Ganglioglioma - Revision history

Jensflorian: /* Molecular */ wikilink

2022-04-04T09:01:21Z

Molecular: wikilink

← Older revision		Revision as of 09:01, 4 April 2022
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	</ref>		</ref>
	*H3F3A wildtype.		*H3F3A wildtype.
	**DDx: consider G34-mutant ~~glioblastoma/NET~~ (rare cases may contain dysplastic ganglion cells).<ref>{{Cite journal \| last1 = Andreiuolo \| first1 = F. \| last2 = Lisner \| first2 = T. \| last3 = Zlocha \| first3 = J. \| last4 = Kramm \| first4 = C. \| last5 = Koch \| first5 = A. \| last6 = Bison \| first6 = B. \| last7 = Gareton \| first7 = A. \| last8 = Zanello \| first8 = M. \| last9 = Waha \| first9 = A. \| title = H3F3A-G34R mutant high grade neuroepithelial neoplasms with glial and dysplastic ganglion cell components. \| journal = Acta Neuropathol Commun \| volume = 7 \| issue = 1 \| pages = 78 \| month = May \| year = 2019 \| doi = 10.1186/s40478-019-0731-5 \| PMID = 31109382 }}</ref>		**DDx: consider [[Diffuse hemispheric glioma, H3 G34-mutant]] (rare cases may contain dysplastic ganglion cells).<ref>{{Cite journal \| last1 = Andreiuolo \| first1 = F. \| last2 = Lisner \| first2 = T. \| last3 = Zlocha \| first3 = J. \| last4 = Kramm \| first4 = C. \| last5 = Koch \| first5 = A. \| last6 = Bison \| first6 = B. \| last7 = Gareton \| first7 = A. \| last8 = Zanello \| first8 = M. \| last9 = Waha \| first9 = A. \| title = H3F3A-G34R mutant high grade neuroepithelial neoplasms with glial and dysplastic ganglion cell components. \| journal = Acta Neuropathol Commun \| volume = 7 \| issue = 1 \| pages = 78 \| month = May \| year = 2019 \| doi = 10.1186/s40478-019-0731-5 \| PMID = 31109382 }}</ref>
	*Rare cases with co-occurrence of K27M mutation.<ref>{{Cite journal \| last1 = Pagès \| first1 = M. \| last2 = Beccaria \| first2 = K. \| last3 = Boddaert \| first3 = N. \| last4 = Saffroy \| first4 = R. \| last5 = Besnard \| first5 = A. \| last6 = Castel \| first6 = D. \| last7 = Fina \| first7 = F. \| last8 = Barets \| first8 = D. \| last9 = Barret \| first9 = E. \| title = Co-occurrence of histone H3 K27M and BRAF V600E mutations in paediatric midline grade I ganglioglioma. \| journal = Brain Pathol \| volume = \| issue = \| pages = \| month = Dec \| year = 2016 \| doi = 10.1111/bpa.12473 \| PMID = 27984673 }}</ref>		*Rare cases with co-occurrence of K27M mutation.<ref>{{Cite journal \| last1 = Pagès \| first1 = M. \| last2 = Beccaria \| first2 = K. \| last3 = Boddaert \| first3 = N. \| last4 = Saffroy \| first4 = R. \| last5 = Besnard \| first5 = A. \| last6 = Castel \| first6 = D. \| last7 = Fina \| first7 = F. \| last8 = Barets \| first8 = D. \| last9 = Barret \| first9 = E. \| title = Co-occurrence of histone H3 K27M and BRAF V600E mutations in paediatric midline grade I ganglioglioma. \| journal = Brain Pathol \| volume = \| issue = \| pages = \| month = Dec \| year = 2016 \| doi = 10.1111/bpa.12473 \| PMID = 27984673 }}</ref>

Michael: vauthors --> fix authors

2021-03-25T17:19:30Z

vauthors --> fix authors

← Older revision		Revision as of 17:19, 25 March 2021
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	**[[MAP2]] +ve		**[[MAP2]] +ve
	**Synaptophysin +ve		**Synaptophysin +ve
	***Perikaryal surface immunoreactivity for synaptophysin.<ref name="pmid8246055">{{cite journal \|~~vauthors~~=Lang FF, Epstein FJ, Ransohoff J, Allen JC, Wisoff J, Abbott IR, Miller DC \|title=Central nervous system gangliogliomas. Part 2: Clinical outcome \|journal=J. Neurosurg. \|volume=79 \|issue=6 \|pages=867–73 \|date=December 1993 \|pmid=8246055 \|doi=10.3171/jns.1993.79.6.0867 \|url=}}</ref>		***Perikaryal surface immunoreactivity for synaptophysin.<ref name="pmid8246055">{{cite journal \|authors=Lang FF, Epstein FJ, Ransohoff J, Allen JC, Wisoff J, Abbott IR, Miller DC \|title=Central nervous system gangliogliomas. Part 2: Clinical outcome \|journal=J. Neurosurg. \|volume=79 \|issue=6 \|pages=867–73 \|date=December 1993 \|pmid=8246055 \|doi=10.3171/jns.1993.79.6.0867 \|url=}}</ref>
	***This is however also seen in reactive changes.<ref name="pmid9591724">{{cite journal \|~~vauthors~~=Quinn B \|title=Synaptophysin staining in normal brain: importance for diagnosis of ganglioglioma \|journal=Am. J. Surg. Pathol. \|volume=22 \|issue=5 \|pages=550–6 \|date=May 1998 \|pmid=9591724 \|doi=10.1097/00000478-199805000-00005 \|url=}}</ref>		***This is however also seen in reactive changes.<ref name="pmid9591724">{{cite journal \|authors=Quinn B \|title=Synaptophysin staining in normal brain: importance for diagnosis of ganglioglioma \|journal=Am. J. Surg. Pathol. \|volume=22 \|issue=5 \|pages=550–6 \|date=May 1998 \|pmid=9591724 \|doi=10.1097/00000478-199805000-00005 \|url=}}</ref>
	** Neurofilament +ve		** Neurofilament +ve
	** Chromogranin +ve		** Chromogranin +ve

