Collagenous colitis - Revision history

Michael: /* Microscopic */

2016-05-25T14:30:00Z

Microscopic

← Older revision		Revision as of 14:30, 25 May 2016
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	==Microscopic==		==Microscopic==
	Features:		Features:
	*Intraepithelial lymphocytes - '''important'''.		*[[Intraepithelial lymphocytes]] - '''important'''.
	*Collagenous material in the lamina propria (pink on H&E) -- '''key feature'''.		*Collagenous material in the lamina propria (pink on H&E) -- '''key feature'''.
	**Can be demonstrated with a trichrome stain -- collagen = green on trichrome.		**Can be demonstrated with a trichrome stain -- collagen = green on trichrome.

Michael: /* Microscopic */

2016-02-23T22:39:12Z

Microscopic

← Older revision		Revision as of 22:39, 23 February 2016
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	**No crypt distortion.		**No crypt distortion.
	*Thickened collagen band uncommon in rectum.<ref name=pmid1740280>{{Cite journal \| last1 = Tanaka \| first1 = M. \| last2 = Mazzoleni \| first2 = G. \| last3 = Riddell \| first3 = RH. \| title = Distribution of collagenous colitis: utility of flexible sigmoidoscopy. \| journal = Gut \| volume = 33 \| issue = 1 \| pages = 65-70 \| month = Jan \| year = 1992 \| doi = \| PMID = 1740280 }}</ref>		*Thickened collagen band uncommon in rectum.<ref name=pmid1740280>{{Cite journal \| last1 = Tanaka \| first1 = M. \| last2 = Mazzoleni \| first2 = G. \| last3 = Riddell \| first3 = RH. \| title = Distribution of collagenous colitis: utility of flexible sigmoidoscopy. \| journal = Gut \| volume = 33 \| issue = 1 \| pages = 65-70 \| month = Jan \| year = 1992 \| doi = \| PMID = 1740280 }}</ref>
			*Described in association of [[pseudomembranous colitis\|pseudomembranes]].<ref name=pmid14508399>{{Cite journal \| last1 = Yuan \| first1 = S. \| last2 = Reyes \| first2 = V. \| last3 = Bronner \| first3 = MP. \| title = Pseudomembranous collagenous colitis. \| journal = Am J Surg Pathol \| volume = 27 \| issue = 10 \| pages = 1375-9 \| month = Oct \| year = 2003 \| doi = \| PMID = 14508399 }}</ref>

	DDx:		DDx:

Michael: touch

2015-02-25T08:25:33Z

touch

← Older revision		Revision as of 08:25, 25 February 2015
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image = Collagenous_colitis_-_high_mag.jpg		\| Image = Collagenous_colitis_-_high_mag.jpg
	\| Width =		\| Width =
	\| Caption = Collagenous colitis. [[H&E stain]].		\| Caption = Collagenous colitis. [[H&E stain]].

Michael: /* General */

2014-07-05T01:27:20Z

General

← Older revision		Revision as of 01:27, 5 July 2014
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	Notes:		Notes:
	*Clinical DDx includes [[irritable bowel syndrome]] - which has no or subtle histopathologic changes.		*Clinical DDx includes [[irritable bowel syndrome]] - which has no or subtle histopathologic changes.
			*This pathology also afflicits rectum; however, it is less commonly found there.
			**The rectum is afflicted in approximately in 65% of cases.<ref name=pmid12018911>{{cite journal \|author=Agnarsdottir M, Gunnlaugsson O, Orvar KB, ''et al.'' \|title=Collagenous and lymphocytic colitis in Iceland \|journal=Dig. Dis. Sci. \|volume=47 \|issue=5 \|pages=1122–8 \|year=2002 \|month=May \|pmid=12018911 \|doi= \|url=}}</ref>

