Follicular lymphoma - Revision history

Michael: /* IHC */

2015-03-20T17:34:58Z

IHC

← Older revision		Revision as of 17:34, 20 March 2015
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	==IHC==		==IHC==
	Features:<ref name=pmid18359244/>		Features:<ref name=pmid18359244/>
	*CD10 +ve.		*[[CD10]] +ve.
	*BCL6 +ve.		*BCL6 +ve.

Michael: fix sp.

2014-05-13T03:19:58Z

fix sp.

← Older revision		Revision as of 03:19, 13 May 2014
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	<gallery>		<gallery>
	Image: Follicular lymphoma -- very low mag.jpg \| FL - very low mag.		Image: Follicular lymphoma -- very low mag.jpg \| FL - very low mag.
	Image: ~~Follicluar~~ lymphoma -- low mag.jpg \| FL - low mag.		Image: Follicular lymphoma -- low mag.jpg \| FL - low mag.
	Image: Follicular lymphoma -- intermed mag.jpg \| FL - intermed. mag.		Image: Follicular lymphoma -- intermed mag.jpg \| FL - intermed. mag.
	Image: Follicular lymphoma -- high mag.jpg \| FL - high mag.		Image: Follicular lymphoma -- high mag.jpg \| FL - high mag.

Michael at 03:16, 13 May 2014

2014-05-13T03:16:44Z

← Older revision		Revision as of 03:16, 13 May 2014
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image = Follicular lymphoma -- ~~very~~ low mag.jpg		\| Image = Follicular lymphoma -- low mag.jpg
	\| Width =		\| Width =
	\| Caption = Follicular lymphoma. [[H&E stain]].		\| Caption = Follicular lymphoma. [[H&E stain]].

Michael: +images

2014-05-13T03:15:03Z

+images

← Older revision		Revision as of 03:15, 13 May 2014
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image = ~~Follicular_Lymphoma,_Paratrabecular_Involvement_of_Bone_Marrow_(5691578596)~~.jpg		\| Image = Follicular lymphoma -- very low mag.jpg
	\| Width =		\| Width =
	\| Caption =		\| Caption = Follicular lymphoma. [[H&E stain]].
	\| Synonyms =		\| Synonyms =
	\| Micro = Lymph node: abundant abnormally-shaped lymphoid follicles with some of the following: non-polarized mantle zone, non-polarized germinal center, loss of tingible body macrophages, sinuses effaced (lost)		\| Micro = Lymph node: abundant abnormally-shaped lymphoid follicles with some of the following: non-polarized mantle zone, non-polarized germinal center, loss of tingible body macrophages, sinuses effaced (lost)
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	===Images===		===Images===
			<gallery>
			Image: Follicular lymphoma -- very low mag.jpg \| FL - very low mag.
			Image: Follicluar lymphoma -- low mag.jpg \| FL - low mag.
			Image: Follicular lymphoma -- intermed mag.jpg \| FL - intermed. mag.
			Image: Follicular lymphoma -- high mag.jpg \| FL - high mag.
			Image: Follicular lymphoma -- very high mag.jpg \| FL - very high mag.
			</gallery>
	<gallery>		<gallery>
	Image:Follicular_Lymphoma,_Paratrabecular_Involvement_of_Bone_Marrow_(5691578596).jpg \| FL - bone marrow. (WC/euthman)		Image:Follicular_Lymphoma,_Paratrabecular_Involvement_of_Bone_Marrow_(5691578596).jpg \| FL - bone marrow. (WC/euthman)
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	*BCL2 +ve<ref name=pmid18359244>{{cite journal \|author=Vitolo U, Ferreri AJ, Montoto S \|title=Follicular lymphomas \|journal=Crit. Rev. Oncol. Hematol. \|volume=66 \|issue=3 \|pages=248–61 \|year=2008 \|month=June \|pmid=18359244 \|doi=10.1016/j.critrevonc.2008.01.014 \|url=}}</ref> - like many other small cell lymphomas.		*BCL2 +ve<ref name=pmid18359244>{{cite journal \|author=Vitolo U, Ferreri AJ, Montoto S \|title=Follicular lymphomas \|journal=Crit. Rev. Oncol. Hematol. \|volume=66 \|issue=3 \|pages=248–61 \|year=2008 \|month=June \|pmid=18359244 \|doi=10.1016/j.critrevonc.2008.01.014 \|url=}}</ref> - like many other small cell lymphomas.
	**Usually negative in benign germinal centres.		**Usually negative in benign germinal centres.

	~~Image:~~
	*[http://www.pathpedia.com/education/eatlas/histopathology/lymph_node/follicular_lymphoma/follicular-lymphoma-%5B16-ln021_cd21%5D.jpeg Follicular lymphoma - CD21 (pathpedia.com)].

