Diffuse tenosynovial giant-cell tumour - Revision history

Jensflorian: /* Molecular */ ENLIVEN study

2019-10-10T09:54:51Z

Molecular: ENLIVEN study

← Older revision		Revision as of 09:54, 10 October 2019
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	==Molecular==		==Molecular==
	*Clonal - overexpresses CSF1.<ref name=pmid22849738>{{Cite journal \| last1 = Lucas \| first1 = DR. \| title = Tenosynovial giant cell tumor: case report and review. \| journal = Arch Pathol Lab Med \| volume = 136 \| issue = 8 \| pages = 901-6 \| month = Aug \| year = 2012 \| doi = 10.5858/arpa.2012-0165-CR \| PMID = 22849738 }}</ref>		*Clonal - overexpresses CSF1.<ref name=pmid22849738>{{Cite journal \| last1 = Lucas \| first1 = DR. \| title = Tenosynovial giant cell tumor: case report and review. \| journal = Arch Pathol Lab Med \| volume = 136 \| issue = 8 \| pages = 901-6 \| month = Aug \| year = 2012 \| doi = 10.5858/arpa.2012-0165-CR \| PMID = 22849738 }}</ref>
			**Possible treatment with CSF1-R inhibitor Pexidartinib.<ref>{{Cite journal \| last1 = Tap \| first1 = WD. \| last2 = Gelderblom \| first2 = H. \| last3 = Palmerini \| first3 = E. \| last4 = Desai \| first4 = J. \| last5 = Bauer \| first5 = S. \| last6 = Blay \| first6 = JY. \| last7 = Alcindor \| first7 = T. \| last8 = Ganjoo \| first8 = K. \| last9 = Martín-Broto \| first9 = J. \| title = Pexidartinib versus placebo for advanced tenosynovial giant cell tumour (ENLIVEN): a randomised phase 3 trial. \| journal = Lancet \| volume = 394 \| issue = 10197 \| pages = 478-487 \| month = 08 \| year = 2019 \| doi = 10.1016/S0140-6736(19)30764-0 \| PMID = 31229240 }}</ref>

	==Sign out==		==Sign out==

Michael: /* Molecular */

2017-03-05T17:16:11Z

Molecular

← Older revision		Revision as of 17:16, 5 March 2017
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	*[http://www.webpathology.com/image.asp?case=357&n=2 PVNS (webpathology.com)].		*[http://www.webpathology.com/image.asp?case=357&n=2 PVNS (webpathology.com)].
	*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687912/figure/F4/ Localized nodular synovitis (nih.gov)].<ref name=pmid23798766>{{Cite journal \| last1 = Park \| first1 = JH. \| last2 = Ro \| first2 = KH. \| last3 = Lee \| first3 = DH. \| title = Localized nodular synovitis of the infrapatellar fat pad. \| journal = Indian J Orthop \| volume = 47 \| issue = 3 \| pages = 313-6 \| month = May \| year = 2013 \| doi = 10.4103/0019-5413.111514 \| PMID = 23798766 }}</ref>		*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687912/figure/F4/ Localized nodular synovitis (nih.gov)].<ref name=pmid23798766>{{Cite journal \| last1 = Park \| first1 = JH. \| last2 = Ro \| first2 = KH. \| last3 = Lee \| first3 = DH. \| title = Localized nodular synovitis of the infrapatellar fat pad. \| journal = Indian J Orthop \| volume = 47 \| issue = 3 \| pages = 313-6 \| month = May \| year = 2013 \| doi = 10.4103/0019-5413.111514 \| PMID = 23798766 }}</ref>
			==IHC==
			*May be desmin positive.<ref name=pmid9796719>{{Cite journal \| last1 = Folpe \| first1 = AL. \| last2 = Weiss \| first2 = SW. \| last3 = Fletcher \| first3 = CD. \| last4 = Gown \| first4 = AM. \| title = Tenosynovial giant cell tumors: evidence for a desmin-positive dendritic cell subpopulation. \| journal = Mod Pathol \| volume = 11 \| issue = 10 \| pages = 939-44 \| month = Oct \| year = 1998 \| doi = \| PMID = 9796719 }}</ref>
			**May lead one to think [[rhabdomyosarcoma]].

