Clear cell sarcoma - Revision history

Michael: tweak

2013-09-23T05:26:18Z

tweak

← Older revision		Revision as of 05:26, 23 September 2013
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	\| Molecular = t(12;22)		\| Molecular = t(12;22)
	\| IF =		\| IF =
	\| Gross =		\| Gross = deep location, usu. extremity
	\| Grossing =		\| Grossing =
	\| Site = [[soft tissue lesions\|soft tissue]]		\| Site = [[soft tissue lesions\|soft tissue]]
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	\| Syndromes =		\| Syndromes =
	\| Clinicalhx =		\| Clinicalhx =
	\| Signs =		\| Signs = mass
	\| Symptoms =		\| Symptoms =
	\| Prevalence =		\| Prevalence = uncommon
	\| Bloodwork =		\| Bloodwork =
	\| Rads =		\| Rads =
	\| Endoscopy =		\| Endoscopy =
	\| Prognosis =		\| Prognosis = guarded
	\| Other =		\| Other =
	\| ClinDDx =		\| ClinDDx =
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	==General==		==General==
	*Molecular changes and origin distinct from [[malignant melanoma]].		*Molecular changes and origin distinct from [[malignant melanoma]].
	*~~Incidence: rare~~ soft tissue tumour.		*Rare soft tissue tumour.<ref name=pmid22693489>{{Cite journal \| last1 = Hocar \| first1 = O. \| last2 = Le Cesne \| first2 = A. \| last3 = Berissi \| first3 = S. \| last4 = Terrier \| first4 = P. \| last5 = Bonvalot \| first5 = S. \| last6 = Vanel \| first6 = D. \| last7 = Auperin \| first7 = A. \| last8 = Le Pechoux \| first8 = C. \| last9 = Bui \| first9 = B. \| title = Clear cell sarcoma (malignant melanoma) of soft parts: a clinicopathologic study of 52 cases. \| journal = Dermatol Res Pract \| volume = 2012 \| issue = \| pages = 984096 \| month = \| year = 2012 \| doi = 10.1155/2012/984096 \| PMID = 22693489 }}</ref>
			*Guarded prognosis: 5 year and 10 year survival ~ 60% and 40% in one series.<ref name=pmid22693489/>
			*First described in 1965.<ref>URL: [http://www.informaworld.com/smpp/723576818-750600/ftinterface~db=all~content=a789166263~fulltext=713240928 http://www.informaworld.com/smpp/723576818-750600/ftinterface~db=all~content=a789166263~fulltext=713240928]. Accessed on: 5 May 2010.</ref>

	==~~=Clinical=~~==		==Gross==
	*Usually - deep soft tissue ''or'' extremities.		*Usually - deep soft tissue ''or'' extremities.
	**Classically associated with tendons and aponeuroses.<ref name=pmid17227118>{{Cite journal \| last1 = Dim \| first1 = DC. \| last2 = Cooley \| first2 = LD. \| last3 = Miranda \| first3 = RN. \| title = Clear cell sarcoma of tendons and aponeuroses: a review. \| journal = Arch Pathol Lab Med \| volume = 131 \| issue = 1 \| pages = 152-6 \| month = Jan \| year = 2007 \| doi = 10.1043/1543-2165(2007)131[152:CCSOTA]2.0.CO;2 \| PMID = 17227118 }}</ref>		**Classically associated with tendons and aponeuroses.<ref name=pmid17227118>{{Cite journal \| last1 = Dim \| first1 = DC. \| last2 = Cooley \| first2 = LD. \| last3 = Miranda \| first3 = RN. \| title = Clear cell sarcoma of tendons and aponeuroses: a review. \| journal = Arch Pathol Lab Med \| volume = 131 \| issue = 1 \| pages = 152-6 \| month = Jan \| year = 2007 \| doi = 10.1043/1543-2165(2007)131[152:CCSOTA]2.0.CO;2 \| PMID = 17227118 }}</ref>
	*Guarded prognosis.
	*First described in 1965.<ref>URL: [http://www.informaworld.com/smpp/723576818-750600/ftinterface~db=all~content=a789166263~fulltext=713240928 http://www.informaworld.com/smpp/723576818-750600/ftinterface~db=all~content=a789166263~fulltext=713240928]. Accessed on: 5 May 2010.</ref>

	==Microscopic==		==Microscopic==

Michael: split out + infobox

2013-09-23T05:14:26Z

split out + infobox

← Older revision		Revision as of 05:14, 23 September 2013
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	~~#redirect~~ [[~~Soft_tissue_lesions#Clear_cell_sarcoma~~]]		{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Clear_cell_sarcoma.Image12.jpg
			\| Width =
			\| Caption = Clear cell sarcoma. [[H&E stain]].
			\| Micro = tumour cells uniform - spindle-shaped ''or'' epithelioid, classically have clear cytoplasm and prominent nucleoli, +/-binucleation; sheeting ''or'' fascicular arrangement with fibrous septae - between tumour cells
			\| Subtypes =
			\| LMDDx = [[malignant melanoma]], [[PEComa]], carcinoma
			\| Stains =
			\| IHC = S100 +ve, HMB-45 +ve, Melan A (MART-1) usu. +ve; sometimes -ve, BCL2 +ve
			\| EM =
			\| Molecular = t(12;22)
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[soft tissue lesions\|soft tissue]]
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms =
			\| Prevalence =
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis =
			\| Other =
			\| ClinDDx =
			}}
			'''Clear cell sarcoma''', abbreviated '''CCS''', is an uncommon malignant soft tissue tumour.