Jensflorian: /* IHC */ staining pattern

2020-09-14T07:12:57Z

IHC: staining pattern

← Older revision		Revision as of 07:12, 14 September 2020
Line 83:		Line 83:
	**[[MAP2]] +ve		**[[MAP2]] +ve
	**Synaptophysin +ve		**Synaptophysin +ve
			***Perikaryal surface immunoreactivity for synaptophysin.<ref name="pmid8246055">{{cite journal \|vauthors=Lang FF, Epstein FJ, Ransohoff J, Allen JC, Wisoff J, Abbott IR, Miller DC \|title=Central nervous system gangliogliomas. Part 2: Clinical outcome \|journal=J. Neurosurg. \|volume=79 \|issue=6 \|pages=867–73 \|date=December 1993 \|pmid=8246055 \|doi=10.3171/jns.1993.79.6.0867 \|url=}}</ref>
			***This is however also seen in reactive changes.<ref name="pmid9591724">{{cite journal \|vauthors=Quinn B \|title=Synaptophysin staining in normal brain: importance for diagnosis of ganglioglioma \|journal=Am. J. Surg. Pathol. \|volume=22 \|issue=5 \|pages=550–6 \|date=May 1998 \|pmid=9591724 \|doi=10.1097/00000478-199805000-00005 \|url=}}</ref>
	** Neurofilament +ve		** Neurofilament +ve
	** Chromogranin +ve		** Chromogranin +ve

Jensflorian: update histo

2019-09-26T11:47:57Z

update histo

← Older revision		Revision as of 11:47, 26 September 2019
Line 59:		Line 59:
	Features:		Features:
	*Dysplastic neurons.		*Dysplastic neurons.
	**Out of regular architecture / ~~abnormal~~ location.		**Out of regular architecture / heterotopic location.
	**Cytomegaly		**Cytomegaly
	**~~Clustering~~		**Abnormal clustering
	**Binucleated (very occassionally).		**Binucleated (very occassionally).
			**Perimembranous Nissl aggreation.
	*Atypical glia (ie neoplastic).		*Atypical glia (ie neoplastic).
	*Eosinophilic granular bodies (more common than rosenthal fibers).		*Eosinophilic granular bodies (more common than rosenthal fibers).