	==Molecular==		==Molecular==
	*Clonal - overexpresses CSF1.<ref name=pmid22849738>{{Cite journal \| last1 = Lucas \| first1 = DR. \| title = Tenosynovial giant cell tumor: case report and review. \| journal = Arch Pathol Lab Med \| volume = 136 \| issue = 8 \| pages = 901-6 \| month = Aug \| year = 2012 \| doi = 10.5858/arpa.2012-0165-CR \| PMID = 22849738 }}</ref>		*Clonal - overexpresses CSF1.<ref name=pmid22849738>{{Cite journal \| last1 = Lucas \| first1 = DR. \| title = Tenosynovial giant cell tumor: case report and review. \| journal = Arch Pathol Lab Med \| volume = 136 \| issue = 8 \| pages = 901-6 \| month = Aug \| year = 2012 \| doi = 10.5858/arpa.2012-0165-CR \| PMID = 22849738 }}</ref>

Michael: /* General */

2014-05-05T18:53:41Z

General

← Older revision		Revision as of 18:53, 5 May 2014
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	==General==		==General==
	*~~Course:~~ benign.		*Usually benign.
	**Occasionally malignant.<ref name=pmid22827766>{{Cite journal \| last1 = Kondo \| first1 = R. \| last2 = Akiba \| first2 = J. \| last3 = Hiraoka \| first3 = K. \| last4 = Hisaoka \| first4 = M. \| last5 = Hashimoto \| first5 = H. \| last6 = Kage \| first6 = M. \| last7 = Yano \| first7 = H. \| title = Malignant diffuse-type tenosynovial giant cell tumor of the buttock. \| journal = Pathol Int \| volume = 62 \| issue = 8 \| pages = 559-64 \| month = Aug \| year = 2012 \| doi = 10.1111/j.1440-1827.2012.02838.x \| PMID = 22827766 }}</ref><ref name=pmid18301053>{{Cite journal \| last1 = Li \| first1 = CF. \| last2 = Wang \| first2 = JW. \| last3 = Huang \| first3 = WW. \| last4 = Hou \| first4 = CC. \| last5 = Chou \| first5 = SC. \| last6 = Eng \| first6 = HL. \| last7 = Lin \| first7 = CN. \| last8 = Yu \| first8 = SC. \| last9 = Huang \| first9 = HY. \| title = Malignant diffuse-type tenosynovial giant cell tumors: a series of 7 cases comparing with 24 benign lesions with review of the literature. \| journal = Am J Surg Pathol \| volume = 32 \| issue = 4 \| pages = 587-99 \| month = Apr \| year = 2008 \| doi = 10.1097/PAS.0b013e318158428f \| PMID = 18301053 }}</ref><ref name=pmid10757395>{{Cite journal \| last1 = Somerhausen \| first1 = NS. \| last2 = Fletcher \| first2 = CD. \| title = Diffuse-type giant cell tumor: clinicopathologic and immunohistochemical analysis of 50 cases with extraarticular disease. \| journal = Am J Surg Pathol \| volume = 24 \| issue = 4 \| pages = 479-92 \| month = Apr \| year = 2000 \| doi = \| PMID = 10757395 }}</ref>		**Occasionally malignant.<ref name=pmid22827766>{{Cite journal \| last1 = Kondo \| first1 = R. \| last2 = Akiba \| first2 = J. \| last3 = Hiraoka \| first3 = K. \| last4 = Hisaoka \| first4 = M. \| last5 = Hashimoto \| first5 = H. \| last6 = Kage \| first6 = M. \| last7 = Yano \| first7 = H. \| title = Malignant diffuse-type tenosynovial giant cell tumor of the buttock. \| journal = Pathol Int \| volume = 62 \| issue = 8 \| pages = 559-64 \| month = Aug \| year = 2012 \| doi = 10.1111/j.1440-1827.2012.02838.x \| PMID = 22827766 }}</ref><ref name=pmid18301053>{{Cite journal \| last1 = Li \| first1 = CF. \| last2 = Wang \| first2 = JW. \| last3 = Huang \| first3 = WW. \| last4 = Hou \| first4 = CC. \| last5 = Chou \| first5 = SC. \| last6 = Eng \| first6 = HL. \| last7 = Lin \| first7 = CN. \| last8 = Yu \| first8 = SC. \| last9 = Huang \| first9 = HY. \| title = Malignant diffuse-type tenosynovial giant cell tumors: a series of 7 cases comparing with 24 benign lesions with review of the literature. \| journal = Am J Surg Pathol \| volume = 32 \| issue = 4 \| pages = 587-99 \| month = Apr \| year = 2008 \| doi = 10.1097/PAS.0b013e318158428f \| PMID = 18301053 }}</ref><ref name=pmid10757395>{{Cite journal \| last1 = Somerhausen \| first1 = NS. \| last2 = Fletcher \| first2 = CD. \| title = Diffuse-type giant cell tumor: clinicopathologic and immunohistochemical analysis of 50 cases with extraarticular disease. \| journal = Am J Surg Pathol \| volume = 24 \| issue = 4 \| pages = 479-92 \| month = Apr \| year = 2000 \| doi = \| PMID = 10757395 }}</ref>
	*''[[~~Giant~~ cell tumour of the tendon sheath]]~~'' is considered to be the soft-tissue counterpart of PVNS~~.<ref>~~URL: [http://emedicine.medscape.com/article/1253223-overview http://emedicine.medscape.com/article/1253223-overview]. Accessed on: 6 January 2011.~~</ref>		*Can be thought of as the large joint version of [[giant cell tumour of the tendon sheath]].<ref name=Ref_DCHH341>{{Ref DCHH\|341}}</ref>