			It is also known as '''soft-tissue melanoma''' and '''melanoma of the soft parts''', as it has a strong morphological resemblance to [[malignant melanoma]].<ref name=pmid18300804>{{cite journal \|author=Hisaoka M, Ishida T, Kuo TT, ''et al.'' \|title=Clear cell sarcoma of soft tissue: a clinicopathologic, immunohistochemical, and molecular analysis of 33 cases \|journal=Am. J. Surg. Pathol. \|volume=32 \|issue=3 \|pages=452–60 \|year=2008 \|month=March \|pmid=18300804 \|doi=10.1097/PAS.0b013e31814b18fb \|url=}}</ref>

			It should '''not''' to be confused with ''[[clear cell sarcoma of the kidney]]''.

			==General==
			*Molecular changes and origin distinct from [[malignant melanoma]].
			*Incidence: rare soft tissue tumour.

			===Clinical===
			*Usually - deep soft tissue ''or'' extremities.
			**Classically associated with tendons and aponeuroses.<ref name=pmid17227118>{{Cite journal \| last1 = Dim \| first1 = DC. \| last2 = Cooley \| first2 = LD. \| last3 = Miranda \| first3 = RN. \| title = Clear cell sarcoma of tendons and aponeuroses: a review. \| journal = Arch Pathol Lab Med \| volume = 131 \| issue = 1 \| pages = 152-6 \| month = Jan \| year = 2007 \| doi = 10.1043/1543-2165(2007)131[152:CCSOTA]2.0.CO;2 \| PMID = 17227118 }}</ref>
			*Guarded prognosis.
			*First described in 1965.<ref>URL: [http://www.informaworld.com/smpp/723576818-750600/ftinterface~db=all~content=a789166263~fulltext=713240928 http://www.informaworld.com/smpp/723576818-750600/ftinterface~db=all~content=a789166263~fulltext=713240928]. Accessed on: 5 May 2010.</ref>

			==Microscopic==
			Features:<ref name=pmid18300804/>
			*Architecture: sheeting ''or'' fascicular (bundles) arrangement.
			**Fibrous septae - between tumour cells.
			*Tumour cells uniform (low pleomorphism) - spindle-shaped ''or'' epithelioid:
			**Classically have clear cytoplasm.
			**Prominent nucleoli - basophilic - '''key feature'''.
			**+/-Binucleation.

			DDx:
			*[[Malignant melanoma]].
			*[[PEComa]].
			*Carcinoma.

			===Images===
			<gallery>
			Image:Clear_cell_sarcoma_-_intermed_mag.jpg \| Clear cell sarcoma - intermed. mag. (WC)
			Image:Clear_cell_sarcoma_-_very_high_mag.jpg \| Clear cell sarcoma - very high mag. (WC)
			Image:Clear_cell_sarcoma.Image12.jpg \| Clear cell sarcoma (WC/Gardner)
			</gallery>
			==IHC==
			Features:<ref name=pmid18300804/>
			*S100 +ve.
			*HMB-45 +ve.
			*Melan A (MART-1) +ve; sometimes -ve.
			*BCL2 +ve.
			*CD57 +ve (usually).

			Keratins:
			*EMA may be +ve.
			*CAM5.2 -ve.
			*AE1/AE3 -ve.

			==Molecular studies==
			*[[Chromosomal translocation]] t(12;22)(q13;q12).<ref name=pmid18300804/>
			**Fusion transcripts:
			***EWSR1-ATF1.
			****Same translocation in: ''[[myxoid liposarcoma]]'',<ref name=pmid21115923>{{Cite journal \| last1 = Suzuki \| first1 = K. \| last2 = Matsui \| first2 = Y. \| last3 = Endo \| first3 = K. \| last4 = Kubo \| first4 = T. \| last5 = Hasegawa \| first5 = T. \| last6 = Kimura \| first6 = T. \| last7 = Ohtani \| first7 = O. \| last8 = Yasui \| first8 = N. \| title = Myxoid liposarcoma with EWS-CHOP type 1 fusion gene. \| journal = Anticancer Res \| volume = 30 \| issue = 11 \| pages = 4679-83 \| month = Nov \| year = 2010 \| doi = \| PMID = 21115923 }}</ref> and ''[[hyalinizing clear cell carcinoma]]''.
			***EWSR1-CREB1 (GI tract associated).

			==See also==
			*[[Soft tissue lesions]].
			*[[Malignant melanoma]].

			==References==
			{{Reflist\|2}}

			[[Category:Soft tissue lesions]]
	[[Category:Diagnosis]]		[[Category:Diagnosis]]

Michael: +cat.

2011-10-20T05:05:03Z

+cat.

← Older revision		Revision as of 05:05, 20 October 2011
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	#redirect [[Soft_tissue_lesions#Clear_cell_sarcoma]]		#redirect [[Soft_tissue_lesions#Clear_cell_sarcoma]]

			[[Category:Diagnosis]]

Michael: redirect for now

2011-01-19T03:34:18Z

redirect for now

New page

#redirect [[Soft_tissue_lesions#Clear_cell_sarcoma]]