Jensflorian: /* Molecular */ DDx G34 mutant glioblastoma

2019-05-22T07:24:15Z

Molecular: DDx G34 mutant glioblastoma

← Older revision		Revision as of 07:24, 22 May 2019
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	*No 1p/19q codeletion.		*No 1p/19q codeletion.
	*Usu. Chr. 7 gain.		*Usu. Chr. 7 gain.
	*Rare cases with KIAA1459-BRAF fusion.<ref>{{Cite journal \| last1 = Mesturoux \| first1 = L. \| last2 = Durand \| first2 = K. \| last3 = Pommepuy \| first3 = I. \| last4 = Robert \| first4 = S. \| last5 = Caire \| first5 = F. \| last6 = Labrousse \| first6 = F. \| title = Molecular Analysis of Tumor Cell Components in Pilocytic Astrocytomas, Gangliogliomas, and Oligodendrogliomas. \| journal = Appl Immunohistochem Mol Morphol \| volume = 24 \| issue = 7 \| pages = 496-500 \| month = Aug \| year = 2016 \| doi = 10.1097/PAI.0000000000000288 \| PMID = 27389560 }}</ref>		*Rare cases with KIAA1459-BRAF fusion.<ref>{{Cite journal \| last1 = Pekmezci \| first1 = M. \| last2 = Villanueva-Meyer \| first2 = JE. \| last3 = Goode \| first3 = B. \| last4 = Van Ziffle \| first4 = J. \| last5 = Onodera \| first5 = C. \| last6 = Grenert \| first6 = JP. \| last7 = Bastian \| first7 = BC. \| last8 = Chamyan \| first8 = G. \| last9 = Maher \| first9 = OM. \| title = The genetic landscape of ganglioglioma. \| journal = Acta Neuropathol Commun \| volume = 6 \| issue = 1 \| pages = 47 \| month = 06 \| year = 2018 \| doi = 10.1186/s40478-018-0551-z \| PMID = 29880043 }}</ref>
			** DDx: consider pilocytic astrocytoma with ganglioglioma component. <ref>{{Cite journal \| last1 = Mesturoux \| first1 = L. \| last2 = Durand \| first2 = K. \| last3 = Pommepuy \| first3 = I. \| last4 = Robert \| first4 = S. \| last5 = Caire \| first5 = F. \| last6 = Labrousse \| first6 = F. \| title = Molecular Analysis of Tumor Cell Components in Pilocytic Astrocytomas, Gangliogliomas, and Oligodendrogliomas. \| journal = Appl Immunohistochem Mol Morphol \| volume = 24 \| issue = 7 \| pages = 496-500 \| month = Aug \| year = 2016 \| doi = 10.1097/PAI.0000000000000288 \| PMID = 27389560 }}</ref>
	*CDKN2A deletions, ATRX loss and TERT promotor mutations in anaplastic ganglioglioma.<ref>{{Cite journal \| last1 = Zanello \| first1 = M. \| last2 = Pages \| first2 = M. \| last3 = Tauziède-Espariat \| first3 = A. \| last4 = Saffroy \| first4 = R. \| last5 = Puget \| first5 = S. \| last6 = Lacroix \| first6 = L. \| last7 = Dezamis \| first7 = E. \| last8 = Devaux \| first8 = B. \| last9 = Chrétien \| first9 = F. \| title = Clinical, Imaging, Histopathological and Molecular Characterization of Anaplastic Ganglioglioma. \| journal = J Neuropathol Exp Neurol \| volume = 75 \| issue = 10 \| pages = 971-980 \| month = Oct \| year = 2016 \| doi = 10.1093/jnen/nlw074 \| PMID = 27539475 }}</ref>		*CDKN2A deletions, ATRX loss and TERT promotor mutations in anaplastic ganglioglioma.<ref>{{Cite journal \| last1 = Zanello \| first1 = M. \| last2 = Pages \| first2 = M. \| last3 = Tauziède-Espariat \| first3 = A. \| last4 = Saffroy \| first4 = R. \| last5 = Puget \| first5 = S. \| last6 = Lacroix \| first6 = L. \| last7 = Dezamis \| first7 = E. \| last8 = Devaux \| first8 = B. \| last9 = Chrétien \| first9 = F. \| title = Clinical, Imaging, Histopathological and Molecular Characterization of Anaplastic Ganglioglioma. \| journal = J Neuropathol Exp Neurol \| volume = 75 \| issue = 10 \| pages = 971-980 \| month = Oct \| year = 2016 \| doi = 10.1093/jnen/nlw074 \| PMID = 27539475 }}</ref>
	**DD: consider anaplastic astrocytoma with piloid features (similiar molecular profile).<ref>{{Cite journal \| last1 = Reinhardt \| first1 = A. \| last2 = Stichel \| first2 = D. \| last3 = Schrimpf \| first3 = D. \| last4 = Sahm \| first4 = F. \| last5 = Korshunov \| first5 = A. \| last6 = Reuss \| first6 = DE. \| last7 = Koelsche \| first7 = C. \| last8 = Huang \| first8 = K. \| last9 = Wefers \| first9 = AK. \| title = Anaplastic astrocytoma with piloid features, a novel molecular class of IDH wildtype glioma with recurrent MAPK pathway, CDKN2A/B and ATRX alterations. \| journal = Acta Neuropathol \| volume = 136 \| issue = 2 \| pages = 273-291 \| month = Aug \| year = 2018 \| doi = 10.1007/s00401-018-1837-8 \| PMID = 29564591 }}		**DD: consider anaplastic astrocytoma with piloid features (similiar molecular profile).<ref>{{Cite journal \| last1 = Reinhardt \| first1 = A. \| last2 = Stichel \| first2 = D. \| last3 = Schrimpf \| first3 = D. \| last4 = Sahm \| first4 = F. \| last5 = Korshunov \| first5 = A. \| last6 = Reuss \| first6 = DE. \| last7 = Koelsche \| first7 = C. \| last8 = Huang \| first8 = K. \| last9 = Wefers \| first9 = AK. \| title = Anaplastic astrocytoma with piloid features, a novel molecular class of IDH wildtype glioma with recurrent MAPK pathway, CDKN2A/B and ATRX alterations. \| journal = Acta Neuropathol \| volume = 136 \| issue = 2 \| pages = 273-291 \| month = Aug \| year = 2018 \| doi = 10.1007/s00401-018-1837-8 \| PMID = 29564591 }}
	</ref>		</ref>
			*H3F3A wildtype.
			**DDx: consider G34-mutant glioblastoma/NET (rare cases may contain dysplastic ganglion cells).<ref>{{Cite journal \| last1 = Andreiuolo \| first1 = F. \| last2 = Lisner \| first2 = T. \| last3 = Zlocha \| first3 = J. \| last4 = Kramm \| first4 = C. \| last5 = Koch \| first5 = A. \| last6 = Bison \| first6 = B. \| last7 = Gareton \| first7 = A. \| last8 = Zanello \| first8 = M. \| last9 = Waha \| first9 = A. \| title = H3F3A-G34R mutant high grade neuroepithelial neoplasms with glial and dysplastic ganglion cell components. \| journal = Acta Neuropathol Commun \| volume = 7 \| issue = 1 \| pages = 78 \| month = May \| year = 2019 \| doi = 10.1186/s40478-019-0731-5 \| PMID = 31109382 }}</ref>
	*Rare cases with co-occurrence of K27M mutation.<ref>{{Cite journal \| last1 = Pagès \| first1 = M. \| last2 = Beccaria \| first2 = K. \| last3 = Boddaert \| first3 = N. \| last4 = Saffroy \| first4 = R. \| last5 = Besnard \| first5 = A. \| last6 = Castel \| first6 = D. \| last7 = Fina \| first7 = F. \| last8 = Barets \| first8 = D. \| last9 = Barret \| first9 = E. \| title = Co-occurrence of histone H3 K27M and BRAF V600E mutations in paediatric midline grade I ganglioglioma. \| journal = Brain Pathol \| volume = \| issue = \| pages = \| month = Dec \| year = 2016 \| doi = 10.1111/bpa.12473 \| PMID = 27984673 }}</ref>		*Rare cases with co-occurrence of K27M mutation.<ref>{{Cite journal \| last1 = Pagès \| first1 = M. \| last2 = Beccaria \| first2 = K. \| last3 = Boddaert \| first3 = N. \| last4 = Saffroy \| first4 = R. \| last5 = Besnard \| first5 = A. \| last6 = Castel \| first6 = D. \| last7 = Fina \| first7 = F. \| last8 = Barets \| first8 = D. \| last9 = Barret \| first9 = E. \| title = Co-occurrence of histone H3 K27M and BRAF V600E mutations in paediatric midline grade I ganglioglioma. \| journal = Brain Pathol \| volume = \| issue = \| pages = \| month = Dec \| year = 2016 \| doi = 10.1111/bpa.12473 \| PMID = 27984673 }}</ref>

