Clear cell carcinoma of the uterine cervix - Revision history

Michael at 06:45, 30 December 2015

2015-12-30T06:45:10Z

← Older revision		Revision as of 06:45, 30 December 2015
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	\| Micro = cells with clear cytoplasm (may be focal), hobnail pattern), moderate-to-severe [[nuclear pleomorphism]], usu. tubular and/or cystic morphology (may be (simple) papillary and/or solid)		\| Micro = cells with clear cytoplasm (may be focal), hobnail pattern), moderate-to-severe [[nuclear pleomorphism]], usu. tubular and/or cystic morphology (may be (simple) papillary and/or solid)
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[clear cell carcinoma of the endometrium]], [[serous carcinoma of the endometrium]], [[serous carcinoma]] of the uterine cervix, [[mesonephric adenocarcinoma]], other [[clear cell tumours]]		\| LMDDx = [[clear cell carcinoma of the vagina]], [[clear cell carcinoma of the endometrium]], [[serous carcinoma of the endometrium]], [[serous carcinoma]] of the uterine cervix, [[mesonephric adenocarcinoma]], other [[clear cell tumours]]
	\| Stains = PAS +ve, PASD -ve		\| Stains = PAS +ve, PASD -ve
	\| IHC = CK7 +ve, ER -ve, PR -ve, CA-125 +ve, CEA -ve		\| IHC = CK7 +ve, ER -ve, PR -ve, CA-125 +ve, CEA -ve

Michael at 06:44, 30 December 2015

2015-12-30T06:44:04Z

← Older revision		Revision as of 06:44, 30 December 2015
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	\| Image = Clear cell carcinoma - gynecologic tract -- very high mag.jpg		\| Image = Clear cell carcinoma - gynecologic tract -- very high mag.jpg
	\| Width =		\| Width =
	\| Caption = Clear cell carcinoma of the gynecologic tract. [[H&E stain]].		\| Caption = Clear cell carcinoma of the gynecologic tract with focal clear cells. [[H&E stain]].
	\| Synonyms =		\| Synonyms =
	\| Micro = cells with clear cytoplasm (may be focal), hobnail pattern), moderate-to-severe [[nuclear pleomorphism]], usu. tubular and/or cystic morphology (may be (simple) papillary and/or solid)		\| Micro = cells with clear cytoplasm (may be focal), hobnail pattern), moderate-to-severe [[nuclear pleomorphism]], usu. tubular and/or cystic morphology (may be (simple) papillary and/or solid)

Michael at 06:43, 30 December 2015

2015-12-30T06:43:30Z

← Older revision		Revision as of 06:43, 30 December 2015
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	\| Micro = cells with clear cytoplasm (may be focal), hobnail pattern), moderate-to-severe [[nuclear pleomorphism]], usu. tubular and/or cystic morphology (may be (simple) papillary and/or solid)		\| Micro = cells with clear cytoplasm (may be focal), hobnail pattern), moderate-to-severe [[nuclear pleomorphism]], usu. tubular and/or cystic morphology (may be (simple) papillary and/or solid)
	\| Subtypes =		\| Subtypes =
	\| LMDDx = c[[~~Clear~~ cell carcinoma of the endometrium]], [[serous carcinoma of the endometrium]], [[serous carcinoma]] of the uterine cervix, [[mesonephric adenocarcinoma]], other [[clear cell tumours]]		\| LMDDx = [[clear cell carcinoma of the endometrium]], [[serous carcinoma of the endometrium]], [[serous carcinoma]] of the uterine cervix, [[mesonephric adenocarcinoma]], other [[clear cell tumours]]
	\| Stains =		\| Stains = PAS +ve, PASD -ve
	\| IHC =		\| IHC = CK7 +ve, ER -ve, PR -ve, CA-125 +ve, CEA -ve
	\| EM =		\| EM =
	\| Molecular =		\| Molecular =
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	\| Assdx =		\| Assdx =
	\| Syndromes =		\| Syndromes =
	\| Clinicalhx = +/-diethylstilbestrol (DES) exposure		\| Clinicalhx = +/-diethylstilbestrol (DES) exposure, "young" (median age ~38 years old)
	\| Signs =		\| Signs =
	\| Symptoms =		\| Symptoms =
	\| Prevalence =		\| Prevalence = rare
	\| Bloodwork =		\| Bloodwork =
	\| Rads =		\| Rads =

Michael at 06:41, 30 December 2015

2015-12-30T06:41:05Z

← Older revision		Revision as of 06:41, 30 December 2015
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Clear cell carcinoma - gynecologic tract -- very high mag.jpg
			\| Width =
			\| Caption = Clear cell carcinoma of the gynecologic tract. [[H&E stain]].
			\| Synonyms =
			\| Micro = cells with clear cytoplasm (may be focal), hobnail pattern), moderate-to-severe [[nuclear pleomorphism]], usu. tubular and/or cystic morphology (may be (simple) papillary and/or solid)
			\| Subtypes =
			\| LMDDx = c[[Clear cell carcinoma of the endometrium]], [[serous carcinoma of the endometrium]], [[serous carcinoma]] of the uterine cervix, [[mesonephric adenocarcinoma]], other [[clear cell tumours]]
			\| Stains =
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Staging =
			\| Site = [[uterine cervix]]
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx = +/-diethylstilbestrol (DES) exposure
			\| Signs =
			\| Symptoms =
			\| Prevalence =
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis =
			\| Other =
			\| ClinDDx =
			\| Tx =
			}}
	'''Clear cell carcinoma of the uterine cervix''', also '''cervical clear cell carcinoma''', is a rare malignancy of the [[uterine cervix]] that classically is associated with diethylstilbestrol (DES) exposure. It typically occurs in younger women.		'''Clear cell carcinoma of the uterine cervix''', also '''cervical clear cell carcinoma''', is a rare malignancy of the [[uterine cervix]] that classically is associated with diethylstilbestrol (DES) exposure. It typically occurs in younger women.

