Cribriform adenocarcinoma of the minor salivary gland - Revision history

Michael: /* Referencess */

2021-02-25T20:23:19Z

Referencess

← Older revision		Revision as of 20:23, 25 February 2021
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	==Referencess==		==Referencess==
	{{Reflist\|1}}		{{Reflist\|2}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
	[[Category:Salivary gland]]		[[Category:Salivary gland]]

Michael at 20:23, 25 February 2021

2021-02-25T20:23:03Z

← Older revision		Revision as of 20:23, 25 February 2021
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	It is also known as '''cribriform adenocarcinoma of the tongue''', abbreviated '''CAT'''.		It is also known as '''cribriform adenocarcinoma of the tongue''', abbreviated '''CAT'''.

			The ''World Health Organization'' lumps this tumour with [[polymorphous adenocarcinoma]], a decision that is considered "controversial".<ref name=pmid29761209>{{cite journal \|authors=Vander Poorten V, Triantafyllou A, Skálová A, Stenman G, Bishop JA, Hauben E, Hunt JL, Hellquist H, Feys S, De Bree R, Mäkitie AA, Quer M, Strojan P, Guntinas-Lichius O, Rinaldo A, Ferlito A \|title=Polymorphous adenocarcinoma of the salivary glands: reappraisal and update \|journal=Eur Arch Otorhinolaryngol \|volume=275 \|issue=7 \|pages=1681–1695 \|date=July 2018 \|pmid=29761209 \|doi=10.1007/s00405-018-4985-5 \|url=}}</ref>

	==General==		==General==

Michael: /* Microscopic */

2021-02-25T19:06:14Z

Microscopic

← Older revision		Revision as of 19:06, 25 February 2021
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	DDx:		DDx:
	*[[Polymorphous low grade adenocarcinoma]] - morphology more varied.		*[[Polymorphous adenocarcinoma]] (previously polymorphous low-grade adenocarcinoma) - morphology more varied.
	*[[Papillary thyroid carcinoma]].		*[[Papillary thyroid carcinoma]].

Michael: /* Microscopic */

2015-10-31T04:14:39Z

Microscopic

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	Features:		Features:
	*Typically covered by an intact squamous epithelium.<ref name=pmid21716087>{{Cite journal \| last1 = Skalova \| first1 = A. \| last2 = Sima \| first2 = R. \| last3 = Kaspirkova-Nemcova \| first3 = J. \| last4 = Simpson \| first4 = RH. \| last5 = Elmberger \| first5 = G. \| last6 = Leivo \| first6 = I. \| last7 = Di Palma \| first7 = S. \| last8 = Jirasek \| first8 = T. \| last9 = Gnepp \| first9 = DR. \| title = Cribriform adenocarcinoma of minor salivary gland origin principally affecting the tongue: characterization of new entity. \| journal = Am J Surg Pathol \| volume = 35 \| issue = 8 \| pages = 1168-76 \| month = Aug \| year = 2011 \| doi = 10.1097/PAS.0b013e31821e1f54 \| PMID = 21716087 }}</ref>		*Typically covered by an intact squamous epithelium.<ref name=pmid21716087>{{Cite journal \| last1 = Skalova \| first1 = A. \| last2 = Sima \| first2 = R. \| last3 = Kaspirkova-Nemcova \| first3 = J. \| last4 = Simpson \| first4 = RH. \| last5 = Elmberger \| first5 = G. \| last6 = Leivo \| first6 = I. \| last7 = Di Palma \| first7 = S. \| last8 = Jirasek \| first8 = T. \| last9 = Gnepp \| first9 = DR. \| title = Cribriform adenocarcinoma of minor salivary gland origin principally affecting the tongue: characterization of new entity. \| journal = Am J Surg Pathol \| volume = 35 \| issue = 8 \| pages = 1168-76 \| month = Aug \| year = 2011 \| doi = 10.1097/PAS.0b013e31821e1f54 \| PMID = 21716087 }}</ref>
	*Growth patterns - cribriform and solid.		*Growth patterns - [[cribriform]] and solid.
	*Cytology similar to [[papillary thyroid carcinoma]].<ref name=pmid21716087/>		*Cytology similar to [[papillary thyroid carcinoma]].<ref name=pmid21716087/>
	**Irregular nuclear membranes (raisin-like nuclei).		**Irregular nuclear membranes (raisin-like nuclei).

