Dysembryoplastic neuroepithelial tumour - Revision history

Michael: fix authors; 'vauthors'

2021-03-25T17:18:23Z

fix authors; 'vauthors'

← Older revision		Revision as of 17:18, 25 March 2021
Line 38:		Line 38:
	*MIB-1 (Ki-67) 0-8%		*MIB-1 (Ki-67) 0-8%

	Molecular:<ref name="pmid27791984">{{cite journal \|~~vauthors~~=Fina F, Barets D, Colin C, Bouvier C, Padovani L, Nanni-Metellus I, Ouafik L, Scavarda D, Korshunov A, Jones DT, Figarella-Branger D \|title=Droplet digital PCR is a powerful technique to demonstrate frequent FGFR1 duplication in dysembryoplastic neuroepithelial tumors \|journal=Oncotarget \|volume=8 \|issue=2 \|pages=2104–2113 \|date=January 2017 \|pmid=27791984 \|pmc=5356784 \|doi=10.18632/oncotarget.12881 \|url=}}</ref>		Molecular:<ref name="pmid27791984">{{cite journal \|authors=Fina F, Barets D, Colin C, Bouvier C, Padovani L, Nanni-Metellus I, Ouafik L, Scavarda D, Korshunov A, Jones DT, Figarella-Branger D \|title=Droplet digital PCR is a powerful technique to demonstrate frequent FGFR1 duplication in dysembryoplastic neuroepithelial tumors \|journal=Oncotarget \|volume=8 \|issue=2 \|pages=2104–2113 \|date=January 2017 \|pmid=27791984 \|pmc=5356784 \|doi=10.18632/oncotarget.12881 \|url=}}</ref>
	* BRAF V600E		* BRAF V600E
	* FGFR1 tandem duplication (FGFR1-TKDD)		* FGFR1 tandem duplication (FGFR1-TKDD)

Jensflorian: /* Microscopic */ Histo + DDx

2020-10-26T13:25:01Z

Microscopic: Histo + DDx

← Older revision		Revision as of 13:25, 26 October 2020
Line 20:		Line 20:
	==Microscopic==		==Microscopic==
	Features:<ref name=pmid18071981>{{Cite journal \| last1 = O'Brien \| first1 = DF. \| last2 = Farrell \| first2 = M. \| last3 = Delanty \| first3 = N. \| last4 = Traunecker \| first4 = H. \| last5 = Perrin \| first5 = R. \| last6 = Smyth \| first6 = MD. \| last7 = Park \| first7 = TS. \| title = The Children's Cancer and Leukaemia Group guidelines for the diagnosis and management of dysembryoplastic neuroepithelial tumours. \| journal = Br J Neurosurg \| volume = 21 \| issue = 6 \| pages = 539-49 \| month = Dec \| year = 2007 \| doi = 10.1080/02688690701594817 \| PMID = 18071981 }}</ref><ref>{{Cite journal \| last1 = Daumas-Duport \| first1 = C. \| title = Dysembryoplastic neuroepithelial tumours. \| journal = Brain Pathol \| volume = 3 \| issue = 3 \| pages = 283-95 \| month = Jul \| year = 1993 \| doi = \| PMID = 8293188 }}</ref>		Features:<ref name=pmid18071981>{{Cite journal \| last1 = O'Brien \| first1 = DF. \| last2 = Farrell \| first2 = M. \| last3 = Delanty \| first3 = N. \| last4 = Traunecker \| first4 = H. \| last5 = Perrin \| first5 = R. \| last6 = Smyth \| first6 = MD. \| last7 = Park \| first7 = TS. \| title = The Children's Cancer and Leukaemia Group guidelines for the diagnosis and management of dysembryoplastic neuroepithelial tumours. \| journal = Br J Neurosurg \| volume = 21 \| issue = 6 \| pages = 539-49 \| month = Dec \| year = 2007 \| doi = 10.1080/02688690701594817 \| PMID = 18071981 }}</ref><ref>{{Cite journal \| last1 = Daumas-Duport \| first1 = C. \| title = Dysembryoplastic neuroepithelial tumours. \| journal = Brain Pathol \| volume = 3 \| issue = 3 \| pages = 283-95 \| month = Jul \| year = 1993 \| doi = \| PMID = 8293188 }}</ref>
	*Specific glioneuronal element:		*Usu. multiple intracortical nodules.
			*Loose textured internodular component (Specific glioneuronal element):
	**Axonal columns oriented to the surface		**Axonal columns oriented to the surface
	**Floating neurons in eosinophilic matrix		**Floating neurons in eosinophilic matrix
Line 28:		Line 29:
	***Clear cytoplasm.		***Clear cytoplasm.
	**few stellated astrocytes		**few stellated astrocytes