Jensflorian: /* Molecular */ DDx

2019-05-22T07:16:30Z

Molecular: DDx

← Older revision		Revision as of 07:16, 22 May 2019
Line 98:		Line 98:
	*Rare cases with KIAA1459-BRAF fusion.<ref>{{Cite journal \| last1 = Mesturoux \| first1 = L. \| last2 = Durand \| first2 = K. \| last3 = Pommepuy \| first3 = I. \| last4 = Robert \| first4 = S. \| last5 = Caire \| first5 = F. \| last6 = Labrousse \| first6 = F. \| title = Molecular Analysis of Tumor Cell Components in Pilocytic Astrocytomas, Gangliogliomas, and Oligodendrogliomas. \| journal = Appl Immunohistochem Mol Morphol \| volume = 24 \| issue = 7 \| pages = 496-500 \| month = Aug \| year = 2016 \| doi = 10.1097/PAI.0000000000000288 \| PMID = 27389560 }}</ref>		*Rare cases with KIAA1459-BRAF fusion.<ref>{{Cite journal \| last1 = Mesturoux \| first1 = L. \| last2 = Durand \| first2 = K. \| last3 = Pommepuy \| first3 = I. \| last4 = Robert \| first4 = S. \| last5 = Caire \| first5 = F. \| last6 = Labrousse \| first6 = F. \| title = Molecular Analysis of Tumor Cell Components in Pilocytic Astrocytomas, Gangliogliomas, and Oligodendrogliomas. \| journal = Appl Immunohistochem Mol Morphol \| volume = 24 \| issue = 7 \| pages = 496-500 \| month = Aug \| year = 2016 \| doi = 10.1097/PAI.0000000000000288 \| PMID = 27389560 }}</ref>
	*CDKN2A deletions, ATRX loss and TERT promotor mutations in anaplastic ganglioglioma.<ref>{{Cite journal \| last1 = Zanello \| first1 = M. \| last2 = Pages \| first2 = M. \| last3 = Tauziède-Espariat \| first3 = A. \| last4 = Saffroy \| first4 = R. \| last5 = Puget \| first5 = S. \| last6 = Lacroix \| first6 = L. \| last7 = Dezamis \| first7 = E. \| last8 = Devaux \| first8 = B. \| last9 = Chrétien \| first9 = F. \| title = Clinical, Imaging, Histopathological and Molecular Characterization of Anaplastic Ganglioglioma. \| journal = J Neuropathol Exp Neurol \| volume = 75 \| issue = 10 \| pages = 971-980 \| month = Oct \| year = 2016 \| doi = 10.1093/jnen/nlw074 \| PMID = 27539475 }}</ref>		*CDKN2A deletions, ATRX loss and TERT promotor mutations in anaplastic ganglioglioma.<ref>{{Cite journal \| last1 = Zanello \| first1 = M. \| last2 = Pages \| first2 = M. \| last3 = Tauziède-Espariat \| first3 = A. \| last4 = Saffroy \| first4 = R. \| last5 = Puget \| first5 = S. \| last6 = Lacroix \| first6 = L. \| last7 = Dezamis \| first7 = E. \| last8 = Devaux \| first8 = B. \| last9 = Chrétien \| first9 = F. \| title = Clinical, Imaging, Histopathological and Molecular Characterization of Anaplastic Ganglioglioma. \| journal = J Neuropathol Exp Neurol \| volume = 75 \| issue = 10 \| pages = 971-980 \| month = Oct \| year = 2016 \| doi = 10.1093/jnen/nlw074 \| PMID = 27539475 }}</ref>
			**DD: consider anaplastic astrocytoma with piloid features (similiar molecular profile).<ref>{{Cite journal \| last1 = Reinhardt \| first1 = A. \| last2 = Stichel \| first2 = D. \| last3 = Schrimpf \| first3 = D. \| last4 = Sahm \| first4 = F. \| last5 = Korshunov \| first5 = A. \| last6 = Reuss \| first6 = DE. \| last7 = Koelsche \| first7 = C. \| last8 = Huang \| first8 = K. \| last9 = Wefers \| first9 = AK. \| title = Anaplastic astrocytoma with piloid features, a novel molecular class of IDH wildtype glioma with recurrent MAPK pathway, CDKN2A/B and ATRX alterations. \| journal = Acta Neuropathol \| volume = 136 \| issue = 2 \| pages = 273-291 \| month = Aug \| year = 2018 \| doi = 10.1007/s00401-018-1837-8 \| PMID = 29564591 }}
			</ref>
	*Rare cases with co-occurrence of K27M mutation.<ref>{{Cite journal \| last1 = Pagès \| first1 = M. \| last2 = Beccaria \| first2 = K. \| last3 = Boddaert \| first3 = N. \| last4 = Saffroy \| first4 = R. \| last5 = Besnard \| first5 = A. \| last6 = Castel \| first6 = D. \| last7 = Fina \| first7 = F. \| last8 = Barets \| first8 = D. \| last9 = Barret \| first9 = E. \| title = Co-occurrence of histone H3 K27M and BRAF V600E mutations in paediatric midline grade I ganglioglioma. \| journal = Brain Pathol \| volume = \| issue = \| pages = \| month = Dec \| year = 2016 \| doi = 10.1111/bpa.12473 \| PMID = 27984673 }}</ref>		*Rare cases with co-occurrence of K27M mutation.<ref>{{Cite journal \| last1 = Pagès \| first1 = M. \| last2 = Beccaria \| first2 = K. \| last3 = Boddaert \| first3 = N. \| last4 = Saffroy \| first4 = R. \| last5 = Besnard \| first5 = A. \| last6 = Castel \| first6 = D. \| last7 = Fina \| first7 = F. \| last8 = Barets \| first8 = D. \| last9 = Barret \| first9 = E. \| title = Co-occurrence of histone H3 K27M and BRAF V600E mutations in paediatric midline grade I ganglioglioma. \| journal = Brain Pathol \| volume = \| issue = \| pages = \| month = Dec \| year = 2016 \| doi = 10.1111/bpa.12473 \| PMID = 27984673 }}</ref>

