Choroid plexus papilloma - Revision history

Michael: /* Gross */ wikify

2015-07-07T02:19:25Z

Gross: wikify

← Older revision		Revision as of 02:19, 7 July 2015
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	* 5% third ventricle.		* 5% third ventricle.
	* 40% fourth ventricle.		* 40% fourth ventricle.
	* 5% multiple tumours or cerebellopontine angle.		* 5% multiple tumours or [[cerebellopontine angle]].

	==Microscopic==		==Microscopic==

Michael: tweak some more

2015-05-01T07:11:59Z

tweak some more

← Older revision		Revision as of 07:11, 1 May 2015
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	\| Micro = papillary epithelial structures with bland cytology, mitoses uncommon		\| Micro = papillary epithelial structures with bland cytology, mitoses uncommon
	\| Subtypes =		\| Subtypes =
	\| LMDDx = metastatic papillary [[adenocarcinoma]], [[ELST]]		\| LMDDx = [[choroid plexus carcinoma]], metastatic papillary [[adenocarcinoma]], [[ELST]]
	\| Stains =		\| Stains =
	\| IHC = Kir 7.1 +ve, EAAT1 +ve, GFAP +ve/-ve, S-100 +ve/-ve, CK +ve/-ve		\| IHC = Kir 7.1 +ve, EAAT1 +ve, GFAP +ve/-ve, S-100 +ve/-ve, CK +ve/-ve
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	* Atypical CPP: 2 or more mitoses /10 HPF.<ref name=pmid19543851>{{Cite journal \| last1 = Wrede \| first1 = B. \| last2 = Hasselblatt \| first2 = M. \| last3 = Peters \| first3 = O. \| last4 = Thall \| first4 = PF. \| last5 = Kutluk \| first5 = T. \| last6 = Moghrabi \| first6 = A. \| last7 = Mahajan \| first7 = A. \| last8 = Rutkowski \| first8 = S. \| last9 = Diez \| first9 = B. \| title = Atypical choroid plexus papilloma: clinical experience in the CPT-SIOP-2000 study. \| journal = J Neurooncol \| volume = 95 \| issue = 3 \| pages = 383-92 \| month = Dec \| year = 2009 \| doi = 10.1007/s11060-009-9936-y \| PMID = 19543851 }}</ref>		* Atypical CPP: 2 or more mitoses /10 HPF.<ref name=pmid19543851>{{Cite journal \| last1 = Wrede \| first1 = B. \| last2 = Hasselblatt \| first2 = M. \| last3 = Peters \| first3 = O. \| last4 = Thall \| first4 = PF. \| last5 = Kutluk \| first5 = T. \| last6 = Moghrabi \| first6 = A. \| last7 = Mahajan \| first7 = A. \| last8 = Rutkowski \| first8 = S. \| last9 = Diez \| first9 = B. \| title = Atypical choroid plexus papilloma: clinical experience in the CPT-SIOP-2000 study. \| journal = J Neurooncol \| volume = 95 \| issue = 3 \| pages = 383-92 \| month = Dec \| year = 2009 \| doi = 10.1007/s11060-009-9936-y \| PMID = 19543851 }}</ref>

	~~==IHC==~~		DDx:
	*~~CK7+ve~~.		*[[Choroid plexus carcinoma]].
	*~~CK20-ve (typically)~~.		*[[Metastatic]] papillary carcinoma.
	*~~S-100+/-.~~		*[[Endolymphatic sac tumour]] (ELST).
	*EMA-ve.
	*GFAP +/-.
	*Kir 7.1+ve.
	*EAAT1+ve.

	===Images===		===Images===
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	www:		www:
	*[http://path.upmc.edu/cases/case551.html Choroid plexus papilloma - oncocytic variant - several images (upmc.edu)].		*[http://path.upmc.edu/cases/case551.html Choroid plexus papilloma - oncocytic variant - several images (upmc.edu)].

