Dermatologic neoplasms - Revision history

Michael at 14:10, 8 October 2024

2024-10-08T14:10:04Z

← Older revision		Revision as of 14:10, 8 October 2024
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	=Benign=		=Benign=
	==Syringoma==		==Syringoma==
	~~===General===~~		{{Main\|Syringoma}}
	*Benign sweat duct tumour.
	*Eccrine differentiation.
	*Usually close to lower [[eyelid]].<ref>{{~~Ref PBoD8~~\|~~1177}}</ref>~~

	~~===Microscopic===~~
	~~Features:<ref>URL: [http://emedicine.medscape.com/article/1059871-diagnosis http://emedicine.medscape.com/article/1059871-diagnosis]. Accessed on: 12 May 2010.</ref>~~
	*Proliferation of benign ducts with lined by a bilayer (as in normal sweat ducts) with abnormal architecture:
	**Tadpole like appearing ducts.

	~~DDx:~~
	*Syringomatous adenomas of nipple (AKA syringoma of the nipple).<ref name=pmid22355740>{{Cite journal \| last1 = Boecker \| first1 = W. \| last2 = Junkers \| first2 = T. \| last3 = Reusch \| first3 = M. \| last4 = Buerger \| first4 = H. \| last5 = Korsching \| first5 = E. \| last6 = Metze \| first6 = D. \| last7 = Decker \| first7 = T. \| last8 = Loening \| first8 = T. \| last9 = Lange \| first9 = A. \| title = Origin and differentiation of breast nipple syringoma. \| journal = Sci Rep \| volume = 2 \| issue = \| pages = 226 \| month = \| year = 2012 \| doi = 10.1038/srep00226 \| PMID = 22355740 \|URL = http://www.nature.com/srep/2012/120117/srep00226/full/srep00226.html }}</ref>
	*[[Chondroid syringoma]]. (???)

	~~Images:~~
	*[http://www.flickr.com/photos/euthman/2329061316/ Syringoma ~~(flickr.com)].~~
	*[http://dermatology.cdlib.org/144/tumors/axillary_syringoma/2.jpg Syringoma (dermatology.cdlib.org)].<ref>{{Cite journal \| last1 = Nosrati \| first1 = N. \| last2 = Coleman \| first2 = NM. \| last3 = Hsu \| first3 = S. \| title = Axillary syringomas. \| journal = Dermatol Online J \| volume = 14 \| issue = 4 \| pages = 13 \| month = \| year = 2008 \| doi = \| PMID = 18627735 \|URL = http://dermatology.cdlib.org/144/tumors/axillary_syringoma/hsu.html}}~~</ref>~~
	~~===Sign out===~~
	~~<pre>~~
	~~A. Right Lower Eyelid Lesion, Biopsy:~~
	~~- Benign syringoma.~~
	~~</pre>~~

	==Chondroid syringoma==		==Chondroid syringoma==

Michael at 13:59, 8 October 2024

2024-10-08T13:59:46Z

← Older revision		Revision as of 13:59, 8 October 2024
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	*[http://www.flickr.com/photos/euthman/2329061316/ Syringoma (flickr.com)].		*[http://www.flickr.com/photos/euthman/2329061316/ Syringoma (flickr.com)].
	*[http://dermatology.cdlib.org/144/tumors/axillary_syringoma/2.jpg Syringoma (dermatology.cdlib.org)].<ref>{{Cite journal \| last1 = Nosrati \| first1 = N. \| last2 = Coleman \| first2 = NM. \| last3 = Hsu \| first3 = S. \| title = Axillary syringomas. \| journal = Dermatol Online J \| volume = 14 \| issue = 4 \| pages = 13 \| month = \| year = 2008 \| doi = \| PMID = 18627735 \|URL = http://dermatology.cdlib.org/144/tumors/axillary_syringoma/hsu.html}}</ref>		*[http://dermatology.cdlib.org/144/tumors/axillary_syringoma/2.jpg Syringoma (dermatology.cdlib.org)].<ref>{{Cite journal \| last1 = Nosrati \| first1 = N. \| last2 = Coleman \| first2 = NM. \| last3 = Hsu \| first3 = S. \| title = Axillary syringomas. \| journal = Dermatol Online J \| volume = 14 \| issue = 4 \| pages = 13 \| month = \| year = 2008 \| doi = \| PMID = 18627735 \|URL = http://dermatology.cdlib.org/144/tumors/axillary_syringoma/hsu.html}}</ref>
			===Sign out===
			<pre>
			A. Right Lower Eyelid Lesion, Biopsy:
			- Benign syringoma.
			</pre>