Jensflorian: /* General */ outcome

2017-09-14T11:05:45Z

General: outcome

← Older revision		Revision as of 11:05, 14 September 2017
Line 40:		Line 40:
	*Recognized as a cause of [[epilepsy]].<ref name=pmid12125968>{{Cite journal \| last1 = Im \| first1 = SH. \| last2 = Chung \| first2 = CK. \| last3 = Cho \| first3 = BK. \| last4 = Lee \| first4 = SK. \| title = Supratentorial ganglioglioma and epilepsy: postoperative seizure outcome. \| journal = J Neurooncol \| volume = 57 \| issue = 1 \| pages = 59-66 \| month = Mar \| year = 2002 \| doi = \| PMID = 12125968 }}</ref>		*Recognized as a cause of [[epilepsy]].<ref name=pmid12125968>{{Cite journal \| last1 = Im \| first1 = SH. \| last2 = Chung \| first2 = CK. \| last3 = Cho \| first3 = BK. \| last4 = Lee \| first4 = SK. \| title = Supratentorial ganglioglioma and epilepsy: postoperative seizure outcome. \| journal = J Neurooncol \| volume = 57 \| issue = 1 \| pages = 59-66 \| month = Mar \| year = 2002 \| doi = \| PMID = 12125968 }}</ref>
	*Favourable prognosis (survival rates up to 97%)		*Favourable prognosis (survival rates up to 97%)
	**Anaplastic ganglioglioma have a recurrence risk of 69%<ref>{{Cite journal \| last1 = Terrier \| first1 = LM. \| last2 = Bauchet \| first2 = L. \| last3 = Rigau \| first3 = V. \| last4 = Amelot \| first4 = A. \| last5 = Zouaoui \| first5 = S. \| last6 = Filipiak \| first6 = I. \| last7 = Caille \| first7 = A. \| last8 = Almairac \| first8 = F. \| last9 = Aubriot-Lorton \| first9 = MH. \| title = Natural course and prognosis of anaplastic gangliogliomas: a multicenter retrospective study of 43 cases from the French Brain Tumor Database. \| journal = Neuro Oncol \| volume = 19 \| issue = 5 \| pages = 678-688 \| month = 05 \| year = 2017 \| doi = 10.1093/neuonc/now186 \| PMID = 28453747 }}</ref>		**Anaplastic ganglioglioma have a recurrence risk of 69%-100% and median OS: 27months<ref>{{Cite journal \| last1 = Terrier \| first1 = LM. \| last2 = Bauchet \| first2 = L. \| last3 = Rigau \| first3 = V. \| last4 = Amelot \| first4 = A. \| last5 = Zouaoui \| first5 = S. \| last6 = Filipiak \| first6 = I. \| last7 = Caille \| first7 = A. \| last8 = Almairac \| first8 = F. \| last9 = Aubriot-Lorton \| first9 = MH. \| title = Natural course and prognosis of anaplastic gangliogliomas: a multicenter retrospective study of 43 cases from the French Brain Tumor Database. \| journal = Neuro Oncol \| volume = 19 \| issue = 5 \| pages = 678-688 \| month = 05 \| year = 2017 \| doi = 10.1093/neuonc/now186 \| PMID = 28453747 }}</ref><ref>{{Cite journal \| last1 = Zanello \| first1 = M. \| last2 = Pages \| first2 = M. \| last3 = Tauziède-Espariat \| first3 = A. \| last4 = Saffroy \| first4 = R. \| last5 = Puget \| first5 = S. \| last6 = Lacroix \| first6 = L. \| last7 = Dezamis \| first7 = E. \| last8 = Devaux \| first8 = B. \| last9 = Chrétien \| first9 = F. \| title = Clinical, Imaging, Histopathological and Molecular Characterization of Anaplastic Ganglioglioma. \| journal = J Neuropathol Exp Neurol \| volume = 75 \| issue = 10 \| pages = 971-980 \| month = Oct \| year = 2016 \| doi = 10.1093/jnen/nlw074 \| PMID = 27539475 }}</ref>

