Connective tissue diseases - Revision history

Michael: /* References */ chg ref.

2012-03-24T16:39:36Z

References: chg ref.

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	==References==		==References==
	{{Reflist\|1}}		{{Reflist\|2}}
	[[Category:Weird stuff]]		[[Category:Weird stuff]]

Michael: /* Mixed connective tissue disease */ +serology

2012-03-24T16:35:02Z

Mixed connective tissue disease: +serology

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	===General===		===General===
	*A wastebasket diagnosis in [[rheumatology]].		*A wastebasket diagnosis in [[rheumatology]].

			Serology - classic, non-[[specificity\|specific]]:
			*Anti-U1-RNP (ribonucleoprotein) +ve,<ref name=pmid20722023>{{Cite journal \| last1 = Sato \| first1 = T. \| last2 = Fujii \| first2 = T. \| last3 = Yokoyama \| first3 = T. \| last4 = Fujita \| first4 = Y. \| last5 = Imura \| first5 = Y. \| last6 = Yukawa \| first6 = N. \| last7 = Kawabata \| first7 = D. \| last8 = Nojima \| first8 = T. \| last9 = Ohmura \| first9 = K. \| title = Anti-U1 RNP antibodies in cerebrospinal fluid are associated with central neuropsychiatric manifestations in systemic lupus erythematosus and mixed connective tissue disease. \| journal = Arthritis Rheum \| volume = 62 \| issue = 12 \| pages = 3730-40 \| month = Dec \| year = 2010 \| doi = 10.1002/art.27700 \| PMID = 20722023 }}</ref>

	Usually has some features of:<ref>URL: [http://www.merckmanuals.com/home/bone_joint_and_muscle_disorders/autoimmune_disorders_of_connective_tissue/mixed_connective_tissue_disease_mctd.html http://www.merckmanuals.com/home/bone_joint_and_muscle_disorders/autoimmune_disorders_of_connective_tissue/mixed_connective_tissue_disease_mctd.html]. Accessed on: 18 February 2012.</ref>		Usually has some features of:<ref>URL: [http://www.merckmanuals.com/home/bone_joint_and_muscle_disorders/autoimmune_disorders_of_connective_tissue/mixed_connective_tissue_disease_mctd.html http://www.merckmanuals.com/home/bone_joint_and_muscle_disorders/autoimmune_disorders_of_connective_tissue/mixed_connective_tissue_disease_mctd.html]. Accessed on: 18 February 2012.</ref>

Michael: create MCTD

2012-02-18T13:42:26Z

create MCTD

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	'''Connective tissue diseases''', also '''connective tissue disorders''', are infrequently seen by [[pathologist]]s.		'''Connective tissue diseases''', also '''connective tissue disorders''', are infrequently seen by [[pathologist]]s.

	They may be very important in the context of [[forensic pathology]], as they may be an explanation for multiple fractures		They may be very important in the context of [[forensic pathology]], as they may be an explanation for multiple fractures, which may be seen in child abuse.

			=Specific entities=
			==Mixed connective tissue disease==
			*Abbreviated ''MCTD''.
			===General===
			*A wastebasket diagnosis in [[rheumatology]].

			Usually has some features of:<ref>URL: [http://www.merckmanuals.com/home/bone_joint_and_muscle_disorders/autoimmune_disorders_of_connective_tissue/mixed_connective_tissue_disease_mctd.html http://www.merckmanuals.com/home/bone_joint_and_muscle_disorders/autoimmune_disorders_of_connective_tissue/mixed_connective_tissue_disease_mctd.html]. Accessed on: 18 February 2012.</ref>
			*[[Systemic lupus erythematosus]].
			*Systemic sclerosis.
			*[[Polymyositis]].

	~~=Specific entities=~~
	==Ehlers-Danlos syndrome==		==Ehlers-Danlos syndrome==
	{{Main\|Ehlers-Danlos syndrome}}		{{Main\|Ehlers-Danlos syndrome}}

Michael: alt. name

2012-02-18T13:34:39Z

alt. name

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	'''Connective tissue diseases''' are infrequently seen by [[pathologist]]s.		'''Connective tissue diseases''', also '''connective tissue disorders''', are infrequently seen by [[pathologist]]s.

	They may be very important in the context of [[forensic pathology]], as they may be an explanation for multiple fractures		They may be very important in the context of [[forensic pathology]], as they may be an explanation for multiple fractures

Michael: /* General */

2012-02-03T03:03:12Z

General

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	===General===		===General===
	*Rare.		*Rare.
	*Numerous subtypes.		*Numerous subtypes - mild-to-severe symptoms/survival.
	*May be misdiagnosed as child abuse.<ref name=pmid21716141>{{Cite journal \| last1 = Singh Kocher \| first1 = M. \| last2 = Dichtel \| first2 = L. \| title = Osteogenesis imperfecta misdiagnosed as child abuse. \| journal = J Pediatr Orthop B \| volume = 20 \| issue = 6 \| pages = 440-3 \| month = Nov \| year = 2011 \| doi = 10.1097/BPB.0b013e328347a2e1 \| PMID = 21716141 }}</ref>		*May be misdiagnosed as child abuse.<ref name=pmid21716141>{{Cite journal \| last1 = Singh Kocher \| first1 = M. \| last2 = Dichtel \| first2 = L. \| title = Osteogenesis imperfecta misdiagnosed as child abuse. \| journal = J Pediatr Orthop B \| volume = 20 \| issue = 6 \| pages = 440-3 \| month = Nov \| year = 2011 \| doi = 10.1097/BPB.0b013e328347a2e1 \| PMID = 21716141 }}</ref>

