Clear cell adenocarcinoma of the urethra - Revision history

Michael at 19:38, 18 June 2024

2024-06-18T19:38:23Z

← Older revision		Revision as of 19:38, 18 June 2024
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	==IHC==		==IHC==
	Features:<ref name=pmid23307189/>		Features:<ref name=pmid23307189/>
	*PAX8 +ve/-ve (2 +ve in 4 cases.		*PAX8 +ve/-ve (2 +ve in 4 cases).
	*CK7 +ve/-ve (2 +ve in 4 cases).		*CK7 +ve/-ve (2 +ve in 4 cases).
	*Vimentin +ve (3 +ve in 4 cases).		*Vimentin +ve (3 +ve in 4 cases).

Michael: /* Microscopic */

2014-11-13T20:59:57Z

Microscopic

← Older revision		Revision as of 20:59, 13 November 2014
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	DDx:		DDx:
	*[[Nephrogenic adenoma]]<ref name=pmid23307189/><ref name=pmid21496868>{{Cite journal \| last1 = Brimo \| first1 = F. \| last2 = Herawi \| first2 = M. \| last3 = Sharma \| first3 = R. \| last4 = Netto \| first4 = GJ. \| last5 = Epstein \| first5 = JI. \| last6 = Illei \| first6 = PB. \| title = Hepatocyte nuclear factor-1β expression in clear cell adenocarcinomas of the bladder and urethra: diagnostic utility and implications for histogenesis. \| journal = Hum Pathol \| volume = 42 \| issue = 11 \| pages = 1613-9 \| month = Nov \| year = 2011 \| doi = 10.1016/j.humpath.2011.01.007 \| PMID = 21496868 }}</ref> - also has hobnailing.		*[[Nephrogenic adenoma]]<ref name=pmid23307189/><ref name=pmid21496868>{{Cite journal \| last1 = Brimo \| first1 = F. \| last2 = Herawi \| first2 = M. \| last3 = Sharma \| first3 = R. \| last4 = Netto \| first4 = GJ. \| last5 = Epstein \| first5 = JI. \| last6 = Illei \| first6 = PB. \| title = Hepatocyte nuclear factor-1β expression in clear cell adenocarcinomas of the bladder and urethra: diagnostic utility and implications for histogenesis. \| journal = Hum Pathol \| volume = 42 \| issue = 11 \| pages = 1613-9 \| month = Nov \| year = 2011 \| doi = 10.1016/j.humpath.2011.01.007 \| PMID = 21496868 }}</ref> - also has hobnailing, not mitotically active, no necrosis, no or mild [[nuclear atypia]].
	*[[Clear cell renal cell carcinoma]].		*[[Clear cell renal cell carcinoma]].
	*[[Clear cell adenocarcinoma]] of the gynecologic tract.		*[[Clear cell adenocarcinoma]] of the gynecologic tract.

Michael: /* IHC */

2014-11-13T20:54:22Z

IHC

← Older revision		Revision as of 20:54, 13 November 2014
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	*[[PSA]] -ve.		*[[PSA]] -ve.
	*p16 -ve.		*p16 -ve.
			*Ki-67 ~ 47/200 on average cells.
			**5.5/200 cells on average in nephrogenic adenoma.<ref name=pmid9865832>{{Cite journal \| last1 = Gilcrease \| first1 = MZ. \| last2 = Delgado \| first2 = R. \| last3 = Vuitch \| first3 = F. \| last4 = Albores-Saavedra \| first4 = J. \| title = Clear cell adenocarcinoma and nephrogenic adenoma of the urethra and urinary bladder: a histopathologic and immunohistochemical comparison. \| journal = Hum Pathol \| volume = 29 \| issue = 12 \| pages = 1451-6 \| month = Dec \| year = 1998 \| doi = \| PMID = 9865832 }}</ref>

