Choriocarcinoma - Revision history

Michael: more IHC

2024-06-18T19:00:27Z

more IHC

← Older revision		Revision as of 19:00, 18 June 2024
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	\| LMDDx = [[mixed germ cell tumour]], [[invasive hydatidiform mole]], [[placental site trophoblastic tumour]]		\| LMDDx = [[mixed germ cell tumour]], [[invasive hydatidiform mole]], [[placental site trophoblastic tumour]]
	\| Stains =		\| Stains =
	\| IHC = beta-hCG +ve, CD10 +ve, p63 +ve, OCT3 -ve		\| IHC = beta-hCG +ve, CD10 +ve, p63 +ve, OCT3 -ve, GATA3 +ve, CK7 +ve
	\| EM =		\| EM =
	\| Molecular =		\| Molecular =

Michael at 18:59, 18 June 2024

2024-06-18T18:59:23Z

← Older revision		Revision as of 18:59, 18 June 2024
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	*MUC-4 +ve.<ref name=pmid18059230>{{Cite journal \| last1 = Mao \| first1 = TL. \| last2 = Kurman \| first2 = RJ. \| last3 = Huang \| first3 = CC. \| last4 = Lin \| first4 = MC. \| last5 = Shih \| first5 = IeM. \| title = Immunohistochemistry of choriocarcinoma: an aid in differential diagnosis and in elucidating pathogenesis. \| journal = Am J Surg Pathol \| volume = 31 \| issue = 11 \| pages = 1726-32 \| month = Nov \| year = 2007 \| doi = 10.1097/PAS.0b013e318058a529 \| PMID = 18059230 }}</ref>		*MUC-4 +ve.<ref name=pmid18059230>{{Cite journal \| last1 = Mao \| first1 = TL. \| last2 = Kurman \| first2 = RJ. \| last3 = Huang \| first3 = CC. \| last4 = Lin \| first4 = MC. \| last5 = Shih \| first5 = IeM. \| title = Immunohistochemistry of choriocarcinoma: an aid in differential diagnosis and in elucidating pathogenesis. \| journal = Am J Surg Pathol \| volume = 31 \| issue = 11 \| pages = 1726-32 \| month = Nov \| year = 2007 \| doi = 10.1097/PAS.0b013e318058a529 \| PMID = 18059230 }}</ref>
	*CD10 +ve (10 +ve of 10 cases<ref name=pmid19145204>{{Cite journal \| last1 = Kalhor \| first1 = N. \| last2 = Ramirez \| first2 = PT. \| last3 = Deavers \| first3 = MT. \| last4 = Malpica \| first4 = A. \| last5 = Silva \| first5 = EG. \| title = Immunohistochemical studies of trophoblastic tumors. \| journal = Am J Surg Pathol \| volume = 33 \| issue = 4 \| pages = 633-8 \| month = Apr \| year = 2009 \| doi = 10.1097/PAS.0b013e318191f2eb \| PMID = 19145204 }}</ref>).		*CD10 +ve (10 +ve of 10 cases<ref name=pmid19145204>{{Cite journal \| last1 = Kalhor \| first1 = N. \| last2 = Ramirez \| first2 = PT. \| last3 = Deavers \| first3 = MT. \| last4 = Malpica \| first4 = A. \| last5 = Silva \| first5 = EG. \| title = Immunohistochemical studies of trophoblastic tumors. \| journal = Am J Surg Pathol \| volume = 33 \| issue = 4 \| pages = 633-8 \| month = Apr \| year = 2009 \| doi = 10.1097/PAS.0b013e318191f2eb \| PMID = 19145204 }}</ref>).
			*[[GATA3]] +ve.<ref name=pmid26772394>{{cite journal \|authors=Osman H, Cheng L, Ulbright TM, Idrees MT \|title=The utility of CDX2, GATA3, and DOG1 in the diagnosis of testicular neoplasms: an immunohistochemical study of 109 cases \|journal=Hum Pathol \|volume=48 \|issue= \|pages=18–24 \|date=February 2016 \|pmid=26772394 \|doi=10.1016/j.humpath.2015.09.028 \|url=}}</ref>

	Notes:		Notes:

Michael: /* Images */ +more images

2017-01-18T15:32:29Z

Images: +more images

← Older revision		Revision as of 15:32, 18 January 2017
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	===Images===		===Images===
			====Case====
	<gallery>		<gallery>
	Image: Choriocarcinoma - intermed mag.jpg \| Choriocarcinoma - intermed. mag. (WC/Nephron)		Image: Choriocarcinoma - intermed mag.jpg \| Choriocarcinoma - intermed. mag. (WC/Nephron)
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	Image: Choriocarcinoma -2- very high mag.jpg \| Choriocarcinoma - very high mag. (WC/Nephron)		Image: Choriocarcinoma -2- very high mag.jpg \| Choriocarcinoma - very high mag. (WC/Nephron)
	</gallery>		</gallery>
	www:		====Case====
			<gallery>
			Image: Choriocarcinoma to lung -- low mag.jpg \| Choriocarcinoma - low mag. (WC)
			Image: Choriocarcinoma to lung -- intermed mag.jpg \| Choriocarcinoma - intermed. mag. (WC)
			Image: Choriocarcinoma to lung -- high mag.jpg \| Choriocarcinoma - high mag. (WC)
			Image: Choriocarcinoma to lung - alt -- high mag.jpg \| Choriocarcinoma - high mag. (WC)
			Image: Choriocarcinoma to lung -- very high mag.jpg \| Choriocarcinoma - very high mag. (WC)
			</gallery>
			====www====
	*[http://www.webpathology.com/image.asp?n=5&Case=36 Choriocarcinoma - low mag. (webpathology.com)].		*[http://www.webpathology.com/image.asp?n=5&Case=36 Choriocarcinoma - low mag. (webpathology.com)].
	*[http://www.webpathology.com/image.asp?case=36&n=1 Choriocarcinoma (webpathology.com)].		*[http://www.webpathology.com/image.asp?case=36&n=1 Choriocarcinoma (webpathology.com)].

Michael: /* Clinical */

2016-12-01T20:16:28Z

Clinical

← Older revision		Revision as of 20:16, 1 December 2016
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	*Vaginal bleeding or testicular mass.		*Vaginal bleeding or testicular mass.
	*Occasionally thyrotoxicosis.<ref name=pmid8395487>{{Cite journal \| last1 = O'Reilly \| first1 = S. \| last2 = Lyons \| first2 = DJ. \| last3 = Harrison \| first3 = M. \| last4 = Gaffney \| first4 = E. \| last5 = Cullen \| first5 = M. \| last6 = Clancy \| first6 = L. \| title = Thyrotoxicosis induced by choriocarcinoma a report of two cases. \| journal = Ir Med J \| volume = 86 \| issue = 4 \| pages = 124, 127 \| month = \| year = \| doi = \| PMID = 8395487 }}</ref>		*Occasionally thyrotoxicosis.<ref name=pmid8395487>{{Cite journal \| last1 = O'Reilly \| first1 = S. \| last2 = Lyons \| first2 = DJ. \| last3 = Harrison \| first3 = M. \| last4 = Gaffney \| first4 = E. \| last5 = Cullen \| first5 = M. \| last6 = Clancy \| first6 = L. \| title = Thyrotoxicosis induced by choriocarcinoma a report of two cases. \| journal = Ir Med J \| volume = 86 \| issue = 4 \| pages = 124, 127 \| month = \| year = \| doi = \| PMID = 8395487 }}</ref>

			Note:
			*Beta-hCG is negative ~3 weeks after pregnancy.<ref name=pmid2436389 >{{Cite journal \| last1 = Haenel \| first1 = AF. \| last2 = Hugentobler \| first2 = W. \| last3 = Brunner \| first3 = S. \| title = [The postpartum course of the HCG titer of maternal blood and its clinical relevance]. \| journal = Z Geburtshilfe Perinatol \| volume = 190 \| issue = 6 \| pages = 275-8 \| month = \| year = \| doi = \| PMID = 2436389 }}</ref>

	===Epidemiology===		===Epidemiology===

Michael at 22:43, 30 November 2016

2016-11-30T22:43:37Z

← Older revision		Revision as of 22:43, 30 November 2016
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	\| LMDDx = [[mixed germ cell tumour]], [[invasive hydatidiform mole]], [[placental site trophoblastic tumour]]		\| LMDDx = [[mixed germ cell tumour]], [[invasive hydatidiform mole]], [[placental site trophoblastic tumour]]
	\| Stains =		\| Stains =
	\| IHC = beta-hCG +ve, CD10 +ve, OCT3 -ve		\| IHC = beta-hCG +ve, CD10 +ve, p63 +ve, OCT3 -ve
	\| EM =		\| EM =
	\| Molecular =		\| Molecular =