	===Classification===		===Classification===

Michael at 18:50, 5 May 2014

2014-05-05T18:50:24Z

← Older revision		Revision as of 18:50, 5 May 2014
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	*''[[Giant cell tumour of the tendon sheath]]'' is considered to be the soft-tissue counterpart of PVNS.<ref>URL: [http://emedicine.medscape.com/article/1253223-overview http://emedicine.medscape.com/article/1253223-overview]. Accessed on: 6 January 2011.</ref>		*''[[Giant cell tumour of the tendon sheath]]'' is considered to be the soft-tissue counterpart of PVNS.<ref>URL: [http://emedicine.medscape.com/article/1253223-overview http://emedicine.medscape.com/article/1253223-overview]. Accessed on: 6 January 2011.</ref>

	~~Subclassification~~:<ref name=pmid10725067>{{Cite journal \| last1 = Perka \| first1 = C. \| last2 = Labs \| first2 = K. \| last3 = Zippel \| first3 = H. \| last4 = Buttgereit \| first4 = F. \| title = Localized pigmented villonodular synovitis of the knee joint: neoplasm or reactive granuloma? A review of 18 cases. \| journal = Rheumatology (Oxford) \| volume = 39 \| issue = 2 \| pages = 172-8 \| month = Feb \| year = 2000 \| doi = \| PMID = 10725067 }}		===Classification===
			Subclassified - clinical:<ref name=pmid10725067>{{Cite journal \| last1 = Perka \| first1 = C. \| last2 = Labs \| first2 = K. \| last3 = Zippel \| first3 = H. \| last4 = Buttgereit \| first4 = F. \| title = Localized pigmented villonodular synovitis of the knee joint: neoplasm or reactive granuloma? A review of 18 cases. \| journal = Rheumatology (Oxford) \| volume = 39 \| issue = 2 \| pages = 172-8 \| month = Feb \| year = 2000 \| doi = \| PMID = 10725067 }}
	</ref>		</ref>
	*Generalized PVNS.		*Generalized PVNS.