	===Epidemiology===		===Epidemiology===
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	**CC females:males = 20:1.<ref name=medscape180664/>		**CC females:males = 20:1.<ref name=medscape180664/>
	*Drugs are associated with LC and CC.		*Drugs are associated with LC and CC.
	**~~NSAIDs~~ - posulated association/weak association,		**[[NSAID]]s - posulated association/weak association,
	**SSRIs (used primarily for depression) - moderate association, dependent on specific drug.		**SSRIs (used primarily for depression) - moderate association, dependent on specific drug.
	*Associated with autoimmune disorders - [[celiac disease]], [[diabetes mellitus]], [[thyroid]] disorders and [[arthritis]].<ref name=pmid19109861>{{cite journal \|author=Tysk C, Bohr J, Nyhlin N, Wickbom A, Eriksson S \|title=Diagnosis and management of microscopic colitis \|journal=World J. Gastroenterol. \|volume=14 \|issue=48 \|pages=7280-8 \|year=2008 \|month=December \|pmid=19109861 \|doi= \|url=http://www.wjgnet.com/1007-9327/14/7280.asp}}</ref>		*Associated with autoimmune disorders - [[celiac disease]], [[diabetes mellitus]], [[thyroid]] disorders and [[arthritis]].<ref name=pmid19109861>{{cite journal \|author=Tysk C, Bohr J, Nyhlin N, Wickbom A, Eriksson S \|title=Diagnosis and management of microscopic colitis \|journal=World J. Gastroenterol. \|volume=14 \|issue=48 \|pages=7280-8 \|year=2008 \|month=December \|pmid=19109861 \|doi= \|url=http://www.wjgnet.com/1007-9327/14/7280.asp}}</ref>

Michael: /* Microscopic */ tweak

2013-09-30T13:10:45Z

Microscopic: tweak

← Older revision		Revision as of 13:10, 30 September 2013
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	DDx:		DDx:
	*[[Lymphocytic colitis]].		*[[Lymphocytic colitis]].
	*[[Crohn's disease]] - may be a perfect mimic.<ref name=pmid10478667>{{Cite journal \| last1 = Goldstein \| first1 = NS. \| last2 = Gyorfi \| first2 = T. \| title = Focal lymphocytic colitis and collagenous colitis: patterns of Crohn's colitis? \| journal = Am J Surg Pathol \| volume = 23 \| issue = 9 \| pages = 1075-81 \| month = Sep \| year = 1999 \| doi = \| PMID = 10478667 }}</ref>		*[[Crohn's disease]] - very rare, may be a perfect mimic.<ref name=pmid10478667>{{Cite journal \| last1 = Goldstein \| first1 = NS. \| last2 = Gyorfi \| first2 = T. \| title = Focal lymphocytic colitis and collagenous colitis: patterns of Crohn's colitis? \| journal = Am J Surg Pathol \| volume = 23 \| issue = 9 \| pages = 1075-81 \| month = Sep \| year = 1999 \| doi = \| PMID = 10478667 }}</ref>

	===Images===		===Images===

Michael: more

2013-09-30T13:10:16Z

← Older revision		Revision as of 13:10, 30 September 2013
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	\| Micro = intraepithelial lymphocytes (>20/100 enterocytes), subepithelial collagen band (>= 10 micrometres thick)		\| Micro = intraepithelial lymphocytes (>20/100 enterocytes), subepithelial collagen band (>= 10 micrometres thick)
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[lymphocytic colitis]], [[Crohn's disease]]		\| LMDDx = [[lymphocytic colitis]], [[Crohn's disease]] (very rare)
	\| Stains =		\| Stains =
	\| IHC =		\| IHC =

Michael: more

2013-09-30T13:08:27Z

← Older revision		Revision as of 13:08, 30 September 2013
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	\| Micro = intraepithelial lymphocytes (>20/100 enterocytes), subepithelial collagen band (>= 10 micrometres thick)		\| Micro = intraepithelial lymphocytes (>20/100 enterocytes), subepithelial collagen band (>= 10 micrometres thick)
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[lymphocytic colitis]]		\| LMDDx = [[lymphocytic colitis]], [[Crohn's disease]]
	\| Stains =		\| Stains =
	\| IHC =		\| IHC =