	==Chondroid syringoma==		==Chondroid syringoma==

Michael: /* Eccrine poroma */

2018-06-06T04:04:11Z

Eccrine poroma

← Older revision		Revision as of 04:04, 6 June 2018
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	{{Main\|Trichilemmoma}}		{{Main\|Trichilemmoma}}

	==~~Eccrine poroma~~==		==Poroma==
	~~===General===~~		{{Main\|Poroma}}
	*Benign tumour arising from the distal sweat duct.
	*Erythematous - gross.

	~~===Microscopic===~~
	Features:<ref>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675(06)70190-5 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675(06)70190-5]. Accessed on: 2 July 2010.</ref>
	*Broad sheets of basaloid cells - attached to the epidermis - containing ductal structures - '''key feature'''.
	*Biphasic stroma:
	*#Edematous stroma.
	*#Sclerotic stroma.
	*Moderate nuclear pleomorphism.
	*+/-Occasional mitoses.

	~~Notes:~~
	*Area above gland appears crusted.

	~~DDx:~~
	*[[Trichilemmoma]].
	*[[Nodular hidradenoma]].

	~~====Images====~~
	~~<gallery>~~
	~~Image: SkinTumors-P7150495.JPG~~ \| ~~EP. (WC)~~
	~~</gallery>~~
	~~www:~~
	*[http://www.flickr.com/photos/40981620@N04/3808316834/in/photostream/ Eccrine poroma - low mag. (flickr.com)]
	*[http://www.flickr.com/photos/40981620@N04/3807502071/in/photostream Eccrine poroma - intermed. mag. (flickr.com)].

	==Nodular hidradenoma==		==Nodular hidradenoma==

Brigitte: /* Microscopic */

2018-05-03T14:33:23Z

Microscopic

← Older revision		Revision as of 14:33, 3 May 2018
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	Images:		Images:
	*[http://archive.ispub.com/journal/the-internet-journal-of-dermatology/volume-7-number-1/cutaneous-mixed-tumor.article-g01.fs.jpg Chondroid syringoma - low mag. (ispub.com)].<ref name=ispub_mts>URL: [http://www.ispub.com/journal/the_internet_journal_of_dermatology/volume_7_number_2_23/article/cutaneous_mixed_tumor.html http://www.~~ispub.com/journal/the_internet_journal_of_dermatology/volume_7_number_2_23/article/cutaneous_mixed_tumor.html]. Access on: 21 September 2011.</ref>~~		*[https://www.dermnetnz.org/topics/apocrine-mixed-tumour-pathology Chondroid syringoma (DermnetNZ)].
	*[http://archive.ispub.~~com~~/~~journal~~/~~the-internet-journal-of-dermatology/volume-7-number-1/cutaneous~~-mixed-~~tumor.article~~-~~g02.fs.jpg~~ Chondroid syringoma ~~- high mag.~~ (~~ispub.com~~)].<ref name=ispub_mts>URL: [http://www.ispub.com/journal/the_internet_journal_of_dermatology/volume_7_number_2_23/article/cutaneous_mixed_tumor.html http://www.ispub.com/journal/the_internet_journal_of_dermatology/volume_7_number_2_23/article/cutaneous_mixed_tumor.html]. Access on: 21 September 2011.</ref>

