Endolymphatic sac tumour - Revision history

Jensflorian: +cat

2015-04-29T08:57:30Z

+cat

← Older revision		Revision as of 08:57, 29 April 2015
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	[[Category:Head and neck pathology]]		[[Category:Head and neck pathology]]
	[[Category:Neuropathology]]		[[Category:Neuropathology]]
			[[Category:Papillary tumour]]

Michael: remove extra space

2015-04-29T05:21:55Z

remove extra space

← Older revision		Revision as of 05:21, 29 April 2015
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	\| Tx =		\| Tx =
	}}		}}

	'''Endolymphatic sac tumour''', abbreviated '''ELST''', is a very rare tumour associated with [[von Hippel-Lindau disease]].		'''Endolymphatic sac tumour''', abbreviated '''ELST''', is a very rare tumour associated with [[von Hippel-Lindau disease]].

Michael: sm. tweak

2015-04-29T05:21:26Z

sm. tweak

← Older revision		Revision as of 05:21, 29 April 2015
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	\| Micro = Papillary epithelial structures.		\| Micro = Papillary epithelial structures.
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[~~choriod~~ plexus papilloma]]		\| LMDDx = [[choroid plexus papilloma]], metastatic [[adenocarcinoma]]
	\| Stains =		\| Stains =
	\| IHC = CK7 +ve		\| IHC = CK7 +ve
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	\| Clinicalhx =		\| Clinicalhx =
	\| Signs =		\| Signs =
	\| Symptoms = ~~Tinnitus~~, dizziness		\| Symptoms = tinnitus, dizziness
	\| Prevalence = very rare		\| Prevalence = very rare
	\| Bloodwork =		\| Bloodwork =
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	*S-100 +ve (focally).		*S-100 +ve (focally).
	*CD31 +ve - marks the outline of the papillary structures.<ref name=pmid24966979/>		*CD31 +ve - marks the outline of the papillary structures.<ref name=pmid24966979/>
	*Kir 7.1-ve - discriminates tumour from plexus papilloma.<ref name=pmid22706862>{{Cite journal \| last1 = Schittenhelm \| first1 = J. \| last2 = Roser \| first2 = F. \| last3 = Tatagiba \| first3 = M. \| last4 = Beschorner \| first4 = R. \| title = Diagnostic value of EAAT-1 and Kir7.1 for distinguishing endolymphatic sac tumors from choroid plexus tumors. \| journal = Am J Clin Pathol \| volume = 138 \| issue = 1 \| pages = 85-9 \| month = Jul \| year = 2012 \| doi = 10.1309/AJCPPRKNNL09JTLP \| PMID = 22706862 }}</ref>		*Kir 7.1 -ve - discriminates tumour from plexus papilloma.<ref name=pmid22706862>{{Cite journal \| last1 = Schittenhelm \| first1 = J. \| last2 = Roser \| first2 = F. \| last3 = Tatagiba \| first3 = M. \| last4 = Beschorner \| first4 = R. \| title = Diagnostic value of EAAT-1 and Kir7.1 for distinguishing endolymphatic sac tumors from choroid plexus tumors. \| journal = Am J Clin Pathol \| volume = 138 \| issue = 1 \| pages = 85-9 \| month = Jul \| year = 2012 \| doi = 10.1309/AJCPPRKNNL09JTLP \| PMID = 22706862 }}</ref>

	==See also==		==See also==

Michael: tweak formating, wikifying

2015-04-29T05:20:24Z

tweak formating, wikifying

← Older revision		Revision as of 05:20, 29 April 2015
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	\| Micro = Papillary epithelial structures.		\| Micro = Papillary epithelial structures.
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[~~Plexus~~ papilloma]]		\| LMDDx = [[choriod plexus papilloma]]
	\| Stains =		\| Stains =
	\| IHC = CK7 +ve		\| IHC = CK7 +ve
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	DDx:		DDx:
	*Choroid plexus papilloma - when infiltrating cerebellopontine angle via petrous bone		*[[Choroid plexus papilloma]] - when infiltrating cerebellopontine angle via petrous bone.
	*Metastatic [[adenocarcinoma]]		*[[Metastatic]] [[adenocarcinoma]].

