Cystic medial degeneration - Revision history

Michael: rm broken links

2024-02-02T18:35:36Z

rm broken links

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	*[[Movat's stain]] - basophilic ground substance in the media.		*[[Movat's stain]] - basophilic ground substance in the media.
	*[[Alcian blue]]-[[PAS]].		*[[Alcian blue]]-[[PAS]].

	~~===Images===~~
	*[http://alf3.urz.unibas.ch/pathopic/e/getpic-fra.cfm?id=10456 CMD - Alcian blue-PAS (unibas.ch)].
	*[http://alf3.urz.unibas.ch/pathopic/e/getpic-fra.cfm?id=8708 CMS - Alcian blue-PAS (unibas.ch)].
	*[http://alf3.urz.unibas.ch/pathopic/e/getpic-fra.cfm?id=10457 CMS - Alcian blue-PAS (unibas.ch)].

	==See also==		==See also==

Michael at 05:58, 19 October 2014

2014-10-19T05:58:59Z

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	\| Width =		\| Width =
	\| Caption = Cystic medial degeneration. [[H&E stain]].		\| Caption = Cystic medial degeneration. [[H&E stain]].
	\| Synonyms =		\| Synonyms = cystic medial necrosis
	\| Micro = basophilic ground substance in the media (seen on Movat's [[stain]]), disruption of the elastic lamina (seen on elastic trichrome stain), +/-focal necrosis.		\| Micro = basophilic ground substance in the media (seen on Movat's [[stain]]), disruption of the elastic lamina (seen on elastic trichrome stain), +/-focal necrosis.
	\| Subtypes =		\| Subtypes =

Michael at 05:58, 19 October 2014

2014-10-19T05:58:18Z

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	\| Site = [[blood vessels\|large arteries]]		\| Site = [[blood vessels\|large arteries]]
	\| Assdx =		\| Assdx =
	\| Syndromes = [[Marfan's syndrome]]		\| Syndromes = [[Marfan's syndrome]], [[Ehlers-Danlos syndrome]], others
	\| Clinicalhx =		\| Clinicalhx =
	\| Signs =		\| Signs =

Michael: /* General */

2014-10-19T05:57:56Z

General

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	Note about ''cystic medial necrosis'':		Note about ''cystic medial necrosis'':
	*Often ''not'' cystic and ''not'' necrotic.		*Often ''not'' cystic and ''not'' necrotic.

			Associations:<ref name=pmid21881719>{{Cite journal \| last1 = Yuan \| first1 = SM. \| last2 = Jing \| first2 = H. \| title = Cystic medial necrosis: pathological findings and clinical implications. \| journal = Rev Bras Cir Cardiovasc \| volume = 26 \| issue = 1 \| pages = 107-15 \| month = \| year = \| doi = \| PMID = 21881719 }}</ref>
			*[[Marfan's syndrome]].
			*[[Ehlers-Danlos syndrome]].
			*Annuloaortic ectasia.

	==Microscopic==		==Microscopic==

Michael at 05:54, 19 October 2014

2014-10-19T05:54:22Z

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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Cystic_medial_degeneration_-_high_mag.jpg
			\| Width =
			\| Caption = Cystic medial degeneration. [[H&E stain]].
			\| Synonyms =
			\| Micro = basophilic ground substance in the media (seen on Movat's [[stain]]), disruption of the elastic lamina (seen on elastic trichrome stain), +/-focal necrosis.
			\| Subtypes =
			\| LMDDx = aortic dissection without apparent underlying pathology
			\| Stains = [[Movat's stain]] (basophilic ground substance present), elastin stain (fragmentation of elastin)
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[blood vessels\|large arteries]]
			\| Assdx =
			\| Syndromes = [[Marfan's syndrome]]
			\| Clinicalhx =
			\| Signs =
			\| Symptoms = chest pain, shortness of breath
			\| Prevalence = uncommon
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = dependent on severity and associated pathology
			\| Other =
			\| ClinDDx = [[myocardial infarction]], other causes of chest pain, others
			\| Tx = surgical repair or conservative management - see [[aortic dissection]]
			}}
	'''Cystic medial degeneration''' (abbreviated '''CMD'''), also '''cystic medial necrosis''',<ref>URL: [http://emedicine.medscape.com/article/756835-overview http://emedicine.medscape.com/article/756835-overview]. Accessed on: 12 August 2010.</ref> is [[vascular disease\|vascular pathology]] of the large [[blood vessel]]s. It is suggestive of an underlying [[connective tissue disorder]].		'''Cystic medial degeneration''' (abbreviated '''CMD'''), also '''cystic medial necrosis''',<ref>URL: [http://emedicine.medscape.com/article/756835-overview http://emedicine.medscape.com/article/756835-overview]. Accessed on: 12 August 2010.</ref> is [[vascular disease\|vascular pathology]] of the large [[blood vessel]]s. It is suggestive of an underlying [[connective tissue disorder]].

Michael: /* Images */

2014-05-16T17:10:34Z

Images

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	Image:Cystic_medial_degeneration_-_movat_-_low_mag.jpg \| Cystic medial degeneration - movat - low mag. (WC/Nephron)		Image:Cystic_medial_degeneration_-_movat_-_low_mag.jpg \| Cystic medial degeneration - movat - low mag. (WC/Nephron)
	Image:Cystic_medial_degeneration_-_movat_-_intermed_mag.jpg \| Cystic medial degeneration - movat - intermed. mag. (WC/Nephron)		Image:Cystic_medial_degeneration_-_movat_-_intermed_mag.jpg \| Cystic medial degeneration - movat - intermed. mag. (WC/Nephron)
			Image:Cystic_medial_degeneration_-_movat_-_high_mag.jpg \| Cystic medial degeneration - movat - high mag. (WC/Nephron)
	</gallery>		</gallery>
	www:		www:

Michael at 17:02, 16 May 2014

2014-05-16T17:02:14Z

← Older revision		Revision as of 17:02, 16 May 2014
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	*Elastin stains (e.g. [[elastic trichrome stain]]) - disruption of the elastic lamina.		*Elastin stains (e.g. [[elastic trichrome stain]]) - disruption of the elastic lamina.
	*[[Movat's stain]] - basophilic ground substance in the media.		*[[Movat's stain]] - basophilic ground substance in the media.
			*[[Alcian blue]]-[[PAS]].

