Desmoplastic small round cell tumour - Revision history

Jensflorian: /* IHC */ WT nuclear + CAM5.2

2020-01-21T11:10:28Z

IHC: WT nuclear + CAM5.2

← Older revision		Revision as of 11:10, 21 January 2020
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	Features:		Features:
	*[[AE1/AE3]] +ve.		*[[AE1/AE3]] +ve.
	*Desmin +ve.		*CAM5.2 usu -ve.
			*Desmin +ve (strongly).
	*[[EMA]] +ve.		*[[EMA]] +ve.
	*Actin -ve.		*Actin -ve.
	*~~WT1~~ (N-terminal) -ve.		*[[WT-1]] (N-terminal) -ve.
	*~~WT1~~ (C-terminal) +ve.		*[[WT-1]] (C-terminal) +ve (nuclear staining).
	*CD57 +ve.		*CD57 +ve.
			*[[Synaptophysin]] focal, patchy +ve.

	==Molecular==		==Molecular==

Jensflorian: cat

2020-01-21T11:06:17Z

cat

← Older revision		Revision as of 11:06, 21 January 2020
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	[[Category:Soft tissue lesions]]		[[Category:Soft tissue lesions]]
			[[Category:Neuropathology]]
	[[Category:Diagnosis]]		[[Category:Diagnosis]]

Jensflorian: /* General */ clinics

2020-01-21T11:05:51Z

General: clinics

← Older revision		Revision as of 11:05, 21 January 2020
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	*Typically retroperitoneal.		*Typically retroperitoneal.
	*Poor prognosis.		*Poor prognosis.

			==Clinics==
			*Rare cases in the CNS reported.

	==Microscopic==		==Microscopic==

Michael: /* IHC */

2016-07-31T19:39:38Z

IHC

← Older revision		Revision as of 19:39, 31 July 2016
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	==IHC==		==IHC==
	Features:		Features:
	*AE1/AE3 +ve.		*[[AE1/AE3]] +ve.
	*Desmin +ve.		*Desmin +ve.
	*EMA +ve.		*[[EMA]] +ve.
	*Actin -ve.		*Actin -ve.
	*WT1 (N-terminal) -ve.		*WT1 (N-terminal) -ve.

Michael: /* See also */

2014-10-01T02:14:54Z

Michael: tweak

2013-09-27T16:07:32Z

tweak

← Older revision		Revision as of 16:07, 27 September 2013
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	\| Micro = small (round) cells in nests with an undulating sharp border, road bands of paucicellular fibrous stroma		\| Micro = small (round) cells in nests with an undulating sharp border, road bands of paucicellular fibrous stroma
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[~~Embryonal RMS~~]], other [[small round cell tumours]]		\| LMDDx = solid variant of [[alveolar rhabdomyosarcoma]], [[embryonal rhabdomyosarcoma]], other [[small round cell tumours]]
	\| Stains =		\| Stains =
	\| IHC = AE1/AE3 +ve, desmin +ve, EMA +ve, actin -ve, WT1 (N-terminal) -ve, WT1 (C-terminal) +ve, CD57 +ve.		\| IHC = AE1/AE3 +ve, desmin +ve, EMA +ve, actin -ve, WT1 (N-terminal) -ve, WT1 (C-terminal) +ve, CD57 +ve.
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	*Solid variant of [[alveolar RMS]].		*Solid variant of [[alveolar RMS]].
	**Nests in alveolar RMS have round edges.		**Nests in alveolar RMS have round edges.
			*Other [[small round cell tumours]].

	===Images===		===Images===
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	==See also==		==See also==
	*[[Soft tissue lesions]].		*[[Soft tissue lesions]].
			*[[Small round cell tumours]].

	==References==		==References==

Michael: +infobox

2013-09-27T16:05:30Z

+infobox

← Older revision		Revision as of 16:05, 27 September 2013
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Desmoplastic_small_round_cell_tumour_-_high_mag.jpg
			\| Width =
			\| Caption = DSRCT. [[H&E stain]].
			\| Micro = small (round) cells in nests with an undulating sharp border, road bands of paucicellular fibrous stroma
			\| Subtypes =
			\| LMDDx = [[Embryonal RMS]], other [[small round cell tumours]]
			\| Stains =
			\| IHC = AE1/AE3 +ve, desmin +ve, EMA +ve, actin -ve, WT1 (N-terminal) -ve, WT1 (C-terminal) +ve, CD57 +ve.
			\| EM =
			\| Molecular = t(11;22)
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[soft tissue lesions]] - typically retroperitoneum
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx = usu. young adults
			\| Signs =
			\| Symptoms =
			\| Prevalence = very rare
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = poor
			\| Other =
			\| ClinDDx = (metastatic) [[germ cell tumour]], [[lymphoma]]
			}}
	'''Desmoplastic small round cell tumour''', abbreviated '''DSRCT''', is a rare malignant soft tissue lesion that tends to afflict young adults.		'''Desmoplastic small round cell tumour''', abbreviated '''DSRCT''', is a rare malignant soft tissue lesion that tends to afflict young adults.