	==Dermal cylindroma==		==Dermal cylindroma==

Michael: /* Cutaneous T-cell lymphoma */ split out

2016-12-06T22:19:43Z

Cutaneous T-cell lymphoma: split out

← Older revision		Revision as of 22:19, 6 December 2016
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	==Cutaneous T-cell lymphoma==		==Cutaneous T-cell lymphoma==
	*Abbreviated CTCL.		*Abbreviated CTCL.
			{{Main\|Cutaneous T-cell lymphoma}}
	~~===General===~~
	*''Mycosis fungoides'' - is a subtype (???).
	*CTCL is more common than cutaneous B-cell lymphoma (CBCL).<ref>URL: [http://emedicine.medscape.com/article/1099540-overview http://emedicine.medscape.com/article/1099540-overview]. Accessed on: 24 August 2010.</ref><ref>URL: [http://emedicine.medscape.com/article/1098342-overview http://emedicine.medscape.com/article/1098342-overview]. Accessed on: 24 August 2010.</ref>

	~~Stages - like [[Kaposi sarcoma]]:~~
	*Patch.
	*Plaque.
	*Nodular.

	~~===Microscopic===~~
	*Atypical lymphocytes:
	**Have folded "cerebriform" nuclei; ''Sezary-Lutzner cells''.<ref name=Ref_Klatt385>{{~~Ref Klatt~~\|~~385}}</ref>~~
	*Grouping:
	**Nests in the epidermis - ~~known as "Pautrier microabscesses".~~
	**Single lymphocytes in epidermis - without accompanying edema.
	**Short linear arrays of lymphocytes along the basal layer of the epidermis; "epidermotropism".<ref name=Ref_Klatt385>{{Ref Klatt\|385}}~~</ref>~~

	~~DDx:~~
	*[[Lymphomatoid papulosis]].

	~~====Images====~~
	~~<gallery>~~
	~~Image:Cutaneous_T-cell_lymphoma_-_very_high_mag.jpg \| CTCL - very high mag. (WC/Nephron)~~
	~~Image:Cutaneous_T-cell_lymphoma_-_intermed_mag.jpg \| CTCL - intermed. mag. (WC/Nephron)~~
	~~</gallery>~~
	~~www:~~
	*[http://www.jci.org/articles/view/24826/figure/2 CTCL (jci.org)].
	*[http://www.mdconsult.com/das/book/body/199872830-2/0/1709/I4-u1.0-B978-0-443-06694-8..50117-2--f2.fig CTCL (mdconsult.com)].

	~~===IHC===~~
	~~Key stain:~~
	*CD4 +ve.<ref>{{Ref PBoD8\|1185}}</ref>

	~~Other stains:~~
	*CD3 +ve.
	*CD8 -ve.
	*CD20 -ve (to r/o significant B cell population).
	*CD30 -ve.
	*CD5 +ve.
	*CD7 -ve (often lost first in T cell lymphomas).
	*Ki-67 high.
	*CD56 -ve.

	==Merkel cell carcinoma==		==Merkel cell carcinoma==

Michael at 12:35, 1 October 2015

2015-10-01T12:35:30Z

← Older revision		Revision as of 12:35, 1 October 2015
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	*Benign sweat duct tumour.		*Benign sweat duct tumour.
	*Eccrine differentiation.		*Eccrine differentiation.
	*Usually close to lower eyelid.<ref>{{Ref PBoD8\|1177}}</ref>		*Usually close to lower [[eyelid]].<ref>{{Ref PBoD8\|1177}}</ref>