Michael: /* Microscopic */

2014-11-12T20:15:18Z

Microscopic

← Older revision		Revision as of 20:15, 12 November 2014
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	==Microscopic==		==Microscopic==
	Features:<ref name=pmid22885379/>		Features:<ref name=pmid22885379/>
	*~~Clear~~ cytoplasm - '''key feature'''.		*Cells with clear cytoplasm - '''key feature'''.
	**May be focal/absent!		**May be focal/absent!
	**Cells have large free/luminal surface area (hobnailing pattern) and small non-free surface.		**Cells have large free/luminal surface area (hobnailing pattern) and small non-free surface.

Michael: /* Microscopic */

2014-11-12T20:14:57Z

Microscopic

← Older revision		Revision as of 20:14, 12 November 2014
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	==Microscopic==		==Microscopic==
	Features:<ref name=pmid22885379/>		Features:<ref name=pmid22885379/>
	*Like [[clear cell carcinoma]] elsewhere:		*Clear cytoplasm - '''key feature'''.
	**Clear cytoplasm - '''key feature'''.		**May be focal/absent!
	***May be absent!
	**Cells have large free/luminal surface area (hobnailing pattern) and small non-free surface.		**Cells have large free/luminal surface area (hobnailing pattern) and small non-free surface.
	**Moderate-to-severe [[nuclear pleomorphism]].		*Moderate-to-severe [[nuclear pleomorphism]].
	**Tubular and/or cystic morphology.		*Tubular and/or cystic morphology.
	***May be (simple) papillary and/or solid.		**May be (simple) papillary and/or solid.
	*Adenosis - typically adjacent.		*Adenosis - typically adjacent.

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	*[[Clear cell carcinoma of the endometrium]] - diagnosis based on clinico-radiologic correlation (IHC & histology not useful).<ref name=pmid22885379>{{Cite journal \| last1 = Offman \| first1 = SL. \| last2 = Longacre \| first2 = TA. \| title = Clear cell carcinoma of the female genital tract (not everything is as clear as it seems). \| journal = Adv Anat Pathol \| volume = 19 \| issue = 5 \| pages = 296-312 \| month = Sep \| year = 2012 \| doi = 10.1097/PAP.0b013e31826663b1 \| PMID = 22885379 }}</ref>		*[[Clear cell carcinoma of the endometrium]] - diagnosis based on clinico-radiologic correlation (IHC & histology not useful).<ref name=pmid22885379>{{Cite journal \| last1 = Offman \| first1 = SL. \| last2 = Longacre \| first2 = TA. \| title = Clear cell carcinoma of the female genital tract (not everything is as clear as it seems). \| journal = Adv Anat Pathol \| volume = 19 \| issue = 5 \| pages = 296-312 \| month = Sep \| year = 2012 \| doi = 10.1097/PAP.0b013e31826663b1 \| PMID = 22885379 }}</ref>
	*[[Serous carcinoma of the endometrium]].		*[[Serous carcinoma of the endometrium]].
	*[[Serous carcinoma of the uterine cervix]].		*[[Serous carcinoma]] of the uterine cervix.
	*[[Mesonephric adenocarcinoma]].		*[[Mesonephric adenocarcinoma]].

Michael: /* IHC */

2014-04-25T18:40:25Z

IHC

← Older revision		Revision as of 18:40, 25 April 2014
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	==IHC==		==IHC==
	Features:<ref>{{~~Ref\|GP~~\|120}}</ref>		Features:<ref>{{Ref_GP\|120}}</ref>
	*CK7 +ve.		*CK7 +ve.
	*ER -ve.		*ER -ve.

Michael: /* IHC */

2014-04-24T14:03:26Z

IHC

← Older revision		Revision as of 14:03, 24 April 2014
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	*ER -ve.		*ER -ve.
	*PR -ve.		*PR -ve.

			Others - one case only:<ref>{{Cite journal \| last1 = Terada \| first1 = T. \| title = Clear cell adenocarcinoma of the uterine cervix in a young pregnant woman: a case report with immunohistochemical study. \| journal = Med Oncol \| volume = 28 \| issue = 1 \| pages = 290-3 \| month = Mar \| year = 2011 \| doi = 10.1007/s12032-009-9410-x \| PMID = 20054717 }}</ref>
			*CA-125 +ve.
			*p53 +ve.
			*CEA -ve.
			*CK34betaE12 -ve.

	==See also==		==See also==

Michael: /* Microscopic */

2014-04-24T13:57:27Z

Microscopic

← Older revision		Revision as of 13:57, 24 April 2014
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	*[[Serous carcinoma of the endometrium]].		*[[Serous carcinoma of the endometrium]].
	*[[Serous carcinoma of the uterine cervix]].		*[[Serous carcinoma of the uterine cervix]].
			*[[Mesonephric adenocarcinoma]].

	===Images===		===Images===

Michael: /* IHC */

2014-04-24T13:56:59Z

IHC

← Older revision		Revision as of 13:56, 24 April 2014
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	==IHC==		==IHC==
	*Essentially considered to be like ''[[endometrial clear cell carcinoma]]''.<ref ~~name=pmid22885379~~/>		Features:<ref>{{Ref\|GP\|120}}</ref>
			*CK7 +ve.
			*ER -ve.
			*PR -ve.

	==See also==		==See also==