Michael at 18:46, 5 May 2014

2014-05-05T18:46:11Z

← Older revision		Revision as of 18:46, 5 May 2014
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	\| Synonyms = pigmented villonodular synovitis (PVNS) - old term		\| Synonyms = pigmented villonodular synovitis (PVNS) - old term
	\| Micro = nodules composed of cells with abundant cytoplasm & pale nuclei, multinucleated giant cells, hemosiderin-laden macrophages, foam cells		\| Micro = nodules composed of cells with abundant cytoplasm & pale nuclei, multinucleated giant cells, hemosiderin-laden macrophages, foam cells
	\| Subtypes =		\| Subtypes = generalized, localized (articular, extra-articular)
	\| LMDDx = [[giant cell lesions]], others		\| LMDDx = [[giant cell lesions]], others
	\| Stains =		\| Stains =
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	\| Molecular =		\| Molecular =
	\| IF =		\| IF =
	\| Gross = pigmented		\| Gross = pigmented, articular or extra-articular
	\| Grossing =		\| Grossing =
	\| Site = large [[joints]] - esp. knee or hip; occ. extra-articular		\| Site = large [[joints]] - esp. knee or hip; occ. extra-articular
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	\| Signs =		\| Signs =
	\| Symptoms =		\| Symptoms =
	\| Prevalence =		\| Prevalence = uncommon
	\| Bloodwork =		\| Bloodwork =
	\| Rads =		\| Rads =
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	**Occasionally malignant.<ref name=pmid22827766>{{Cite journal \| last1 = Kondo \| first1 = R. \| last2 = Akiba \| first2 = J. \| last3 = Hiraoka \| first3 = K. \| last4 = Hisaoka \| first4 = M. \| last5 = Hashimoto \| first5 = H. \| last6 = Kage \| first6 = M. \| last7 = Yano \| first7 = H. \| title = Malignant diffuse-type tenosynovial giant cell tumor of the buttock. \| journal = Pathol Int \| volume = 62 \| issue = 8 \| pages = 559-64 \| month = Aug \| year = 2012 \| doi = 10.1111/j.1440-1827.2012.02838.x \| PMID = 22827766 }}</ref><ref name=pmid18301053>{{Cite journal \| last1 = Li \| first1 = CF. \| last2 = Wang \| first2 = JW. \| last3 = Huang \| first3 = WW. \| last4 = Hou \| first4 = CC. \| last5 = Chou \| first5 = SC. \| last6 = Eng \| first6 = HL. \| last7 = Lin \| first7 = CN. \| last8 = Yu \| first8 = SC. \| last9 = Huang \| first9 = HY. \| title = Malignant diffuse-type tenosynovial giant cell tumors: a series of 7 cases comparing with 24 benign lesions with review of the literature. \| journal = Am J Surg Pathol \| volume = 32 \| issue = 4 \| pages = 587-99 \| month = Apr \| year = 2008 \| doi = 10.1097/PAS.0b013e318158428f \| PMID = 18301053 }}</ref><ref name=pmid10757395>{{Cite journal \| last1 = Somerhausen \| first1 = NS. \| last2 = Fletcher \| first2 = CD. \| title = Diffuse-type giant cell tumor: clinicopathologic and immunohistochemical analysis of 50 cases with extraarticular disease. \| journal = Am J Surg Pathol \| volume = 24 \| issue = 4 \| pages = 479-92 \| month = Apr \| year = 2000 \| doi = \| PMID = 10757395 }}</ref>		**Occasionally malignant.<ref name=pmid22827766>{{Cite journal \| last1 = Kondo \| first1 = R. \| last2 = Akiba \| first2 = J. \| last3 = Hiraoka \| first3 = K. \| last4 = Hisaoka \| first4 = M. \| last5 = Hashimoto \| first5 = H. \| last6 = Kage \| first6 = M. \| last7 = Yano \| first7 = H. \| title = Malignant diffuse-type tenosynovial giant cell tumor of the buttock. \| journal = Pathol Int \| volume = 62 \| issue = 8 \| pages = 559-64 \| month = Aug \| year = 2012 \| doi = 10.1111/j.1440-1827.2012.02838.x \| PMID = 22827766 }}</ref><ref name=pmid18301053>{{Cite journal \| last1 = Li \| first1 = CF. \| last2 = Wang \| first2 = JW. \| last3 = Huang \| first3 = WW. \| last4 = Hou \| first4 = CC. \| last5 = Chou \| first5 = SC. \| last6 = Eng \| first6 = HL. \| last7 = Lin \| first7 = CN. \| last8 = Yu \| first8 = SC. \| last9 = Huang \| first9 = HY. \| title = Malignant diffuse-type tenosynovial giant cell tumors: a series of 7 cases comparing with 24 benign lesions with review of the literature. \| journal = Am J Surg Pathol \| volume = 32 \| issue = 4 \| pages = 587-99 \| month = Apr \| year = 2008 \| doi = 10.1097/PAS.0b013e318158428f \| PMID = 18301053 }}</ref><ref name=pmid10757395>{{Cite journal \| last1 = Somerhausen \| first1 = NS. \| last2 = Fletcher \| first2 = CD. \| title = Diffuse-type giant cell tumor: clinicopathologic and immunohistochemical analysis of 50 cases with extraarticular disease. \| journal = Am J Surg Pathol \| volume = 24 \| issue = 4 \| pages = 479-92 \| month = Apr \| year = 2000 \| doi = \| PMID = 10757395 }}</ref>
	*''[[Giant cell tumour of the tendon sheath]]'' is considered to be the soft-tissue counterpart of PVNS.<ref>URL: [http://emedicine.medscape.com/article/1253223-overview http://emedicine.medscape.com/article/1253223-overview]. Accessed on: 6 January 2011.</ref>		*''[[Giant cell tumour of the tendon sheath]]'' is considered to be the soft-tissue counterpart of PVNS.<ref>URL: [http://emedicine.medscape.com/article/1253223-overview http://emedicine.medscape.com/article/1253223-overview]. Accessed on: 6 January 2011.</ref>