Michael: fix spelling

2015-09-18T04:35:40Z

fix spelling

← Older revision		Revision as of 04:35, 18 September 2015
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	\| Width =		\| Width =
	\| Caption = Cribriform adenocarcinoma of the minor salivary gland. [[H&E stain]].		\| Caption = Cribriform adenocarcinoma of the minor salivary gland. [[H&E stain]].
	\| Synonyms = cribriform ~~adenocarcioma~~ of the tongue		\| Synonyms = cribriform adenocarcinoma of the tongue
	\| Micro = cribriform and solid architecture, cytology similar to papillary thyroid carcinoma (irregular nuclear membranes, nuclear overlap), usually covered by an intact squamous epithelium		\| Micro = cribriform and solid architecture, cytology similar to papillary thyroid carcinoma (irregular nuclear membranes, nuclear overlap), usually covered by an intact squamous epithelium
	\| Subtypes =		\| Subtypes =
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	'''Cribriform adenocarcinoma of the minor salivary gland''', abbreviated '''CAMSG''', is a rare [[malignancy]] of the [[salivary gland]], typically of the [[tongue]].<ref name=pmid21716087/>		'''Cribriform adenocarcinoma of the minor salivary gland''', abbreviated '''CAMSG''', is a rare [[malignancy]] of the [[salivary gland]], typically of the [[tongue]].<ref name=pmid21716087/>

	It is also known as '''cribriform ~~adenocarcioma~~ of the tongue''', abbreviated '''CAT'''.		It is also known as '''cribriform adenocarcinoma of the tongue''', abbreviated '''CAT'''.

	==General==		==General==

Michael: /* IHC */ +molecular

2015-06-17T18:22:16Z

IHC: +molecular

← Older revision		Revision as of 18:22, 17 June 2015
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	*Vimentin +ve (12/12 cases).		*Vimentin +ve (12/12 cases).
	*CD117 -ve/+ve (5+ve/12 cases).		*CD117 -ve/+ve (5+ve/12 cases).

			==Molecular==
			*Rearrangement of the PRKD genes (PRKD1, PRKD2, PRKD3).<ref name=pmid24942367>{{Cite journal \| last1 = Weinreb \| first1 = I. \| last2 = Zhang \| first2 = L. \| last3 = Tirunagari \| first3 = LM. \| last4 = Sung \| first4 = YS. \| last5 = Chen \| first5 = CL. \| last6 = Perez-Ordonez \| first6 = B. \| last7 = Clarke \| first7 = BA. \| last8 = Skalova \| first8 = A. \| last9 = Chiosea \| first9 = SI. \| title = Novel PRKD gene rearrangements and variant fusions in cribriform adenocarcinoma of salivary gland origin. \| journal = Genes Chromosomes Cancer \| volume = 53 \| issue = 10 \| pages = 845-56 \| month = Oct \| year = 2014 \| doi = 10.1002/gcc.22195 \| PMID = 24942367 }}</ref>

	==See also==		==See also==

Michael: +images

2015-05-18T22:06:44Z

+images

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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image =		\| Image = Cribriform adenocarcinoma of the tongue - a2 -- intermed mag.jpg
	\| Width =		\| Width =
	\| Caption =		\| Caption = Cribriform adenocarcinoma of the minor salivary gland. [[H&E stain]].
	\| Synonyms = cribriform adenocarcioma of the tongue		\| Synonyms = cribriform adenocarcioma of the tongue
	\| Micro = cribriform and solid architecture, cytology similar to papillary thyroid carcinoma (irregular nuclear membranes, nuclear overlap), usually covered by an intact squamous epithelium		\| Micro = cribriform and solid architecture, cytology similar to papillary thyroid carcinoma (irregular nuclear membranes, nuclear overlap), usually covered by an intact squamous epithelium
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	===Images===		===Images===
	www:		<gallery>
			Image: Cribriform adenocarcinoma of the tongue -- low mag.jpg \| CAT - low mag.
			Image: Cribriform adenocarcinoma of the tongue -- intermed mag.jpg \| CAT - intermed. mag.
			Image: Cribriform adenocarcinoma of the tongue -- high mag.jpg \| CAT - high mag.
			Image: Cribriform adenocarcinoma of the tongue -- very high mag.jpg \| CAT - very high mag.

			Image: Cribriform adenocarcinoma of the tongue - a1 -- low mag.jpg \| CAT - low mag.
			Image: Cribriform adenocarcinoma of the tongue - a1 -- intermed mag.jpg \| CAT - intermed. mag.
			Image: Cribriform adenocarcinoma of the tongue - a1b -- intermed mag.jpg \| CAT - intermed. mag.

