Dermatopathic lymphadenopathy - Revision history

Michael at 03:48, 10 December 2013

2013-12-10T03:48:46Z

← Older revision		Revision as of 03:48, 10 December 2013
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	\| Width =		\| Width =
	\| Caption = Dermatopathic lymphadenopathy. [[H&E stain]].		\| Caption = Dermatopathic lymphadenopathy. [[H&E stain]].
	\| Micro =		\| Micro = sinus histiocytosis with melanin pigment, esoinophils, plasma cells
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[malignant melanoma]], [[sinus histiocytosis]]		\| LMDDx = [[malignant melanoma]], [[sinus histiocytosis]], [[Hodgkin lymphoma]]
	\| Stains =		\| Stains = [[Fontana-Masson stain]]
	\| IHC =		\| IHC =
	\| EM =		\| EM =

Michael at 03:45, 10 December 2013

2013-12-10T03:45:10Z

← Older revision		Revision as of 03:45, 10 December 2013
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	==General==		==General==
	*Lymphadenopathy associated with a skin lesion.		*Lymphadenopathy associated with a [[skin]] lesion.
	**May not always be true.<ref name=pmid3178430>{{Cite journal \| last1 = Gould \| first1 = E. \| last2 = Porto \| first2 = R. \| last3 = Albores-Saavedra \| first3 = J. \| last4 = Ibe \| first4 = MJ. \| title = Dermatopathic lymphadenitis. The spectrum and significance of its morphologic features. \| journal = Arch Pathol Lab Med \| volume = 112 \| issue = 11 \| pages = 1145-50 \| month = Nov \| year = 1988 \| doi = \| PMID = 3178430 }}</ref>		**May not always be true.<ref name=pmid3178430>{{Cite journal \| last1 = Gould \| first1 = E. \| last2 = Porto \| first2 = R. \| last3 = Albores-Saavedra \| first3 = J. \| last4 = Ibe \| first4 = MJ. \| title = Dermatopathic lymphadenitis. The spectrum and significance of its morphologic features. \| journal = Arch Pathol Lab Med \| volume = 112 \| issue = 11 \| pages = 1145-50 \| month = Nov \| year = 1988 \| doi = \| PMID = 3178430 }}</ref>
	*Benign in itself.<ref name=pmid17176922>{{Cite journal \| last1 = Westhoff \| first1 = TH. \| last2 = Loddenkemper \| first2 = C. \| last3 = Hörl \| first3 = MP. \| last4 = Schmidt \| first4 = S. \| last5 = Anagnostopoulos \| first5 = I. \| last6 = Hummel \| first6 = M. \| last7 = Zidek \| first7 = W. \| last8 = van der Giet \| first8 = M. \| title = Dermatopathic lymphadenopathy: a differential diagnosis of enlarged lymph nodes in uremic pruritus. \| journal = Clin Nephrol \| volume = 66 \| issue = 6 \| pages = 472-5 \| month = Dec \| year = 2006 \| doi = \| PMID = 17176922 }}</ref>		*Benign in itself.<ref name=pmid17176922>{{Cite journal \| last1 = Westhoff \| first1 = TH. \| last2 = Loddenkemper \| first2 = C. \| last3 = Hörl \| first3 = MP. \| last4 = Schmidt \| first4 = S. \| last5 = Anagnostopoulos \| first5 = I. \| last6 = Hummel \| first6 = M. \| last7 = Zidek \| first7 = W. \| last8 = van der Giet \| first8 = M. \| title = Dermatopathic lymphadenopathy: a differential diagnosis of enlarged lymph nodes in uremic pruritus. \| journal = Clin Nephrol \| volume = 66 \| issue = 6 \| pages = 472-5 \| month = Dec \| year = 2006 \| doi = \| PMID = 17176922 }}</ref>

Michael: more

2013-12-10T03:44:45Z

← Older revision		Revision as of 03:44, 10 December 2013
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Dermatopathic_lymphadenopathy_-_high_mag.jpg
			\| Width =
			\| Caption = Dermatopathic lymphadenopathy. [[H&E stain]].
			\| Micro =
			\| Subtypes =
			\| LMDDx = [[malignant melanoma]], [[sinus histiocytosis]]
			\| Stains =
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[lymph node]] - see ''[[lymph node pathology]]''
			\| Assdx = T-cell lymphoma
			\| Syndromes =
			\| Clinicalhx =
			\| Signs = enlarged lymph node
			\| Symptoms =
			\| Prevalence = uncommon
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = benign
			\| Other =
			\| ClinDDx = other cause of lymphadenopathy
			}}
	'''Dermatopathic lymphadenopathy''', abbreviated '''DL''', is a rare [[lymph node pathology\|pathology of the lymph nodes]].		'''Dermatopathic lymphadenopathy''', abbreviated '''DL''', is a rare [[lymph node pathology\|pathology of the lymph nodes]].