	===Images===		===Images===
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	==IHC==		==IHC==
	*CK7 +ve		*CK7 +ve.
	*S-100 +ve (focally)		*S-100 +ve (focally).
	*CD31 +ve - marks the outline of the papillary structures.<ref name=pmid24966979/>		*CD31 +ve - marks the outline of the papillary structures.<ref name=pmid24966979/>
	*Kir 7.1-ve - discriminates ~~tumor~~ from plexus papilloma.<ref>{{Cite journal \| last1 = Schittenhelm \| first1 = J. \| last2 = Roser \| first2 = F. \| last3 = Tatagiba \| first3 = M. \| last4 = Beschorner \| first4 = R. \| title = Diagnostic value of EAAT-1 and Kir7.1 for distinguishing endolymphatic sac tumors from choroid plexus tumors. \| journal = Am J Clin Pathol \| volume = 138 \| issue = 1 \| pages = 85-9 \| month = Jul \| year = 2012 \| doi = 10.1309/AJCPPRKNNL09JTLP \| PMID = 22706862 }}</ref>		*Kir 7.1-ve - discriminates tumour from plexus papilloma.<ref name=pmid22706862>{{Cite journal \| last1 = Schittenhelm \| first1 = J. \| last2 = Roser \| first2 = F. \| last3 = Tatagiba \| first3 = M. \| last4 = Beschorner \| first4 = R. \| title = Diagnostic value of EAAT-1 and Kir7.1 for distinguishing endolymphatic sac tumors from choroid plexus tumors. \| journal = Am J Clin Pathol \| volume = 138 \| issue = 1 \| pages = 85-9 \| month = Jul \| year = 2012 \| doi = 10.1309/AJCPPRKNNL09JTLP \| PMID = 22706862 }}</ref>

	==See also==		==See also==

Jensflorian: pictures + infobox

2015-04-28T12:51:42Z

pictures + infobox

← Older revision		Revision as of 12:51, 28 April 2015
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = ELST_high_magnification_HE.jpg
			\| Width =
			\| Caption = Endolymphatic sac tumor [[H&E stain]].
			\| Synonyms =
			\| Micro = Papillary epithelial structures.
			\| Subtypes =
			\| LMDDx = [[Plexus papilloma]]
			\| Stains =
			\| IHC = CK7 +ve
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = usually inner ear
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms = Tinnitus, dizziness
			\| Prevalence = very rare
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = locally agressive
			\| Other =
			\| ClinDDx =
			\| Tx =
			}}

	'''Endolymphatic sac tumour''', abbreviated '''ELST''', is a very rare tumour associated with [[von Hippel-Lindau disease]].		'''Endolymphatic sac tumour''', abbreviated '''ELST''', is a very rare tumour associated with [[von Hippel-Lindau disease]].

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	*Papillary structures.		*Papillary structures.
	*Low grade cytomorphology (lack [[nuclear pleomorphism]]).		*Low grade cytomorphology (lack [[nuclear pleomorphism]]).

			DDx:
			*Choroid plexus papilloma - when infiltrating cerebellopontine angle via petrous bone
			*Metastatic [[adenocarcinoma]]