Michael: /* IHC */ more

2016-11-30T22:43:11Z

IHC: more

← Older revision		Revision as of 22:43, 30 November 2016
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	**[[Exaggerated placental site]] and [[placental site trophoblastic tumour]] -ve.		**[[Exaggerated placental site]] and [[placental site trophoblastic tumour]] -ve.
	*Ki-67 +ve -- typically >30%.		*Ki-67 +ve -- typically >30%.
	*CK7 +ve.<ref name=pmid25469347>{{Cite journal \| last1 = Park \| first1 = SY. \| last2 = Lee \| first2 = DE. \| last3 = Park \| first3 = HJ. \| last4 = Kim \| first4 = KC. \| last5 = Kim \| first5 = YH. \| title = Retroperitoneal nongestational choriocarcinoma in a 25-year-old woman. \| journal = Obstet Gynecol Sci \| volume = 57 \| issue = 6 \| pages = 544-8 \| month = Nov \| year = 2014 \| doi = 10.5468/ogs.2014.57.6.544 \| PMID = 25469347 }}</ref>		*CK7 +ve.<ref name=pmid25469347>{{Cite journal \| last1 = Park \| first1 = SY. \| last2 = Lee \| first2 = DE. \| last3 = Park \| first3 = HJ. \| last4 = Kim \| first4 = KC. \| last5 = Kim \| first5 = YH. \| title = Retroperitoneal nongestational choriocarcinoma in a 25-year-old woman. \| journal = Obstet Gynecol Sci \| volume = 57 \| issue = 6 \| pages = 544-8 \| month = Nov \| year = 2014 \| doi = 10.5468/ogs.2014.57.6.544 \| PMID = 25469347 }}</ref><ref name=pmid22091297>{{Cite journal \| last1 = Hemati \| first1 = S. \| last2 = Esnaashari \| first2 = O. \| last3 = Mohajeri \| first3 = M. \| last4 = Sarvizadeh \| first4 = M. \| title = Choriocarcinoma of the breast; a case report and review of literatures. \| journal = J Res Med Sci \| volume = 16 \| issue = 5 \| pages = 707-11 \| month = May \| year = 2011 \| doi = \| PMID = 22091297 }}</ref>
	*MUC-4 +ve.<ref name=pmid18059230>{{Cite journal \| last1 = Mao \| first1 = TL. \| last2 = Kurman \| first2 = RJ. \| last3 = Huang \| first3 = CC. \| last4 = Lin \| first4 = MC. \| last5 = Shih \| first5 = IeM. \| title = Immunohistochemistry of choriocarcinoma: an aid in differential diagnosis and in elucidating pathogenesis. \| journal = Am J Surg Pathol \| volume = 31 \| issue = 11 \| pages = 1726-32 \| month = Nov \| year = 2007 \| doi = 10.1097/PAS.0b013e318058a529 \| PMID = 18059230 }}</ref>		*MUC-4 +ve.<ref name=pmid18059230>{{Cite journal \| last1 = Mao \| first1 = TL. \| last2 = Kurman \| first2 = RJ. \| last3 = Huang \| first3 = CC. \| last4 = Lin \| first4 = MC. \| last5 = Shih \| first5 = IeM. \| title = Immunohistochemistry of choriocarcinoma: an aid in differential diagnosis and in elucidating pathogenesis. \| journal = Am J Surg Pathol \| volume = 31 \| issue = 11 \| pages = 1726-32 \| month = Nov \| year = 2007 \| doi = 10.1097/PAS.0b013e318058a529 \| PMID = 18059230 }}</ref>
	*CD10 +ve (10 +ve of 10 cases<ref name=pmid19145204>{{Cite journal \| last1 = Kalhor \| first1 = N. \| last2 = Ramirez \| first2 = PT. \| last3 = Deavers \| first3 = MT. \| last4 = Malpica \| first4 = A. \| last5 = Silva \| first5 = EG. \| title = Immunohistochemical studies of trophoblastic tumors. \| journal = Am J Surg Pathol \| volume = 33 \| issue = 4 \| pages = 633-8 \| month = Apr \| year = 2009 \| doi = 10.1097/PAS.0b013e318191f2eb \| PMID = 19145204 }}</ref>).		*CD10 +ve (10 +ve of 10 cases<ref name=pmid19145204>{{Cite journal \| last1 = Kalhor \| first1 = N. \| last2 = Ramirez \| first2 = PT. \| last3 = Deavers \| first3 = MT. \| last4 = Malpica \| first4 = A. \| last5 = Silva \| first5 = EG. \| title = Immunohistochemical studies of trophoblastic tumors. \| journal = Am J Surg Pathol \| volume = 33 \| issue = 4 \| pages = 633-8 \| month = Apr \| year = 2009 \| doi = 10.1097/PAS.0b013e318191f2eb \| PMID = 19145204 }}</ref>).