	==See also==		==See also==

Michael: /* Microscopic */

2014-11-13T20:34:06Z

Microscopic

← Older revision		Revision as of 20:34, 13 November 2014
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	DDx:		DDx:
	*[[Nephrogenic adenoma]]<ref name=pmid23307189/> - also has hobnailing.		*[[Nephrogenic adenoma]]<ref name=pmid23307189/><ref name=pmid21496868>{{Cite journal \| last1 = Brimo \| first1 = F. \| last2 = Herawi \| first2 = M. \| last3 = Sharma \| first3 = R. \| last4 = Netto \| first4 = GJ. \| last5 = Epstein \| first5 = JI. \| last6 = Illei \| first6 = PB. \| title = Hepatocyte nuclear factor-1β expression in clear cell adenocarcinomas of the bladder and urethra: diagnostic utility and implications for histogenesis. \| journal = Hum Pathol \| volume = 42 \| issue = 11 \| pages = 1613-9 \| month = Nov \| year = 2011 \| doi = 10.1016/j.humpath.2011.01.007 \| PMID = 21496868 }}</ref> - also has hobnailing.
	*[[Clear cell renal cell carcinoma]].		*[[Clear cell renal cell carcinoma]].
	*[[Clear cell adenocarcinoma]] of the gynecologic tract.		*[[Clear cell adenocarcinoma]] of the gynecologic tract.

Michael: /* Microscopic */

2014-11-13T20:27:52Z

Microscopic

← Older revision		Revision as of 20:27, 13 November 2014
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	www:		www:
	*[http://www.ncbi.nlm.nih.gov/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&p=PMC3&id=3936309_gr1.jpg CCA of the urethra (nih.gov)].<ref name=pmid24389164/>		*[http://www.ncbi.nlm.nih.gov/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&p=PMC3&id=3936309_gr1.jpg CCA of the urethra (nih.gov)].<ref name=pmid24389164/>
			*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479785/figure/F3/ CCA of the urethra (nih.gov)].<ref>{{Cite journal \| last1 = Han \| first1 = JY. \| last2 = Kim \| first2 = KH. \| last3 = Kim \| first3 = L. \| last4 = Choi \| first4 = SJ. \| last5 = Park \| first5 = IS. \| last6 = Kim \| first6 = JM. \| last7 = Chu \| first7 = YC. \| last8 = Yoon \| first8 = SM. \| title = Cytologic findings of clear cell adenocarcinoma of the urethra: a case report. \| journal = Korean J Pathol \| volume = 46 \| issue = 2 \| pages = 210-4 \| month = Apr \| year = 2012 \| doi = 10.4132/KoreanJPathol.2012.46.2.210 \| PMID = 23110004 }}</ref>

	==IHC==		==IHC==

Michael: /* General */

2014-11-12T20:26:03Z

General

← Older revision		Revision as of 20:26, 12 November 2014
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	==General==		==General==
	*Predominantly in women.<ref name=pmid24389164>{{Cite journal \| last1 = Mehra \| first1 = R. \| last2 = Vats \| first2 = P. \| last3 = Kalyana-Sundaram \| first3 = S. \| last4 = Udager \| first4 = AM. \| last5 = Roh \| first5 = M. \| last6 = Alva \| first6 = A. \| last7 = Pan \| first7 = J. \| last8 = Lonigro \| first8 = RJ. \| last9 = Siddiqui \| first9 = J. \| title = Primary urethral clear-cell adenocarcinoma: comprehensive analysis by surgical pathology, cytopathology, and next-generation sequencing. \| journal = Am J Pathol \| volume = 184 \| issue = 3 \| pages = 584-91 \| month = Mar \| year = 2014 \| doi = 10.1016/j.ajpath.2013.11.023 \| PMID = 24389164 }}</ref>		*Predominantly in women.<ref name=pmid24389164>{{Cite journal \| last1 = Mehra \| first1 = R. \| last2 = Vats \| first2 = P. \| last3 = Kalyana-Sundaram \| first3 = S. \| last4 = Udager \| first4 = AM. \| last5 = Roh \| first5 = M. \| last6 = Alva \| first6 = A. \| last7 = Pan \| first7 = J. \| last8 = Lonigro \| first8 = RJ. \| last9 = Siddiqui \| first9 = J. \| title = Primary urethral clear-cell adenocarcinoma: comprehensive analysis by surgical pathology, cytopathology, and next-generation sequencing. \| journal = Am J Pathol \| volume = 184 \| issue = 3 \| pages = 584-91 \| month = Mar \| year = 2014 \| doi = 10.1016/j.ajpath.2013.11.023 \| PMID = 24389164 }}</ref>
	*Pathogenesis not well understood - may arise from:
	**Muellerian rests or [[urothelium]].<ref name=pmid24389164/>		Pathogenesis not well understood - may arise from:
	**Shed [[kidney tumours\|kidney cells]].<ref name=pmid23307189/>		*Muellerian rests or [[urothelium]].<ref name=pmid24389164/>
	**[[Nephrogenic adenoma]] - malignant transformation.<ref name=pmid24389164/>		*Shed [[kidney tumours\|kidney cells]].<ref name=pmid23307189/>
			*[[Nephrogenic adenoma]] - malignant transformation.<ref name=pmid24389164/>