Michael at 03:41, 10 December 2013

2013-12-10T03:41:49Z

← Older revision		Revision as of 03:41, 10 December 2013
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	==General==		==General==
	*Lymphadenopathy associated with a skin lesion - ~~'''key feature'''~~.		*Lymphadenopathy associated with a skin lesion.
			**May not always be true.<ref name=pmid3178430>{{Cite journal \| last1 = Gould \| first1 = E. \| last2 = Porto \| first2 = R. \| last3 = Albores-Saavedra \| first3 = J. \| last4 = Ibe \| first4 = MJ. \| title = Dermatopathic lymphadenitis. The spectrum and significance of its morphologic features. \| journal = Arch Pathol Lab Med \| volume = 112 \| issue = 11 \| pages = 1145-50 \| month = Nov \| year = 1988 \| doi = \| PMID = 3178430 }}</ref>
	*Benign in itself.<ref name=pmid17176922>{{Cite journal \| last1 = Westhoff \| first1 = TH. \| last2 = Loddenkemper \| first2 = C. \| last3 = Hörl \| first3 = MP. \| last4 = Schmidt \| first4 = S. \| last5 = Anagnostopoulos \| first5 = I. \| last6 = Hummel \| first6 = M. \| last7 = Zidek \| first7 = W. \| last8 = van der Giet \| first8 = M. \| title = Dermatopathic lymphadenopathy: a differential diagnosis of enlarged lymph nodes in uremic pruritus. \| journal = Clin Nephrol \| volume = 66 \| issue = 6 \| pages = 472-5 \| month = Dec \| year = 2006 \| doi = \| PMID = 17176922 }}</ref>		*Benign in itself.<ref name=pmid17176922>{{Cite journal \| last1 = Westhoff \| first1 = TH. \| last2 = Loddenkemper \| first2 = C. \| last3 = Hörl \| first3 = MP. \| last4 = Schmidt \| first4 = S. \| last5 = Anagnostopoulos \| first5 = I. \| last6 = Hummel \| first6 = M. \| last7 = Zidek \| first7 = W. \| last8 = van der Giet \| first8 = M. \| title = Dermatopathic lymphadenopathy: a differential diagnosis of enlarged lymph nodes in uremic pruritus. \| journal = Clin Nephrol \| volume = 66 \| issue = 6 \| pages = 472-5 \| month = Dec \| year = 2006 \| doi = \| PMID = 17176922 }}</ref>
	**May be associated with a malignancy - esp. T-cell lymphoma.<ref name=pmid5341844>{{Cite journal \| last1 = Cooper \| first1 = RA. \| last2 = Dawson \| first2 = PJ. \| last3 = Rambo \| first3 = ON. \| title = Dermatopathic lymphadenopathy a clinicopathologic analysis of lymph node biopsy over a fifteen-year period. \| journal = Calif Med \| volume = 106 \| issue = 3 \| pages = 170-5 \| month = Mar \| year = 1967 \| doi = \| PMID = 5341844 }}		**May be associated with a malignancy - esp. T-cell lymphoma.<ref name=pmid5341844>{{Cite journal \| last1 = Cooper \| first1 = RA. \| last2 = Dawson \| first2 = PJ. \| last3 = Rambo \| first3 = ON. \| title = Dermatopathic lymphadenopathy a clinicopathologic analysis of lymph node biopsy over a fifteen-year period. \| journal = Calif Med \| volume = 106 \| issue = 3 \| pages = 170-5 \| month = Mar \| year = 1967 \| doi = \| PMID = 5341844 }}

