Cystic nephroma - Revision history

Michael at 15:44, 10 March 2022

2022-03-10T15:44:31Z

← Older revision		Revision as of 15:44, 10 March 2022
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	'''Cystic nephroma''' refers to two morphologically identical tumours with different molecular changes:		'''Cystic nephroma''' refers to two morphologically identical tumours with different molecular changes:
	*[[Cystic nephroma, adult type]] - do '''not''' have DICER1 mutations.		*[[Cystic nephroma, adult type]] - do '''not''' have DICER1 mutations.
	*[[Cystic nephroma, pediatric type]] - generally have DICER1 mutations ~~present~~, as seen in [[DICER1 syndrome]].		*[[Cystic nephroma, pediatric type]] - generally have DICER1 mutations, as seen in [[DICER1 syndrome]].

	{{disambiguation}}		{{disambiguation}}
	[[Category:Genitourinary pathology]]		[[Category:Genitourinary pathology]]

Michael at 15:44, 10 March 2022

2022-03-10T15:44:21Z

← Older revision		Revision as of 15:44, 10 March 2022
Line 1:		Line 1:
	'''Cystic nephroma''' refers to two morphologically identical tumours with different molecular changes:		'''Cystic nephroma''' refers to two morphologically identical tumours with different molecular changes:
	*[[Cystic nephroma, adult type]] - do '''not''' have DICER1 ~~muations~~.		*[[Cystic nephroma, adult type]] - do '''not''' have DICER1 mutations.
	*[[Cystic nephroma, pediatric type]] - DICER1 mutations present.		*[[Cystic nephroma, pediatric type]] - generally have DICER1 mutations present, as seen in [[DICER1 syndrome]].

	{{disambiguation}}		{{disambiguation}}
	[[Category:Genitourinary pathology]]		[[Category:Genitourinary pathology]]

Michael at 18:26, 13 March 2016

2016-03-13T18:26:28Z

← Older revision		Revision as of 18:26, 13 March 2016
Line 1:		Line 1:
	'''Cystic nephroma''' refers to two morphologically identical tumours with different molecular changes:		'''Cystic nephroma''' refers to two morphologically identical tumours with different molecular changes:
	*[[Cystic nephroma, adult type]] - do '''not''' have DICER1 muations.		*[[Cystic nephroma, adult type]] - do '''not''' have DICER1 muations.
	*[[Cystic nephroma, ~~juvenile~~ type]] - DICER1 mutations present.		*[[Cystic nephroma, pediatric type]] - DICER1 mutations present.

	{{disambiguation}}		{{disambiguation}}
	[[Category:Genitourinary pathology]]		[[Category:Genitourinary pathology]]

Michael: Replaced content with "'''Cystic nephroma''' refers to two morphologically identical tumours with different molecular changes: *Cystic nephroma, adult type - do '''not''' have DICER1 muation..."

2016-03-13T18:22:46Z

Replaced content with "'''Cystic nephroma''' refers to two morphologically identical tumours with different molecular changes: *Cystic nephroma, adult type - do '''not''' have DICER1 muation..."

← Older revision		Revision as of 18:22, 13 March 2016
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	~~{{ Infobox diagnosis~~		'''Cystic nephroma''' refers to two morphologically identical tumours with different molecular changes:
	~~\| Name = {{PAGENAME}}~~		*[[Cystic nephroma, adult type]] - do '''not''' have DICER1 muations.
	~~\| Image =~~ Cystic nephroma ~~- alt -- high mag.jpg~~		*[[Cystic nephroma, juvenile type]] - DICER1 mutations present.
	~~\| Width =~~
	~~\| Caption = Micrograph of cystic nephroma showing the characteristic stroma and hobnailed epithelium. [[H&E stain]].~~
	~~\| Synonyms =~~
	~~\| Micro = cysts lined by simple epithelium~~ with ~~hobnailing, stroma has an ovarian look (blue, spindle cells)~~
	~~\| Subtypes =~~
	~~\| LMDDx =~~ [[~~mixed epithelial stromal tumour]]~~, ~~[[localized cystic disease of the kidney~~]]
	~~\| Stains =~~
	~~\| IHC = ER +ve, PR +ve, CD10 +ve~~
	~~\| EM =~~
	~~\| Molecular =~~
	~~\| IF =~~
	~~\| Gross = bubble wrap~~-~~like appearance~~
	~~\| Grossing =~~
	~~\| Site = [[kidney]] - see~~ '~~'[[kidney tumours]]~~''
	~~\| Assdx =~~
	~~\| Syndromes =~~
	~~\| Clinicalhx =~~
	~~\| Signs =~~
	~~\| Symptoms =~~
	~~\| Prevalence = rare~~
	~~\| Bloodwork =~~
	~~\| Rads =~~
	~~\| Endoscopy =~~
	~~\| Prognosis = benign~~
	~~\| Other =~~
	~~\| ClinDDx = other cystic kidney tumours~~
	~~\| Tx =~~
	}}
	'''Cystic nephroma~~''' is a rare~~, ~~benign [[kidney tumours\|kidney tumour~~]].