			Subclassification:<ref name=pmid10725067>{{Cite journal \| last1 = Perka \| first1 = C. \| last2 = Labs \| first2 = K. \| last3 = Zippel \| first3 = H. \| last4 = Buttgereit \| first4 = F. \| title = Localized pigmented villonodular synovitis of the knee joint: neoplasm or reactive granuloma? A review of 18 cases. \| journal = Rheumatology (Oxford) \| volume = 39 \| issue = 2 \| pages = 172-8 \| month = Feb \| year = 2000 \| doi = \| PMID = 10725067 }}
			</ref>
			*Generalized PVNS.
			*Localized PVNS.<ref name=pmid12876042>{{Cite journal \| last1 = Huang \| first1 = GS. \| last2 = Lee \| first2 = CH. \| last3 = Chan \| first3 = WP. \| last4 = Chen \| first4 = CY. \| last5 = Yu \| first5 = JS. \| last6 = Resnick \| first6 = D. \| title = Localized nodular synovitis of the knee: MR imaging appearance and clinical correlates in 21 patients. \| journal = AJR Am J Roentgenol \| volume = 181 \| issue = 2 \| pages = 539-43 \| month = Aug \| year = 2003 \| doi = 10.2214/ajr.181.2.1810539 \| PMID = 12876042 }}</ref>
			**Articular.
			**Extra-articular.

	==Gross==		==Gross==
	*Typically knee or hip.<ref name=pmid10524485>{{Cite journal \| last1 = Frassica \| first1 = FJ. \| last2 = Bhimani \| first2 = MA. \| last3 = McCarthy \| first3 = EF. \| last4 = Wenz \| first4 = J. \| title = Pigmented villonodular synovitis of the hip and knee. \| journal = Am Fam Physician \| volume = 60 \| issue = 5 \| pages = 1404-10; discussion 1415 \| month = Oct \| year = 1999 \| doi = \| PMID = 10524485 \| URL = http://www.aafp.org/afp/1999/1001/p1404.html }}</ref>		*Typically knee or hip.<ref name=pmid10524485>{{Cite journal \| last1 = Frassica \| first1 = FJ. \| last2 = Bhimani \| first2 = MA. \| last3 = McCarthy \| first3 = EF. \| last4 = Wenz \| first4 = J. \| title = Pigmented villonodular synovitis of the hip and knee. \| journal = Am Fam Physician \| volume = 60 \| issue = 5 \| pages = 1404-10; discussion 1415 \| month = Oct \| year = 1999 \| doi = \| PMID = 10524485 \| URL = http://www.aafp.org/afp/1999/1001/p1404.html }}</ref>
	*May be extra-articular.<ref name=pmid10757395/>		*May be extra-articular.<ref name=pmid10757395/>

