Cystinosis - Revision history

Michael: /* Bone marrow */ fiz

2016-04-24T00:49:05Z

Bone marrow: fiz

← Older revision		Revision as of 00:49, 24 April 2016
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	===Bone marrow===		===Bone marrow===
	*Histiocytes with (cysteine) crystals.<ref name=pmid18493119>{{Cite journal \| last1 = Emadi \| first1 = A. \| last2 = Burns \| first2 = KH. \| last3 = Confer \| first3 = B. \| last4 = Borowitz \| first4 = MJ. \| last5 = Streiff \| first5 = MB. \| title = Hematological manifestations of nephropathic cystinosis. \| journal = Acta Haematol \| volume = 119 \| issue = 3 \| pages = 169-72 \| month = \| year = 2008 \| doi = 10.1159/000134222 \| PMID = 18493119 }}</ref>		*Histiocytes with (cysteine) crystals.<ref name=pmid18493119>{{Cite journal \| last1 = Emadi \| first1 = A. \| last2 = Burns \| first2 = KH. \| last3 = Confer \| first3 = B. \| last4 = Borowitz \| first4 = MJ. \| last5 = Streiff \| first5 = MB. \| title = Hematological manifestations of nephropathic cystinosis. \| journal = Acta Haematol \| volume = 119 \| issue = 3 \| pages = 169-72 \| month = \| year = 2008 \| doi = 10.1159/000134222 \| PMID = 18493119 }}</ref>
	**Birefringent with polarized light.		**Birefringent with [[polarized light]].

	====Images====		====Images====

Michael at 02:45, 16 July 2015

2015-07-16T02:45:40Z

← Older revision		Revision as of 02:45, 16 July 2015
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	\| Gross =		\| Gross =
	\| Grossing =		\| Grossing =
	\| Site = [[kidney]]		\| Site = [[kidney]], [[bone marrow]], others
	\| Assdx = [[nephrolithiasis]], [[chronic renal failure]]		\| Assdx = [[nephrolithiasis]], [[chronic renal failure]]
	\| Syndromes =		\| Syndromes =

Michael: /* Image */

2015-07-11T02:47:07Z

Image

← Older revision		Revision as of 02:47, 11 July 2015
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	*Multinucleation of podocytes.<ref name=pmid21769177/><ref name=pmid21030980>{{Cite journal \| last1 = Chandra \| first1 = M. \| last2 = Stokes \| first2 = MB. \| last3 = Kaskel \| first3 = F. \| title = Multinucleated podocytes: a diagnostic clue to cystinosis. \| journal = Kidney Int \| volume = 78 \| issue = 10 \| pages = 1052 \| month = Nov \| year = 2010 \| doi = 10.1038/ki.2010.341 \| PMID = 21030980 }}</ref>		*Multinucleation of podocytes.<ref name=pmid21769177/><ref name=pmid21030980>{{Cite journal \| last1 = Chandra \| first1 = M. \| last2 = Stokes \| first2 = MB. \| last3 = Kaskel \| first3 = F. \| title = Multinucleated podocytes: a diagnostic clue to cystinosis. \| journal = Kidney Int \| volume = 78 \| issue = 10 \| pages = 1052 \| month = Nov \| year = 2010 \| doi = 10.1038/ki.2010.341 \| PMID = 21030980 }}</ref>

	====~~Image~~====		====Images====
	=====Case=====		=====Case=====
	<gallery>		<gallery>