	~~Turbiner ''et al.''<ref name=pmid17414095>~~{{Cite journal \| last1 = Turbiner \| first1 = J. \| last2 = Amin \| first2 = MB. \| last3 = Humphrey \| first3 = PA. \| last4 = Srigley \| first4 = JR. \| last5 = De Leval \| first5 = L. \| last6 = Radhakrishnan \| first6 = A. \| last7 = Oliva \| first7 = E. \| title = Cystic nephroma and mixed epithelial and stromal tumor of kidney: a detailed clinicopathologic analysis of 34 cases and proposal for renal epithelial and stromal tumor (REST) as a unifying term. \| journal = Am J Surg Pathol \| volume = 31 \| issue = 4 \| pages = 489-500 \| month = Apr \| year = 2007 \| doi = 10.1097/PAS.0b013e31802bdd56 \| PMID = 17414095 }}</ref> have suggested that ''cystic nephroma'' and ''[[mixed epithelial and stromal tumour]] (MEST)'' are one tumour; the lumping term is ''[[renal epithelial and stromal tumour]]'' (abbreviated ''REST'').		{{disambiguation}}
			[[Category:Genitourinary pathology]]
	~~==General==~~
	*Rare.<ref name=pmid20427881>{{Cite journal \| last1 = Mohanty \| first1 = D. \| last2 = Jain \| first2 = BK. \| last3 = Agrawal \| first3 = V. \| last4 = Gupta \| first4 = A. \| title = Cystic nephroma: a diagnostic dilemma. \| journal = Saudi J Kidney Dis Transpl \| volume = 21 \| issue = 3 \| pages = 518-20 \| month = May \| year = 2010 \| doi = \| PMID = 20427881 }}</ref>
	*Good prognosis/benign.<ref name=pmid20427881/><ref name=pmid19172100/>
	*Considered to be on a spectrum with ''cystic partially differentiated [[nephroblastoma]]'' and ''[[Wilms tumour]].<ref name=pmid19172100>{{Cite journal \| last1 = van den Hoek \| first1 = J. \| last2 = de Krijger \| first2 = R. \| last3 = van de Ven \| first3 = K. \| last4 = Lequin \| first4 = M. \| last5 = van den Heuvel-Eibrink \| first5 = MM. \| title = Cystic nephroma, cystic partially differentiated nephroblastoma and cystic Wilms' tumor in children: a spectrum with therapeutic dilemmas. \| journal = Urol Int \| volume = 82 \| issue = 1 \| pages = 65-70 \| month = \| year = 2009 \| doi = 10.1159/000176028 \| PMID = 19172100 }}</ref>

	~~==Gross==~~
	*Bubble wrap-like appearance.

	~~===Image===~~
	~~<gallery>~~
	~~Image:Bubble_Wrap.jpg\| Bubble wrap. (WC)~~
	~~</gallery>~~
	~~www:~~
	*[http://www.sjkdt.org/viewimage.asp?img=SaudiJKidneyDisTranspl_2010_21_3_518_62699_u2.jpg Cystic nephroma (sjkdt.org)].<ref name=pmid20427881/>
	~~==Microscopic==~~
	~~Features:~~
	*Cysts lined by simple epithelium with hobnailing - '''key feature'''.
	*Stroma has an ovarian look:
	**''Blue'' (basophilic).
	**''Spindle cells''.

	~~Notes:~~
	*Parenchymal elements (e.g. glomueruli, tubules) are not found in the septa between the cysts.