			==IHC==
			*CK7 +ve.
			*CK20 -ve (typically).
			*S-100 +ve/-ve.
			*EMA -ve.
			*GFAP +ve/-ve.
			*Kir 7.1 +ve.
			*EAAT1 +ve.

	==See also==		==See also==

Michael: tweak

2015-05-01T07:07:59Z

tweak

← Older revision		Revision as of 07:07, 1 May 2015
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	\| Caption = Choroid plexus papilloma [[H&E stain]].		\| Caption = Choroid plexus papilloma [[H&E stain]].
	\| Synonyms =		\| Synonyms =
	\| Micro = ~~Papillary~~ epithelial structures.		\| Micro = papillary epithelial structures with bland cytology, mitoses uncommon
	\| Subtypes =		\| Subtypes =
	\| LMDDx = metastatic papillary [[adenocarcinoma]], [[ELST]]		\| LMDDx = metastatic papillary [[adenocarcinoma]], [[ELST]]
	\| Stains =		\| Stains =
	\| IHC = Kir 7.1+ve, EAAT1+ve, GFAP+/-, S-100+/-, CK+/-		\| IHC = Kir 7.1 +ve, EAAT1 +ve, GFAP +ve/-ve, S-100 +ve/-ve, CK +ve/-ve
	\| EM =		\| EM =
	\| Molecular =		\| Molecular =
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	\| Gross =		\| Gross =
	\| Grossing =		\| Grossing =
	\| Site = all ventricles, cerebellopontine angle		\| Site = all ventricles, [[cerebellopontine angle]] - see ''[[brain tumours]]''
	\| Assdx =		\| Assdx =
	\| Syndromes =		\| Syndromes =
	\| Clinicalhx =		\| Clinicalhx = children
	\| Signs =		\| Signs =
	\| Symptoms = hydrocephalus		\| Symptoms = hydrocephalus
	\| Prevalence = ~~Children~~		\| Prevalence =
	\| Bloodwork =		\| Bloodwork =
	\| Rads =		\| Rads =
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	\| Tx =		\| Tx =
	}}		}}
			'''Choroid plexus papilloma''', abbreviated '''CPP''', is a benign [[neuropathology]] arising in the ventricles of the brain.
	'''Choroid plexus papilloma''' is a benign [[neuropathology]] arising in the ventricles of the brain.

	==General==		==General==
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	**WHO grade I (ICD-O: 9390/1).		**WHO grade I (ICD-O: 9390/1).
	**WHO grade II - atypical choroid plexus papilloma (ICD-O: 9390/1).		**WHO grade II - atypical choroid plexus papilloma (ICD-O: 9390/1).
	* Less than 1% of all brain ~~tumors~~.		* Less than 1% of all [[brain tumours]].
	** ~~Approx.~~ 10-20% of all ~~tumors~~ in the first year of life.		** Approximately 10-20% of all tumours in the first year of life.
	** Congenital ~~tumors~~ reported.		** Congenital tumours reported.
	*~~Usu.~~ laternal ventricle in ~~kids~~.<ref>URL: [http://emedicine.medscape.com/article/250795-overview http://emedicine.medscape.com/article/250795-overview]. Accessed on: 3 June 2011.</ref>		*Usually laternal ventricle in children.<ref>URL: [http://emedicine.medscape.com/article/250795-overview http://emedicine.medscape.com/article/250795-overview]. Accessed on: 3 June 2011.</ref>

	==Gross==		==Gross==
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	* 5% third ventricle.		* 5% third ventricle.
	* 40% fourth ventricle.		* 40% fourth ventricle.
	* 5% multiple ~~tumors~~ or cerebellopontine angle.		* 5% multiple tumours or cerebellopontine angle.