Michael at 12:53, 30 September 2013

2013-09-30T12:53:07Z

← Older revision		Revision as of 12:53, 30 September 2013
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	*Collagenous colitis may be related to [[lymphocytic colitis]].		*Collagenous colitis may be related to [[lymphocytic colitis]].
	**It is hypothesized that these conditions may be the same pathology at different time points.<ref name=medscape180664/>		**It is hypothesized that these conditions may be the same pathology at different time points.<ref name=medscape180664/>
	*~~Associated~~ with to [[collagenous gastritis]] in adults.<ref name=pmid19730387>{{Cite journal \| last1 = Brain \| first1 = O. \| last2 = Rajaguru \| first2 = C. \| last3 = Warren \| first3 = B. \| last4 = Booth \| first4 = J. \| last5 = Travis \| first5 = S. \| title = Collagenous gastritis: reports and systematic review. \| journal = Eur J Gastroenterol Hepatol \| volume = 21 \| issue = 12 \| pages = 1419-24 \| month = Dec \| year = 2009 \| doi = 10.1097/MEG.0b013e32832770fa \| PMID = 19730387 }}</ref>		*May be associated with to [[collagenous gastritis]] in adults.<ref name=pmid19730387>{{Cite journal \| last1 = Brain \| first1 = O. \| last2 = Rajaguru \| first2 = C. \| last3 = Warren \| first3 = B. \| last4 = Booth \| first4 = J. \| last5 = Travis \| first5 = S. \| title = Collagenous gastritis: reports and systematic review. \| journal = Eur J Gastroenterol Hepatol \| volume = 21 \| issue = 12 \| pages = 1419-24 \| month = Dec \| year = 2009 \| doi = 10.1097/MEG.0b013e32832770fa \| PMID = 19730387 }}</ref>

	Presentation:		Presentation:

Michael: /* General */ tweak

2013-09-30T12:41:53Z

General: tweak

← Older revision		Revision as of 12:41, 30 September 2013
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	==General==		==General==
			*Collagenous colitis may be related to [[lymphocytic colitis]].
			**It is hypothesized that these conditions may be the same pathology at different time points.<ref name=medscape180664/>
			*Associated with to [[collagenous gastritis]] in adults.<ref name=pmid19730387>{{Cite journal \| last1 = Brain \| first1 = O. \| last2 = Rajaguru \| first2 = C. \| last3 = Warren \| first3 = B. \| last4 = Booth \| first4 = J. \| last5 = Travis \| first5 = S. \| title = Collagenous gastritis: reports and systematic review. \| journal = Eur J Gastroenterol Hepatol \| volume = 21 \| issue = 12 \| pages = 1419-24 \| month = Dec \| year = 2009 \| doi = 10.1097/MEG.0b013e32832770fa \| PMID = 19730387 }}</ref>

	Presentation:		Presentation:
	*Chronic diarrhea, non-bloody.<ref name=medscape180664>URL: [http://emedicine.medscape.com/article/180664-overview http://emedicine.medscape.com/article/180664-overview]. Accessed on: 31 May 2010.</ref>		*Chronic diarrhea, non-bloody.<ref name=medscape180664>URL: [http://emedicine.medscape.com/article/180664-overview http://emedicine.medscape.com/article/180664-overview]. Accessed on: 31 May 2010.</ref>

	*Collagenous colitis may be related to [[lymphocytic colitis]].
	**It is hypothesized that these conditions may be the same pathology at different time points.<ref name=medscape180664/>

	Notes:		Notes:

Michael: /* Microscopic */

2013-08-06T09:35:58Z

Microscopic

← Older revision		Revision as of 09:35, 6 August 2013
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	DDx:		DDx:
	*[[Lymphocytic colitis]].		*[[Lymphocytic colitis]].
			*[[Crohn's disease]] - may be a perfect mimic.<ref name=pmid10478667>{{Cite journal \| last1 = Goldstein \| first1 = NS. \| last2 = Gyorfi \| first2 = T. \| title = Focal lymphocytic colitis and collagenous colitis: patterns of Crohn's colitis? \| journal = Am J Surg Pathol \| volume = 23 \| issue = 9 \| pages = 1075-81 \| month = Sep \| year = 1999 \| doi = \| PMID = 10478667 }}</ref>

	===Images===		===Images===