	~~DDx:~~
	*[[Mixed epithelial stromal tumour]].
	*[[Localized cystic disease of the kidney]].

	~~===Images===~~
	~~====Case 1====~~
	~~<gallery>~~
	~~Image:Cystic_nephroma_low_mag.jpg \|Cystic nephroma - low mag. (WC/Nephron)~~
	~~Image:Cystic_nephroma_intermed_mag.jpg \|Cystic nephroma - intermed. mag. (WC/Nephron)~~
	~~</gallery>~~
	~~====Case 2====~~
	~~<gallery>~~
	~~Image: Cystic nephroma -- low mag.jpg \| CN - low mag. (WC/Nephron)~~
	~~Image: Cystic nephroma -- intermed mag.jpg \| CN - intermed. mag. (WC/Nephron)~~
	~~Image: Cystic nephroma -- high mag.jpg \| CN - high mag. (WC/Nephron)~~
	~~Image: Cystic nephroma - alt -- high mag.jpg \| CN - high mag. (WC/Nephron)~~
	~~Image: Cystic nephroma -- very high mag.jpg \| CN - very high mag. (WC/Nephron)~~

	~~Image: Cystic nephroma - a -- low mag.jpg \| CN - low mag. (WC/Nephron)~~
	~~Image: Cystic nephroma - b -- low mag.jpg \| CN - low mag. (WC/Nephron)~~
	~~Image: Cystic nephroma - b -- intermed mag.jpg \| CN - intermed. mag. (WC/Nephron)~~
	~~Image: Cystic nephroma - b -- high mag.jpg \| CN - high mag. (WC/Nephron)~~
	~~</gallery>~~

	~~==IHC==~~
	~~Features:~~
	*ER +ve.
	*PR +ve.
	*CD10 +ve.

	~~==See also==~~
	*[[Kidney tumours]].

	~~==References==~~
	~~{{Reflist\|2}}~~

	~~[[Category:Diagnosis]]~~
	[[Category:~~Kidney tumours~~]]

Michael at 18:13, 13 March 2016

2016-03-13T18:13:29Z

← Older revision		Revision as of 18:13, 13 March 2016
Line 1:		Line 1:
	~~#REDIRECT~~ [[Cystic nephroma, ~~adult type~~]]		{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Cystic nephroma - alt -- high mag.jpg
			\| Width =
			\| Caption = Micrograph of cystic nephroma showing the characteristic stroma and hobnailed epithelium. [[H&E stain]].
			\| Synonyms =
			\| Micro = cysts lined by simple epithelium with hobnailing, stroma has an ovarian look (blue, spindle cells)
			\| Subtypes =
			\| LMDDx = [[mixed epithelial stromal tumour]], [[localized cystic disease of the kidney]]
			\| Stains =
			\| IHC = ER +ve, PR +ve, CD10 +ve
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross = bubble wrap-like appearance
			\| Grossing =
			\| Site = [[kidney]] - see ''[[kidney tumours]]''
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms =
			\| Prevalence = rare
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = benign
			\| Other =
			\| ClinDDx = other cystic kidney tumours
			\| Tx =
			}}
			'''Cystic nephroma''' is a rare, benign [[kidney tumours\|kidney tumour]].

			Turbiner ''et al.''<ref name=pmid17414095>{{Cite journal \| last1 = Turbiner \| first1 = J. \| last2 = Amin \| first2 = MB. \| last3 = Humphrey \| first3 = PA. \| last4 = Srigley \| first4 = JR. \| last5 = De Leval \| first5 = L. \| last6 = Radhakrishnan \| first6 = A. \| last7 = Oliva \| first7 = E. \| title = Cystic nephroma and mixed epithelial and stromal tumor of kidney: a detailed clinicopathologic analysis of 34 cases and proposal for renal epithelial and stromal tumor (REST) as a unifying term. \| journal = Am J Surg Pathol \| volume = 31 \| issue = 4 \| pages = 489-500 \| month = Apr \| year = 2007 \| doi = 10.1097/PAS.0b013e31802bdd56 \| PMID = 17414095 }}</ref> have suggested that ''cystic nephroma'' and ''[[mixed epithelial and stromal tumour]] (MEST)'' are one tumour; the lumping term is ''[[renal epithelial and stromal tumour]]'' (abbreviated ''REST'').