	A panel to work-up:		A panel to work-up:
	*BCL2, BCL6, CD3, CD5, CD10, CD20, CD23, cyclin D1.		*BCL2, BCL6, CD3, CD5, CD10, CD20, CD23, cyclin D1.
			===Images===
			<gallery>
			Image: Follicluar lymphoma - bcl2 -- low mag.jpg \| FL - BCL2 - low mag.
			Image: Follicular lymphoma - control bcl2 -- low mag.jpg \| FL - BCL2 control - low mag.
			</gallery>
			www:
			*[http://www.pathpedia.com/education/eatlas/histopathology/lymph_node/follicular_lymphoma/follicular-lymphoma-%5B16-ln021_cd21%5D.jpeg Follicular lymphoma - CD21 (pathpedia.com)].

	==Molecular==		==Molecular==

Michael at 02:11, 30 December 2013

2013-12-30T02:11:30Z

← Older revision		Revision as of 02:11, 30 December 2013
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	\| IHC = CD20 +ve, CD10 +ve, BCL-6 +ve, BCL-2 +ve		\| IHC = CD20 +ve, CD10 +ve, BCL-6 +ve, BCL-2 +ve
	\| EM =		\| EM =
	\| Molecular =		\| Molecular = t(14;18)(q32;q21) / IGH-BCL2
	\| IF =		\| IF =
	\| Gross = white lesions +/-subtle fine nodularity (fish flesh-like appearance)		\| Gross = white lesions +/-subtle fine nodularity (fish flesh-like appearance)

Michael at 02:07, 30 December 2013

2013-12-30T02:07:52Z

← Older revision		Revision as of 02:07, 30 December 2013
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	\| Caption =		\| Caption =
	\| Synonyms =		\| Synonyms =
	\| Micro = Lymph node -- abundant abnormally-shaped lymphoid follicles with some of the following: non-polarized mantle zone, non-polarized germinal center, loss of tingible body macrophages, sinuses effaced (lost)		\| Micro = Lymph node: abundant abnormally-shaped lymphoid follicles with some of the following: non-polarized mantle zone, non-polarized germinal center, loss of tingible body macrophages, sinuses effaced (lost)
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[diffuse large B-cell lymphoma]], other [[small cell lymphomas]], reactive follicular hyperplasia		\| LMDDx = [[diffuse large B-cell lymphoma]], other [[small cell lymphomas]], reactive follicular hyperplasia

Michael: /* IHC */

2013-12-29T23:40:02Z

IHC

← Older revision		Revision as of 23:40, 29 December 2013
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	*CD21 -ve in tumour cells; highlights follicular dendritic cells.		*CD21 -ve in tumour cells; highlights follicular dendritic cells.
	*BCL2 +ve<ref name=pmid18359244>{{cite journal \|author=Vitolo U, Ferreri AJ, Montoto S \|title=Follicular lymphomas \|journal=Crit. Rev. Oncol. Hematol. \|volume=66 \|issue=3 \|pages=248–61 \|year=2008 \|month=June \|pmid=18359244 \|doi=10.1016/j.critrevonc.2008.01.014 \|url=}}</ref> - like many other small cell lymphomas.		*BCL2 +ve<ref name=pmid18359244>{{cite journal \|author=Vitolo U, Ferreri AJ, Montoto S \|title=Follicular lymphomas \|journal=Crit. Rev. Oncol. Hematol. \|volume=66 \|issue=3 \|pages=248–61 \|year=2008 \|month=June \|pmid=18359244 \|doi=10.1016/j.critrevonc.2008.01.014 \|url=}}</ref> - like many other small cell lymphomas.
	**Usually negative in germinal centres.		**Usually negative in benign germinal centres.

	Image:		Image:

Michael at 23:31, 29 December 2013

2013-12-29T23:31:26Z

← Older revision		Revision as of 23:31, 29 December 2013
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	\| Caption =		\| Caption =
	\| Synonyms =		\| Synonyms =
	\| Micro =		\| Micro = Lymph node -- abundant abnormally-shaped lymphoid follicles with some of the following: non-polarized mantle zone, non-polarized germinal center, loss of tingible body macrophages, sinuses effaced (lost)
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[diffuse large B-cell lymphoma]], other [[small cell lymphomas]], reactive follicular hyperplasia		\| LMDDx = [[diffuse large B-cell lymphoma]], other [[small cell lymphomas]], reactive follicular hyperplasia