Michael: tweak

2015-07-11T02:03:47Z

tweak

← Older revision		Revision as of 02:03, 11 July 2015
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image =		\| Image = Cystinosis_-_kidney_-_alt_--_high_mag.jpg
	\| Width =		\| Width =
	\| Caption =		\| Caption = Changes of cystinosis in the [[kidney]]. [[H&E stain]].
	\| Synonyms =		\| Synonyms =
	\| Micro = dependent on site, kidney: multinucleation of podocytes, bone marrow: histiocytes with (cysteine) crystals		\| Micro = dependent on site, kidney: multinucleation of podocytes, bone marrow: histiocytes with (cysteine) crystals
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	====Image====		====Image====
			=====Case=====
			<gallery>
			Image: Cystinosis - kidney -- intermed mag.jpg \| Cystinosis - intermed. mag.
			Image: Cystinosis - kidney -- high mag.jpg \| Cystinosis - high mag.
			Image: Cystinosis - kidney - alt -- high mag.jpg \| Cystinosis - high mag.
			Image: Cystinosis - kidney -- very high mag.jpg \| Cystinosis - very high mag.
			Image: Cystinosis - kidney - alt -- very high mag.jpg \| Cystinosis - very high mag.
			</gallery>

			<gallery>
			Image: Cystinosis - kidney - 2 -- high mag.jpg \| Cystinosis - high mag.
			Image: Cystinosis - kidney - 2 -- very high mag.jpg \| Cystinosis - very high mag.
			</gallery>

			<gallery>
			Image: Cystinosis - kidney - 3 -- intermed mag.jpg \| Cystinosis - intermed. mag.
			Image: Cystinosis - kidney - 3 -- high mag.jpg \| Cystinosis - high mag.
			Image: Cystinosis - kidney - 3 -- very high mag.jpg \| Cystinosis - very high mag.
			</gallery>
			=====www=====
	*[http://www.nature.com/ki/journal/v78/n10/fig_tab/ki2010341f1.html Multinucleated podocytes (nature.com)].<ref name=pmid21030980/>		*[http://www.nature.com/ki/journal/v78/n10/fig_tab/ki2010341f1.html Multinucleated podocytes (nature.com)].<ref name=pmid21030980/>
	*[http://medind.nic.in/iav/t11/i2/IndianJNephrol_2011_21_2_123_78067_f1.jpg Cystinosis (medind.nic.in)].<ref name=pmid21769177>{{Cite journal \| last1 = Sharma \| first1 = A. \| last2 = Gupta \| first2 = R. \| last3 = Sethi \| first3 = SK. \| last4 = Bagga \| first4 = A. \| last5 = Dinda \| first5 = AK. \| title = Giant cell transformation of podocytes: A unique histological feature associated with cystinosis. \| journal = Indian J Nephrol \| volume = 21 \| issue = 2 \| pages = 123-5 \| month = Apr \| year = 2011 \| doi = 10.4103/0971-4065.78067 \| PMID = 21769177 }}</ref>		*[http://medind.nic.in/iav/t11/i2/IndianJNephrol_2011_21_2_123_78067_f1.jpg Cystinosis (medind.nic.in)].<ref name=pmid21769177>{{Cite journal \| last1 = Sharma \| first1 = A. \| last2 = Gupta \| first2 = R. \| last3 = Sethi \| first3 = SK. \| last4 = Bagga \| first4 = A. \| last5 = Dinda \| first5 = AK. \| title = Giant cell transformation of podocytes: A unique histological feature associated with cystinosis. \| journal = Indian J Nephrol \| volume = 21 \| issue = 2 \| pages = 123-5 \| month = Apr \| year = 2011 \| doi = 10.4103/0971-4065.78067 \| PMID = 21769177 }}</ref>

