Eosinophilic vacuolated tumour - Revision history

Michael at 01:02, 19 March 2025

2025-03-19T01:02:24Z

← Older revision		Revision as of 01:02, 19 March 2025
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	\| Image = High-grade oncocytic renal tumour -- high mag.jpg		\| Image = High-grade oncocytic renal tumour -- high mag.jpg
	\| Width =		\| Width =
	\| Caption = Micrograph of ~~a high-grade oncocytic~~ tumour ~~of the kidney~~. [[H&E stain]].		\| Caption = Micrograph of an eosinophilic vacuolated tumour. [[H&E stain]].
	\| Synonyms = high-grade oncocytic tumour		\| Synonyms = high-grade oncocytic tumour
	\| Micro = abundant oncocytic cytoplasm with prominent intracytoplasmic vacuoles,		\| Micro = abundant oncocytic cytoplasm with prominent intracytoplasmic vacuoles,

Michael at 04:15, 20 March 2024

2024-03-20T04:15:28Z

← Older revision		Revision as of 04:15, 20 March 2024
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	\| IHC = PAX8 +ve, CD117 +ve, CD10 +ve, SDHB +ve, TFE3 -ve		\| IHC = PAX8 +ve, CD117 +ve, CD10 +ve, SDHB +ve, TFE3 -ve
	\| EM =		\| EM =
	\| Molecular =		\| Molecular = TSC1 or TSC2 mutation
	\| IF =		\| IF =
	\| Gross =		\| Gross =
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	*CD56 +ve.{{fact}}		*CD56 +ve.{{fact}}
	**Typically negative in [[renal oncocytoma]].		**Typically negative in [[renal oncocytoma]].

			==Molecular==
			*TSC1 or TSC2 mutation - see [[renal neoplasms with TSC/mTOR pathway mutations]].

	==See also==		==See also==

Michael at 16:43, 28 May 2023

2023-05-28T16:43:40Z

← Older revision		Revision as of 16:43, 28 May 2023
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	*TFE3 -ve.		*TFE3 -ve.
	*[[CD117]] +ve (9 of 14 cases).		*[[CD117]] +ve (9 of 14 cases).

			Others:
			*CD56 +ve.{{fact}}
			**Typically negative in [[renal oncocytoma]].

	==See also==		==See also==

Michael at 16:22, 14 November 2021

2021-11-14T16:22:53Z

← Older revision		Revision as of 16:22, 14 November 2021
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	\| Width =		\| Width =
	\| Caption = Micrograph of a high-grade oncocytic tumour of the kidney. [[H&E stain]].		\| Caption = Micrograph of a high-grade oncocytic tumour of the kidney. [[H&E stain]].
	\| Synonyms = high-grade oncocytic ~~renal~~ tumour		\| Synonyms = high-grade oncocytic tumour
	\| Micro = abundant oncocytic cytoplasm with prominent intracytoplasmic vacuoles,		\| Micro = abundant oncocytic cytoplasm with prominent intracytoplasmic vacuoles,
	round nuclei, [[prominent nucleoli]] ([[ISUP nucleolar grade]] 3), no perinuclear halos		round nuclei, [[prominent nucleoli]] ([[ISUP nucleolar grade]] 3), no perinuclear halos
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	'''Eosinophilic vacuolated tumour''', abbreviated '''EVT''', is a [[kidney tumour]] type currently not recognized by the WHO classification as per the 2016 Blue Book.		'''Eosinophilic vacuolated tumour''', abbreviated '''EVT''', is a [[kidney tumour]] type currently not recognized by the WHO classification as per the 2016 Blue Book.