	==Imaging==		==Imaging==

Jensflorian: /* Molecular */ update for AGG

2017-09-14T10:56:12Z

Molecular: update for AGG

← Older revision		Revision as of 10:56, 14 September 2017
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	*Usu. Chr. 7 gain.		*Usu. Chr. 7 gain.
	*Rare cases with KIAA1459-BRAF fusion.<ref>{{Cite journal \| last1 = Mesturoux \| first1 = L. \| last2 = Durand \| first2 = K. \| last3 = Pommepuy \| first3 = I. \| last4 = Robert \| first4 = S. \| last5 = Caire \| first5 = F. \| last6 = Labrousse \| first6 = F. \| title = Molecular Analysis of Tumor Cell Components in Pilocytic Astrocytomas, Gangliogliomas, and Oligodendrogliomas. \| journal = Appl Immunohistochem Mol Morphol \| volume = 24 \| issue = 7 \| pages = 496-500 \| month = Aug \| year = 2016 \| doi = 10.1097/PAI.0000000000000288 \| PMID = 27389560 }}</ref>		*Rare cases with KIAA1459-BRAF fusion.<ref>{{Cite journal \| last1 = Mesturoux \| first1 = L. \| last2 = Durand \| first2 = K. \| last3 = Pommepuy \| first3 = I. \| last4 = Robert \| first4 = S. \| last5 = Caire \| first5 = F. \| last6 = Labrousse \| first6 = F. \| title = Molecular Analysis of Tumor Cell Components in Pilocytic Astrocytomas, Gangliogliomas, and Oligodendrogliomas. \| journal = Appl Immunohistochem Mol Morphol \| volume = 24 \| issue = 7 \| pages = 496-500 \| month = Aug \| year = 2016 \| doi = 10.1097/PAI.0000000000000288 \| PMID = 27389560 }}</ref>
	*CDKN2A deletions in anaplastic ganglioglioma.		*CDKN2A deletions, ATRX loss and TERT promotor mutations in anaplastic ganglioglioma.<ref>{{Cite journal \| last1 = Zanello \| first1 = M. \| last2 = Pages \| first2 = M. \| last3 = Tauziède-Espariat \| first3 = A. \| last4 = Saffroy \| first4 = R. \| last5 = Puget \| first5 = S. \| last6 = Lacroix \| first6 = L. \| last7 = Dezamis \| first7 = E. \| last8 = Devaux \| first8 = B. \| last9 = Chrétien \| first9 = F. \| title = Clinical, Imaging, Histopathological and Molecular Characterization of Anaplastic Ganglioglioma. \| journal = J Neuropathol Exp Neurol \| volume = 75 \| issue = 10 \| pages = 971-980 \| month = Oct \| year = 2016 \| doi = 10.1093/jnen/nlw074 \| PMID = 27539475 }}</ref>
	*~~rare~~ cases with co-occurrence of K27M mutation.<ref>{{Cite journal \| last1 = Pagès \| first1 = M. \| last2 = Beccaria \| first2 = K. \| last3 = Boddaert \| first3 = N. \| last4 = Saffroy \| first4 = R. \| last5 = Besnard \| first5 = A. \| last6 = Castel \| first6 = D. \| last7 = Fina \| first7 = F. \| last8 = Barets \| first8 = D. \| last9 = Barret \| first9 = E. \| title = Co-occurrence of histone H3 K27M and BRAF V600E mutations in paediatric midline grade I ganglioglioma. \| journal = Brain Pathol \| volume = \| issue = \| pages = \| month = Dec \| year = 2016 \| doi = 10.1111/bpa.12473 \| PMID = 27984673 }}</ref>		*Rare cases with co-occurrence of K27M mutation.<ref>{{Cite journal \| last1 = Pagès \| first1 = M. \| last2 = Beccaria \| first2 = K. \| last3 = Boddaert \| first3 = N. \| last4 = Saffroy \| first4 = R. \| last5 = Besnard \| first5 = A. \| last6 = Castel \| first6 = D. \| last7 = Fina \| first7 = F. \| last8 = Barets \| first8 = D. \| last9 = Barret \| first9 = E. \| title = Co-occurrence of histone H3 K27M and BRAF V600E mutations in paediatric midline grade I ganglioglioma. \| journal = Brain Pathol \| volume = \| issue = \| pages = \| month = Dec \| year = 2016 \| doi = 10.1111/bpa.12473 \| PMID = 27984673 }}</ref>

