Dermatofibroma - Revision history

Michael at 15:50, 7 August 2024

2024-08-07T15:50:13Z

← Older revision		Revision as of 15:50, 7 August 2024
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	==General==		==General==
	*~~Reactive~~ process -~~- it is~~ ''not'' a neoplasm.		*Classically considered a reactive process - ''not'' a neoplasm.
	*Usually associated with previous trauma.		*Usually associated with previous trauma.
	**In women... usually legs.		**In women... usually legs.
			*Multiple dermatofibromas are described in association [[Down syndrome]].<ref name=pmid36219648>{{cite journal \|authors=Zimmerman TJ, George SJ \|title=Multiple Eruptive Dermatofibromas Associated With Down Syndrome \|journal=Cutis \|volume=110 \|issue=2 \|pages=E21–E23 \|date=August 2022 \|pmid=36219648 \|doi=10.12788/cutis.0600 \|url=}}</ref><ref name=pmid23879455>{{cite journal \|authors=Lamb RC, Gangopadhyay M, MacDonald A \|title=Multiple dermatofibromas in Down syndrome \|journal=Int J Dermatol \|volume=53 \|issue=4 \|pages=e274–5 \|date=April 2014 \|pmid=23879455 \|doi=10.1111/ijd.12037 \|url=}}</ref>

	==Microscopic==		==Microscopic==

Michael: /* Microscopic */

2015-11-19T13:34:18Z

Microscopic

← Older revision		Revision as of 13:34, 19 November 2015
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	*[[Melanoma]], esp. desmoplastic neurotropic-type.		*[[Melanoma]], esp. desmoplastic neurotropic-type.
	*[[Fibromatosis]].		*[[Fibromatosis]].
			*[[Dermal scar]].

	Images:		Images:

Michael: /* Subtypes */

2014-06-21T11:42:15Z

Subtypes

← Older revision		Revision as of 11:42, 21 June 2014
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	*[http://www.surgicalpathologyatlas.com/glfusion/mediagallery/media.php?f=0&sort=0&s=20080802171836877 Cellular dermatofibroma (surgicalpathologyatlas.com)].		*[http://www.surgicalpathologyatlas.com/glfusion/mediagallery/media.php?f=0&sort=0&s=20080802171836877 Cellular dermatofibroma (surgicalpathologyatlas.com)].
	*[http://www.dermpedia.org/node/2292 Cellular dermatofibroma (dermpedia.org)].<ref>URL: [http://www.dermpedia.org/case/cellular-dermatofibroma-mimicking-dermatofibrosarcoma-protuberans# http://www.dermpedia.org/case/cellular-dermatofibroma-mimicking-dermatofibrosarcoma-protuberans#]. Accessed on: 4 February 2012.</ref>		*[http://www.dermpedia.org/node/2292 Cellular dermatofibroma (dermpedia.org)].<ref>URL: [http://www.dermpedia.org/case/cellular-dermatofibroma-mimicking-dermatofibrosarcoma-protuberans# http://www.dermpedia.org/case/cellular-dermatofibroma-mimicking-dermatofibrosarcoma-protuberans#]. Accessed on: 4 February 2012.</ref>

			===Epithelioid cell histiocytoma===
			Features:
			*Epithelioid cells.
			*No lesional cells in epidermis.

			DDx:
			*[[Melanocytic lesions]] - esp. [[malignant melanoma]].

	==IHC==		==IHC==

Michael at 07:26, 21 August 2013

2013-08-21T07:26:03Z

← Older revision		Revision as of 07:26, 21 August 2013
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	\| Width =		\| Width =
	\| Caption = Dermatofibroma. [[H&E stain]].		\| Caption = Dermatofibroma. [[H&E stain]].
	\| Micro = ~~Prominent~~ fibrous bundles - especially at the edge of the lesion ("collagen-trapping"), loss of adnexal structures, +/-"dirty fingers" ([[acanthosis]], basal keratinocyte hyperpigmentation)		\| Micro = prominent fibrous bundles - especially at the edge of the lesion ("collagen-trapping"), loss of adnexal structures, +/-"dirty fingers" ([[acanthosis]], basal keratinocyte hyperpigmentation)
	\| Subtypes = ~~Cellular~~, deep penetrating, lipidized, epithelioid cell histiocytoma, fibrotic, aneurysmal, granular cell dermatofibroma, dermatofibroma with monster cells		\| Subtypes = cellular, deep penetrating, lipidized, epithelioid cell histiocytoma, fibrotic, aneurysmal, granular cell dermatofibroma, dermatofibroma with monster cells
	\| LMDDx = [[DFSP]], [[neurofibroma]], [[blue nevus]], [[melanoma]], esp. desmoplastic neurotropic-type, [[fibromatosis]]		\| LMDDx = [[DFSP]], [[neurofibroma]], [[blue nevus]], [[melanoma]], esp. desmoplastic neurotropic-type, [[fibromatosis]]
	\| Stains =		\| Stains =

Michael at 07:25, 21 August 2013

2013-08-21T07:25:32Z

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	\| Signs =		\| Signs =
	\| Symptoms =		\| Symptoms =
	\| Prevalence =		\| Prevalence = common
	\| Bloodwork =		\| Bloodwork =
	\| Rads =		\| Rads =
	\| Endoscopy =		\| Endoscopy =
	\| Prognosis =		\| Prognosis = benign
	\| Other =		\| Other =
	\| ClinDDx =		\| ClinDDx =

Michael: /* Sign out */ rm extra spaces

2013-08-21T07:25:01Z

Sign out: rm extra spaces

← Older revision		Revision as of 07:25, 21 August 2013
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	is negative and a factor XIIIa immunostain is weakly positive.		is negative and a factor XIIIa immunostain is weakly positive.
	</pre>		</pre>


	===Micro===		===Micro===
	The sections show skin with bland spindle cells interspersed between fibrous bundles.		The sections show skin with bland spindle cells interspersed between fibrous bundles.