Michael: split-out

2013-09-27T15:58:55Z

split-out

← Older revision		Revision as of 15:58, 27 September 2013
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	~~#redirect [[Soft_tissue_lesions#Desmoplastic_small_round_cell_tumour]]~~		'''Desmoplastic small round cell tumour''', abbreviated '''DSRCT''', is a rare malignant soft tissue lesion that tends to afflict young adults.

			==General==
			*Males > females.
			*Usu. affects young adults.
			*Typically retroperitoneal.
			*Poor prognosis.

			==Microscopic==
			Features:<ref name=pmid10207460>{{cite journal \|author=Pickhardt PJ, Fisher AJ, Balfe DM, Dehner LP, Huettner PC \|title=Desmoplastic small round cell tumor of the abdomen: radiologic-histopathologic correlation \|journal=Radiology \|volume=210 \|issue=3 \|pages=633–8 \|year=1999 \|month=March \|pmid=10207460 \|doi= \|url=http://radiology.rsna.org/content/210/3/633.full}}</ref>
			#Broad bands of paucicellular fibrous stroma with:
			#Small round cells in nests with an undulating sharp border.
			#*The small round cells lack distinct nucleoli and have scant cytoplasm; they are ''[[small round cell tumour]]'' cells.

			Notes:
			*Usu. abundant mitoses.
			*+/-Necrosis.

			DDx:
			*Metastatic [[germ cell tumour]] (DDx of location and age).
			*[[Embryonal RMS]].
			**It should be noted that DSRCT, like embryonal RMS, is +ve for desmin!
			*Solid variant of [[alveolar RMS]].
			**Nests in alveolar RMS have round edges.

			===Images===
			<gallery>
			Image:Desmoplastic_small_round_cell_tumour_-_intermed_mag.jpg \| DSRCT - intermed. mag. (WC/Nephron)
			Image:Desmoplastic_small_round_cell_tumour_-_high_mag.jpg \| DSRCT - high mag. (WC/Nephron)
			Image:Desmoplastic_small_round_cell_tumour_-_very_high_mag.jpg \| DSRCT - very high mag. (WC/Nephron)
			</gallery>

			==IHC==
			Features:
			*AE1/AE3 +ve.
			*Desmin +ve.
			*EMA +ve.
			*Actin -ve.
			*WT1 (N-terminal) -ve.
			*WT1 (C-terminal) +ve.
			*CD57 +ve.

			==Molecular==
			*t(11;22)(p13;q12).<ref name=pmid17964965>{{cite journal \|author=Lee YS, Hsiao CH \|title=Desmoplastic small round cell tumor: a clinicopathologic, immunohistochemical and molecular study of four patients \|journal=J. Formos. Med. Assoc. \|volume=106 \|issue=10 \|pages=854–60 \|year=2007 \|month=October \|pmid=17964965 \|doi=10.1016/S0929-6646(08)60051-0 \|url=}}</ref><ref>{{cite journal \|author=Lal DR, Su WT, Wolden SL, Loh KC, Modak S, La Quaglia MP \|title=Results of multimodal treatment for desmoplastic small round cell tumors \|journal=J. Pediatr. Surg. \|volume=40 \|issue=1 \|pages=251–5 \|year=2005 \|month=January \|pmid=15868593 \|doi=10.1016/j.jpedsurg.2004.09.046 \|url=http://www.dsrct.com/JPS%20Article.pdf}}</ref>

			==See also==
			*[[Soft tissue lesions]].

			==References==
			{{Reflist\|2}}

			[[Category:Soft tissue lesions]]
	[[Category:Diagnosis]]		[[Category:Diagnosis]]

Michael: +cat.

2011-10-20T04:40:02Z

+cat.

← Older revision		Revision as of 04:40, 20 October 2011
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	#redirect [[Soft_tissue_lesions#Desmoplastic_small_round_cell_tumour]]		#redirect [[Soft_tissue_lesions#Desmoplastic_small_round_cell_tumour]]

			[[Category:Diagnosis]]

Michael: redirect for now

2011-04-07T23:29:53Z

redirect for now

New page

#redirect [[Soft_tissue_lesions#Desmoplastic_small_round_cell_tumour]]

← Older revision		Revision as of 02:14, 1 October 2014
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	*[[Soft tissue lesions]].		*[[Soft tissue lesions]].
	*[[Small round cell tumours]].		*[[Small round cell tumours]].
			*[[Stromal desmoplasia]].

	==References==		==References==