	==Microscopic==		==Microscopic==

Michael: /* General */

2014-11-12T20:25:34Z

General

← Older revision		Revision as of 20:25, 12 November 2014
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	==General==		==General==
	*Predominantly in women.<ref name=pmid24389164>{{Cite journal \| last1 = Mehra \| first1 = R. \| last2 = Vats \| first2 = P. \| last3 = Kalyana-Sundaram \| first3 = S. \| last4 = Udager \| first4 = AM. \| last5 = Roh \| first5 = M. \| last6 = Alva \| first6 = A. \| last7 = Pan \| first7 = J. \| last8 = Lonigro \| first8 = RJ. \| last9 = Siddiqui \| first9 = J. \| title = Primary urethral clear-cell adenocarcinoma: comprehensive analysis by surgical pathology, cytopathology, and next-generation sequencing. \| journal = Am J Pathol \| volume = 184 \| issue = 3 \| pages = 584-91 \| month = Mar \| year = 2014 \| doi = 10.1016/j.ajpath.2013.11.023 \| PMID = 24389164 }}</ref>		*Predominantly in women.<ref name=pmid24389164>{{Cite journal \| last1 = Mehra \| first1 = R. \| last2 = Vats \| first2 = P. \| last3 = Kalyana-Sundaram \| first3 = S. \| last4 = Udager \| first4 = AM. \| last5 = Roh \| first5 = M. \| last6 = Alva \| first6 = A. \| last7 = Pan \| first7 = J. \| last8 = Lonigro \| first8 = RJ. \| last9 = Siddiqui \| first9 = J. \| title = Primary urethral clear-cell adenocarcinoma: comprehensive analysis by surgical pathology, cytopathology, and next-generation sequencing. \| journal = Am J Pathol \| volume = 184 \| issue = 3 \| pages = 584-91 \| month = Mar \| year = 2014 \| doi = 10.1016/j.ajpath.2013.11.023 \| PMID = 24389164 }}</ref>
	*~~May be of~~ [[kidney tumours\|~~renal origin~~]].<ref name=pmid23307189/>		*Pathogenesis not well understood - may arise from:
			**Muellerian rests or [[urothelium]].<ref name=pmid24389164/>
			**Shed [[kidney tumours\|kidney cells]].<ref name=pmid23307189/>
			**[[Nephrogenic adenoma]] - malignant transformation.<ref name=pmid24389164/>

	==Microscopic==		==Microscopic==

Michael: /* General */

2014-11-12T20:02:46Z

General

← Older revision		Revision as of 20:02, 12 November 2014
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	==General==		==General==
	*Predominantly in women.<ref name=pmid24389164>{{Cite journal \| last1 = Mehra \| first1 = R. \| last2 = Vats \| first2 = P. \| last3 = Kalyana-Sundaram \| first3 = S. \| last4 = Udager \| first4 = AM. \| last5 = Roh \| first5 = M. \| last6 = Alva \| first6 = A. \| last7 = Pan \| first7 = J. \| last8 = Lonigro \| first8 = RJ. \| last9 = Siddiqui \| first9 = J. \| title = Primary urethral clear-cell adenocarcinoma: comprehensive analysis by surgical pathology, cytopathology, and next-generation sequencing. \| journal = Am J Pathol \| volume = 184 \| issue = 3 \| pages = 584-91 \| month = Mar \| year = 2014 \| doi = 10.1016/j.ajpath.2013.11.023 \| PMID = 24389164 }}</ref>		*Predominantly in women.<ref name=pmid24389164>{{Cite journal \| last1 = Mehra \| first1 = R. \| last2 = Vats \| first2 = P. \| last3 = Kalyana-Sundaram \| first3 = S. \| last4 = Udager \| first4 = AM. \| last5 = Roh \| first5 = M. \| last6 = Alva \| first6 = A. \| last7 = Pan \| first7 = J. \| last8 = Lonigro \| first8 = RJ. \| last9 = Siddiqui \| first9 = J. \| title = Primary urethral clear-cell adenocarcinoma: comprehensive analysis by surgical pathology, cytopathology, and next-generation sequencing. \| journal = Am J Pathol \| volume = 184 \| issue = 3 \| pages = 584-91 \| month = Mar \| year = 2014 \| doi = 10.1016/j.ajpath.2013.11.023 \| PMID = 24389164 }}</ref>
	*May be of renal origin.<ref name=pmid23307189/>		*May be of [[kidney tumours\|renal origin]].<ref name=pmid23307189/>

