Differentiated vulvar intraepithelial neoplasia - Revision history

Michael at 02:24, 25 February 2014

2014-02-25T02:24:55Z

← Older revision		Revision as of 02:24, 25 February 2014
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	\| Width =		\| Width =
	\| Caption = Differentiated vulvar intraepithelial neoplasia. [[H&E stain]].		\| Caption = Differentiated vulvar intraepithelial neoplasia. [[H&E stain]].
	\| Synonyms =		\| Synonyms = VIN simplex, simplex-type VIN
	\| Micro = thickening of the stratum spinosum ([[acanthosis]]), elongation of rete ridges with bridging/anastomoses between rete ridges, nuclear atypia - esp. basal layer, nuclei in stratum corneum (parakeratosis), +/-atypical mitoses		\| Micro = thickening of the stratum spinosum ([[acanthosis]]), elongation of rete ridges with bridging/anastomoses between rete ridges, nuclear atypia - esp. basal layer, nuclei in stratum corneum (parakeratosis), +/-atypical mitoses
	\| Subtypes =		\| Subtypes =

Michael at 01:44, 25 February 2014

2014-02-25T01:44:55Z

← Older revision		Revision as of 01:44, 25 February 2014
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	'''Differentiated vulvar intraepithelial neoplasia''', abbreviated '''dVIN''', is a pre-neoplastic pathology of the [[vulva]] typically arising in the context of [[lichen sclerosus]].		'''Differentiated vulvar intraepithelial neoplasia''', abbreviated '''dVIN''', is a pre-neoplastic pathology of the [[vulva]] typically arising in the context of [[lichen sclerosus]].

	It is also known as '''VIN simplex''',<ref name=pmid15910611>{{Cite journal \| last1 = Ruhul Quddus \| first1 = M. \| last2 = Xu \| first2 = C. \| last3 = Steinhoff \| first3 = MM. \| last4 = Zhang \| first4 = C. \| last5 = Lawrence \| first5 = WD. \| last6 = Sung \| first6 = CJ. \| title = Simplex (differentiated) type VIN: absence of p16INK4 supports its weak association with HPV and its probable precursor role in non-HPV related vulvar squamous cancers. \| journal = Histopathology \| volume = 46 \| issue = 6 \| pages = 718-20 \| month = Jun \| year = 2005 \| doi = 10.1111/j.1365-2559.2005.02036.x \| PMID = 15910611 }}</ref>		It is also known as '''VIN simplex''',<ref name=pmid15910611>{{Cite journal \| last1 = Ruhul Quddus \| first1 = M. \| last2 = Xu \| first2 = C. \| last3 = Steinhoff \| first3 = MM. \| last4 = Zhang \| first4 = C. \| last5 = Lawrence \| first5 = WD. \| last6 = Sung \| first6 = CJ. \| title = Simplex (differentiated) type VIN: absence of p16INK4 supports its weak association with HPV and its probable precursor role in non-HPV related vulvar squamous cancers. \| journal = Histopathology \| volume = 46 \| issue = 6 \| pages = 718-20 \| month = Jun \| year = 2005 \| doi = 10.1111/j.1365-2559.2005.02036.x \| PMID = 15910611 }}</ref> and '''simplex-type VIN'''.<ref name=pmid24399036/>
	and '''~~Simplex~~-type VIN'''.<ref name=pmid24399036/>
	==General==		==General==
	Epidemiology:		Epidemiology:

Michael at 01:44, 25 February 2014

2014-02-25T01:44:28Z

← Older revision		Revision as of 01:44, 25 February 2014
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	'''Differentiated vulvar intraepithelial neoplasia''', abbreviated '''dVIN''', is a pre-neoplastic pathology of the [[vulva]] typically arising in the context of [[lichen sclerosus]].		'''Differentiated vulvar intraepithelial neoplasia''', abbreviated '''dVIN''', is a pre-neoplastic pathology of the [[vulva]] typically arising in the context of [[lichen sclerosus]].

