| last5 = Ishii \| first5 = K. \| last6 = Karakida \| first6 = O. \| last7 = Imai \| first7 = S. \| last8 = Sakai \| first8 = F. \| last9 = Imai \| first9 = Y. \| title = Giant cell tumors of bone containing large amounts of hemosiderin: MR-pathologic correlation. \| journal = J Comput Assist Tomogr \| volume = 15 \| issue = 6 \| pages = 1024-7 \| month = \| year = \| doi = \| PMID = 1939753 }}</ref><ref name=pmid18554912>{{Cite journal \| last1 = Matsushige \| first1 = T. \| last2 = Nakaoka \| first2 = M. \| last3 = Yahara \| first3 = K. \| last4 = Kagawa \| first4 = K. \| last5 = Miura \| first5 = H. \| last6 = Ohnuma \| first6 = H. \| last7 = Kurisu \| first7 = K. \| title = Giant cell tumor of the temporal bone with intratumoral hemorrhage. \| journal = J Clin Neurosci \| volume = 15 \| issue = 8 \| pages = 923-7 \| month = Aug \| year = 2008 \| doi = 10.1016/j.jocn.2007.03.013 \| PMID = 18554912 }}</ref>

			Notes:
			*Giant cells typically present in abundance.

			DDx:
			*[[Giant cell lesions]].
			**[[Aneurysmal bone cyst]] - typically has spindle cells around the giant cells.

			===Images===
			<gallery>
			Image:Giant_cell_tumour_of_bone_-_low_mag.jpg \| GCT of bone - low mag. (WC)
			Image:Giant cell tumour of bone - intermed mag.jpg \| GCT of bone - intermed. mag. (WC)
			Image:Giant_cell_tumour_of_bone_-_high_mag.jpg \| GCT of bone - high mag. (WC)
			Image:Giant cell tumour of bone - very high mag.jpg \| GCT of bone - very high mag. (WC)
			</gallery>

			==IHC==
			*p63 +ve in scattered mononuclear cells.<ref name=pmid18311114>{{cite journal \|author=Dickson BC, Li SQ, Wunder JS, ''et al.'' \|title=Giant cell tumor of bone express p63 \|journal=Mod. Pathol. \|volume=21 \|issue=4 \|pages=369–75 \|year=2008 \|month=April \|pmid=18311114 \|doi=10.1038/modpathol.2008.29 \|url=}}</ref>
			**This seems to be contradicted by another paper.<ref name=pmid20012988>{{cite journal \|author=Alberghini M, Kliskey K, Krenacs T, ''et al.'' \|title=Morphological and immunophenotypic features of primary and metastatic giant cell tumour of bone \|journal=Virchows Arch. \|volume=456 \|issue=1 \|pages=97–103 \|year=2010 \|month=January \|pmid=20012988 \|doi=10.1007/s00428-009-0863-2 \|url=}}</ref>

			==See also==
			*[[Chondro-osseous tumours]].
			*[[Bone]].

			==References==
			{{Reflist\|2}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Chondro-osseous tumours]]

Michael: +cat.

2011-10-20T04:36:03Z

+cat.

← Older revision		Revision as of 04:36, 20 October 2011
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	#redirect [[Chondro-osseous tumours#Giant_cell_tumour_of_bone]]		#redirect [[Chondro-osseous tumours#Giant_cell_tumour_of_bone]]

			[[Category:Diagnosis]]

Michael: fix redirect

2011-04-14T13:14:30Z

fix redirect

← Older revision		Revision as of 13:14, 14 April 2011
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	#redirect [[~~Bone_tumours~~#Giant_cell_tumour_of_bone]]		#redirect [[Chondro-osseous tumours#Giant_cell_tumour_of_bone]]

Michael: redirect for now

2011-04-08T05:12:44Z

redirect for now

New page

#redirect [[Bone_tumours#Giant_cell_tumour_of_bone]]

← Older revision		Revision as of 12:47, 25 August 2013
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	==See also==		==See also==
			*[[Bone]].
	*[[Chondro-osseous tumours]].		*[[Chondro-osseous tumours]].
	*[[~~Bone~~]].		*[[Giant cells]].
	*[[Giant cell lesions]].		*[[Giant cell lesions]].

← Older revision		Revision as of 12:33, 25 August 2013
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	*[[Chondro-osseous tumours]].		*[[Chondro-osseous tumours]].
	*[[Bone]].		*[[Bone]].
			*[[Giant cell lesions]].

	==References==		==References==