Michael at 19:14, 12 April 2014

2014-04-12T19:14:36Z

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	\| Site = [[duodenum]] usually		\| Site = [[duodenum]] usually
	\| Assdx =		\| Assdx =
	\| Syndromes =		\| Syndromes = [[neurofibromatosis type 1]]
	\| Clinicalhx =		\| Clinicalhx =
	\| Signs = +/-GI bleed		\| Signs = +/-GI bleed

Michael: +infobox

2014-04-12T19:14:04Z

+infobox

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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Gangliocytic_paraganglioma_-_intermed_mag.jpg
			\| Width =
			\| Caption = Gangliocytic paraganglioma. [[H&E stain]].
			\| Synonyms =
			\| Micro =
			\| Subtypes =
			\| LMDDx =
			\| Stains =
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[duodenum]] usually
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs = +/-GI bleed
			\| Symptoms = +/-abdominal pain
			\| Prevalence = extremely rare
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis =
			\| Other =
			\| ClinDDx =
			\| Tx =
			}}
	'''Gangliocytic paraganglioma''', abbreviated '''GP''', is an extremely rare tumour most often found in the [[duodenum]].		'''Gangliocytic paraganglioma''', abbreviated '''GP''', is an extremely rare tumour most often found in the [[duodenum]].

Michael: split out

2014-04-12T19:12:11Z

split out

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	~~#redirect~~ [[~~Duodenum#Gangliocytic_paraganglioma~~]]		'''Gangliocytic paraganglioma''', abbreviated '''GP''', is an extremely rare tumour most often found in the [[duodenum]].

			==General==
			*Extremely rare.<ref name=pmid22340577>{{Cite journal \| last1 = Wu \| first1 = GC. \| last2 = Wang \| first2 = KL. \| last3 = Zhang \| first3 = ZT. \| title = Gangliocytic paraganglioma of the duodenum: a case report. \| journal = Chin Med J (Engl) \| volume = 125 \| issue = 2 \| pages = 388-9 \| month = Jan \| year = 2012 \| doi = \| PMID = 22340577 }}</ref>
			*May be associated with [[neurofibromatosis type 1]].<ref name=pmid12754392>{{Cite journal \| last1 = Castoldi \| first1 = L. \| last2 = De Rai \| first2 = P. \| last3 = Marini \| first3 = A. \| last4 = Ferrero \| first4 = S. \| last5 = De Luca \| first5 = V. \| last6 = Tiberio \| first6 = G. \| title = Neurofibromatosis-1 and Ampullary Gangliocytic Paraganglioma Causing Biliary and Pancreatic Obstruction. \| journal = Int J Gastrointest Cancer \| volume = 29 \| issue = 2 \| pages = 93-98 \| month = \| year = 2001 \| doi = \| PMID = 12754392 }}</ref>
			*Classified a [[neuroendocrine tumour]].<ref>URL: [http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/SmallbowelNET_11protocol.pdf http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/SmallbowelNET_11protocol.pdf]. Accessed on: 29 March 2012.</ref>
			*Usually has a mix of the features seen in: [[neuroendocrine tumour]]s, [[paraganglioma]]s and [[ganglioneuroma]]s.

			Clinical - presentation:<ref name=pmid21599949/>
			*GI bleed ~ 45% of cases.
			*Abdominal pain ~ 43% of cases.
			*[[Anemia]] ~ 15% of cases.