Michael: +infobox

2015-07-11T02:01:16Z

+infobox

← Older revision		Revision as of 02:01, 11 July 2015
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image =
			\| Width =
			\| Caption =
			\| Synonyms =
			\| Micro = dependent on site, kidney: multinucleation of podocytes, bone marrow: histiocytes with (cysteine) crystals
			\| Subtypes =
			\| LMDDx =
			\| Stains =
			\| IHC =
			\| EM =
			\| Molecular = cystinosin gene mutation
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[kidney]]
			\| Assdx = [[nephrolithiasis]], [[chronic renal failure]]
			\| Syndromes =
			\| Clinicalhx = +/-consanguinity
			\| Signs =
			\| Symptoms =
			\| Prevalence = rare
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis =
			\| Other = hexagonal shaped [[urine crystals\|crystals in urine]]
			\| ClinDDx =
			\| Tx =
			}}
	'''Cystinosis''' is a [[lysosomal storage disease]] and very rare.<ref name=pmid25560059>{{Cite journal \| last1 = Veys \| first1 = KR. \| last2 = Besouw \| first2 = MT. \| last3 = Pinxten \| first3 = AM. \| last4 = Dyck \| first4 = MV. \| last5 = Casteels \| first5 = I. \| last6 = Levtchenko \| first6 = EN. \| title = Cystinosis: a new perspective. \| journal = Acta Clin Belg \| volume = \| issue = \| pages = 2295333714Y0000000113 \| month = Jan \| year = 2015 \| doi = 10.1179/2295333714Y.0000000113 \| PMID = 25560059 }}</ref>		'''Cystinosis''' is a [[lysosomal storage disease]] and very rare.<ref name=pmid25560059>{{Cite journal \| last1 = Veys \| first1 = KR. \| last2 = Besouw \| first2 = MT. \| last3 = Pinxten \| first3 = AM. \| last4 = Dyck \| first4 = MV. \| last5 = Casteels \| first5 = I. \| last6 = Levtchenko \| first6 = EN. \| title = Cystinosis: a new perspective. \| journal = Acta Clin Belg \| volume = \| issue = \| pages = 2295333714Y0000000113 \| month = Jan \| year = 2015 \| doi = 10.1179/2295333714Y.0000000113 \| PMID = 25560059 }}</ref>

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	*Associated with [[nephrolithiasis]] (renal stones)<ref name=pmid7577398>{{Cite journal \| last1 = Theodoropoulos \| first1 = DS. \| last2 = Shawker \| first2 = TH. \| last3 = Heinrichs \| first3 = C. \| last4 = Gahl \| first4 = WA. \| title = Medullary nephrocalcinosis in nephropathic cystinosis. \| journal = Pediatr Nephrol \| volume = 9 \| issue = 4 \| pages = 412-8 \| month = Aug \| year = 1995 \| doi = \| PMID = 7577398 }}</ref> and [[renal failure]].		*Associated with [[nephrolithiasis]] (renal stones)<ref name=pmid7577398>{{Cite journal \| last1 = Theodoropoulos \| first1 = DS. \| last2 = Shawker \| first2 = TH. \| last3 = Heinrichs \| first3 = C. \| last4 = Gahl \| first4 = WA. \| title = Medullary nephrocalcinosis in nephropathic cystinosis. \| journal = Pediatr Nephrol \| volume = 9 \| issue = 4 \| pages = 412-8 \| month = Aug \| year = 1995 \| doi = \| PMID = 7577398 }}</ref> and [[renal failure]].
	*Autosomal recessive.<ref name=pmid25560059/>		*Autosomal recessive.<ref name=pmid25560059/>
			*Mutation in cystinosin gene (CTNS).<ref>{{OMIM\|606272}}</ref><ref>{{OMIM\|219800}}</ref><ref>{{OMIM\|219900}}</ref>