	===Images===		===Images===
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	*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069932/figure/fig02/ ELST (nih.gov)].<ref name=pmid24966975>{{Cite journal \| last1 = Yang \| first1 = X. \| last2 = Liu \| first2 = XS. \| last3 = Fang \| first3 = Y. \| last4 = Zhang \| first4 = XH. \| last5 = Zhang \| first5 = YK. \| title = Endolymphatic sac tumor with von Hippel-Lindau disease: report of a case with atypical pathology of endolymphatic sac tumor. \| journal = Int J Clin Exp Pathol \| volume = 7 \| issue = 5 \| pages = 2609-14 \| month = \| year = 2014 \| doi = \| PMID = 24966975 }}</ref>		*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069932/figure/fig02/ ELST (nih.gov)].<ref name=pmid24966975>{{Cite journal \| last1 = Yang \| first1 = X. \| last2 = Liu \| first2 = XS. \| last3 = Fang \| first3 = Y. \| last4 = Zhang \| first4 = XH. \| last5 = Zhang \| first5 = YK. \| title = Endolymphatic sac tumor with von Hippel-Lindau disease: report of a case with atypical pathology of endolymphatic sac tumor. \| journal = Int J Clin Exp Pathol \| volume = 7 \| issue = 5 \| pages = 2609-14 \| month = \| year = 2014 \| doi = \| PMID = 24966975 }}</ref>
	*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069893/figure/fig03/ ELST (nih.gov)].<ref name=pmid24966979>{{Cite journal \| last1 = Künzel \| first1 = J. \| last2 = Agaimy \| first2 = A. \| last3 = Hornung \| first3 = J. \| last4 = Lell \| first4 = M. \| last5 = Ganslandt \| first5 = O. \| last6 = Semrau \| first6 = S. \| last7 = Zenk \| first7 = J. \| title = Sporadic endolymphatic sac tumor--a diagnostic and therapeutic challenge. \| journal = Int J Clin Exp Pathol \| volume = 7 \| issue = 5 \| pages = 2641-6 \| month = \| year = 2014 \| doi = \| PMID = 24966979 \| PMC = 4069893}}</ref>		*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069893/figure/fig03/ ELST (nih.gov)].<ref name=pmid24966979>{{Cite journal \| last1 = Künzel \| first1 = J. \| last2 = Agaimy \| first2 = A. \| last3 = Hornung \| first3 = J. \| last4 = Lell \| first4 = M. \| last5 = Ganslandt \| first5 = O. \| last6 = Semrau \| first6 = S. \| last7 = Zenk \| first7 = J. \| title = Sporadic endolymphatic sac tumor--a diagnostic and therapeutic challenge. \| journal = Int J Clin Exp Pathol \| volume = 7 \| issue = 5 \| pages = 2641-6 \| month = \| year = 2014 \| doi = \| PMID = 24966979 \| PMC = 4069893}}</ref>

			<gallery>
			File:Ear_Endolymphatic_Sac_Tumor_H_and_E_Low_power_LDRT.tif \| ELST low power, HE (WC/Soca1zim)
			File:Ear Endolymphatic Sac Tumor H & E High power LDRT.tif \| ELST high magnification, HE (WC/Soca1zim)
			File:ELST_high_magnification_HE.jpg \| ELST very high magnification, HE (WC/jensflorian)
			File:ELST_frozen_section_HE.jpg \| Intraoperative frozen section, ELST, HE (WC/jensflorian)
			</gallery>

	==IHC==		==IHC==
			*CK7 +ve
			*S-100 +ve (focally)
	*CD31 +ve - marks the outline of the papillary structures.<ref name=pmid24966979/>		*CD31 +ve - marks the outline of the papillary structures.<ref name=pmid24966979/>
			*Kir 7.1-ve - discriminates tumor from plexus papilloma.<ref>{{Cite journal \| last1 = Schittenhelm \| first1 = J. \| last2 = Roser \| first2 = F. \| last3 = Tatagiba \| first3 = M. \| last4 = Beschorner \| first4 = R. \| title = Diagnostic value of EAAT-1 and Kir7.1 for distinguishing endolymphatic sac tumors from choroid plexus tumors. \| journal = Am J Clin Pathol \| volume = 138 \| issue = 1 \| pages = 85-9 \| month = Jul \| year = 2012 \| doi = 10.1309/AJCPPRKNNL09JTLP \| PMID = 22706862 }}</ref>

	==See also==		==See also==

Michael: /* IHC */

2015-03-03T22:29:51Z

IHC

← Older revision		Revision as of 22:29, 3 March 2015
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	==IHC==		==IHC==
	*CD31 +ve - ~~mark~~ the outline of the papillary structures.<ref name=pmid24966979/>		*CD31 +ve - marks the outline of the papillary structures.<ref name=pmid24966979/>

