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	#~~redirect~~ [[Liver pathology~~#Cirrhosis~~]]		'''Cirrhosis''' is end stage [[liver fibrosis\|fibrosis]] of the [[liver]].

			==General==
			*Cirrhosis ''is'' stage 4 (Laennec).

			Etiology:
			*Perisinusoidal fibrosis may suggest congestive hepatopathy.<ref>OA. September 15, 2009.</ref>
			*In NAFLD portal-to-portal fibrosis (septal/bridging fibrosis) tends to be more common than perivenular fibrosis.<ref name=pmid14991537>Pathologic features associated with fibrosis in nonalcoholic fatty liver disease. Gramlich T, Kleiner DE, McCullough AJ, Matteoni CA, Boparai N, Younossi ZM. Hum Pathol. 2004 Feb;35(2):196-9. PMID 14991537.</ref>
			*The etiology of late stage fibrosis (cirrhosis), may be impossible to determine.

			Prognosis:
			*The classic teaching is that cirrhosis is irreversible; however, there is increasing evidence that it regresses.<ref name=pmid11079009>{{Cite journal \| last1 = Wanless \| first1 = IR. \| last2 = Nakashima \| first2 = E. \| last3 = Sherman \| first3 = M. \| title = Regression of human cirrhosis. Morphologic features and the genesis of incomplete septal cirrhosis. \| journal = Arch Pathol Lab Med \| volume = 124 \| issue = 11 \| pages = 1599-607 \| month = Nov \| year = 2000 \| doi = 10.1043/0003-9985(2000)1241599:ROHC2.0.CO;2 \| PMID = 11079009 }}</ref><ref name=pmid21286337>{{Cite journal \| last1 = Kim \| first1 = SU. \| last2 = Park \| first2 = JY. \| last3 = Kim \| first3 = do Y. \| last4 = Ahn \| first4 = SH. \| last5 = Choi \| first5 = EH. \| last6 = Seok \| first6 = JY. \| last7 = Lee \| first7 = JM. \| last8 = Park \| first8 = YN. \| last9 = Chon \| first9 = CY. \| title = Non-invasive assessment of changes in liver fibrosis via liver stiffness measurement in patients with chronic hepatitis B: impact of antiviral treatment on fibrosis regression. \| journal = Hepatol Int \| volume = 4 \| issue = 4 \| pages = 673-80 \| month = \| year = 2010 \| doi = 10.1007/s12072-010-9201-7 \| PMID = 21286337 }}</ref><ref name=pmid24304452>{{Cite journal \| last1 = Casado \| first1 = JL. \| last2 = Quereda \| first2 = C. \| last3 = Moreno \| first3 = A. \| last4 = Pérez-Elías \| first4 = MJ. \| last5 = Martí-Belda \| first5 = P. \| last6 = Moreno \| first6 = S. \| title = Regression of liver fibrosis is progressive after sustained virological response to HCV therapy in patients with hepatitis C and HIV coinfection. \| journal = J Viral Hepat \| volume = 20 \| issue = 12 \| pages = 829-37 \| month = Dec \| year = 2013 \| doi = 10.1111/jvh.12108 \| PMID = 24304452 }}</ref>

			Special types:
			*Garland cirrhosis ([[AKA]] holly leaf cirrhosis) - see ''[[primary biliary cirrhosis]]''.

			==Gross==
			Cirrhosis can be divided (in gross pathology) into:
			*Micronodular cirrhosis - classically due to [[alcohol]].
			**Uniform, diffuse.
			*Macronodular cirrhosis - classically due to viral hepatitis.
			**Irregular.

			===Images===
			*[http://www.meddean.luc.edu/lumen/MedEd/orfpath/cirhosis.htm Cirrhosis - macronodular & micronodular (meddean.luc.edu)].

			==Microscopic==
			Formal Robbins definitions (all three required) is:<ref name=Ref_PCPBoD8_439>{{Ref PCPBoD8\|439}}</ref>
			#Bridging fibrosis.
			#Nodule formation.
			#Disruption of the hepatic architecture.

			===Images===
			<gallery>
			Image:Cirrhosis_high_mag.jpg \| Cirrhotic liver - trichrome stain. (WC/Nephron)
			</gallery>

			==See also==
			*[[Medical liver pathology]].

			==References==
			{{Reflist\|1}}

			[[Category:Diagnosis]]
			[[Category:Liver pathology]]

Michael: redirect

2011-11-20T02:07:50Z

redirect

New page

#redirect [[Liver pathology#Cirrhosis]]

Cirrhosis - Revision history

Michael: split out

Michael: redirect