Michael: /* IHC */

2016-11-30T22:41:42Z

IHC

← Older revision		Revision as of 22:41, 30 November 2016
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	**[[Exaggerated placental site]] and [[placental site trophoblastic tumour]] -ve.		**[[Exaggerated placental site]] and [[placental site trophoblastic tumour]] -ve.
	*Ki-67 +ve -- typically >30%.		*Ki-67 +ve -- typically >30%.
			*CK7 +ve.<ref name=pmid25469347>{{Cite journal \| last1 = Park \| first1 = SY. \| last2 = Lee \| first2 = DE. \| last3 = Park \| first3 = HJ. \| last4 = Kim \| first4 = KC. \| last5 = Kim \| first5 = YH. \| title = Retroperitoneal nongestational choriocarcinoma in a 25-year-old woman. \| journal = Obstet Gynecol Sci \| volume = 57 \| issue = 6 \| pages = 544-8 \| month = Nov \| year = 2014 \| doi = 10.5468/ogs.2014.57.6.544 \| PMID = 25469347 }}</ref>
	*MUC-4 +ve.<ref name=pmid18059230>{{Cite journal \| last1 = Mao \| first1 = TL. \| last2 = Kurman \| first2 = RJ. \| last3 = Huang \| first3 = CC. \| last4 = Lin \| first4 = MC. \| last5 = Shih \| first5 = IeM. \| title = Immunohistochemistry of choriocarcinoma: an aid in differential diagnosis and in elucidating pathogenesis. \| journal = Am J Surg Pathol \| volume = 31 \| issue = 11 \| pages = 1726-32 \| month = Nov \| year = 2007 \| doi = 10.1097/PAS.0b013e318058a529 \| PMID = 18059230 }}</ref>		*MUC-4 +ve.<ref name=pmid18059230>{{Cite journal \| last1 = Mao \| first1 = TL. \| last2 = Kurman \| first2 = RJ. \| last3 = Huang \| first3 = CC. \| last4 = Lin \| first4 = MC. \| last5 = Shih \| first5 = IeM. \| title = Immunohistochemistry of choriocarcinoma: an aid in differential diagnosis and in elucidating pathogenesis. \| journal = Am J Surg Pathol \| volume = 31 \| issue = 11 \| pages = 1726-32 \| month = Nov \| year = 2007 \| doi = 10.1097/PAS.0b013e318058a529 \| PMID = 18059230 }}</ref>
	*CD10 +ve (10 +ve of 10 cases<ref name=pmid19145204>{{Cite journal \| last1 = Kalhor \| first1 = N. \| last2 = Ramirez \| first2 = PT. \| last3 = Deavers \| first3 = MT. \| last4 = Malpica \| first4 = A. \| last5 = Silva \| first5 = EG. \| title = Immunohistochemical studies of trophoblastic tumors. \| journal = Am J Surg Pathol \| volume = 33 \| issue = 4 \| pages = 633-8 \| month = Apr \| year = 2009 \| doi = 10.1097/PAS.0b013e318191f2eb \| PMID = 19145204 }}</ref>).		*CD10 +ve (10 +ve of 10 cases<ref name=pmid19145204>{{Cite journal \| last1 = Kalhor \| first1 = N. \| last2 = Ramirez \| first2 = PT. \| last3 = Deavers \| first3 = MT. \| last4 = Malpica \| first4 = A. \| last5 = Silva \| first5 = EG. \| title = Immunohistochemical studies of trophoblastic tumors. \| journal = Am J Surg Pathol \| volume = 33 \| issue = 4 \| pages = 633-8 \| month = Apr \| year = 2009 \| doi = 10.1097/PAS.0b013e318191f2eb \| PMID = 19145204 }}</ref>).