	It was previously known as '''~~High~~-grade oncocytic ~~renal~~ tumour''', abbreviated '''HOT'''.<ref name=pmid34521993>{{cite journal \|authors=Farcaş M, Gatalica Z, Trpkov K, Swensen J, Zhou M, Alaghehbandan R, Williamson SR, Magi-Galluzzi C, Gill AJ, Tretiakova M, Lopez JI, Montiel DP, Sperga M, Comperat E, Brimo F, Yilmaz A, Siadat F, Sangoi A, Gao Y, Ptákova N, Kuthi L, Pivovarcikova K, Rogala J, Agaimy A, Hartmann A, Fraune C, Rychly B, Hurnik P, Durcansky D, Bonert M, Gakis G, Michal M, Hora M, Hes O \|title=Eosinophilic vacuolated tumor (EVT) of kidney demonstrates sporadic TSC/MTOR mutations: next-generation sequencing multi-institutional study of 19 cases \|journal=Mod Pathol \|volume= \|issue= \|pages= \|date=September 2021 \|pmid=34521993 \|doi=10.1038/s41379-021-00923-6 \|url=}}</ref>		It was previously known as '''high-grade oncocytic tumour''', abbreviated '''HOT'''.<ref name=pmid34521993>{{cite journal \|authors=Farcaş M, Gatalica Z, Trpkov K, Swensen J, Zhou M, Alaghehbandan R, Williamson SR, Magi-Galluzzi C, Gill AJ, Tretiakova M, Lopez JI, Montiel DP, Sperga M, Comperat E, Brimo F, Yilmaz A, Siadat F, Sangoi A, Gao Y, Ptákova N, Kuthi L, Pivovarcikova K, Rogala J, Agaimy A, Hartmann A, Fraune C, Rychly B, Hurnik P, Durcansky D, Bonert M, Gakis G, Michal M, Hora M, Hes O \|title=Eosinophilic vacuolated tumor (EVT) of kidney demonstrates sporadic TSC/MTOR mutations: next-generation sequencing multi-institutional study of 19 cases \|journal=Mod Pathol \|volume= \|issue= \|pages= \|date=September 2021 \|pmid=34521993 \|doi=10.1038/s41379-021-00923-6 \|url=}}</ref>

	==General==		==General==

Michael: +ref

2021-11-13T22:47:18Z

+ref

← Older revision		Revision as of 22:47, 13 November 2021
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	'''Eosinophilic vacuolated tumour''', abbreviated '''EVT''', is a [[kidney tumour]] type currently not recognized by the WHO classification as per the 2016 Blue Book.		'''Eosinophilic vacuolated tumour''', abbreviated '''EVT''', is a [[kidney tumour]] type currently not recognized by the WHO classification as per the 2016 Blue Book.

	It was previously known as '''High-grade oncocytic renal tumour''', abbreviated '''HOT'''.		It was previously known as '''High-grade oncocytic renal tumour''', abbreviated '''HOT'''.<ref name=pmid34521993>{{cite journal \|authors=Farcaş M, Gatalica Z, Trpkov K, Swensen J, Zhou M, Alaghehbandan R, Williamson SR, Magi-Galluzzi C, Gill AJ, Tretiakova M, Lopez JI, Montiel DP, Sperga M, Comperat E, Brimo F, Yilmaz A, Siadat F, Sangoi A, Gao Y, Ptákova N, Kuthi L, Pivovarcikova K, Rogala J, Agaimy A, Hartmann A, Fraune C, Rychly B, Hurnik P, Durcansky D, Bonert M, Gakis G, Michal M, Hora M, Hes O \|title=Eosinophilic vacuolated tumor (EVT) of kidney demonstrates sporadic TSC/MTOR mutations: next-generation sequencing multi-institutional study of 19 cases \|journal=Mod Pathol \|volume= \|issue= \|pages= \|date=September 2021 \|pmid=34521993 \|doi=10.1038/s41379-021-00923-6 \|url=}}</ref>

	==General==		==General==
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	==References==		==References==
	{{Reflist\|1}}		{{Reflist\|2}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]

Michael: update

2021-11-13T21:54:24Z

update

← Older revision		Revision as of 21:54, 13 November 2021
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	\| Width =		\| Width =
	\| Caption = Micrograph of a high-grade oncocytic tumour of the kidney. [[H&E stain]].		\| Caption = Micrograph of a high-grade oncocytic tumour of the kidney. [[H&E stain]].
	\| Synonyms =		\| Synonyms = high-grade oncocytic renal tumour
	\| Micro = abundant oncocytic cytoplasm with prominent intracytoplasmic vacuoles,		\| Micro = abundant oncocytic cytoplasm with prominent intracytoplasmic vacuoles,
	round nuclei, [[prominent nucleoli]] ([[ISUP nucleolar grade]] 3), no perinuclear halos		round nuclei, [[prominent nucleoli]] ([[ISUP nucleolar grade]] 3), no perinuclear halos
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	\| Tx = excision		\| Tx = excision
	}}		}}
	'''~~High-grade oncocytic renal~~ tumour''', abbreviated '''~~HOT~~''', is a [[kidney tumour]] type currently not recognized by the WHO classification as per the 2016 Blue Book.		'''Eosinophilic vacuolated tumour''', abbreviated '''EVT''', is a [[kidney tumour]] type currently not recognized by the WHO classification as per the 2016 Blue Book.