Michael: /* General */

2013-12-10T03:36:19Z

General

← Older revision		Revision as of 03:36, 10 December 2013
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	*Lymphadenopathy associated with a skin lesion - '''key feature'''.		*Lymphadenopathy associated with a skin lesion - '''key feature'''.
	*Benign in itself.<ref name=pmid17176922>{{Cite journal \| last1 = Westhoff \| first1 = TH. \| last2 = Loddenkemper \| first2 = C. \| last3 = Hörl \| first3 = MP. \| last4 = Schmidt \| first4 = S. \| last5 = Anagnostopoulos \| first5 = I. \| last6 = Hummel \| first6 = M. \| last7 = Zidek \| first7 = W. \| last8 = van der Giet \| first8 = M. \| title = Dermatopathic lymphadenopathy: a differential diagnosis of enlarged lymph nodes in uremic pruritus. \| journal = Clin Nephrol \| volume = 66 \| issue = 6 \| pages = 472-5 \| month = Dec \| year = 2006 \| doi = \| PMID = 17176922 }}</ref>		*Benign in itself.<ref name=pmid17176922>{{Cite journal \| last1 = Westhoff \| first1 = TH. \| last2 = Loddenkemper \| first2 = C. \| last3 = Hörl \| first3 = MP. \| last4 = Schmidt \| first4 = S. \| last5 = Anagnostopoulos \| first5 = I. \| last6 = Hummel \| first6 = M. \| last7 = Zidek \| first7 = W. \| last8 = van der Giet \| first8 = M. \| title = Dermatopathic lymphadenopathy: a differential diagnosis of enlarged lymph nodes in uremic pruritus. \| journal = Clin Nephrol \| volume = 66 \| issue = 6 \| pages = 472-5 \| month = Dec \| year = 2006 \| doi = \| PMID = 17176922 }}</ref>
	**May be associated with a malignancy ~~(e.g~~. T-cell lymphoma).<ref name=pmid15173917>{{Cite journal \| last1 = Kojima \| first1 = M. \| last2 = Nakamura \| first2 = S. \| last3 = Itoh \| first3 = H. \| last4 = Yamane \| first4 = Y. \| last5 = Shimizu \| first5 = K. \| last6 = Murayama \| first6 = K. \| last7 = Ohno \| first7 = Y. \| last8 = Tanaka \| first8 = H. \| last9 = Sugihara \| first9 = S. \| title = Clinical implication of dermatopathic lymphadenopathy among Japanese: a report of 19 cases. \| journal = Int J Surg Pathol \| volume = 12 \| issue = 2 \| pages = 127-32 \| month = Apr \| year = 2004 \| doi = \| PMID = 15173917 }}</ref>		**May be associated with a malignancy - esp. T-cell lymphoma.<ref name=pmid5341844>{{Cite journal \| last1 = Cooper \| first1 = RA. \| last2 = Dawson \| first2 = PJ. \| last3 = Rambo \| first3 = ON. \| title = Dermatopathic lymphadenopathy a clinicopathologic analysis of lymph node biopsy over a fifteen-year period. \| journal = Calif Med \| volume = 106 \| issue = 3 \| pages = 170-5 \| month = Mar \| year = 1967 \| doi = \| PMID = 5341844 }}
			</ref><ref name=pmid15173917>{{Cite journal \| last1 = Kojima \| first1 = M. \| last2 = Nakamura \| first2 = S. \| last3 = Itoh \| first3 = H. \| last4 = Yamane \| first4 = Y. \| last5 = Shimizu \| first5 = K. \| last6 = Murayama \| first6 = K. \| last7 = Ohno \| first7 = Y. \| last8 = Tanaka \| first8 = H. \| last9 = Sugihara \| first9 = S. \| title = Clinical implication of dermatopathic lymphadenopathy among Japanese: a report of 19 cases. \| journal = Int J Surg Pathol \| volume = 12 \| issue = 2 \| pages = 127-32 \| month = Apr \| year = 2004 \| doi = \| PMID = 15173917 }}</ref>