	IHC:<ref>{{Cite journal \| last1 = Thom \| first1 = M. \| last2 = Toma \| first2 = A. \| last3 = An \| first3 = S. \| last4 = Martinian \| first4 = L. \| last5 = Hadjivassiliou \| first5 = G. \| last6 = Ratilal \| first6 = B. \| last7 = Dean \| first7 = A. \| last8 = McEvoy \| first8 = A. \| last9 = Sisodiya \| first9 = SM. \| title = One hundred and one dysembryoplastic neuroepithelial tumors: an adult epilepsy series with immunohistochemical, molecular genetic, and clinical correlations and a review of the literature. \| journal = J Neuropathol Exp Neurol \| volume = 70 \| issue = 10 \| pages = 859-78 \| month = Oct \| year = 2011 \| doi = 10.1097/NEN.0b013e3182302475 \| PMID = 21937911 }}</ref>		IHC:<ref>{{Cite journal \| last1 = Thom \| first1 = M. \| last2 = Toma \| first2 = A. \| last3 = An \| first3 = S. \| last4 = Martinian \| first4 = L. \| last5 = Hadjivassiliou \| first5 = G. \| last6 = Ratilal \| first6 = B. \| last7 = Dean \| first7 = A. \| last8 = McEvoy \| first8 = A. \| last9 = Sisodiya \| first9 = SM. \| title = One hundred and one dysembryoplastic neuroepithelial tumors: an adult epilepsy series with immunohistochemical, molecular genetic, and clinical correlations and a review of the literature. \| journal = J Neuropathol Exp Neurol \| volume = 70 \| issue = 10 \| pages = 859-78 \| month = Oct \| year = 2011 \| doi = 10.1097/NEN.0b013e3182302475 \| PMID = 21937911 }}</ref>
Line 47:		Line 49:
	**infiltrative microcystic formations may mimic glioneuronal element		**infiltrative microcystic formations may mimic glioneuronal element
	*[[Ganglioglioma]].		*[[Ganglioglioma]].
	**~~has~~ reticulin fibers, lymphocytic cuffs and large cysts.		**Has reticulin fibers, lymphocytic cuffs and large cysts.
			*Polymorphous low-grade neuroepithelial tumor of the young” (PLNTY).
			**Usu. strongly CD34+ve.

	===Images===		===Images===

Jensflorian: /* Microscopic */ +molecular

2020-10-26T10:33:29Z

Microscopic: +molecular

← Older revision		Revision as of 10:33, 26 October 2020
Line 36:		Line 36:
	*MIB-1 (Ki-67) 0-8%		*MIB-1 (Ki-67) 0-8%

	Molecular:		Molecular:<ref name="pmid27791984">{{cite journal \|vauthors=Fina F, Barets D, Colin C, Bouvier C, Padovani L, Nanni-Metellus I, Ouafik L, Scavarda D, Korshunov A, Jones DT, Figarella-Branger D \|title=Droplet digital PCR is a powerful technique to demonstrate frequent FGFR1 duplication in dysembryoplastic neuroepithelial tumors \|journal=Oncotarget \|volume=8 \|issue=2 \|pages=2104–2113 \|date=January 2017 \|pmid=27791984 \|pmc=5356784 \|doi=10.18632/oncotarget.12881 \|url=}}</ref>
			* BRAF V600E
			* FGFR1 tandem duplication (FGFR1-TKDD)

	DDx:		DDx:
	*[[Oligodendroglioma]].		*[[Oligodendroglioma]].