	==See also==		==See also==

Michael at 17:43, 3 March 2015

2015-03-03T17:43:04Z

← Older revision		Revision as of 17:43, 3 March 2015
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	*Locally aggressive.<ref name=pmid24966979>{{Cite journal \| last1 = Künzel \| first1 = J. \| last2 = Agaimy \| first2 = A. \| last3 = Hornung \| first3 = J. \| last4 = Lell \| first4 = M. \| last5 = Ganslandt \| first5 = O. \| last6 = Semrau \| first6 = S. \| last7 = Zenk \| first7 = J. \| title = Sporadic endolymphatic sac tumor--a diagnostic and therapeutic challenge. \| journal = Int J Clin Exp Pathol \| volume = 7 \| issue = 5 \| pages = 2641-6 \| month = \| year = 2014 \| doi = \| PMID = 24966979 }}</ref>		*Locally aggressive.<ref name=pmid24966979>{{Cite journal \| last1 = Künzel \| first1 = J. \| last2 = Agaimy \| first2 = A. \| last3 = Hornung \| first3 = J. \| last4 = Lell \| first4 = M. \| last5 = Ganslandt \| first5 = O. \| last6 = Semrau \| first6 = S. \| last7 = Zenk \| first7 = J. \| title = Sporadic endolymphatic sac tumor--a diagnostic and therapeutic challenge. \| journal = Int J Clin Exp Pathol \| volume = 7 \| issue = 5 \| pages = 2641-6 \| month = \| year = 2014 \| doi = \| PMID = 24966979 }}</ref>
	*Associated with [[von Hippel-Lindau disease]].		*Associated with [[von Hippel-Lindau disease]].
			*May be sporadic.<ref name=pmid24966979/>

	Clinical - common:<ref name=pmid24436884>{{Cite journal \| last1 = Friedman \| first1 = RA. \| last2 = Hoa \| first2 = M. \| last3 = Brackmann \| first3 = DE. \| title = Surgical management of endolymphatic sac tumors. \| journal = J Neurol Surg B Skull Base \| volume = 74 \| issue = 1 \| pages = 12-9 \| month = Feb \| year = 2013 \| doi = 10.1055/s-0032-1329622 \| PMID = 24436884 }}</ref>		Clinical - common:<ref name=pmid24436884>{{Cite journal \| last1 = Friedman \| first1 = RA. \| last2 = Hoa \| first2 = M. \| last3 = Brackmann \| first3 = DE. \| title = Surgical management of endolymphatic sac tumors. \| journal = J Neurol Surg B Skull Base \| volume = 74 \| issue = 1 \| pages = 12-9 \| month = Feb \| year = 2013 \| doi = 10.1055/s-0032-1329622 \| PMID = 24436884 }}</ref>
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	==References==		==References==
	{{Reflist\|1}}		{{Reflist\|2}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Head and neck pathology]]
			[[Category:Neuropathology]]

Michael at 17:39, 3 March 2015

2015-03-03T17:39:22Z

← Older revision		Revision as of 17:39, 3 March 2015
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	*Associated with [[von Hippel-Lindau disease]].		*Associated with [[von Hippel-Lindau disease]].

	Clinical - common:<ref name=pmid24436884/>		Clinical - common:<ref name=pmid24436884>{{Cite journal \| last1 = Friedman \| first1 = RA. \| last2 = Hoa \| first2 = M. \| last3 = Brackmann \| first3 = DE. \| title = Surgical management of endolymphatic sac tumors. \| journal = J Neurol Surg B Skull Base \| volume = 74 \| issue = 1 \| pages = 12-9 \| month = Feb \| year = 2013 \| doi = 10.1055/s-0032-1329622 \| PMID = 24436884 }}</ref>
	*Hearing loss (sensorineural).		*Hearing loss (sensorineural).
	*Tinnitus.		*Tinnitus.

Michael: more

2015-03-03T17:38:49Z

← Older revision		Revision as of 17:38, 3 March 2015
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	*Locally aggressive.<ref name=pmid24966979>{{Cite journal \| last1 = Künzel \| first1 = J. \| last2 = Agaimy \| first2 = A. \| last3 = Hornung \| first3 = J. \| last4 = Lell \| first4 = M. \| last5 = Ganslandt \| first5 = O. \| last6 = Semrau \| first6 = S. \| last7 = Zenk \| first7 = J. \| title = Sporadic endolymphatic sac tumor--a diagnostic and therapeutic challenge. \| journal = Int J Clin Exp Pathol \| volume = 7 \| issue = 5 \| pages = 2641-6 \| month = \| year = 2014 \| doi = \| PMID = 24966979 }}</ref>		*Locally aggressive.<ref name=pmid24966979>{{Cite journal \| last1 = Künzel \| first1 = J. \| last2 = Agaimy \| first2 = A. \| last3 = Hornung \| first3 = J. \| last4 = Lell \| first4 = M. \| last5 = Ganslandt \| first5 = O. \| last6 = Semrau \| first6 = S. \| last7 = Zenk \| first7 = J. \| title = Sporadic endolymphatic sac tumor--a diagnostic and therapeutic challenge. \| journal = Int J Clin Exp Pathol \| volume = 7 \| issue = 5 \| pages = 2641-6 \| month = \| year = 2014 \| doi = \| PMID = 24966979 }}</ref>
	*Associated with [[von Hippel-Lindau disease]].		*Associated with [[von Hippel-Lindau disease]].