			===Images===
			*[http://alf3.urz.unibas.ch/pathopic/e/getpic-fra.cfm?id=10456 CMD - Alcian blue-PAS (unibas.ch)].
			*[http://alf3.urz.unibas.ch/pathopic/e/getpic-fra.cfm?id=8708 CMS - Alcian blue-PAS (unibas.ch)].
			*[http://alf3.urz.unibas.ch/pathopic/e/getpic-fra.cfm?id=10457 CMS - Alcian blue-PAS (unibas.ch)].

	==See also==		==See also==

Michael at 16:59, 16 May 2014

2014-05-16T16:59:08Z

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	*Disruption of the elastic lamina (seen on elastic trichrome stain).		*Disruption of the elastic lamina (seen on elastic trichrome stain).
	*+/-Focal necrosis.		*+/-Focal necrosis.

			DDx:
			*[[Aortic dissection]] without apparent underlying pathology.

	===Images===		===Images===
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	==See also==		==See also==
	*[[Vascular disease]].		*[[Vascular disease]].
			*[[Aortic dissection]].

	==References==		==References==

Michael at 16:58, 16 May 2014

2014-05-16T16:58:07Z

← Older revision		Revision as of 16:58, 16 May 2014
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	'''Cystic medial degeneration''' (abbreviated '''CMD'''), also '''cystic medial necrosis''',<ref>URL: [http://emedicine.medscape.com/article/756835-overview http://emedicine.medscape.com/article/756835-overview]. Accessed on: 12 August 2010.</ref> is vascular pathology of the large [[blood vessel]]s suggestive of an underlying [[connective tissue disorder]].		'''Cystic medial degeneration''' (abbreviated '''CMD'''), also '''cystic medial necrosis''',<ref>URL: [http://emedicine.medscape.com/article/756835-overview http://emedicine.medscape.com/article/756835-overview]. Accessed on: 12 August 2010.</ref> is [[vascular disease\|vascular pathology]] of the large [[blood vessel]]s. It is suggestive of an underlying [[connective tissue disorder]].

	==General==		==General==
	*Nonspecific finding - may be seen in a number of conditions.		*Nonspecific finding - may be seen in a number of conditions.
			*"Medial" refers to ''tunica media'' the middle (muscle) layer of an artery.

	Note about ''cystic medial necrosis'':		Note about ''cystic medial necrosis'':

Michael: split out

2014-05-16T16:54:48Z

split out

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	~~#redirect~~ [[~~Vascular_disease#Cystic_medial_degeneration~~]]		'''Cystic medial degeneration''' (abbreviated '''CMD'''), also '''cystic medial necrosis''',<ref>URL: [http://emedicine.medscape.com/article/756835-overview http://emedicine.medscape.com/article/756835-overview]. Accessed on: 12 August 2010.</ref> is vascular pathology of the large [[blood vessel]]s suggestive of an underlying [[connective tissue disorder]].

			==General==
			*Nonspecific finding - may be seen in a number of conditions.

			Note about ''cystic medial necrosis'':
			*Often ''not'' cystic and ''not'' necrotic.

			==Microscopic==
			Features:<ref>URL: [http://emedicine.medscape.com/article/756835-overview http://emedicine.medscape.com/article/756835-overview]. Accessed on: 12 August 2010.</ref><ref name=pmid17620463>{{cite journal \|author=Ha HI, Seo JB, Lee SH, ''et al.'' \|title=Imaging of Marfan syndrome: multisystemic manifestations \|journal=Radiographics \|volume=27 \|issue=4 \|pages=989–1004 \|year=2007 \|pmid=17620463 \|doi=10.1148/rg.274065171 \|url=http://radiographics.rsna.org/content/27/4/989.full}}</ref>
			*Basophilic ground substance in the media (seen on Movat's [[stain]]).
			*Disruption of the elastic lamina (seen on elastic trichrome stain).
			*+/-Focal necrosis.

			===Images===
			<gallery>
			Image:Cystic_medial_degeneration_-_low_mag.jpg \| Cystic medial degeneration - low mag. (WC/Nephron)
			Image:Cystic_medial_degeneration_-_high_mag.jpg \| Cystic medial degeneration - high mag. (WC/Nephron)
			Image:Cystic_medial_degeneration_-_movat_-_low_mag.jpg \| Cystic medial degeneration - movat - low mag. (WC/Nephron)
			Image:Cystic_medial_degeneration_-_movat_-_intermed_mag.jpg \| Cystic medial degeneration - movat - intermed. mag. (WC/Nephron)
			</gallery>
			www:
			*[http://radiographics.rsna.org/content/27/4/989.full Marfan's syndrome (radiographics.rsna.org)].

			==Stains==
			*Elastin stains (e.g. [[elastic trichrome stain]]) - disruption of the elastic lamina.
			*[[Movat's stain]] - basophilic ground substance in the media.

			==See also==
			*[[Vascular disease]].

			==References==
			{{Reflist\|2}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Vascular disease]]