			It was previously known as '''High-grade oncocytic renal tumour''', abbreviated '''HOT'''.

	==General==		==General==

Michael: Michael moved page High-grade oncocytic renal tumour to Eosinophilic vacuolated tumour: entity renamed

2021-11-13T21:52:50Z

Michael moved page High-grade oncocytic renal tumour to Eosinophilic vacuolated tumour: entity renamed

← Older revision

Revision as of 21:52, 13 November 2021

Michael at 22:00, 14 July 2019

2019-07-14T22:00:04Z

← Older revision		Revision as of 22:00, 14 July 2019
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	\| Caption = Micrograph of a high-grade oncocytic tumour of the kidney. [[H&E stain]].		\| Caption = Micrograph of a high-grade oncocytic tumour of the kidney. [[H&E stain]].
	\| Synonyms =		\| Synonyms =
	\| Micro =		\| Micro = abundant oncocytic cytoplasm with prominent intracytoplasmic vacuoles,
			round nuclei, [[prominent nucleoli]] ([[ISUP nucleolar grade]] 3), no perinuclear halos
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[renal oncocytoma]], [[renal hybrid oncocytic/chromophobe tumour]], [[chromophobe renal cell carcinoma]], other [[renal tumours with eosinophilic cytoplasm]]		\| LMDDx = [[renal oncocytoma]], [[renal hybrid oncocytic/chromophobe tumour]], [[chromophobe renal cell carcinoma]], other [[renal tumours with eosinophilic cytoplasm]]

Michael: /* IHC */

2019-07-14T21:58:02Z

IHC

← Older revision		Revision as of 21:58, 14 July 2019
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	==IHC==		==IHC==
	Features:<ref name=pmid30232607/>		Features:<ref name=pmid30232607/>
	*PAX8 +ve ~~(13 of 13 cases)~~.		*PAX8 +ve.
	*AE1/AE3 +ve.		*AE1/AE3 +ve.
	*CK18 +ve.		*CK18 +ve.
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	*Melan A -ve.		*Melan A -ve.
	*TFE3 -ve.		*TFE3 -ve.
			*[[CD117]] +ve (9 of 14 cases).

	==See also==		==See also==

Michael at 21:55, 14 July 2019

2019-07-14T21:55:38Z

← Older revision		Revision as of 21:55, 14 July 2019
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	\| Micro =		\| Micro =
	\| Subtypes =		\| Subtypes =
	\| LMDDx =		\| LMDDx = [[renal oncocytoma]], [[renal hybrid oncocytic/chromophobe tumour]], [[chromophobe renal cell carcinoma]], other [[renal tumours with eosinophilic cytoplasm]]
	\| Stains =		\| Stains =
	\| IHC =		\| IHC = PAX8 +ve, CD117 +ve, CD10 +ve, SDHB +ve, TFE3 -ve
	\| EM =		\| EM =
	\| Molecular =		\| Molecular =
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	\| Grossing =		\| Grossing =
	\| Staging =		\| Staging =
	\| Site =		\| Site = [[kidney]] - see ''[[kidney tumours]]''
	\| Assdx =		\| Assdx =
	\| Syndromes =		\| Syndromes = [[tuberous sclerosis]]
	\| Clinicalhx =		\| Clinicalhx =
	\| Signs =		\| Signs =
	\| Symptoms =		\| Symptoms =
	\| Prevalence =		\| Prevalence = very rare? (evolving entity)
	\| Bloodwork =		\| Bloodwork =
	\| Rads =		\| Rads =
	\| Endoscopy =		\| Endoscopy =
	\| Prognosis =		\| Prognosis = unknown (evolving entity)
	\| Other =		\| Other =
	\| ClinDDx =		\| ClinDDx = other [[renal tumours]]
	\| Tx =		\| Tx = excision
	}}		}}
	'''High-grade oncocytic renal tumour''', abbreviated '''HOT''', is a [[kidney tumour]] type currently not recognized by the WHO classification as per the 2016 Blue Book.		'''High-grade oncocytic renal tumour''', abbreviated '''HOT''', is a [[kidney tumour]] type currently not recognized by the WHO classification as per the 2016 Blue Book.