			Note:
			*Localized form - classically fat pad inferior to patella.<ref name=pmid23798766/>

	==Microscopic==		==Microscopic==
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	*Degenerative changes ([[osteoarthritis]]).		*Degenerative changes ([[osteoarthritis]]).
	*[[Rheumatic joint disease\|Rheumatic disease]].		*[[Rheumatic joint disease\|Rheumatic disease]].
	*[[Localized nodular synovitis]] - histology very similar.<ref name=pmid12876042>{{Cite journal \| last1 = Huang \| first1 = GS. \| last2 = Lee \| first2 = CH. \| last3 = Chan \| first3 = WP. \| last4 = Chen \| first4 = CY. \| last5 = Yu \| first5 = JS. \| last6 = Resnick \| first6 = D. \| title = Localized nodular synovitis of the knee: MR imaging appearance and clinical correlates in 21 patients. \| journal = AJR Am J Roentgenol \| volume = 181 \| issue = 2 \| pages = 539-43 \| month = Aug \| year = 2003 \| doi = 10.2214/ajr.181.2.1810539 \| PMID = 12876042 }}</ref>

	===Images===		===Images===
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	*[http://path.upmc.edu/cases/case251/micro.html PVNS - several images (upmc.edu)].		*[http://path.upmc.edu/cases/case251/micro.html PVNS - several images (upmc.edu)].
	*[http://www.webpathology.com/image.asp?case=357&n=2 PVNS (webpathology.com)].		*[http://www.webpathology.com/image.asp?case=357&n=2 PVNS (webpathology.com)].
			*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687912/figure/F4/ Localized nodular synovitis (nih.gov)].<ref name=pmid23798766>{{Cite journal \| last1 = Park \| first1 = JH. \| last2 = Ro \| first2 = KH. \| last3 = Lee \| first3 = DH. \| title = Localized nodular synovitis of the infrapatellar fat pad. \| journal = Indian J Orthop \| volume = 47 \| issue = 3 \| pages = 313-6 \| month = May \| year = 2013 \| doi = 10.4103/0019-5413.111514 \| PMID = 23798766 }}</ref>
	==Molecular==		==Molecular==
	*Clonal - overexpresses CSF1.<ref name=pmid22849738>{{Cite journal \| last1 = Lucas \| first1 = DR. \| title = Tenosynovial giant cell tumor: case report and review. \| journal = Arch Pathol Lab Med \| volume = 136 \| issue = 8 \| pages = 901-6 \| month = Aug \| year = 2012 \| doi = 10.5858/arpa.2012-0165-CR \| PMID = 22849738 }}</ref>		*Clonal - overexpresses CSF1.<ref name=pmid22849738>{{Cite journal \| last1 = Lucas \| first1 = DR. \| title = Tenosynovial giant cell tumor: case report and review. \| journal = Arch Pathol Lab Med \| volume = 136 \| issue = 8 \| pages = 901-6 \| month = Aug \| year = 2012 \| doi = 10.5858/arpa.2012-0165-CR \| PMID = 22849738 }}</ref>

Michael: /* Microscopic */

2014-05-05T11:47:07Z

Microscopic

← Older revision		Revision as of 11:47, 5 May 2014
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	*Degenerative changes ([[osteoarthritis]]).		*Degenerative changes ([[osteoarthritis]]).
	*[[Rheumatic joint disease\|Rheumatic disease]].		*[[Rheumatic joint disease\|Rheumatic disease]].
			*[[Localized nodular synovitis]] - histology very similar.<ref name=pmid12876042>{{Cite journal \| last1 = Huang \| first1 = GS. \| last2 = Lee \| first2 = CH. \| last3 = Chan \| first3 = WP. \| last4 = Chen \| first4 = CY. \| last5 = Yu \| first5 = JS. \| last6 = Resnick \| first6 = D. \| title = Localized nodular synovitis of the knee: MR imaging appearance and clinical correlates in 21 patients. \| journal = AJR Am J Roentgenol \| volume = 181 \| issue = 2 \| pages = 539-43 \| month = Aug \| year = 2003 \| doi = 10.2214/ajr.181.2.1810539 \| PMID = 12876042 }}</ref>