			Image: Cribriform adenocarcinoma of the tongue - a2 -- intermed mag.jpg \| CAT - intermed. mag.
			Image: Cribriform adenocarcinoma of the tongue - a2 -- high mag.jpg \| CAT - high mag.
			Image: Cribriform adenocarcinoma of the tongue - a2 -- very high mag.jpg \| CAT - very high mag.
			</gallery>
			====www====
	*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712093/figure/Fig1/ CAMSG (nih.gov)].<ref name=pmid23821209/>		*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712093/figure/Fig1/ CAMSG (nih.gov)].<ref name=pmid23821209/>
	*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712093/figure/Fig3/ CAMSG (nih.gov)].<ref name=pmid23821209>{{Cite journal \| last1 = Michal \| first1 = M. \| last2 = Kacerovska \| first2 = D. \| last3 = Kazakov \| first3 = DV. \| title = Cribriform adenocarcinoma of the tongue and minor salivary glands: a review. \| journal = Head Neck Pathol \| volume = 7 Suppl 1 \| issue = \| pages = S3-11 \| month = Jul \| year = 2013 \| doi = 10.1007/s12105-013-0457-9 \| PMID = 23821209 }}</ref>		*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712093/figure/Fig3/ CAMSG (nih.gov)].<ref name=pmid23821209>{{Cite journal \| last1 = Michal \| first1 = M. \| last2 = Kacerovska \| first2 = D. \| last3 = Kazakov \| first3 = DV. \| title = Cribriform adenocarcinoma of the tongue and minor salivary glands: a review. \| journal = Head Neck Pathol \| volume = 7 Suppl 1 \| issue = \| pages = S3-11 \| month = Jul \| year = 2013 \| doi = 10.1007/s12105-013-0457-9 \| PMID = 23821209 }}</ref>

Michael at 20:08, 18 March 2015

2015-03-18T20:08:41Z

← Older revision		Revision as of 20:08, 18 March 2015
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	==General==		==General==
	*Rare.		*Rare - small case series and case reports.
	*Typically [[tongue]] - first described there.<ref name=pmid10583573>{{Cite journal \| last1 = Michal \| first1 = M. \| last2 = Skálová \| first2 = A. \| last3 = Simpson \| first3 = RH. \| last4 = Raslan \| first4 = WF. \| last5 = Curík \| first5 = R. \| last6 = Leivo \| first6 = I. \| last7 = Mukensnábl \| first7 = P. \| title = Cribriform adenocarcinoma of the tongue: a hitherto unrecognized type of adenocarcinoma characteristically occurring in the tongue. \| journal = Histopathology \| volume = 35 \| issue = 6 \| pages = 495-501 \| month = Dec \| year = 1999 \| doi = \| PMID = 10583573 }}</ref>		*Typically [[tongue]] - first described there.<ref name=pmid10583573>{{Cite journal \| last1 = Michal \| first1 = M. \| last2 = Skálová \| first2 = A. \| last3 = Simpson \| first3 = RH. \| last4 = Raslan \| first4 = WF. \| last5 = Curík \| first5 = R. \| last6 = Leivo \| first6 = I. \| last7 = Mukensnábl \| first7 = P. \| title = Cribriform adenocarcinoma of the tongue: a hitherto unrecognized type of adenocarcinoma characteristically occurring in the tongue. \| journal = Histopathology \| volume = 35 \| issue = 6 \| pages = 495-501 \| month = Dec \| year = 1999 \| doi = \| PMID = 10583573 }}</ref>
	*Good prognosis<ref name=pmid21716087/> - on limited data.		*Good prognosis<ref name=pmid21716087/> - on limited data.

Michael: +infobox

2015-03-18T20:07:13Z

+infobox

← Older revision		Revision as of 20:07, 18 March 2015
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image =
			\| Width =
			\| Caption =
			\| Synonyms = cribriform adenocarcioma of the tongue
			\| Micro = cribriform and solid architecture, cytology similar to papillary thyroid carcinoma (irregular nuclear membranes, nuclear overlap), usually covered by an intact squamous epithelium
			\| Subtypes =
			\| LMDDx = [[polymorphous low grade adenocarcinoma]], [[papillary thyroid carcinoma]]
			\| Stains =
			\| IHC = CK7 +ve, vimentin +ve, CD117 -ve/+ve, S-100 +ve
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[head and neck pathology\|head and neck]] - usually [[tongue]]
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms =
			\| Prevalence = very rare
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = good
			\| Other =
			\| ClinDDx = other [[salivary gland]] tumours
			\| Tx = excision
			}}
	'''Cribriform adenocarcinoma of the minor salivary gland''', abbreviated '''CAMSG''', is a rare [[malignancy]] of the [[salivary gland]], typically of the [[tongue]].<ref name=pmid21716087/>		'''Cribriform adenocarcinoma of the minor salivary gland''', abbreviated '''CAMSG''', is a rare [[malignancy]] of the [[salivary gland]], typically of the [[tongue]].<ref name=pmid21716087/>

Michael: /* Microscopic */

2015-03-18T20:01:58Z

Microscopic

← Older revision		Revision as of 20:01, 18 March 2015
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	*Growth patterns - cribriform and solid.		*Growth patterns - cribriform and solid.
	*Cytology similar to [[papillary thyroid carcinoma]].<ref name=pmid21716087/>		*Cytology similar to [[papillary thyroid carcinoma]].<ref name=pmid21716087/>
	**Irregular (raisin-like) ~~nuclear membranes~~.		**Irregular nuclear membranes (raisin-like nuclei).
	**Nuclear overlap.		**Nuclear overlap.