Michael at 23:28, 29 December 2013

2013-12-29T23:28:19Z

← Older revision		Revision as of 23:28, 29 December 2013
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	\| Rads =		\| Rads =
	\| Endoscopy =		\| Endoscopy =
	\| Prognosis = ~~usually~~ good		\| Prognosis = moderate to good
	\| Other =		\| Other =
	\| ClinDDx = other causes of lymphadenopathy - other [[lymphoma]]s, metastatic carcinoma		\| ClinDDx = other causes of lymphadenopathy - other [[lymphoma]]s, metastatic carcinoma
	\| Tx =		\| Tx =
	}}		}}
	'''Follicular lymphoma''', abbreviated '''FL''', is a very common [[non-Hodgkin lymphoma]]. It is a [[small cell lymphoma]] ~~and usually has an indolent behaviour~~.		'''Follicular lymphoma''', abbreviated '''FL''', is a very common [[non-Hodgkin lymphoma]]. It is a [[small cell lymphoma]].

	==General==		==General==
	*A very common type of lymphoma.		*A very common type of lymphoma.
	*~~Usually an indolent course~~.		*Moderate prognosis - overall five year survival ~ 66% in one cohort without transformation.<ref name=pmid23897955>{{Cite journal \| last1 = Link \| first1 = BK. \| last2 = Maurer \| first2 = MJ. \| last3 = Nowakowski \| first3 = GS. \| last4 = Ansell \| first4 = SM. \| last5 = Macon \| first5 = WR. \| last6 = Syrbu \| first6 = SI. \| last7 = Slager \| first7 = SL. \| last8 = Thompson \| first8 = CA. \| last9 = Inwards \| first9 = DJ. \| title = Rates and outcomes of follicular lymphoma transformation in the immunochemotherapy era: a report from the University of Iowa/MayoClinic Specialized Program of Research Excellence Molecular Epidemiology Resource. \| journal = J Clin Oncol \| volume = 31 \| issue = 26 \| pages = 3272-8 \| month = Sep \| year = 2013 \| doi = 10.1200/JCO.2012.48.3990 \| PMID = 23897955 }}
	*May transform to [[diffuse large B-cell lymphoma]].		</ref>
			*May transform to a more aggressive lymphoma, e.g. [[diffuse large B-cell lymphoma]].
			**Prognosis after transformation significantly worse - five year survival ~ 22%.<ref name=pmid23897955/>
			**Approximately 2% transform per year, or 10.7% in five years.<ref name=pmid23897955/>

	==Gross==		==Gross==

Michael at 23:19, 29 December 2013

2013-12-29T23:19:56Z

← Older revision		Revision as of 23:19, 29 December 2013
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image =		\| Image = Follicular_Lymphoma,_Paratrabecular_Involvement_of_Bone_Marrow_(5691578596).jpg
	\| Width =		\| Width =
	\| Caption =		\| Caption =
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	\| Gross = white lesions +/-subtle fine nodularity (fish flesh-like appearance)		\| Gross = white lesions +/-subtle fine nodularity (fish flesh-like appearance)
	\| Grossing =		\| Grossing =
	\| Site = [[lymph node]], [[spleen]]		\| Site = [[lymph node]], [[spleen]], [[bone marrow]], others
	\| Assdx =		\| Assdx =
	\| Syndromes =		\| Syndromes =
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	===Images===		===Images===
			<gallery>
			Image:Follicular_Lymphoma,_Paratrabecular_Involvement_of_Bone_Marrow_(5691578596).jpg \| FL - bone marrow. (WC/euthman)
			</gallery>
			www:
	*[http://www.flickr.com/photos/euthman/3311641845/ Follicular lymphoma - bone marrow (flickr.com)].		*[http://www.flickr.com/photos/euthman/3311641845/ Follicular lymphoma - bone marrow (flickr.com)].
	*[http://library.med.utah.edu/WebPath/HEMEHTML/HEME034.html Follicular lymphoma (utah.edu)].		*[http://library.med.utah.edu/WebPath/HEMEHTML/HEME034.html Follicular lymphoma (utah.edu)].

← Older revision		Revision as of 03:19, 13 May 2014
Line 70:		Line 70:
	<gallery>		<gallery>
	Image: Follicular lymphoma -- very low mag.jpg \| FL - very low mag.		Image: Follicular lymphoma -- very low mag.jpg \| FL - very low mag.
	Image: ~~Follicluar~~ lymphoma -- low mag.jpg \| FL - low mag.		Image: Follicular lymphoma -- low mag.jpg \| FL - low mag.
	Image: Follicular lymphoma -- intermed mag.jpg \| FL - intermed. mag.		Image: Follicular lymphoma -- intermed mag.jpg \| FL - intermed. mag.
	Image: Follicular lymphoma -- high mag.jpg \| FL - high mag.		Image: Follicular lymphoma -- high mag.jpg \| FL - high mag.