	===Images===		===Images===

Jensflorian: /* DDx: */ DIA/DIG added

2017-09-14T10:50:32Z

DDx:: DIA/DIG added

← Older revision		Revision as of 10:50, 14 September 2017
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	*[[Oligodendroglioma]].		*[[Oligodendroglioma]].
	*[[PXA]].		*[[PXA]].
			*Desmoplastic infantile astrocytoma and ganglioglioma.
	*Cortical tuber.		*Cortical tuber.
	*Trapped cortical neurons in diffuse astrocytoma.		*Trapped cortical neurons in diffuse astrocytoma.

Jensflorian: /* Molecular */ update

2017-09-14T10:48:43Z

Molecular: update

← Older revision		Revision as of 10:48, 14 September 2017
Line 98:		Line 98:
	*Rare cases with KIAA1459-BRAF fusion.<ref>{{Cite journal \| last1 = Mesturoux \| first1 = L. \| last2 = Durand \| first2 = K. \| last3 = Pommepuy \| first3 = I. \| last4 = Robert \| first4 = S. \| last5 = Caire \| first5 = F. \| last6 = Labrousse \| first6 = F. \| title = Molecular Analysis of Tumor Cell Components in Pilocytic Astrocytomas, Gangliogliomas, and Oligodendrogliomas. \| journal = Appl Immunohistochem Mol Morphol \| volume = 24 \| issue = 7 \| pages = 496-500 \| month = Aug \| year = 2016 \| doi = 10.1097/PAI.0000000000000288 \| PMID = 27389560 }}</ref>		*Rare cases with KIAA1459-BRAF fusion.<ref>{{Cite journal \| last1 = Mesturoux \| first1 = L. \| last2 = Durand \| first2 = K. \| last3 = Pommepuy \| first3 = I. \| last4 = Robert \| first4 = S. \| last5 = Caire \| first5 = F. \| last6 = Labrousse \| first6 = F. \| title = Molecular Analysis of Tumor Cell Components in Pilocytic Astrocytomas, Gangliogliomas, and Oligodendrogliomas. \| journal = Appl Immunohistochem Mol Morphol \| volume = 24 \| issue = 7 \| pages = 496-500 \| month = Aug \| year = 2016 \| doi = 10.1097/PAI.0000000000000288 \| PMID = 27389560 }}</ref>
	*CDKN2A deletions in anaplastic ganglioglioma.		*CDKN2A deletions in anaplastic ganglioglioma.
			*rare cases with co-occurrence of K27M mutation.<ref>{{Cite journal \| last1 = Pagès \| first1 = M. \| last2 = Beccaria \| first2 = K. \| last3 = Boddaert \| first3 = N. \| last4 = Saffroy \| first4 = R. \| last5 = Besnard \| first5 = A. \| last6 = Castel \| first6 = D. \| last7 = Fina \| first7 = F. \| last8 = Barets \| first8 = D. \| last9 = Barret \| first9 = E. \| title = Co-occurrence of histone H3 K27M and BRAF V600E mutations in paediatric midline grade I ganglioglioma. \| journal = Brain Pathol \| volume = \| issue = \| pages = \| month = Dec \| year = 2016 \| doi = 10.1111/bpa.12473 \| PMID = 27984673 }}</ref>