	It is also known as '''VIN simplex'''.<ref name=pmid15910611>{{Cite journal \| last1 = Ruhul Quddus \| first1 = M. \| last2 = Xu \| first2 = C. \| last3 = Steinhoff \| first3 = MM. \| last4 = Zhang \| first4 = C. \| last5 = Lawrence \| first5 = WD. \| last6 = Sung \| first6 = CJ. \| title = Simplex (differentiated) type VIN: absence of p16INK4 supports its weak association with HPV and its probable precursor role in non-HPV related vulvar squamous cancers. \| journal = Histopathology \| volume = 46 \| issue = 6 \| pages = 718-20 \| month = Jun \| year = 2005 \| doi = 10.1111/j.1365-2559.2005.02036.x \| PMID = 15910611 }}</ref>		It is also known as '''VIN simplex''',<ref name=pmid15910611>{{Cite journal \| last1 = Ruhul Quddus \| first1 = M. \| last2 = Xu \| first2 = C. \| last3 = Steinhoff \| first3 = MM. \| last4 = Zhang \| first4 = C. \| last5 = Lawrence \| first5 = WD. \| last6 = Sung \| first6 = CJ. \| title = Simplex (differentiated) type VIN: absence of p16INK4 supports its weak association with HPV and its probable precursor role in non-HPV related vulvar squamous cancers. \| journal = Histopathology \| volume = 46 \| issue = 6 \| pages = 718-20 \| month = Jun \| year = 2005 \| doi = 10.1111/j.1365-2559.2005.02036.x \| PMID = 15910611 }}</ref>
			and '''Simplex-type VIN'''.<ref name=pmid24399036/>
	==General==		==General==
	Epidemiology:		Epidemiology:

Michael: /* General */

2014-02-25T01:41:31Z

General

← Older revision		Revision as of 01:41, 25 February 2014
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	*Associated with [[lichen sclerosus]].		*Associated with [[lichen sclerosus]].
	*Seen in older women - typically 50s-70s.<ref name=pmid19730361>{{Cite journal \| last1 = Ordi \| first1 = J. \| last2 = Alejo \| first2 = M. \| last3 = Fusté \| first3 = V. \| last4 = Lloveras \| first4 = B. \| last5 = Del Pino \| first5 = M. \| last6 = Alonso \| first6 = I. \| last7 = Torné \| first7 = A. \| title = HPV-negative vulvar intraepithelial neoplasia (VIN) with basaloid histologic pattern: an unrecognized variant of simplex (differentiated) VIN. \| journal = Am J Surg Pathol \| volume = 33 \| issue = 11 \| pages = 1659-65 \| month = Nov \| year = 2009 \| doi = 10.1097/PAS.0b013e3181b40081 \| PMID = 19730361 }}</ref>		*Seen in older women - typically 50s-70s.<ref name=pmid19730361>{{Cite journal \| last1 = Ordi \| first1 = J. \| last2 = Alejo \| first2 = M. \| last3 = Fusté \| first3 = V. \| last4 = Lloveras \| first4 = B. \| last5 = Del Pino \| first5 = M. \| last6 = Alonso \| first6 = I. \| last7 = Torné \| first7 = A. \| title = HPV-negative vulvar intraepithelial neoplasia (VIN) with basaloid histologic pattern: an unrecognized variant of simplex (differentiated) VIN. \| journal = Am J Surg Pathol \| volume = 33 \| issue = 11 \| pages = 1659-65 \| month = Nov \| year = 2009 \| doi = 10.1097/PAS.0b013e3181b40081 \| PMID = 19730361 }}</ref>
	*More common than ''[[classic VIN]]'' caused by HPV;<ref name=pmid21946295>{{Cite journal \| last1 = Kokka \| first1 = F. \| last2 = Singh \| first2 = N. \| last3 = Faruqi \| first3 = A. \| last4 = Gibbon \| first4 = K. \| last5 = Rosenthal \| first5 = AN. \| title = Is differentiated vulval intraepithelial neoplasia the precursor lesion of human papillomavirus-negative vulval squamous cell carcinoma? \| journal = Int J Gynecol Cancer \| volume = 21 \| issue = 7 \| pages = 1297-305 \| month = Oct \| year = 2011 \| doi = 10.1097/IGC.0b013e31822dbe26 \| PMID = 21946295 }}</ref>		*More common than ''[[classic VIN]]'' caused by HPV.<ref name=pmid21946295>{{Cite journal \| last1 = Kokka \| first1 = F. \| last2 = Singh \| first2 = N. \| last3 = Faruqi \| first3 = A. \| last4 = Gibbon \| first4 = K. \| last5 = Rosenthal \| first5 = AN. \| title = Is differentiated vulval intraepithelial neoplasia the precursor lesion of human papillomavirus-negative vulval squamous cell carcinoma? \| journal = Int J Gynecol Cancer \| volume = 21 \| issue = 7 \| pages = 1297-305 \| month = Oct \| year = 2011 \| doi = 10.1097/IGC.0b013e31822dbe26 \| PMID = 21946295 }}</ref>
	**Differentiated VIN -> keratinizing SCC (~60% of cases).<ref name=pmid24399036/>		**Differentiated VIN -> keratinizing SCC (~60% of cases).<ref name=pmid24399036/>
	**Classic VIN -> warty SCC (~40% of cases).<ref name=pmid24399036>{{Cite journal \| last1 = Reyes \| first1 = MC. \| last2 = Cooper \| first2 = K. \| title = An update on vulvar intraepithelial neoplasia: terminology and a practical approach to diagnosis. \| journal = J Clin Pathol \| volume = \| issue = \| pages = \| month = Jan \| year = 2014 \| doi = 10.1136/jclinpath-2013-202117 \| PMID = 24399036 }}</ref>		**Classic VIN -> warty SCC (~40% of cases).<ref name=pmid24399036>{{Cite journal \| last1 = Reyes \| first1 = MC. \| last2 = Cooper \| first2 = K. \| title = An update on vulvar intraepithelial neoplasia: terminology and a practical approach to diagnosis. \| journal = J Clin Pathol \| volume = \| issue = \| pages = \| month = Jan \| year = 2014 \| doi = 10.1136/jclinpath-2013-202117 \| PMID = 24399036 }}</ref>