			==Gross==
			*Classically in the duodenum ~90% of cases.<ref name=pmid21599949>{{Cite journal \| last1 = Okubo \| first1 = Y. \| last2 = Wakayama \| first2 = M. \| last3 = Nemoto \| first3 = T. \| last4 = Kitahara \| first4 = K. \| last5 = Nakayama \| first5 = H. \| last6 = Shibuya \| first6 = K. \| last7 = Yokose \| first7 = T. \| last8 = Yamada \| first8 = M. \| last9 = Shimodaira \| first9 = K. \| title = Literature survey on epidemiology and pathology of gangliocytic paraganglioma. \| journal = BMC Cancer \| volume = 11 \| issue = \| pages = 187 \| month = \| year = 2011 \| doi = 10.1186/1471-2407-11-187 \| PMID = 21599949 }}</ref>

			==Microscopic==
			Features - three components:<ref name=pmid15740625>{{Cite journal \| last1 = Wong \| first1 = A. \| last2 = Miller \| first2 = AR. \| last3 = Metter \| first3 = J. \| last4 = Thomas \| first4 = CR. \| title = Locally advanced duodenal gangliocytic paraganglioma treated with adjuvant radiation therapy: case report and review of the literature. \| journal = World J Surg Oncol \| volume = 3 \| issue = 1 \| pages = 15 \| month = Mar \| year = 2005 \| doi = 10.1186/1477-7819-3-15 \| PMID = 15740625 }}</ref><ref>URL: [http://surgpathcriteria.stanford.edu/gitumors/gangliocytic-paraganglioma/printable.html http://surgpathcriteria.stanford.edu/gitumors/gangliocytic-paraganglioma/printable.html]. Accessed on: 31 May 2012.</ref>
			#Ganglion cells = large cells with:
			#*Round large nucleus.
			#*Prominent [[nucleolus]].
			#*Moderate or abundant cytoplasm.
			#Epithelioid cells (neuroendocrine component):
			#*Arranged in nests or cords.
			#*Stippled chromatin.
			#Spindle cells ([[Schwannoma\|schwannian]] component):
			#*Moderate or abundant cytoplasm.
			#*Nucleus spindle-shaped or ellipsoid.

			DDx:<ref name=pmid15740625/>
			*Poorly differentiated carcinoma.
			*[[Neuroendocrine tumour]].
			*[[Paraganglioma]].

			===Images===
			<gallery>
			Image:Gangliocytic_paraganglioma_-_intermed_mag.jpg \| GP - intermed. mag. (WC)
			Image:Gangliocytic_paraganglioma_-_high_mag.jpg \| GP - high mag. (WC)
			Image:Gangliocytic_paraganglioma_-_very_high_mag.jpg \| GP - very high mag. (WC)
			Image:Gangliocytic_paraganglioma_-_2_-_intermed_mag.jpg \| GP - 2 - intermed. mag. (WC)
			Image:Gangliocytic_paraganglioma_-_2_-_high_mag.jpg \| GP - 2 - high mag. (WC)
			</gallery>
			www:
			*[http://www.wjso.com/content/3/1/15/figure/F2 Epithelioid cells of a GP (wjso.com)].
			*[http://www.wjso.com/content/3/1/15/figure/F4 Ganglion cell in a GP (wjso.com)].
			*[http://www.pubcan.org/images/large/Fig_5-17_A.jpg Ganglion cells in a GP (pubcan.org)].<ref>URL: [http://www.pubcan.org/printicdotopo.php?id=5028 http://www.pubcan.org/printicdotopo.php?id=5028]. Accessed on: 15 April 2012.</ref>
			*[http://www.surgicalpathologyatlas.com/glfusion/mediagallery/media.php?f=0&sort=0&s=20080802175012135 GP (surgicalpathologyatlas.com)].

			==IHC==
			*Synaptophysin +ve.
			*CD56 +ve.
			*Chromogranin A +ve.
			*HU +ve in ganglion-like cells.
			*S100 +ve in spindle cells & sustentacular cells.

			==See also==
			*[[Duodenum]].

			==References==
			{{Reflist\|2}}


			[[Category:Duodenum]]
	[[Category:Diagnosis]]		[[Category:Diagnosis]]

Michael: redirect

2011-12-02T04:14:15Z

redirect

New page

#redirect [[Duodenum#Gangliocytic_paraganglioma]]

[[Category:Diagnosis]]

Gangliocytic paraganglioma - Revision history

Michael at 19:14, 12 April 2014

Michael: +infobox

Michael: split out

Michael: redirect