	===Images===		===Images===

Michael: tweak

2014-04-01T00:16:58Z

tweak

← Older revision		Revision as of 00:16, 1 April 2014
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image =		\| Image = Pigmented villonodular synovitis high mag.jpg
	\| Width =		\| Width =
	\| Caption =		\| Caption = Diffuse tenosynovial giant-cell tumour. [[H&E stain]].
	\| Synonyms =		\| Synonyms = pigmented villonodular synovitis (PVNS) - old term
	\| Micro = nodules composed of cells with abundant cytoplasm & pale nuclei, multinucleated giant cells, hemosiderin-laden macrophages, foam cells		\| Micro = nodules composed of cells with abundant cytoplasm & pale nuclei, multinucleated giant cells, hemosiderin-laden macrophages, foam cells
	\| Subtypes =		\| Subtypes =

Michael at 00:14, 1 April 2014

2014-04-01T00:14:48Z

← Older revision		Revision as of 00:14, 1 April 2014
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image =
			\| Width =
			\| Caption =
			\| Synonyms =
			\| Micro = nodules composed of cells with abundant cytoplasm & pale nuclei, multinucleated giant cells, hemosiderin-laden macrophages, foam cells
			\| Subtypes =
			\| LMDDx = [[giant cell lesions]], others
			\| Stains =
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross = pigmented
			\| Grossing =
			\| Site = large [[joints]] - esp. knee or hip; occ. extra-articular
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms =
			\| Prevalence =
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = usually benign
			\| Other =
			\| ClinDDx =
			\| Tx =
			}}
	'''Diffuse tenosynovial giant-cell tumour''' is relatively common mostly benign [[chondro-osseous tumour]] of the large [[joints]].		'''Diffuse tenosynovial giant-cell tumour''' is relatively common mostly benign [[chondro-osseous tumour]] of the large [[joints]].

Michael: /* Molecular */

2014-03-31T23:32:41Z

Molecular

← Older revision		Revision as of 23:32, 31 March 2014
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	==Molecular==		==Molecular==
	*Clonal.<ref name=pmid22849738>{{Cite journal \| last1 = Lucas \| first1 = DR. \| title = Tenosynovial giant cell tumor: case report and review. \| journal = Arch Pathol Lab Med \| volume = 136 \| issue = 8 \| pages = 901-6 \| month = Aug \| year = 2012 \| doi = 10.5858/arpa.2012-0165-CR \| PMID = 22849738 }}</ref>		*Clonal - overexpresses CSF1.<ref name=pmid22849738>{{Cite journal \| last1 = Lucas \| first1 = DR. \| title = Tenosynovial giant cell tumor: case report and review. \| journal = Arch Pathol Lab Med \| volume = 136 \| issue = 8 \| pages = 901-6 \| month = Aug \| year = 2012 \| doi = 10.5858/arpa.2012-0165-CR \| PMID = 22849738 }}</ref>

	==Sign out==		==Sign out==

Michael at 23:29, 31 March 2014

2014-03-31T23:29:02Z

← Older revision		Revision as of 23:29, 31 March 2014
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	'''Diffuse tenosynovial giant-cell tumour''' is relatively common mostly benign [[chondro-osseous tumour]] of the large [[joints]].		'''Diffuse tenosynovial giant-cell tumour''' is relatively common mostly benign [[chondro-osseous tumour]] of the large [[joints]].

	It is also known as '''''tenosynovial giant-cell tumour, diffuse type'''''.		It is also known as '''tenosynovial giant-cell tumour, diffuse type'''.
	Previously, it was known as '''pigmented villonodular synovitis''', abbreviated '''PVNS'''.<ref>{{Ref PBoD8\|1247}}</ref>		Previously, it was known as '''pigmented villonodular synovitis''', abbreviated '''PVNS'''.<ref>{{Ref PBoD8\|1247}}</ref>