Michael: /* General */

2014-02-25T01:40:53Z

General

← Older revision		Revision as of 01:40, 25 February 2014
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	*Associated with [[lichen sclerosus]].		*Associated with [[lichen sclerosus]].
	*Seen in older women - typically 50s-70s.<ref name=pmid19730361>{{Cite journal \| last1 = Ordi \| first1 = J. \| last2 = Alejo \| first2 = M. \| last3 = Fusté \| first3 = V. \| last4 = Lloveras \| first4 = B. \| last5 = Del Pino \| first5 = M. \| last6 = Alonso \| first6 = I. \| last7 = Torné \| first7 = A. \| title = HPV-negative vulvar intraepithelial neoplasia (VIN) with basaloid histologic pattern: an unrecognized variant of simplex (differentiated) VIN. \| journal = Am J Surg Pathol \| volume = 33 \| issue = 11 \| pages = 1659-65 \| month = Nov \| year = 2009 \| doi = 10.1097/PAS.0b013e3181b40081 \| PMID = 19730361 }}</ref>		*Seen in older women - typically 50s-70s.<ref name=pmid19730361>{{Cite journal \| last1 = Ordi \| first1 = J. \| last2 = Alejo \| first2 = M. \| last3 = Fusté \| first3 = V. \| last4 = Lloveras \| first4 = B. \| last5 = Del Pino \| first5 = M. \| last6 = Alonso \| first6 = I. \| last7 = Torné \| first7 = A. \| title = HPV-negative vulvar intraepithelial neoplasia (VIN) with basaloid histologic pattern: an unrecognized variant of simplex (differentiated) VIN. \| journal = Am J Surg Pathol \| volume = 33 \| issue = 11 \| pages = 1659-65 \| month = Nov \| year = 2009 \| doi = 10.1097/PAS.0b013e3181b40081 \| PMID = 19730361 }}</ref>
	*More common than ''[[classic VIN]]'' caused by HPV;<ref name=pmid21946295>{{Cite journal \| last1 = Kokka \| first1 = F. \| last2 = Singh \| first2 = N. \| last3 = Faruqi \| first3 = A. \| last4 = Gibbon \| first4 = K. \| last5 = Rosenthal \| first5 = AN. \| title = Is differentiated vulval intraepithelial neoplasia the precursor lesion of human papillomavirus-negative vulval squamous cell carcinoma? \| journal = Int J Gynecol Cancer \| volume = 21 \| issue = 7 \| pages = 1297-305 \| month = Oct \| year = 2011 \| doi = 10.1097/IGC.0b013e31822dbe26 \| PMID = 21946295 }}</ref> ~~dVIN~~ ~60% vs. ~~classic~~ VIN ~40%.<ref name=pmid24399036>{{Cite journal \| last1 = Reyes \| first1 = MC. \| last2 = Cooper \| first2 = K. \| title = An update on vulvar intraepithelial neoplasia: terminology and a practical approach to diagnosis. \| journal = J Clin Pathol \| volume = \| issue = \| pages = \| month = Jan \| year = 2014 \| doi = 10.1136/jclinpath-2013-202117 \| PMID = 24399036 }}</ref>		*More common than ''[[classic VIN]]'' caused by HPV;<ref name=pmid21946295>{{Cite journal \| last1 = Kokka \| first1 = F. \| last2 = Singh \| first2 = N. \| last3 = Faruqi \| first3 = A. \| last4 = Gibbon \| first4 = K. \| last5 = Rosenthal \| first5 = AN. \| title = Is differentiated vulval intraepithelial neoplasia the precursor lesion of human papillomavirus-negative vulval squamous cell carcinoma? \| journal = Int J Gynecol Cancer \| volume = 21 \| issue = 7 \| pages = 1297-305 \| month = Oct \| year = 2011 \| doi = 10.1097/IGC.0b013e31822dbe26 \| PMID = 21946295 }}</ref>
			**Differentiated VIN -> keratinizing SCC (~60% of cases).<ref name=pmid24399036/>
			**Classic VIN -> warty SCC (~40% of cases).<ref name=pmid24399036>{{Cite journal \| last1 = Reyes \| first1 = MC. \| last2 = Cooper \| first2 = K. \| title = An update on vulvar intraepithelial neoplasia: terminology and a practical approach to diagnosis. \| journal = J Clin Pathol \| volume = \| issue = \| pages = \| month = Jan \| year = 2014 \| doi = 10.1136/jclinpath-2013-202117 \| PMID = 24399036 }}</ref>

	Note:		Note:

Michael: /* General */

2014-02-25T01:39:11Z

General

← Older revision		Revision as of 01:39, 25 February 2014
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	*Associated with [[lichen sclerosus]].		*Associated with [[lichen sclerosus]].
	*Seen in older women - typically 50s-70s.<ref name=pmid19730361>{{Cite journal \| last1 = Ordi \| first1 = J. \| last2 = Alejo \| first2 = M. \| last3 = Fusté \| first3 = V. \| last4 = Lloveras \| first4 = B. \| last5 = Del Pino \| first5 = M. \| last6 = Alonso \| first6 = I. \| last7 = Torné \| first7 = A. \| title = HPV-negative vulvar intraepithelial neoplasia (VIN) with basaloid histologic pattern: an unrecognized variant of simplex (differentiated) VIN. \| journal = Am J Surg Pathol \| volume = 33 \| issue = 11 \| pages = 1659-65 \| month = Nov \| year = 2009 \| doi = 10.1097/PAS.0b013e3181b40081 \| PMID = 19730361 }}</ref>		*Seen in older women - typically 50s-70s.<ref name=pmid19730361>{{Cite journal \| last1 = Ordi \| first1 = J. \| last2 = Alejo \| first2 = M. \| last3 = Fusté \| first3 = V. \| last4 = Lloveras \| first4 = B. \| last5 = Del Pino \| first5 = M. \| last6 = Alonso \| first6 = I. \| last7 = Torné \| first7 = A. \| title = HPV-negative vulvar intraepithelial neoplasia (VIN) with basaloid histologic pattern: an unrecognized variant of simplex (differentiated) VIN. \| journal = Am J Surg Pathol \| volume = 33 \| issue = 11 \| pages = 1659-65 \| month = Nov \| year = 2009 \| doi = 10.1097/PAS.0b013e3181b40081 \| PMID = 19730361 }}</ref>
	*More common than ''[[classic VIN]]'' caused by HPV.<ref name=pmid21946295>{{Cite journal \| last1 = Kokka \| first1 = F. \| last2 = Singh \| first2 = N. \| last3 = Faruqi \| first3 = A. \| last4 = Gibbon \| first4 = K. \| last5 = Rosenthal \| first5 = AN. \| title = Is differentiated vulval intraepithelial neoplasia the precursor lesion of human papillomavirus-negative vulval squamous cell carcinoma? \| journal = Int J Gynecol Cancer \| volume = 21 \| issue = 7 \| pages = 1297-305 \| month = Oct \| year = 2011 \| doi = 10.1097/IGC.0b013e31822dbe26 \| PMID = 21946295 }}</ref>		*More common than ''[[classic VIN]]'' caused by HPV;<ref name=pmid21946295>{{Cite journal \| last1 = Kokka \| first1 = F. \| last2 = Singh \| first2 = N. \| last3 = Faruqi \| first3 = A. \| last4 = Gibbon \| first4 = K. \| last5 = Rosenthal \| first5 = AN. \| title = Is differentiated vulval intraepithelial neoplasia the precursor lesion of human papillomavirus-negative vulval squamous cell carcinoma? \| journal = Int J Gynecol Cancer \| volume = 21 \| issue = 7 \| pages = 1297-305 \| month = Oct \| year = 2011 \| doi = 10.1097/IGC.0b013e31822dbe26 \| PMID = 21946295 }}</ref> dVIN ~60% vs. classic VIN ~40%.<ref name=pmid24399036>{{Cite journal \| last1 = Reyes \| first1 = MC. \| last2 = Cooper \| first2 = K. \| title = An update on vulvar intraepithelial neoplasia: terminology and a practical approach to diagnosis. \| journal = J Clin Pathol \| volume = \| issue = \| pages = \| month = Jan \| year = 2014 \| doi = 10.1136/jclinpath-2013-202117 \| PMID = 24399036 }}</ref>

	Note:		Note:

Michael: /* General */

2014-02-25T01:35:16Z

General

← Older revision		Revision as of 01:35, 25 February 2014
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	Epidemiology:		Epidemiology:
	*Associated with [[lichen sclerosus]].		*Associated with [[lichen sclerosus]].
	*Seen in older women.		*Seen in older women - typically 50s-70s.<ref name=pmid19730361>{{Cite journal \| last1 = Ordi \| first1 = J. \| last2 = Alejo \| first2 = M. \| last3 = Fusté \| first3 = V. \| last4 = Lloveras \| first4 = B. \| last5 = Del Pino \| first5 = M. \| last6 = Alonso \| first6 = I. \| last7 = Torné \| first7 = A. \| title = HPV-negative vulvar intraepithelial neoplasia (VIN) with basaloid histologic pattern: an unrecognized variant of simplex (differentiated) VIN. \| journal = Am J Surg Pathol \| volume = 33 \| issue = 11 \| pages = 1659-65 \| month = Nov \| year = 2009 \| doi = 10.1097/PAS.0b013e3181b40081 \| PMID = 19730361 }}</ref>
	*More common than ''[[classic VIN]]'' caused by HPV.<ref name=pmid21946295>{{Cite journal \| last1 = Kokka \| first1 = F. \| last2 = Singh \| first2 = N. \| last3 = Faruqi \| first3 = A. \| last4 = Gibbon \| first4 = K. \| last5 = Rosenthal \| first5 = AN. \| title = Is differentiated vulval intraepithelial neoplasia the precursor lesion of human papillomavirus-negative vulval squamous cell carcinoma? \| journal = Int J Gynecol Cancer \| volume = 21 \| issue = 7 \| pages = 1297-305 \| month = Oct \| year = 2011 \| doi = 10.1097/IGC.0b013e31822dbe26 \| PMID = 21946295 }}</ref>		*More common than ''[[classic VIN]]'' caused by HPV.<ref name=pmid21946295>{{Cite journal \| last1 = Kokka \| first1 = F. \| last2 = Singh \| first2 = N. \| last3 = Faruqi \| first3 = A. \| last4 = Gibbon \| first4 = K. \| last5 = Rosenthal \| first5 = AN. \| title = Is differentiated vulval intraepithelial neoplasia the precursor lesion of human papillomavirus-negative vulval squamous cell carcinoma? \| journal = Int J Gynecol Cancer \| volume = 21 \| issue = 7 \| pages = 1297-305 \| month = Oct \| year = 2011 \| doi = 10.1097/IGC.0b013e31822dbe26 \| PMID = 21946295 }}</ref>

	Note:		Note:
	*'''Not''' associated with [[HPV]].<ref name=pmid10716158>{{Cite journal \| last1 = Yang \| first1 = B. \| last2 = Hart \| first2 = WR. \| title = Vulvar intraepithelial neoplasia of the simplex (differentiated) type: a clinicopathologic study including analysis of HPV and p53 expression. \| journal = Am J Surg Pathol \| volume = 24 \| issue = 3 \| pages = 429-41 \| month = Mar \| year = 2000 \| doi = \| PMID = 10716158 }}</ref>		*'''Not''' associated with [[HPV]].<ref name=pmid10716158>{{Cite journal \| last1 = Yang \| first1 = B. \| last2 = Hart \| first2 = WR. \| title = Vulvar intraepithelial neoplasia of the simplex (differentiated) type: a clinicopathologic study including analysis of HPV and p53 expression. \| journal = Am J Surg Pathol \| volume = 24 \| issue = 3 \| pages = 429-41 \| month = Mar \| year = 2000 \| doi = \| PMID = 10716158 }}</ref>

	==Microscopic==		==Microscopic==

Michael: tweak

2014-02-25T01:29:30Z

tweak

← Older revision		Revision as of 01:29, 25 February 2014
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	*Associated with [[lichen sclerosus]].		*Associated with [[lichen sclerosus]].
	*Seen in older women.		*Seen in older women.
			*More common than ''[[classic VIN]]'' caused by HPV.<ref name=pmid21946295>{{Cite journal \| last1 = Kokka \| first1 = F. \| last2 = Singh \| first2 = N. \| last3 = Faruqi \| first3 = A. \| last4 = Gibbon \| first4 = K. \| last5 = Rosenthal \| first5 = AN. \| title = Is differentiated vulval intraepithelial neoplasia the precursor lesion of human papillomavirus-negative vulval squamous cell carcinoma? \| journal = Int J Gynecol Cancer \| volume = 21 \| issue = 7 \| pages = 1297-305 \| month = Oct \| year = 2011 \| doi = 10.1097/IGC.0b013e31822dbe26 \| PMID = 21946295 }}</ref>

	Note:		Note:

Michael: /* Microscopic */ +so

2014-02-25T01:26:06Z

Microscopic: +so

← Older revision		Revision as of 01:26, 25 February 2014
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	*[http://www.nature.com/modpathol/journal/v23/n3/fig_tab/modpathol2009179f1.html Differentiated VIN with bridging rete ridges (nature.com)].<ref name=pmid20062014>{{Cite journal \| last1 = Pinto \| first1 = AP. \| last2 = Miron \| first2 = A. \| last3 = Yassin \| first3 = Y. \| last4 = Monte \| first4 = N. \| last5 = Woo \| first5 = TY. \| last6 = Mehra \| first6 = KK. \| last7 = Medeiros \| first7 = F. \| last8 = Crum \| first8 = CP. \| title = Differentiated vulvar intraepithelial neoplasia contains Tp53 mutations and is genetically linked to vulvar squamous cell carcinoma. \| journal = Mod Pathol \| volume = 23 \| issue = 3 \| pages = 404-12 \| month = Mar \| year = 2010 \| doi = 10.1038/modpathol.2009.179 \| PMID = 20062014 }}</ref>		*[http://www.nature.com/modpathol/journal/v23/n3/fig_tab/modpathol2009179f1.html Differentiated VIN with bridging rete ridges (nature.com)].<ref name=pmid20062014>{{Cite journal \| last1 = Pinto \| first1 = AP. \| last2 = Miron \| first2 = A. \| last3 = Yassin \| first3 = Y. \| last4 = Monte \| first4 = N. \| last5 = Woo \| first5 = TY. \| last6 = Mehra \| first6 = KK. \| last7 = Medeiros \| first7 = F. \| last8 = Crum \| first8 = CP. \| title = Differentiated vulvar intraepithelial neoplasia contains Tp53 mutations and is genetically linked to vulvar squamous cell carcinoma. \| journal = Mod Pathol \| volume = 23 \| issue = 3 \| pages = 404-12 \| month = Mar \| year = 2010 \| doi = 10.1038/modpathol.2009.179 \| PMID = 20062014 }}</ref>

	===IHC===		==IHC==
	*Differentiated VIN: p16 -ve, p53 +ve.<ref name=pmid20062014/>		*Differentiated VIN: p16 -ve, p53 +ve.<ref name=pmid20062014/>
	*Classic VIN: p16 +ve, p53 -ve.		*Classic VIN: p16 +ve, p53 -ve.
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	Note:		Note:
	*p16 can be thought of as a poor man's [[HPV]] test.		*p16 can be thought of as a poor man's [[HPV]] test.

			==Sign out==
			<pre>
			LABIA MINUS, RIGHT, PUNCH BIOPSY:
			- DIFFERENTIATED VULVAR INTRAEPITHELIAL NEOPLASIA.
			- LICHEN SCLEROSUS.
			</pre>