	==Microscopic==		==Microscopic==

Michael: /* General */

2013-12-10T03:33:14Z

General

← Older revision		Revision as of 03:33, 10 December 2013
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	==General==		==General==
	*Lymphadenopathy associated with a skin lesion - '''key feature'''.		*Lymphadenopathy associated with a skin lesion - '''key feature'''.
	*May be ~~benign ''or'' malignant~~ (e.g. T-cell lymphoma).		*Benign in itself.<ref name=pmid17176922>{{Cite journal \| last1 = Westhoff \| first1 = TH. \| last2 = Loddenkemper \| first2 = C. \| last3 = Hörl \| first3 = MP. \| last4 = Schmidt \| first4 = S. \| last5 = Anagnostopoulos \| first5 = I. \| last6 = Hummel \| first6 = M. \| last7 = Zidek \| first7 = W. \| last8 = van der Giet \| first8 = M. \| title = Dermatopathic lymphadenopathy: a differential diagnosis of enlarged lymph nodes in uremic pruritus. \| journal = Clin Nephrol \| volume = 66 \| issue = 6 \| pages = 472-5 \| month = Dec \| year = 2006 \| doi = \| PMID = 17176922 }}</ref>
			**May be associated with a malignancy (e.g. T-cell lymphoma).<ref name=pmid15173917>{{Cite journal \| last1 = Kojima \| first1 = M. \| last2 = Nakamura \| first2 = S. \| last3 = Itoh \| first3 = H. \| last4 = Yamane \| first4 = Y. \| last5 = Shimizu \| first5 = K. \| last6 = Murayama \| first6 = K. \| last7 = Ohno \| first7 = Y. \| last8 = Tanaka \| first8 = H. \| last9 = Sugihara \| first9 = S. \| title = Clinical implication of dermatopathic lymphadenopathy among Japanese: a report of 19 cases. \| journal = Int J Surg Pathol \| volume = 12 \| issue = 2 \| pages = 127-32 \| month = Apr \| year = 2004 \| doi = \| PMID = 15173917 }}</ref>

	==Microscopic==		==Microscopic==

Michael at 03:26, 10 December 2013

2013-12-10T03:26:44Z

← Older revision		Revision as of 03:26, 10 December 2013
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	'''Dermatopathic lymphadenopathy''' is a rare [[lymph node pathology\|pathology of the lymph nodes]].		'''Dermatopathic lymphadenopathy''', abbreviated '''DL''', is a rare [[lymph node pathology\|pathology of the lymph nodes]].

	==General==		==General==

Michael: split-out

2013-12-10T03:26:03Z

split-out

← Older revision		Revision as of 03:26, 10 December 2013
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	~~#redirect~~ [[~~Lymph_node_pathology#Dermatopathic_lymphadenopathy~~]]		'''Dermatopathic lymphadenopathy''' is a rare [[lymph node pathology\|pathology of the lymph nodes]].

			==General==
			*Lymphadenopathy associated with a skin lesion - '''key feature'''.
			*May be benign ''or'' malignant (e.g. T-cell lymphoma).

			==Microscopic==
			Features:<ref name=ILNP226>{{Ref ILNP\|226}}</ref>
			*Abundant histiocytes & special histiocytes - in loose irregular clusters - located in the sinuses, i.e. sinus histiocytosis - '''key feature''':
			**Do ''not'' form granuloma; may be similar to ''toxoplasma''.
			*Plasma cells (medulla).
			*Eosinophils.

			Histiocytes & special histiocytes:
			*Histiocytes:
			**+/-Melanin pigment '''key feature''' (if present).
			**Lipid-laden macrophages.
			*Interdigitating dendritic cells:
			**Need IHC to identify definitively.
			*Langerhans cells:
			**Classically have a kidney bean nuclei.
			**Need IHC to identify definitively.

			DDx:
			*[[Metastatic]] [[malignant melanoma]] - (melanin) pigmented cells have nuclear atypia, not histiocytes.
			*[[Sinus histiocytosis]] - no cells with melanin.

			===Images===
			<gallery>
			Image:Dermatopathic_lymphadenopathy_-_very_low_mag.jpg \| DL - very low mag. (WC)
			Image:Dermatopathic_lymphadenopathy_-_low_mag.jpg \| DL - low mag. (WC)
			Image:Dermatopathic_lymphadenopathy_-_intermed_mag.jpg \| DL - intermed. mag. (WC)
			Image:Dermatopathic_lymphadenopathy_-_high_mag.jpg \| DL - high mag. (WC)
			Image:Dermatopathic_lymphadenopathy_-_very_high_mag.jpg \| DL - very high mag. (WC)
			</gallery>

			==IHC==
			*Interdigitating dendritic cells: S100 +ve, CD1a -ve.
			*Langerhans cells: S100 +ve, CD1a +ve.

			==See also==
			*[[Lymph node pathology]].

			==References==
			{{Reflist\|2}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Lymph node pathology]]

Michael: redirect w/ cat.

2011-10-21T04:39:04Z

redirect w/ cat.

New page

#redirect [[Lymph_node_pathology#Dermatopathic_lymphadenopathy]]

[[Category:Diagnosis]]