			Clinical - common:<ref name=pmid24436884/>
			*Hearing loss (sensorineural).
			*Tinnitus.
			*Dizziness.

			Treatment:
			*Surgical excision.<ref name=pmid24436884/>

	==Microscopic==		==Microscopic==

Michael: more

2015-03-03T17:34:38Z

← Older revision		Revision as of 17:34, 3 March 2015
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	==General==		==General==
	*Rare.		*Rare.
			*Locally aggressive.<ref name=pmid24966979>{{Cite journal \| last1 = Künzel \| first1 = J. \| last2 = Agaimy \| first2 = A. \| last3 = Hornung \| first3 = J. \| last4 = Lell \| first4 = M. \| last5 = Ganslandt \| first5 = O. \| last6 = Semrau \| first6 = S. \| last7 = Zenk \| first7 = J. \| title = Sporadic endolymphatic sac tumor--a diagnostic and therapeutic challenge. \| journal = Int J Clin Exp Pathol \| volume = 7 \| issue = 5 \| pages = 2641-6 \| month = \| year = 2014 \| doi = \| PMID = 24966979 }}</ref>
			*Associated with [[von Hippel-Lindau disease]].

	==Microscopic==		==Microscopic==
			Features:<ref name=pmid24966979/>
			*Cystic spaces.
			*Papillary structures.
			*Low grade cytomorphology (lack [[nuclear pleomorphism]]).

	===Images===		===Images===
			www:
	*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069932/figure/fig02/ ELST (nih.gov)].<ref name=pmid24966975>{{Cite journal \| last1 = Yang \| first1 = X. \| last2 = Liu \| first2 = XS. \| last3 = Fang \| first3 = Y. \| last4 = Zhang \| first4 = XH. \| last5 = Zhang \| first5 = YK. \| title = Endolymphatic sac tumor with von Hippel-Lindau disease: report of a case with atypical pathology of endolymphatic sac tumor. \| journal = Int J Clin Exp Pathol \| volume = 7 \| issue = 5 \| pages = 2609-14 \| month = \| year = 2014 \| doi = \| PMID = 24966975 }}</ref>		*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069932/figure/fig02/ ELST (nih.gov)].<ref name=pmid24966975>{{Cite journal \| last1 = Yang \| first1 = X. \| last2 = Liu \| first2 = XS. \| last3 = Fang \| first3 = Y. \| last4 = Zhang \| first4 = XH. \| last5 = Zhang \| first5 = YK. \| title = Endolymphatic sac tumor with von Hippel-Lindau disease: report of a case with atypical pathology of endolymphatic sac tumor. \| journal = Int J Clin Exp Pathol \| volume = 7 \| issue = 5 \| pages = 2609-14 \| month = \| year = 2014 \| doi = \| PMID = 24966975 }}</ref>
			*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069893/figure/fig03/ ELST (nih.gov)].<ref name=pmid24966979>{{Cite journal \| last1 = Künzel \| first1 = J. \| last2 = Agaimy \| first2 = A. \| last3 = Hornung \| first3 = J. \| last4 = Lell \| first4 = M. \| last5 = Ganslandt \| first5 = O. \| last6 = Semrau \| first6 = S. \| last7 = Zenk \| first7 = J. \| title = Sporadic endolymphatic sac tumor--a diagnostic and therapeutic challenge. \| journal = Int J Clin Exp Pathol \| volume = 7 \| issue = 5 \| pages = 2641-6 \| month = \| year = 2014 \| doi = \| PMID = 24966979 \| PMC = 4069893}}</ref>

			==IHC==
			*CD31 +ve - mark the outline of the papillary structures.<ref name=pmid24966979/>

	==See also==		==See also==