			==General==
			*Rare.<ref name=pmid20427881>{{Cite journal \| last1 = Mohanty \| first1 = D. \| last2 = Jain \| first2 = BK. \| last3 = Agrawal \| first3 = V. \| last4 = Gupta \| first4 = A. \| title = Cystic nephroma: a diagnostic dilemma. \| journal = Saudi J Kidney Dis Transpl \| volume = 21 \| issue = 3 \| pages = 518-20 \| month = May \| year = 2010 \| doi = \| PMID = 20427881 }}</ref>
			*Good prognosis/benign.<ref name=pmid20427881/><ref name=pmid19172100/>
			*Considered to be on a spectrum with ''cystic partially differentiated [[nephroblastoma]]'' and ''[[Wilms tumour]].<ref name=pmid19172100>{{Cite journal \| last1 = van den Hoek \| first1 = J. \| last2 = de Krijger \| first2 = R. \| last3 = van de Ven \| first3 = K. \| last4 = Lequin \| first4 = M. \| last5 = van den Heuvel-Eibrink \| first5 = MM. \| title = Cystic nephroma, cystic partially differentiated nephroblastoma and cystic Wilms' tumor in children: a spectrum with therapeutic dilemmas. \| journal = Urol Int \| volume = 82 \| issue = 1 \| pages = 65-70 \| month = \| year = 2009 \| doi = 10.1159/000176028 \| PMID = 19172100 }}</ref>

			==Gross==
			*Bubble wrap-like appearance.

			===Image===
			<gallery>
			Image:Bubble_Wrap.jpg\| Bubble wrap. (WC)
			</gallery>
			www:
			*[http://www.sjkdt.org/viewimage.asp?img=SaudiJKidneyDisTranspl_2010_21_3_518_62699_u2.jpg Cystic nephroma (sjkdt.org)].<ref name=pmid20427881/>
			==Microscopic==
			Features:
			*Cysts lined by simple epithelium with hobnailing - '''key feature'''.
			*Stroma has an ovarian look:
			**''Blue'' (basophilic).
			**''Spindle cells''.

			Notes:
			*Parenchymal elements (e.g. glomueruli, tubules) are not found in the septa between the cysts.

			DDx:
			*[[Mixed epithelial stromal tumour]].
			*[[Localized cystic disease of the kidney]].

			===Images===
			====Case 1====
			<gallery>
			Image:Cystic_nephroma_low_mag.jpg \|Cystic nephroma - low mag. (WC/Nephron)
			Image:Cystic_nephroma_intermed_mag.jpg \|Cystic nephroma - intermed. mag. (WC/Nephron)
			</gallery>
			====Case 2====
			<gallery>
			Image: Cystic nephroma -- low mag.jpg \| CN - low mag. (WC/Nephron)
			Image: Cystic nephroma -- intermed mag.jpg \| CN - intermed. mag. (WC/Nephron)
			Image: Cystic nephroma -- high mag.jpg \| CN - high mag. (WC/Nephron)
			Image: Cystic nephroma - alt -- high mag.jpg \| CN - high mag. (WC/Nephron)
			Image: Cystic nephroma -- very high mag.jpg \| CN - very high mag. (WC/Nephron)

			Image: Cystic nephroma - a -- low mag.jpg \| CN - low mag. (WC/Nephron)
			Image: Cystic nephroma - b -- low mag.jpg \| CN - low mag. (WC/Nephron)
			Image: Cystic nephroma - b -- intermed mag.jpg \| CN - intermed. mag. (WC/Nephron)
			Image: Cystic nephroma - b -- high mag.jpg \| CN - high mag. (WC/Nephron)
			</gallery>

			==IHC==
			Features:
			*ER +ve.
			*PR +ve.
			*CD10 +ve.

			==See also==
			*[[Kidney tumours]].

			==References==
			{{Reflist\|2}}

			[[Category:Diagnosis]]
			[[Category:Kidney tumours]]

Michael: Michael moved page Cystic nephroma to Cystic nephroma, adult type

2016-03-13T18:11:36Z

Michael moved page Cystic nephroma to Cystic nephroma, adult type

New page

#REDIRECT [[Cystic nephroma, adult type]]