			Clinical:
			*+/-Blue sclerae.<ref name=pmid1202551>{{Cite journal \| last1 = Smith \| first1 = R. \| last2 = Francis \| first2 = MJ. \| last3 = Bauze \| first3 = RJ. \| title = Osteogenesis imperfecta. A clinical and biochemical study of a generalized connective tissue disorder. \| journal = Q J Med \| volume = 44 \| issue = 176 \| pages = 555-73 \| month = Oct \| year = 1975 \| doi = \| PMID = 1202551 }}</ref>
			*Multiple fractures.

	===General===		===General===

Michael: /* Osteogenesis imperfecta */

2012-02-03T02:59:13Z

Osteogenesis imperfecta

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	*Abundant plump osteoblasts (infants only).		*Abundant plump osteoblasts (infants only).
	*Paucity of bony matrix.		*Paucity of bony matrix.
			*Premature calcification of osteoid.

	Images:		Images:

Michael: /* Osteogenesis imperfecta */ more

2012-02-03T02:57:36Z

Osteogenesis imperfecta: more

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	*May be misdiagnosed as child abuse.<ref name=pmid21716141>{{Cite journal \| last1 = Singh Kocher \| first1 = M. \| last2 = Dichtel \| first2 = L. \| title = Osteogenesis imperfecta misdiagnosed as child abuse. \| journal = J Pediatr Orthop B \| volume = 20 \| issue = 6 \| pages = 440-3 \| month = Nov \| year = 2011 \| doi = 10.1097/BPB.0b013e328347a2e1 \| PMID = 21716141 }}</ref>		*May be misdiagnosed as child abuse.<ref name=pmid21716141>{{Cite journal \| last1 = Singh Kocher \| first1 = M. \| last2 = Dichtel \| first2 = L. \| title = Osteogenesis imperfecta misdiagnosed as child abuse. \| journal = J Pediatr Orthop B \| volume = 20 \| issue = 6 \| pages = 440-3 \| month = Nov \| year = 2011 \| doi = 10.1097/BPB.0b013e328347a2e1 \| PMID = 21716141 }}</ref>

			===General===
			*Classic - tibial bowing (saber shins).<ref name=pmid4703203>{{Cite journal \| last1 = Milgram \| first1 = JW. \| last2 = Flick \| first2 = MR. \| last3 = Engh \| first3 = CA. \| title = Osteogenesis imperfecta. A histopathological case report. \| journal = J Bone Joint Surg Am \| volume = 55 \| issue = 3 \| pages = 506-15 \| month = Apr \| year = 1973 \| doi = \| PMID = 4703203 \|URL = http://www.jbjs.org/article.aspx?volume=55&page=506 }}
			</ref>
	===Microscopic===		===Microscopic===
	?		Features:<ref name=pmid4703203/>
			*Abundant plump osteoblasts (infants only).
			*Paucity of bony matrix.

	Images:		Images:

Michael: /* Specific entities */

2012-02-03T02:37:19Z

Specific entities

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	=Specific entities=		=Specific entities=
	==Ehlers-Danlos ~~disease~~==		==Ehlers-Danlos syndrome==
	~~===General===~~		{{Main\|Ehlers-Danlos syndrome}}
	*Several subtypes.
	*May be cause of [[aortic dissection]].

	==Marfan syndrome==		==Marfan syndrome==

Michael at 02:35, 3 February 2012

2012-02-03T02:35:31Z

← Older revision		Revision as of 02:35, 3 February 2012
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	=Specific entities=		=Specific entities=
	==Ehlers-Danlos disease==		==Ehlers-Danlos disease==
			===General===
			*Several subtypes.
			*May be cause of [[aortic dissection]].

	==Marfan syndrome==		==Marfan syndrome==
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	Images:		Images:
	*[http://path.upmc.edu/cases/case706.html OI - type 2 (upmc.edu)].		*[http://path.upmc.edu/cases/case706.html OI - type 2 (upmc.edu)].

			==See also==
			*[[Basics]].

	==References==		==References==
			{{Reflist\|1}}
	[[Category:Weird stuff]]		[[Category:Weird stuff]]

Michael: /* Osteogenesis imperfecta */

2012-02-03T02:34:18Z

Osteogenesis imperfecta

← Older revision		Revision as of 02:34, 3 February 2012
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	==Osteogenesis imperfecta==		==Osteogenesis imperfecta==
			*Abbreviated ''OI''.
	===General===		===General===
	*Rare.		*Rare.
	*Numerous subtypes.		*Numerous subtypes.
			*May be misdiagnosed as child abuse.<ref name=pmid21716141>{{Cite journal \| last1 = Singh Kocher \| first1 = M. \| last2 = Dichtel \| first2 = L. \| title = Osteogenesis imperfecta misdiagnosed as child abuse. \| journal = J Pediatr Orthop B \| volume = 20 \| issue = 6 \| pages = 440-3 \| month = Nov \| year = 2011 \| doi = 10.1097/BPB.0b013e328347a2e1 \| PMID = 21716141 }}</ref>

	===Microscopic===		===Microscopic===