	===Images===		===Images===

← Older revision		Revision as of 07:16, 22 May 2019
Line 98:		Line 98:
	*Rare cases with KIAA1459-BRAF fusion.<ref>{{Cite journal \| last1 = Mesturoux \| first1 = L. \| last2 = Durand \| first2 = K. \| last3 = Pommepuy \| first3 = I. \| last4 = Robert \| first4 = S. \| last5 = Caire \| first5 = F. \| last6 = Labrousse \| first6 = F. \| title = Molecular Analysis of Tumor Cell Components in Pilocytic Astrocytomas, Gangliogliomas, and Oligodendrogliomas. \| journal = Appl Immunohistochem Mol Morphol \| volume = 24 \| issue = 7 \| pages = 496-500 \| month = Aug \| year = 2016 \| doi = 10.1097/PAI.0000000000000288 \| PMID = 27389560 }}</ref>		*Rare cases with KIAA1459-BRAF fusion.<ref>{{Cite journal \| last1 = Mesturoux \| first1 = L. \| last2 = Durand \| first2 = K. \| last3 = Pommepuy \| first3 = I. \| last4 = Robert \| first4 = S. \| last5 = Caire \| first5 = F. \| last6 = Labrousse \| first6 = F. \| title = Molecular Analysis of Tumor Cell Components in Pilocytic Astrocytomas, Gangliogliomas, and Oligodendrogliomas. \| journal = Appl Immunohistochem Mol Morphol \| volume = 24 \| issue = 7 \| pages = 496-500 \| month = Aug \| year = 2016 \| doi = 10.1097/PAI.0000000000000288 \| PMID = 27389560 }}</ref>
	*CDKN2A deletions, ATRX loss and TERT promotor mutations in anaplastic ganglioglioma.<ref>{{Cite journal \| last1 = Zanello \| first1 = M. \| last2 = Pages \| first2 = M. \| last3 = Tauziède-Espariat \| first3 = A. \| last4 = Saffroy \| first4 = R. \| last5 = Puget \| first5 = S. \| last6 = Lacroix \| first6 = L. \| last7 = Dezamis \| first7 = E. \| last8 = Devaux \| first8 = B. \| last9 = Chrétien \| first9 = F. \| title = Clinical, Imaging, Histopathological and Molecular Characterization of Anaplastic Ganglioglioma. \| journal = J Neuropathol Exp Neurol \| volume = 75 \| issue = 10 \| pages = 971-980 \| month = Oct \| year = 2016 \| doi = 10.1093/jnen/nlw074 \| PMID = 27539475 }}</ref>		*CDKN2A deletions, ATRX loss and TERT promotor mutations in anaplastic ganglioglioma.<ref>{{Cite journal \| last1 = Zanello \| first1 = M. \| last2 = Pages \| first2 = M. \| last3 = Tauziède-Espariat \| first3 = A. \| last4 = Saffroy \| first4 = R. \| last5 = Puget \| first5 = S. \| last6 = Lacroix \| first6 = L. \| last7 = Dezamis \| first7 = E. \| last8 = Devaux \| first8 = B. \| last9 = Chrétien \| first9 = F. \| title = Clinical, Imaging, Histopathological and Molecular Characterization of Anaplastic Ganglioglioma. \| journal = J Neuropathol Exp Neurol \| volume = 75 \| issue = 10 \| pages = 971-980 \| month = Oct \| year = 2016 \| doi = 10.1093/jnen/nlw074 \| PMID = 27539475 }}</ref>
			**DD: consider anaplastic astrocytoma with piloid features (similiar molecular profile).<ref>{{Cite journal \| last1 = Reinhardt \| first1 = A. \| last2 = Stichel \| first2 = D. \| last3 = Schrimpf \| first3 = D. \| last4 = Sahm \| first4 = F. \| last5 = Korshunov \| first5 = A. \| last6 = Reuss \| first6 = DE. \| last7 = Koelsche \| first7 = C. \| last8 = Huang \| first8 = K. \| last9 = Wefers \| first9 = AK. \| title = Anaplastic astrocytoma with piloid features, a novel molecular class of IDH wildtype glioma with recurrent MAPK pathway, CDKN2A/B and ATRX alterations. \| journal = Acta Neuropathol \| volume = 136 \| issue = 2 \| pages = 273-291 \| month = Aug \| year = 2018 \| doi = 10.1007/s00401-018-1837-8 \| PMID = 29564591 }}
			</ref>
	*Rare cases with co-occurrence of K27M mutation.<ref>{{Cite journal \| last1 = Pagès \| first1 = M. \| last2 = Beccaria \| first2 = K. \| last3 = Boddaert \| first3 = N. \| last4 = Saffroy \| first4 = R. \| last5 = Besnard \| first5 = A. \| last6 = Castel \| first6 = D. \| last7 = Fina \| first7 = F. \| last8 = Barets \| first8 = D. \| last9 = Barret \| first9 = E. \| title = Co-occurrence of histone H3 K27M and BRAF V600E mutations in paediatric midline grade I ganglioglioma. \| journal = Brain Pathol \| volume = \| issue = \| pages = \| month = Dec \| year = 2016 \| doi = 10.1111/bpa.12473 \| PMID = 27984673 }}</ref>		*Rare cases with co-occurrence of K27M mutation.<ref>{{Cite journal \| last1 = Pagès \| first1 = M. \| last2 = Beccaria \| first2 = K. \| last3 = Boddaert \| first3 = N. \| last4 = Saffroy \| first4 = R. \| last5 = Besnard \| first5 = A. \| last6 = Castel \| first6 = D. \| last7 = Fina \| first7 = F. \| last8 = Barets \| first8 = D. \| last9 = Barret \| first9 = E. \| title = Co-occurrence of histone H3 K27M and BRAF V600E mutations in paediatric midline grade I ganglioglioma. \| journal = Brain Pathol \| volume = \| issue = \| pages = \| month = Dec \| year = 2016 \| doi = 10.1111/bpa.12473 \| PMID = 27984673 }}</ref>