	==Microscopic==		==Microscopic==

Michael: /* Microscopic */

2014-11-12T19:08:49Z

Microscopic

← Older revision		Revision as of 19:08, 12 November 2014
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	==Microscopic==		==Microscopic==
	Features:<ref name=pmid24389164/>		Features:<ref name=pmid24389164/>
	*Clear cells - at least focally.		*Clear cells (at least focally).
	*Hobnailing - classic feature.		**Columnar or cuboidal morphology.
			**At least moderate [[nuclear pleomorphism]].<ref name=pmid23307189/>
			*Hobnailing (classic feature).

	Note:		Note:

Michael at 19:06, 12 November 2014

2014-11-12T19:06:20Z

← Older revision		Revision as of 19:06, 12 November 2014
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	==General==		==General==
	*Predominantly in women.<ref name=pmid24389164>{{Cite journal \| last1 = Mehra \| first1 = R. \| last2 = Vats \| first2 = P. \| last3 = Kalyana-Sundaram \| first3 = S. \| last4 = Udager \| first4 = AM. \| last5 = Roh \| first5 = M. \| last6 = Alva \| first6 = A. \| last7 = Pan \| first7 = J. \| last8 = Lonigro \| first8 = RJ. \| last9 = Siddiqui \| first9 = J. \| title = Primary urethral clear-cell adenocarcinoma: comprehensive analysis by surgical pathology, cytopathology, and next-generation sequencing. \| journal = Am J Pathol \| volume = 184 \| issue = 3 \| pages = 584-91 \| month = Mar \| year = 2014 \| doi = 10.1016/j.ajpath.2013.11.023 \| PMID = 24389164 }}</ref>		*Predominantly in women.<ref name=pmid24389164>{{Cite journal \| last1 = Mehra \| first1 = R. \| last2 = Vats \| first2 = P. \| last3 = Kalyana-Sundaram \| first3 = S. \| last4 = Udager \| first4 = AM. \| last5 = Roh \| first5 = M. \| last6 = Alva \| first6 = A. \| last7 = Pan \| first7 = J. \| last8 = Lonigro \| first8 = RJ. \| last9 = Siddiqui \| first9 = J. \| title = Primary urethral clear-cell adenocarcinoma: comprehensive analysis by surgical pathology, cytopathology, and next-generation sequencing. \| journal = Am J Pathol \| volume = 184 \| issue = 3 \| pages = 584-91 \| month = Mar \| year = 2014 \| doi = 10.1016/j.ajpath.2013.11.023 \| PMID = 24389164 }}</ref>
			*May be of renal origin.<ref name=pmid23307189/>

	==Microscopic==		==Microscopic==
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	DDx:		DDx:
	*[[Nephrogenic adenoma]] - also has hobnailing.		*[[Nephrogenic adenoma]]<ref name=pmid23307189/> - also has hobnailing.
	*[[Clear cell ~~tumours~~]].		*[[Clear cell renal cell carcinoma]].
	**[[Clear cell adenocarcinoma]] of the gynecologic tract.		*[[Clear cell adenocarcinoma]] of the gynecologic tract.
	**[[~~Clear~~ cell ~~renal cell carcinoma~~]].		*Other [[clear cell tumours]].
	**Others.

	===Images===		===Images===
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	==IHC==		==IHC==
	Features:		Features:<ref name=pmid23307189/>
	*PAX8 +ve.		*PAX8 +ve/-ve (2 +ve in 4 cases.
	*CK7 +ve.		*CK7 +ve/-ve (2 +ve in 4 cases).
			*Vimentin +ve (3 +ve in 4 cases).
			*CK20 -ve/+ve (1 +ve in 4 cases).

	Others:		Others:<ref name=pmid23307189/>
	*CK20 -ve.
	*ER -ve.		*ER -ve.
	*PR -ve.
	*p53 -ve.
	*p63 -ve.		*p63 -ve.
			*[[PSA]] -ve.
			*p16 -ve.

	==See also==		==See also==