	==See also==		==See also==

Michael: /* Images */

2014-02-25T01:24:17Z

Images

← Older revision		Revision as of 01:24, 25 February 2014
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	Image:Differentiated_vulvar_intraepithelial_neoplasia_-_low_mag.jpg \| Differentiated VIN - low mag. (WC)		Image:Differentiated_vulvar_intraepithelial_neoplasia_-_low_mag.jpg \| Differentiated VIN - low mag. (WC)
	Image:Differentiated_vulvar_intraepithelial_neoplasia_-_intermed_mag.jpg \| Differentiated VIN - intermed. mag. (WC)		Image:Differentiated_vulvar_intraepithelial_neoplasia_-_intermed_mag.jpg \| Differentiated VIN - intermed. mag. (WC)
			Image: Differentiated vulvar intraepithelial neoplasia - superficial - high mag.jpg \| Differentiated VIN - superficial - high mag. (WC)
	Image:Differentiated_vulvar_intraepithelial_neoplasia_-_deep_-_high_mag.jpg \| Differentiated VIN - deep - high mag. (WC)		Image:Differentiated_vulvar_intraepithelial_neoplasia_-_deep_-_high_mag.jpg \| Differentiated VIN - deep - high mag. (WC)
	</gallery>		</gallery>
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	*[http://www.nature.com/modpathol/journal/v24/n2/fig_tab/modpathol2010192f3.html#figure-title Differentiated VIN (nature.com)].<ref name=pmid21057461>{{Cite journal \| last1 = van de Nieuwenhof \| first1 = HP. \| last2 = Bulten \| first2 = J. \| last3 = Hollema \| first3 = H. \| last4 = Dommerholt \| first4 = RG. \| last5 = Massuger \| first5 = LF. \| last6 = van der Zee \| first6 = AG. \| last7 = de Hullu \| first7 = JA. \| last8 = van Kempen \| first8 = LC. \| title = Differentiated vulvar intraepithelial neoplasia is often found in lesions, previously diagnosed as lichen sclerosus, which have progressed to vulvar squamous cell carcinoma. \| journal = Mod Pathol \| volume = 24 \| issue = 2 \| pages = 297-305 \| month = Feb \| year = 2011 \| doi = 10.1038/modpathol.2010.192 \| PMID = 21057461 }}</ref>		*[http://www.nature.com/modpathol/journal/v24/n2/fig_tab/modpathol2010192f3.html#figure-title Differentiated VIN (nature.com)].<ref name=pmid21057461>{{Cite journal \| last1 = van de Nieuwenhof \| first1 = HP. \| last2 = Bulten \| first2 = J. \| last3 = Hollema \| first3 = H. \| last4 = Dommerholt \| first4 = RG. \| last5 = Massuger \| first5 = LF. \| last6 = van der Zee \| first6 = AG. \| last7 = de Hullu \| first7 = JA. \| last8 = van Kempen \| first8 = LC. \| title = Differentiated vulvar intraepithelial neoplasia is often found in lesions, previously diagnosed as lichen sclerosus, which have progressed to vulvar squamous cell carcinoma. \| journal = Mod Pathol \| volume = 24 \| issue = 2 \| pages = 297-305 \| month = Feb \| year = 2011 \| doi = 10.1038/modpathol.2010.192 \| PMID = 21057461 }}</ref>
	*[http://www.nature.com/modpathol/journal/v23/n3/fig_tab/modpathol2009179f1.html Differentiated VIN with bridging rete ridges (nature.com)].<ref name=pmid20062014>{{Cite journal \| last1 = Pinto \| first1 = AP. \| last2 = Miron \| first2 = A. \| last3 = Yassin \| first3 = Y. \| last4 = Monte \| first4 = N. \| last5 = Woo \| first5 = TY. \| last6 = Mehra \| first6 = KK. \| last7 = Medeiros \| first7 = F. \| last8 = Crum \| first8 = CP. \| title = Differentiated vulvar intraepithelial neoplasia contains Tp53 mutations and is genetically linked to vulvar squamous cell carcinoma. \| journal = Mod Pathol \| volume = 23 \| issue = 3 \| pages = 404-12 \| month = Mar \| year = 2010 \| doi = 10.1038/modpathol.2009.179 \| PMID = 20062014 }}</ref>		*[http://www.nature.com/modpathol/journal/v23/n3/fig_tab/modpathol2009179f1.html Differentiated VIN with bridging rete ridges (nature.com)].<ref name=pmid20062014>{{Cite journal \| last1 = Pinto \| first1 = AP. \| last2 = Miron \| first2 = A. \| last3 = Yassin \| first3 = Y. \| last4 = Monte \| first4 = N. \| last5 = Woo \| first5 = TY. \| last6 = Mehra \| first6 = KK. \| last7 = Medeiros \| first7 = F. \| last8 = Crum \| first8 = CP. \| title = Differentiated vulvar intraepithelial neoplasia contains Tp53 mutations and is genetically linked to vulvar squamous cell carcinoma. \| journal = Mod Pathol \| volume = 23 \| issue = 3 \| pages = 404-12 \| month = Mar \| year = 2010 \| doi = 10.1038/modpathol.2009.179 \| PMID = 20062014 }}</ref>

	===IHC===		===IHC===
	*Differentiated VIN: p16 -ve, p53 +ve.<ref name=pmid20062014/>		*Differentiated VIN: p16 -ve, p53 +ve.<ref name=pmid20062014/>