Jensflorian: + references +histology +IHC

2015-04-14T09:57:51Z

+ references +histology +IHC

← Older revision		Revision as of 09:57, 14 April 2015
Line 2:		Line 2:

	==General==		==General==
	*Common tumour cause of drug resistant [[epilepsy]].<ref name=pmid15881751>{{Cite journal \| last1 = Cataltepe \| first1 = O. \| last2 = Turanli \| first2 = G. \| last3 = Yalnizoglu \| first3 = D. \| last4 = Topçu \| first4 = M. \| last5 = Akalan \| first5 = N. \| title = Surgical management of temporal lobe tumor-related epilepsy in children. \| journal = J Neurosurg \| volume = 102 \| issue = 3 Suppl \| pages = 280-7 \| month = Apr \| year = 2005 \| doi = 10.3171/ped.2005.102.3.0280 \| PMID = 15881751 }}</ref>		*Common benign mixed neuronal-glial tumour cause of drug resistant [[epilepsy]].<ref name=pmid15881751>{{Cite journal \| last1 = Cataltepe \| first1 = O. \| last2 = Turanli \| first2 = G. \| last3 = Yalnizoglu \| first3 = D. \| last4 = Topçu \| first4 = M. \| last5 = Akalan \| first5 = N. \| title = Surgical management of temporal lobe tumor-related epilepsy in children. \| journal = J Neurosurg \| volume = 102 \| issue = 3 Suppl \| pages = 280-7 \| month = Apr \| year = 2005 \| doi = 10.3171/ped.2005.102.3.0280 \| PMID = 15881751 }}</ref>
	*Paediatric population.		*Paediatric population.
			* WHO grade I (ICD-O: 9413/0)

	==Gross/radiology==		==Gross/radiology==
	*Temporal lobe.		*Temporal lobe, usually cortical.
	*Variable architecture:<ref name=pmid18071981/> cystic, solitary nodular, multinodular.		*Variable architecture:<ref name=pmid18071981/> cystic, solitary nodular, multinodular.
			** DNET, simple form (only glioneuronal element)<ref>{{Cite journal \| last1 = Daumas-Duport \| first1 = C. \| title = Dysembryoplastic neuroepithelial tumours. \| journal = Brain Pathol \| volume = 3 \| issue = 3 \| pages = 283-95 \| month = Jul \| year = 1993 \| doi = \| PMID = 8293188 }}</ref>
			** DNET, complex form (multinodular architecture of astrocytic or oligodendroglial origin)<ref>{{Cite journal \| last1 = Daumas-Duport \| first1 = C. \| last2 = Scheithauer \| first2 = BW. \| last3 = Chodkiewicz \| first3 = JP. \| last4 = Laws \| first4 = ER. \| last5 = Vedrenne \| first5 = C. \| title = Dysembryoplastic neuroepithelial tumor: a surgically curable tumor of young patients with intractable partial seizures. Report of thirty-nine cases. \| journal = Neurosurgery \| volume = 23 \| issue = 5 \| pages = 545-56 \| month = Nov \| year = 1988 \| doi = \| PMID = 3143922 }}</ref>
			** DNET, non-specific histological form (debated, lacking glioneuronal element) <ref>{{Cite journal \| last1 = Sung \| first1 = CO. \| last2 = Suh \| first2 = YL. \| title = Different pattern of expression of nestin in the non-specific form of dysembryoplastic neuroepithelial tumors compared to the simple and complex forms. \| journal = J Neurooncol \| volume = 92 \| issue = 1 \| pages = 7-13 \| month = Mar \| year = 2009 \| doi = 10.1007/s11060-008-9725-z \| PMID = 18998057 }}</ref>
			*Adjacent cortical dysplasia in up to 80%<ref>{{Cite journal \| last1 = Sakuta \| first1 = R. \| last2 = Otsubo \| first2 = H. \| last3 = Nolan \| first3 = MA. \| last4 = Weiss \| first4 = SK. \| last5 = Hawkins \| first5 = C. \| last6 = Rutka \| first6 = JT. \| last7 = Chuang \| first7 = NA. \| last8 = Chuang \| first8 = SH. \| last9 = Snead \| first9 = OC. \| title = Recurrent intractable seizures in children with cortical dysplasia adjacent to dysembryoplastic neuroepithelial tumor. \| journal = J Child Neurol \| volume = 20 \| issue = 4 \| pages = 377-84 \| month = Apr \| year = 2005 \| doi = \| PMID = 15921242 }}</ref>

			<gallery>
			File:DNET02.jpg \| DNET on FLAIR MRI (wc/Dr Frank Gaillard)
			</gallery>