	==Microscopic==		==Microscopic==
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	*Rarely [[oncocytoma\|oncocytic]] changes, mucinous degeneration.		*Rarely [[oncocytoma\|oncocytic]] changes, mucinous degeneration.
	*[[Necrosis]] and brain invasion is uncommon.		*[[Necrosis]] and brain invasion is uncommon.
	* Atypical CPP: 2 or more mitoses /10 HPF.<ref>{{Cite journal \| last1 = Wrede \| first1 = B. \| last2 = Hasselblatt \| first2 = M. \| last3 = Peters \| first3 = O. \| last4 = Thall \| first4 = PF. \| last5 = Kutluk \| first5 = T. \| last6 = Moghrabi \| first6 = A. \| last7 = Mahajan \| first7 = A. \| last8 = Rutkowski \| first8 = S. \| last9 = Diez \| first9 = B. \| title = Atypical choroid plexus papilloma: clinical experience in the CPT-SIOP-2000 study. \| journal = J Neurooncol \| volume = 95 \| issue = 3 \| pages = 383-92 \| month = Dec \| year = 2009 \| doi = 10.1007/s11060-009-9936-y \| PMID = 19543851 }}</ref>		* Atypical CPP: 2 or more mitoses /10 HPF.<ref name=pmid19543851>{{Cite journal \| last1 = Wrede \| first1 = B. \| last2 = Hasselblatt \| first2 = M. \| last3 = Peters \| first3 = O. \| last4 = Thall \| first4 = PF. \| last5 = Kutluk \| first5 = T. \| last6 = Moghrabi \| first6 = A. \| last7 = Mahajan \| first7 = A. \| last8 = Rutkowski \| first8 = S. \| last9 = Diez \| first9 = B. \| title = Atypical choroid plexus papilloma: clinical experience in the CPT-SIOP-2000 study. \| journal = J Neurooncol \| volume = 95 \| issue = 3 \| pages = 383-92 \| month = Dec \| year = 2009 \| doi = 10.1007/s11060-009-9936-y \| PMID = 19543851 }}</ref>


	==IHC==		==IHC==

Jensflorian: +cat

2015-04-29T08:44:24Z

+cat

← Older revision		Revision as of 08:44, 29 April 2015
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	[[Category:Neuropathology tumours]]		[[Category:Neuropathology tumours]]
	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Papillary tumour]]

Jensflorian: update + pictures

2015-04-29T08:33:26Z

update + pictures

← Older revision		Revision as of 08:33, 29 April 2015
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	\| Signs =		\| Signs =
	\| Symptoms = hydrocephalus		\| Symptoms = hydrocephalus
	\| Prevalence =		\| Prevalence = Children
	\| Bloodwork =		\| Bloodwork =
	\| Rads =		\| Rads =
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	==General==		==General==
	*Benign - WHO grade I.<ref name=~~pmid20644273~~>{{~~Cite journal~~ \| last1 = Menon \| first1 = G. \| last2 = Nair \| first2 = SN. \| last3 = Baldawa \| first3 = SS. \| last4 = Rao \| first4 = RB. \| last5 = Krishnakumar \| first5 = KP. \| last6 = Gopalakrishnan \| first6 = CV. \| title = Choroid plexus tumors: ~~an institutional series of 25 patients~~. ~~\| journal = Neurol India \| volume = 58 \| issue = 3 \| pages = 429~~-~~35 \| month = \| year = \| doi = 10.4103/0028~~-~~3886.66455 \| PMID = 20644273 \|URL = http~~:/~~/www~~.~~neurologyindia~~.~~com/article~~.~~asp?issn=0028~~-~~3886;~~year~~=2010;volume=58;issue=3;spage=429;epage=435;aulast=Menon }}</ref>~~		Features: <ref name=Ref_WHOCNS_82>{{Ref WHOCNS\|82}}</ref>
			*Low grade
			**WHO grade I (ICD-O: 9390/1).
			**WHO grade II - atypical choroid plexus papilloma (ICD-O: 9390/1).
			* Less than 1% of all brain tumors.
			** Approx. 10-20% of all tumors in the first year of life.
			** Congenital tumors reported.
	*Usu. laternal ventricle in kids.<ref>URL: [http://emedicine.medscape.com/article/250795-overview http://emedicine.medscape.com/article/250795-overview]. Accessed on: 3 June 2011.</ref>		*Usu. laternal ventricle in kids.<ref>URL: [http://emedicine.medscape.com/article/250795-overview http://emedicine.medscape.com/article/250795-overview]. Accessed on: 3 June 2011.</ref>