	==Microscopic==		==Microscopic==

Michael: /* General */

2015-07-10T04:12:51Z

General

← Older revision		Revision as of 04:12, 10 July 2015
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	==General==		==General==
	*Rare.		*Rare.
	*Associated with [[nephrolithiasis]] (renal stones)<ref name=pmid7577398>{{Cite journal \| last1 = Theodoropoulos \| first1 = DS. \| last2 = Shawker \| first2 = TH. \| last3 = Heinrichs \| first3 = C. \| last4 = Gahl \| first4 = WA. \| title = Medullary nephrocalcinosis in nephropathic cystinosis. \| journal = Pediatr Nephrol \| volume = 9 \| issue = 4 \| pages = 412-8 \| month = Aug \| year = 1995 \| doi = \| PMID = 7577398 }}</ref> and [[renal failure]]		*Associated with [[nephrolithiasis]] (renal stones)<ref name=pmid7577398>{{Cite journal \| last1 = Theodoropoulos \| first1 = DS. \| last2 = Shawker \| first2 = TH. \| last3 = Heinrichs \| first3 = C. \| last4 = Gahl \| first4 = WA. \| title = Medullary nephrocalcinosis in nephropathic cystinosis. \| journal = Pediatr Nephrol \| volume = 9 \| issue = 4 \| pages = 412-8 \| month = Aug \| year = 1995 \| doi = \| PMID = 7577398 }}</ref> and [[renal failure]].
	*Autosomal recessive.<ref name=pmid25560059/>		*Autosomal recessive.<ref name=pmid25560059/>

Michael: /* General */

2015-07-10T04:12:39Z

General

← Older revision		Revision as of 04:12, 10 July 2015
Line 3:		Line 3:
	==General==		==General==
	*Rare.		*Rare.
	*Associated with [[renal failure]].		*Associated with [[nephrolithiasis]] (renal stones)<ref name=pmid7577398>{{Cite journal \| last1 = Theodoropoulos \| first1 = DS. \| last2 = Shawker \| first2 = TH. \| last3 = Heinrichs \| first3 = C. \| last4 = Gahl \| first4 = WA. \| title = Medullary nephrocalcinosis in nephropathic cystinosis. \| journal = Pediatr Nephrol \| volume = 9 \| issue = 4 \| pages = 412-8 \| month = Aug \| year = 1995 \| doi = \| PMID = 7577398 }}</ref> and [[renal failure]]
	*Autosomal recessive.<ref name=pmid25560059/>		*Autosomal recessive.<ref name=pmid25560059/>

	==Microscopic==		==Microscopic==

Michael: /* Microscopic */

2015-06-18T22:49:36Z

Microscopic

← Older revision		Revision as of 22:49, 18 June 2015
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	====Image====		====Image====
	*[http://www.nature.com/ki/journal/v78/n10/fig_tab/ki2010341f1.html Multinucleated podocytes (nature.com)].<ref name=pmid21030980/>		*[http://www.nature.com/ki/journal/v78/n10/fig_tab/ki2010341f1.html Multinucleated podocytes (nature.com)].<ref name=pmid21030980/>
			*[http://medind.nic.in/iav/t11/i2/IndianJNephrol_2011_21_2_123_78067_f1.jpg Cystinosis (medind.nic.in)].<ref name=pmid21769177>{{Cite journal \| last1 = Sharma \| first1 = A. \| last2 = Gupta \| first2 = R. \| last3 = Sethi \| first3 = SK. \| last4 = Bagga \| first4 = A. \| last5 = Dinda \| first5 = AK. \| title = Giant cell transformation of podocytes: A unique histological feature associated with cystinosis. \| journal = Indian J Nephrol \| volume = 21 \| issue = 2 \| pages = 123-5 \| month = Apr \| year = 2011 \| doi = 10.4103/0971-4065.78067 \| PMID = 21769177 }}</ref>

	===Urine===		===Urine===
	*Hexagonal shaped crystals.		*Hexagonal shaped crystals.