	==Microscopic==		==Microscopic==
	Features:<ref name=pmid18071981>{{Cite journal \| last1 = O'Brien \| first1 = DF. \| last2 = Farrell \| first2 = M. \| last3 = Delanty \| first3 = N. \| last4 = Traunecker \| first4 = H. \| last5 = Perrin \| first5 = R. \| last6 = Smyth \| first6 = MD. \| last7 = Park \| first7 = TS. \| title = The Children's Cancer and Leukaemia Group guidelines for the diagnosis and management of dysembryoplastic neuroepithelial tumours. \| journal = Br J Neurosurg \| volume = 21 \| issue = 6 \| pages = 539-49 \| month = Dec \| year = 2007 \| doi = 10.1080/02688690701594817 \| PMID = 18071981 }}</ref>		Features:<ref name=pmid18071981>{{Cite journal \| last1 = O'Brien \| first1 = DF. \| last2 = Farrell \| first2 = M. \| last3 = Delanty \| first3 = N. \| last4 = Traunecker \| first4 = H. \| last5 = Perrin \| first5 = R. \| last6 = Smyth \| first6 = MD. \| last7 = Park \| first7 = TS. \| title = The Children's Cancer and Leukaemia Group guidelines for the diagnosis and management of dysembryoplastic neuroepithelial tumours. \| journal = Br J Neurosurg \| volume = 21 \| issue = 6 \| pages = 539-49 \| month = Dec \| year = 2007 \| doi = 10.1080/02688690701594817 \| PMID = 18071981 }}</ref><ref>{{Cite journal \| last1 = Daumas-Duport \| first1 = C. \| title = Dysembryoplastic neuroepithelial tumours. \| journal = Brain Pathol \| volume = 3 \| issue = 3 \| pages = 283-95 \| month = Jul \| year = 1993 \| doi = \| PMID = 8293188 }}</ref>
	*~~Cells~~ similar to oligodendrocytes:		*Specific glioneuronal element:
	**Large central nuclei with indentations.		**Axonal columns oriented to the surface
	**Multiple small nucleoli (common).		**Floating neurons in eosinophilic matrix
	**Clear cytoplasm.		**Lined by cells similar to oligodendrocytes:
			***Large central nuclei with indentations.
			***Multiple small nucleoli (common).
			***Clear cytoplasm.
			**few stellated astrocytes

			IHC:<ref>{{Cite journal \| last1 = Thom \| first1 = M. \| last2 = Toma \| first2 = A. \| last3 = An \| first3 = S. \| last4 = Martinian \| first4 = L. \| last5 = Hadjivassiliou \| first5 = G. \| last6 = Ratilal \| first6 = B. \| last7 = Dean \| first7 = A. \| last8 = McEvoy \| first8 = A. \| last9 = Sisodiya \| first9 = SM. \| title = One hundred and one dysembryoplastic neuroepithelial tumors: an adult epilepsy series with immunohistochemical, molecular genetic, and clinical correlations and a review of the literature. \| journal = J Neuropathol Exp Neurol \| volume = 70 \| issue = 10 \| pages = 859-78 \| month = Oct \| year = 2011 \| doi = 10.1097/NEN.0b013e3182302475 \| PMID = 21937911 }}</ref>
			*MAP2+ve in oligodendroglia-like cells
			*CD34 in 61%
			*Calbindin in 57%
			*Nestin in 86%
			*MIB-1 (Ki-67) 0-8%

			Molecular:
	DDx:		DDx:
	*[[Oligodendroglioma]].		*[[Oligodendroglioma]].
	**These have rounder, smaller nuclei with occasional nucleoli.<ref name=pmid18071981/>		**These have rounder, smaller nuclei with occasional nucleoli.<ref name=pmid18071981/>
			**LOH1p/19q is not seen in DNET. <ref>{{Cite journal \| last1 = Fujisawa \| first1 = H. \| last2 = Marukawa \| first2 = K. \| last3 = Hasegawa \| first3 = M. \| last4 = Tohma \| first4 = Y. \| last5 = Hayashi \| first5 = Y. \| last6 = Uchiyama \| first6 = N. \| last7 = Tachibana \| first7 = O. \| last8 = Yamashita \| first8 = J. \| title = Genetic differences between neurocytoma and dysembryoplastic neuroepithelial tumor and oligodendroglial tumors. \| journal = J Neurosurg \| volume = 97 \| issue = 6 \| pages = 1350-5 \| month = Dec \| year = 2002 \| doi = 10.3171/jns.2002.97.6.1350 \| PMID = 12507133 }}</ref>
			*[[Astrocytoma]], protoplasmatic variant.
			**infiltrative microcystic formations may mimic glioneuronal element
			*[[Ganglioglioma]].
			**has reticulin fibers, lymphocytic cuffs and large cysts.