Michael: /* IHC */

2016-11-30T22:37:21Z

IHC

← Older revision		Revision as of 22:37, 30 November 2016
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	Others:		Others:
			*p63 +ve.<ref name=pmid18318583>{{Cite journal \| last1 = Mittal \| first1 = K. \| last2 = Soslow \| first2 = R. \| last3 = McCluggage \| first3 = WG. \| title = Application of immunohistochemistry to gynecologic pathology. \| journal = Arch Pathol Lab Med \| volume = 132 \| issue = 3 \| pages = 402-23 \| month = Mar \| year = 2008 \| doi = 10.1043/1543-2165(2008)132[402:AOITGP]2.0.CO;2 \| PMID = 18318583 }}</ref>
			**[[Placental site nodule]] and [[epithelioid trophoblastic tumour]] +ve.
			**[[Exaggerated placental site]] and [[placental site trophoblastic tumour]] -ve.
	*Ki-67 +ve -- typically >30%.		*Ki-67 +ve -- typically >30%.
	*MUC-4 +ve.<ref name=pmid18059230>{{Cite journal \| last1 = Mao \| first1 = TL. \| last2 = Kurman \| first2 = RJ. \| last3 = Huang \| first3 = CC. \| last4 = Lin \| first4 = MC. \| last5 = Shih \| first5 = IeM. \| title = Immunohistochemistry of choriocarcinoma: an aid in differential diagnosis and in elucidating pathogenesis. \| journal = Am J Surg Pathol \| volume = 31 \| issue = 11 \| pages = 1726-32 \| month = Nov \| year = 2007 \| doi = 10.1097/PAS.0b013e318058a529 \| PMID = 18059230 }}</ref>		*MUC-4 +ve.<ref name=pmid18059230>{{Cite journal \| last1 = Mao \| first1 = TL. \| last2 = Kurman \| first2 = RJ. \| last3 = Huang \| first3 = CC. \| last4 = Lin \| first4 = MC. \| last5 = Shih \| first5 = IeM. \| title = Immunohistochemistry of choriocarcinoma: an aid in differential diagnosis and in elucidating pathogenesis. \| journal = Am J Surg Pathol \| volume = 31 \| issue = 11 \| pages = 1726-32 \| month = Nov \| year = 2007 \| doi = 10.1097/PAS.0b013e318058a529 \| PMID = 18059230 }}</ref>

Michael at 20:56, 26 April 2016

2016-04-26T20:56:47Z

← Older revision		Revision as of 20:56, 26 April 2016
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	\| Gross = dark friable, hemorrhagic/necrotic-appearing mass with an invasive border		\| Gross = dark friable, hemorrhagic/necrotic-appearing mass with an invasive border
	\| Grossing = [[orchiectomy grossing]]		\| Grossing = [[orchiectomy grossing]]
			\| Staging = [[testicular cancer staging]]
	\| Site = [[ovary]], [[testis]], [[uterus]]		\| Site = [[ovary]], [[testis]], [[uterus]]
	\| Assdx = [[complete hydatidiform mole]]		\| Assdx = [[complete hydatidiform mole]]

Michael: /* IHC */

2015-09-30T01:02:16Z

IHC

← Older revision		Revision as of 01:02, 30 September 2015
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	[[ISUP]] consensus paper by Ulbright ''et al.'':<ref name=pmid24832161>{{cite journal \|author=Ulbright TM, Tickoo SK, Berney DM, Srigley JR \|title=Best practices recommendations in the application of immunohistochemistry in testicular tumors: report from the international society of urological pathology consensus conference \|journal=Am. J. Surg. Pathol. \|volume=38 \|issue=8 \|pages=e50–9 \|year=2014 \|month=August \|pmid=24832161 \|doi=10.1097/PAS.0000000000000233 \|url=}}</ref>		[[ISUP]] consensus paper by Ulbright ''et al.'':<ref name=pmid24832161>{{cite journal \|author=Ulbright TM, Tickoo SK, Berney DM, Srigley JR \|title=Best practices recommendations in the application of immunohistochemistry in testicular tumors: report from the international society of urological pathology consensus conference \|journal=Am. J. Surg. Pathol. \|volume=38 \|issue=8 \|pages=e50–9 \|year=2014 \|month=August \|pmid=24832161 \|doi=10.1097/PAS.0000000000000233 \|url=}}</ref>
	*Beta-hCG +ve.		*Beta-hCG +ve.
	*Glypican 3 +ve/-ve.		*[[Glypican 3]] +ve/-ve.
	*OCT3 -ve.		*OCT3 -ve.
	*AFP -ve.		*AFP -ve.