	===~~Images~~===		===Bone marrow===
	*~~[http://medind.nic.in/iav/t11/i2/IndianJNephrol_2011_21_2_123_78067_f1.jpg Cystinosis~~ (~~medind.nic.in~~)].<ref name=~~pmid21769177~~>{{Cite journal \| last1 = ~~Sharma~~ \| first1 = A. \| last2 = ~~Gupta~~ \| first2 = R. \| last3 = ~~Sethi~~ \| first3 = SK. \| last4 = ~~Bagga~~ \| first4 = A. \| last5 = ~~Dinda~~ \| first5 = AK. \| title = ~~Giant cell transformation~~ of ~~podocytes: A unique histological feature associated with~~ cystinosis. \| journal = ~~Indian J Nephrol~~ \| volume = 21 \| issue = 2 \| pages = ~~123~~-5 \| month = ~~Apr~~ \| year = ~~2011~~ \| doi = 10.~~4103~~/~~0971-4065.78067~~ \| PMID = ~~21769177~~ }}		*Histiocytes with (cysteine) crystals.<ref name=pmid18493119>{{Cite journal \| last1 = Emadi \| first1 = A. \| last2 = Burns \| first2 = KH. \| last3 = Confer \| first3 = B. \| last4 = Borowitz \| first4 = MJ. \| last5 = Streiff \| first5 = MB. \| title = Hematological manifestations of nephropathic cystinosis. \| journal = Acta Haematol \| volume = 119 \| issue = 3 \| pages = 169-72 \| month = \| year = 2008 \| doi = 10.1159/000134222 \| PMID = 18493119 }}</ref>
	</ref>		**Birefringent with polarized light.

			====Images====
	*[http://www.pathpedia.com/education/eatlas/histopathology/bone_marrow/bone_marrow_cystinosis.aspx Bone marrow cystinosis (pathpedia.com)].		*[http://www.pathpedia.com/education/eatlas/histopathology/bone_marrow/bone_marrow_cystinosis.aspx Bone marrow cystinosis (pathpedia.com)].

Michael at 20:46, 10 April 2015

2015-04-10T20:46:26Z

← Older revision		Revision as of 20:46, 10 April 2015
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	==Microscopic==		==Microscopic==
	===Kidney===		===Kidney===
	*~~Giant cell transformation~~ of podocytes.<ref name=pmid21769177/><ref name=pmid21030980>{{Cite journal \| last1 = Chandra \| first1 = M. \| last2 = Stokes \| first2 = MB. \| last3 = Kaskel \| first3 = F. \| title = Multinucleated podocytes: a diagnostic clue to cystinosis. \| journal = Kidney Int \| volume = 78 \| issue = 10 \| pages = 1052 \| month = Nov \| year = 2010 \| doi = 10.1038/ki.2010.341 \| PMID = 21030980 }}</ref>		*Multinucleation of podocytes.<ref name=pmid21769177/><ref name=pmid21030980>{{Cite journal \| last1 = Chandra \| first1 = M. \| last2 = Stokes \| first2 = MB. \| last3 = Kaskel \| first3 = F. \| title = Multinucleated podocytes: a diagnostic clue to cystinosis. \| journal = Kidney Int \| volume = 78 \| issue = 10 \| pages = 1052 \| month = Nov \| year = 2010 \| doi = 10.1038/ki.2010.341 \| PMID = 21030980 }}</ref>

			====Image====
			*[http://www.nature.com/ki/journal/v78/n10/fig_tab/ki2010341f1.html Multinucleated podocytes (nature.com)].<ref name=pmid21030980/>

	===Urine===		===Urine===

Michael: /* Microscopic */

2015-04-10T20:42:30Z

Microscopic

← Older revision		Revision as of 20:42, 10 April 2015
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	==Microscopic==		==Microscopic==
	===Kidney===		===Kidney===
	*Giant cell transformation of podocytes.<ref name=pmid21769177/>		*Giant cell transformation of podocytes.<ref name=pmid21769177/><ref name=pmid21030980>{{Cite journal \| last1 = Chandra \| first1 = M. \| last2 = Stokes \| first2 = MB. \| last3 = Kaskel \| first3 = F. \| title = Multinucleated podocytes: a diagnostic clue to cystinosis. \| journal = Kidney Int \| volume = 78 \| issue = 10 \| pages = 1052 \| month = Nov \| year = 2010 \| doi = 10.1038/ki.2010.341 \| PMID = 21030980 }}</ref>

	===Urine===		===Urine===