			==Gross==
			Features: <ref name=Ref_WHOCNS_82>{{Ref WHOCNS\|82}}</ref>
			* Adhere to ventricular walls.
			* Circumscribed.
			* Villous architecture.
			* 50% lateral ventricles.
			* 5% third ventricle.
			* 40% fourth ventricle.
			* 5% multiple tumors or cerebellopontine angle.

	==Microscopic==		==Microscopic==
	Features:		Features: <ref name=pmid20644273>{{Cite journal \| last1 = Menon \| first1 = G. \| last2 = Nair \| first2 = SN. \| last3 = Baldawa \| first3 = SS. \| last4 = Rao \| first4 = RB. \| last5 = Krishnakumar \| first5 = KP. \| last6 = Gopalakrishnan \| first6 = CV. \| title = Choroid plexus tumors: an institutional series of 25 patients. \| journal = Neurol India \| volume = 58 \| issue = 3 \| pages = 429-35 \| month = \| year = \| doi = 10.4103/0028-3886.66455 \| PMID = 20644273 \|URL = http://www.neurologyindia.com/article.asp?issn=0028-3886;year=2010;volume=58;issue=3;spage=429;epage=435;aulast=Menon }}</ref>
	*Simple epithelium.		*Simple epithelium.
	*Papillae.		*Papillae.
	*[[Psammoma body\|Psammoma bodies]].		*[[Psammoma body\|Psammoma bodies]].
			*Rarely [[oncocytoma\|oncocytic]] changes, mucinous degeneration.
			*[[Necrosis]] and brain invasion is uncommon.
			* Atypical CPP: 2 or more mitoses /10 HPF.<ref>{{Cite journal \| last1 = Wrede \| first1 = B. \| last2 = Hasselblatt \| first2 = M. \| last3 = Peters \| first3 = O. \| last4 = Thall \| first4 = PF. \| last5 = Kutluk \| first5 = T. \| last6 = Moghrabi \| first6 = A. \| last7 = Mahajan \| first7 = A. \| last8 = Rutkowski \| first8 = S. \| last9 = Diez \| first9 = B. \| title = Atypical choroid plexus papilloma: clinical experience in the CPT-SIOP-2000 study. \| journal = J Neurooncol \| volume = 95 \| issue = 3 \| pages = 383-92 \| month = Dec \| year = 2009 \| doi = 10.1007/s11060-009-9936-y \| PMID = 19543851 }}</ref>


			==IHC==
			*CK7+ve.
			*CK20-ve (typically).
			*S-100+/-.
			*EMA-ve.
			*GFAP +/-.
			*Kir 7.1+ve.
			*EAAT1+ve.

	===Images===		===Images===
	<gallery>		<gallery>
			File:Plexuspapillom_Makroskopie.png \| Choroid plexus papilloma can become quite large. (WC/marvin101)
			File:Plexuspapilloma_intraoperative_smear.jpg \| Intraoperative smear of a choroid plexus papilloma. (WC/jensflorian)
	Image:Choroid_plexus_papilloma_micrograph.jpg \| Choroid plexus papilloma. (WC)		Image:Choroid_plexus_papilloma_micrograph.jpg \| Choroid plexus papilloma. (WC)
			File:Atypical CPP Ki67 MIB1.jpg \| Elevated proliferative activity (MIB-1) in atypical CPP. (WC/marvin101)
	</gallery>		</gallery>
	www:		www:

Jensflorian: +infobox

2015-04-29T06:34:06Z

+infobox

← Older revision		Revision as of 06:34, 29 April 2015
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	'''Choroid plexus papilloma''' is a benign [[neuropathology]].		{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Choroidplexuspapilloma_HE400x.png
			\| Width =
			\| Caption = Choroid plexus papilloma [[H&E stain]].
			\| Synonyms =
			\| Micro = Papillary epithelial structures.
			\| Subtypes =
			\| LMDDx = metastatic papillary [[adenocarcinoma]], [[ELST]]
			\| Stains =
			\| IHC = Kir 7.1+ve, EAAT1+ve, GFAP+/-, S-100+/-, CK+/-
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = all ventricles, cerebellopontine angle
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms = hydrocephalus
			\| Prevalence =
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis =
			\| Other =
			\| ClinDDx =
			\| Tx =
			}}

			'''Choroid plexus papilloma''' is a benign [[neuropathology]] arising in the ventricles of the brain.

	==General==		==General==
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	*Simple epithelium.		*Simple epithelium.
	*Papillae.		*Papillae.
	*Psammoma bodies.		*[[Psammoma body\|Psammoma bodies]].

	===Images===		===Images===

Michael: /* See also */

2014-02-17T04:01:22Z

Michael at 04:01, 17 February 2014

2014-02-17T04:01:02Z

← Older revision		Revision as of 04:01, 17 February 2014
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	==See also==		==See also==
	*[[Neuropathology tumours]].		*[[Neuropathology tumours]].

			==References==
			{{Reflist\|2}}

	[[Category:Neuropathology tumours]]		[[Category:Neuropathology tumours]]
	[[Category:Diagnosis]]		[[Category:Diagnosis]]

Michael: split out

2014-02-17T04:00:13Z

split out

← Older revision		Revision as of 04:00, 17 February 2014
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	~~#redirect [[Neuropathology tumours#~~Choroid plexus papilloma]]		'''Choroid plexus papilloma''' is a benign [[neuropathology]].

			==General==
			*Benign - WHO grade I.<ref name=pmid20644273>{{Cite journal \| last1 = Menon \| first1 = G. \| last2 = Nair \| first2 = SN. \| last3 = Baldawa \| first3 = SS. \| last4 = Rao \| first4 = RB. \| last5 = Krishnakumar \| first5 = KP. \| last6 = Gopalakrishnan \| first6 = CV. \| title = Choroid plexus tumors: an institutional series of 25 patients. \| journal = Neurol India \| volume = 58 \| issue = 3 \| pages = 429-35 \| month = \| year = \| doi = 10.4103/0028-3886.66455 \| PMID = 20644273 \|URL = http://www.neurologyindia.com/article.asp?issn=0028-3886;year=2010;volume=58;issue=3;spage=429;epage=435;aulast=Menon }}</ref>
			*Usu. laternal ventricle in kids.<ref>URL: [http://emedicine.medscape.com/article/250795-overview http://emedicine.medscape.com/article/250795-overview]. Accessed on: 3 June 2011.</ref>

			==Microscopic==
			Features:
			*Simple epithelium.
			*Papillae.
			*Psammoma bodies.

			===Images===
			<gallery>
			Image:Choroid_plexus_papilloma_micrograph.jpg \| Choroid plexus papilloma. (WC)
			</gallery>
			www:
			*[http://path.upmc.edu/cases/case551.html Choroid plexus papilloma - oncocytic variant - several images (upmc.edu)].

			==See also==
			*[[Neuropathology tumours]].

			[[Category:Neuropathology tumours]]
	[[Category:Diagnosis]]		[[Category:Diagnosis]]

Michael: redirect

2011-10-18T04:02:31Z

redirect

New page

#redirect [[Neuropathology tumours#Choroid plexus papilloma]]

[[Category:Diagnosis]]