	===Microscopic===		===Microscopic===

Michael: /* Papillary eccrine adenoma */

2014-06-27T17:35:32Z

Papillary eccrine adenoma

← Older revision		Revision as of 17:35, 27 June 2014
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	Note:		Note:
	*The ''digital papillary adenoma'' is considered malignant; the AFIP says these are best classified as ''adenocarcinomas'', i.e. ''digital papillary adenocarcinoma''.<ref name=pmid10843279>{{Cite journal \| last1 = Duke \| first1 = WH. \| last2 = Sherrod \| first2 = TT. \| last3 = Lupton \| first3 = GP. \| title = Aggressive digital papillary adenocarcinoma (aggressive digital papillary adenoma and adenocarcinoma revisited). \| journal = Am J Surg Pathol \| volume = 24 \| issue = 6 \| pages = 775-84 \| month = Jun \| year = 2000 \| doi = \| PMID = 10843279 }}</ref>		*The ''digital papillary adenoma'' is considered malignant; the AFIP says these are best classified as ''adenocarcinomas'', i.e. ''[[digital papillary adenocarcinoma]]''.<ref name=pmid10843279>{{Cite journal \| last1 = Duke \| first1 = WH. \| last2 = Sherrod \| first2 = TT. \| last3 = Lupton \| first3 = GP. \| title = Aggressive digital papillary adenocarcinoma (aggressive digital papillary adenoma and adenocarcinoma revisited). \| journal = Am J Surg Pathol \| volume = 24 \| issue = 6 \| pages = 775-84 \| month = Jun \| year = 2000 \| doi = \| PMID = 10843279 }}</ref>

	===Microscopic===		===Microscopic===
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	DDx:		DDx:
	*Digital papillary adenocarcinoma - location important.		*[[Digital papillary adenocarcinoma]] - location important.
	*[[Tubular apocrine adenoma]] (tubulopapillary hidradenoma<ref name=pmid1566975>{{Cite journal \| last1 = Fox \| first1 = SB. \| last2 = Cotton \| first2 = DW. \| title = Tubular apocrine adenoma and papillary eccrine adenoma. Entities or unity? \| journal = Am J Dermatopathol \| volume = 14 \| issue = 2 \| pages = 149-54 \| month = Apr \| year = 1992 \| doi = \| PMID = 1566975 }}</ref>) - a related tumour.<ref name=pmid8238787>{{Cite journal \| last1 = Ishiko \| first1 = A. \| last2 = Shimizu \| first2 = H. \| last3 = Inamoto \| first3 = N. \| last4 = Nakmura \| first4 = K. \| title = Is tubular apocrine adenoma a distinct clinical entity? \| journal = Am J Dermatopathol \| volume = 15 \| issue = 5 \| pages = 482-7 \| month = Oct \| year = 1993 \| doi = \| PMID = 8238787 }}</ref>		*[[Tubular apocrine adenoma]] (tubulopapillary hidradenoma<ref name=pmid1566975>{{Cite journal \| last1 = Fox \| first1 = SB. \| last2 = Cotton \| first2 = DW. \| title = Tubular apocrine adenoma and papillary eccrine adenoma. Entities or unity? \| journal = Am J Dermatopathol \| volume = 14 \| issue = 2 \| pages = 149-54 \| month = Apr \| year = 1992 \| doi = \| PMID = 1566975 }}</ref>) - a related tumour.<ref name=pmid8238787>{{Cite journal \| last1 = Ishiko \| first1 = A. \| last2 = Shimizu \| first2 = H. \| last3 = Inamoto \| first3 = N. \| last4 = Nakmura \| first4 = K. \| title = Is tubular apocrine adenoma a distinct clinical entity? \| journal = Am J Dermatopathol \| volume = 15 \| issue = 5 \| pages = 482-7 \| month = Oct \| year = 1993 \| doi = \| PMID = 8238787 }}</ref>

Michael at 03:12, 22 June 2014

2014-06-22T03:12:57Z

← Older revision		Revision as of 03:12, 22 June 2014
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	*Vimentin +ve.		*Vimentin +ve.
	*CEA +ve.		*CEA +ve.
	*EMA +ve.		*[[EMA]] +ve.
	*S-100 +ve.		*S-100 +ve.