	===Images===		===Images===
	<gallery>		<gallery>
	Image:DNET_HE.jpg \| DNT. (WC/Sbrandner)		Image:DNET_HE.jpg \| DNT. (WC/Sbrandner)
			File:DNT low power.jpg \| DNT, low power view (WC/jensflorian)
			File:Synaptophysin DNET.jpg \| Synaptophysin IHC (WC/jensflorian)
			File:He cytology DNET.jpg \| Smear (WC/jensflorian)
	</gallery>		</gallery>
	www:		www:

Michael: alt abbrev.

2015-02-16T22:16:32Z

alt abbrev.

← Older revision		Revision as of 22:16, 16 February 2015
Line 1:		Line 1:
	'''Dysembryoplastic neuroepithelial tumour''', abbreviated '''DNET''',<ref name=pmid25311417>{{Cite journal \| last1 = Alexander \| first1 = H. \| last2 = Tannenburg \| first2 = A. \| last3 = Walker \| first3 = DG. \| last4 = Coyne \| first4 = T. \| title = Progressive dysembryoplastic neuroepithelial tumour. \| journal = J Clin Neurosci \| volume = 22 \| issue = 1 \| pages = 221-4 \| month = Jan \| year = 2015 \| doi = 10.1016/j.jocn.2014.07.022 \| PMID = 25311417 }}</ref> is a rare [[neuropathology tumour]] that is associated with [[epilepsy]].		'''Dysembryoplastic neuroepithelial tumour''', abbreviated '''DNET'''<ref name=pmid25311417>{{Cite journal \| last1 = Alexander \| first1 = H. \| last2 = Tannenburg \| first2 = A. \| last3 = Walker \| first3 = DG. \| last4 = Coyne \| first4 = T. \| title = Progressive dysembryoplastic neuroepithelial tumour. \| journal = J Clin Neurosci \| volume = 22 \| issue = 1 \| pages = 221-4 \| month = Jan \| year = 2015 \| doi = 10.1016/j.jocn.2014.07.022 \| PMID = 25311417 }}</ref> and '''DNT''',<ref name=pmid24735014>{{Cite journal \| last1 = Matyja \| first1 = E. \| last2 = Grajkowska \| first2 = W. \| last3 = Kunert \| first3 = P. \| last4 = Marchel \| first4 = A. \| title = A peculiar histopathological form of dysembryoplastic neuroepithelial tumor with separated pilocytic astrocytoma and rosette-forming glioneuronal tumor components. \| journal = Neuropathology \| volume = 34 \| issue = 5 \| pages = 491-8 \| month = Oct \| year = 2014 \| doi = 10.1111/neup.12124 \| PMID = 24735014 }}</ref> is a rare [[neuropathology tumour]] that is associated with [[epilepsy]].

	==General==		==General==

Michael: DNT --> DNET

2015-02-16T22:14:38Z

DNT --> DNET

← Older revision		Revision as of 22:14, 16 February 2015
Line 1:		Line 1:
	'''Dysembryoplastic neuroepithelial tumour''', abbreviated '''~~DNT~~''', is a rare [[neuropathology tumour]] that is associated with [[epilepsy]].		'''Dysembryoplastic neuroepithelial tumour''', abbreviated '''DNET''',<ref name=pmid25311417>{{Cite journal \| last1 = Alexander \| first1 = H. \| last2 = Tannenburg \| first2 = A. \| last3 = Walker \| first3 = DG. \| last4 = Coyne \| first4 = T. \| title = Progressive dysembryoplastic neuroepithelial tumour. \| journal = J Clin Neurosci \| volume = 22 \| issue = 1 \| pages = 221-4 \| month = Jan \| year = 2015 \| doi = 10.1016/j.jocn.2014.07.022 \| PMID = 25311417 }}</ref> is a rare [[neuropathology tumour]] that is associated with [[epilepsy]].