Michael: /* Sign out */

2013-08-21T07:09:33Z

Sign out

← Older revision		Revision as of 07:09, 21 August 2013
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	- DERMATOFIBROMA.		- DERMATOFIBROMA.
	</pre>		</pre>

			<pre>
			SKIN LESION, LEFT UPPER ARM, EXCISION:
			- DERMATOFIBROMA.

			COMMENT:
			The histologic impression is supported by immunostains; a CD34 immunostain
			is negative and a factor XIIIa immunostain is weakly positive.
			</pre>


	===Micro===		===Micro===

Michael: +image CD34

2013-08-21T07:05:36Z

+image CD34

← Older revision		Revision as of 07:05, 21 August 2013
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	**Usually negative in DFSP.		**Usually negative in DFSP.
	**There is not much literature on D2-40 in this context. Molecular work on the protein (podoplanin) the antibody is directed at has shown it is present in DFSP.<ref name=pmid21234520>{{Cite journal \| last1 = Xu \| first1 = Y. \| last2 = Ogose \| first2 = A. \| last3 = Kawashima \| first3 = H. \| last4 = Hotta \| first4 = T. \| last5 = Ariizumi \| first5 = T. \| last6 = Li \| first6 = G. \| last7 = Umezu \| first7 = H. \| last8 = Endo \| first8 = N. \| title = High-level expression of podoplanin in benign and malignant soft tissue tumors: immunohistochemical and quantitative real-time RT-PCR analysis. \| journal = Oncol Rep \| volume = 25 \| issue = 3 \| pages = 599-607 \| month = Mar \| year = 2011 \| doi = 10.3892/or.2011.1141 \| PMID = 21234520 }}</ref>		**There is not much literature on D2-40 in this context. Molecular work on the protein (podoplanin) the antibody is directed at has shown it is present in DFSP.<ref name=pmid21234520>{{Cite journal \| last1 = Xu \| first1 = Y. \| last2 = Ogose \| first2 = A. \| last3 = Kawashima \| first3 = H. \| last4 = Hotta \| first4 = T. \| last5 = Ariizumi \| first5 = T. \| last6 = Li \| first6 = G. \| last7 = Umezu \| first7 = H. \| last8 = Endo \| first8 = N. \| title = High-level expression of podoplanin in benign and malignant soft tissue tumors: immunohistochemical and quantitative real-time RT-PCR analysis. \| journal = Oncol Rep \| volume = 25 \| issue = 3 \| pages = 599-607 \| month = Mar \| year = 2011 \| doi = 10.3892/or.2011.1141 \| PMID = 21234520 }}</ref>

			Image:
			*[http://pathinfo.wikia.com/wiki/File:CD34.DFSP.100x.jpg DFSP - CD34 (wikia.com)].

	==Sign out==		==Sign out==

Michael: /* Microscopic */

2013-07-19T11:38:17Z

Microscopic

← Older revision		Revision as of 11:38, 19 July 2013
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	*[http://www.pacificderm.org/newsflashcpcapril04.html DF - several images (pacificderm.org)].		*[http://www.pacificderm.org/newsflashcpcapril04.html DF - several images (pacificderm.org)].
	*[http://biocare.net/products/antibodies/f/357/ DF stained with factor XIIIa (biocare.net)].		*[http://biocare.net/products/antibodies/f/357/ DF stained with factor XIIIa (biocare.net)].
			*[http://dermpathexpert.com/imagelib/sitebuilder/misc/show_image.html?linkedwidth=560&linkpath=http://dermpathexpert.com/sitebuildercontent/sitebuilderpictures/webassets/.pond/SB073911DermatofibromaFactorXIIIa40x.jpg.w560h422.jpg&target=_self&title=Dermatofibroma DF stained with factor XIIIa (dermpathexpert.com)].<ref>URL: [http://dermpathexpert.com/id8.html http://dermpathexpert.com/id8.html]. Accessed on: 19 July 2013.</ref>

	===Subtypes===		===Subtypes===

Rudolf: more

2013-07-05T20:46:04Z

← Older revision		Revision as of 20:46, 5 July 2013
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	\| Assdx =		\| Assdx =
	\| Syndromes =		\| Syndromes =
			\| Clinicalhx = previous trauma
	\| Signs =		\| Signs =
	\| Symptoms =		\| Symptoms =
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	\| Endoscopy =		\| Endoscopy =
	\| Prognosis =		\| Prognosis =
	\| Other = ~~previous trauma~~		\| Other =
	\| ClinDDx =		\| ClinDDx =
	}}		}}