Michael: /* Trichilemmoma */

2014-05-28T03:45:00Z

Trichilemmoma

← Older revision		Revision as of 03:45, 28 May 2014
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	==Trichilemmoma==		==Trichilemmoma==
	*May be spelled ''tricholemmoma''.		*May be spelled ''tricholemmoma''.
	~~===General===~~		{{Main\|Trichilemmoma}}
	*Benign neoplasm with features of the pilosebaceous follicular epithelium.<ref>URL: [http://emedicine.medscape.com/article/1059940-overview http://emedicine.medscape.com/article/1059940-overview]. Accessed on: 2 September 2011.</ref>
	*Associated with ''nevus sebaceous''.<ref name=pmid16503928>{{~~Cite journal~~ \| last1 = Baykal \| first1 = C. \| last2 = Buyukbabani \| first2 = N. \| last3 = Yazganoglu \| first3 = KD. \| last4 = Saglik \| first4 = E. \| title = [Tumors associated with nevus sebaceous]. \| journal = J Dtsch Dermatol Ges \| volume = 4 \| issue = 1 \| pages = 28-31 \| month = Jan \| year = 2006 \| doi = 10.1111/j.1610-0387.2006.05855.x \| PMID = 16503928 }}~~</ref>~~
	*Muliple trichilemmomas associated with [[Cowden syndrome]].<ref name=Ref_Derm386>{{Ref Derm\|386}}</ref>

	~~===Microscopic===~~
	~~Features:<ref name=Ref_Derm386>{{Ref Derm\|386}}</ref>~~
	*Superficial dermal lesion contiguous with the epidermis:
	**Core of lesion:
	***Cuboidal cells with round nuclei, eosinophilic-clear cytoplasm.
	**Periphery of lesion:
	***Surrounded by hyaline band.
	***Peripheral palisading.

	~~DDx:~~
	*[[Trichilemmal carcinoma]].
	*[[Basal cell carcinoma]].
	*[[Inverted follicular keratosis]].

	~~Images:~~
	*[http://ccr.cancer.gov/staff/images/9033_12822_Lee_1520.jpg Trichilemmoma - low mag. (cancer.gov)].<ref name=lee>URL: [http://ccr.cancer.gov/staff/gallery.asp?profileid=12822 http://ccr.cancer.gov/staff/gallery.asp?profileid=12822]. Accessed on: 2 September 2011.</ref>
	*[http://ccr.cancer.gov/staff/images/9033_12822_Lee_1521.jpg Trichilemmoma - high mag. (cancer.gov)].<ref name=lee/>
	*[http://dermimages.med.jhmi.edu/images/trichilemmoma_1_060109.jpg Trichilemmoma (jhmi.edu)].<ref>URL: [http://dermatlas.med.jhmi.edu/derm/indexDisplay.cfm?ImageID=667496720 http://dermatlas.med.jhmi.edu/derm/indexDisplay.cfm?ImageID=667496720]. Accessed on: 2 September 2011.</ref>
	*[http://www.flickr.com/photos/40981620@N04/3812019838/in/pool-1185084@N23/ Trichilemmoma - low mag. (flickr.com/Irlam)].
	*[http://www.flickr.com/photos/40981620@N04/3812019930/in/pool-1185084@N23/ Trichilemmoma - intermed. mag. (flickr.com/Irlam)].
	*[http://www.flickr.com/photos/40981620@N04/3811204517/in/pool-1185084@N23/ Trichilemmoma - high mag. (flickr.com/Irlam)].

	==Eccrine poroma==		==Eccrine poroma==

Michael: /* Trichilemmal carcinoma */ split out

2014-05-22T03:21:30Z

Trichilemmal carcinoma: split out

← Older revision		Revision as of 03:21, 22 May 2014
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	==Trichilemmal carcinoma==		==Trichilemmal carcinoma==
	~~===General===~~		{{Main\|Trichilemmal carcinoma}}
	*Super rare.
	*Not well-described.

	~~===Microscopic===~~
	~~Features:<ref>~~{{~~Ref Derm~~\|~~399-400~~}}~~</ref>~~
	*Clear (glycogen-rich) cytoplasm in center of lesion.
	*Peripheral palisading at edge of lesion - root sheath differentiation (hair follicle).
	*Contiguous with hair follicle ''or'' assoc. with [[trichilemmoma]].

	~~DDx:~~
	*[[Squamous cell carcinoma]], clear cell variant.
	*[[Basal cell carcinoma]], clear cell variant.
	*[[Trichilemmoma]].

	==Lymphomatoid papulosis==		==Lymphomatoid papulosis==