	==General==		==General==

Michael: /* Images */

2014-12-09T07:05:19Z

Images

← Older revision		Revision as of 07:05, 9 December 2014
Line 22:		Line 22:
	===Images===		===Images===
	<gallery>		<gallery>
	Image:DNET_HE.jpg \| DNT (WC)		Image:DNET_HE.jpg \| DNT. (WC/Sbrandner)
	</gallery>		</gallery>
	www:		www:

Michael: tweak

2014-12-09T07:04:54Z

tweak

← Older revision		Revision as of 07:04, 9 December 2014
Line 1:		Line 1:
	'''Dysembryoplastic neuroepithelial tumour''', abbreviated '''DNT'', is a rare [[neuropathology tumour]] that is associated with [[epilepsy]].		'''Dysembryoplastic neuroepithelial tumour''', abbreviated '''DNT''', is a rare [[neuropathology tumour]] that is associated with [[epilepsy]].

	==General==		==General==

Michael: split out

2014-12-09T07:04:15Z

split out

← Older revision		Revision as of 07:04, 9 December 2014
Line 1:		Line 1:
	~~#redirect~~ [[Neuropathology tumours~~#Dysembryoplastic neuroepithelial tumour~~]]		'''Dysembryoplastic neuroepithelial tumour''', abbreviated '''DNT'', is a rare [[neuropathology tumour]] that is associated with [[epilepsy]].

			==General==
			*Common tumour cause of drug resistant [[epilepsy]].<ref name=pmid15881751>{{Cite journal \| last1 = Cataltepe \| first1 = O. \| last2 = Turanli \| first2 = G. \| last3 = Yalnizoglu \| first3 = D. \| last4 = Topçu \| first4 = M. \| last5 = Akalan \| first5 = N. \| title = Surgical management of temporal lobe tumor-related epilepsy in children. \| journal = J Neurosurg \| volume = 102 \| issue = 3 Suppl \| pages = 280-7 \| month = Apr \| year = 2005 \| doi = 10.3171/ped.2005.102.3.0280 \| PMID = 15881751 }}</ref>
			*Paediatric population.

			==Gross/radiology==
			*Temporal lobe.
			*Variable architecture:<ref name=pmid18071981/> cystic, solitary nodular, multinodular.

			==Microscopic==
			Features:<ref name=pmid18071981>{{Cite journal \| last1 = O'Brien \| first1 = DF. \| last2 = Farrell \| first2 = M. \| last3 = Delanty \| first3 = N. \| last4 = Traunecker \| first4 = H. \| last5 = Perrin \| first5 = R. \| last6 = Smyth \| first6 = MD. \| last7 = Park \| first7 = TS. \| title = The Children's Cancer and Leukaemia Group guidelines for the diagnosis and management of dysembryoplastic neuroepithelial tumours. \| journal = Br J Neurosurg \| volume = 21 \| issue = 6 \| pages = 539-49 \| month = Dec \| year = 2007 \| doi = 10.1080/02688690701594817 \| PMID = 18071981 }}</ref>
			*Cells similar to oligodendrocytes:
			**Large central nuclei with indentations.
			**Multiple small nucleoli (common).
			**Clear cytoplasm.

			DDx:
			*[[Oligodendroglioma]].
			**These have rounder, smaller nuclei with occasional nucleoli.<ref name=pmid18071981/>

			===Images===
			<gallery>
			Image:DNET_HE.jpg \| DNT (WC)
			</gallery>
			www:
			*[http://path.upmc.edu/cases/case106.html DNT - several images (upmc.edu)].

			==See also==
			*[[Neuropathology tumours]].

			==References==
			{{Reflist\|1}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Neuropathology tumours]]

Michael: +cat.

2011-10-18T03:56:32Z

+cat.

← Older revision		Revision as of 03:56, 18 October 2011
Line 1:		Line 1:
	#redirect [[Neuropathology tumours#Dysembryoplastic neuroepithelial tumour]]		#redirect [[Neuropathology tumours#Dysembryoplastic neuroepithelial tumour]]

			[[Category:Diagnosis]]