Cholesteatoma - Revision history

Michael: /* Microscopic */

2017-04-25T16:40:25Z

Microscopic

← Older revision		Revision as of 16:40, 25 April 2017
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	*Cholesterol granuloma.<ref>URL: [http://path.upmc.edu/cases/case273/dx.html http://path.upmc.edu/cases/case273/dx.html]. Accessed on: 14 January 2012.</ref>		*Cholesterol granuloma.<ref>URL: [http://path.upmc.edu/cases/case273/dx.html http://path.upmc.edu/cases/case273/dx.html]. Accessed on: 14 January 2012.</ref>
	*[[Squamous cell carcinoma]].<ref name=pmid19563937/>		*[[Squamous cell carcinoma]].<ref name=pmid19563937/>
	*[[Epidermal inclusion cyst]] - history different.{{~~fact~~}}		*[[Epidermal inclusion cyst]] - history different.
			**Obscure immunostains different.<ref name=pmid7515549>{{Cite journal \| last1 = Dallari \| first1 = S. \| last2 = Cavani \| first2 = A. \| last3 = Bergamini \| first3 = G. \| last4 = Girolomoni \| first4 = G. \| title = Integrin expression in middle ear cholesteatoma. \| journal = Acta Otolaryngol \| volume = 114 \| issue = 2 \| pages = 188-92 \| month = Mar \| year = 1994 \| doi = \| PMID = 7515549 }}</ref>

	===Images===		===Images===
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	Image: Consistent with cholesteatoma -- high mag.jpg \| Cholesteatoma -- high mag.		Image: Consistent with cholesteatoma -- high mag.jpg \| Cholesteatoma -- high mag.
	</gallery>		</gallery>

	==Sign out==		==Sign out==
	<pre>		<pre>

Michael: +images

2017-02-19T03:23:57Z

+images

← Older revision		Revision as of 03:23, 19 February 2017
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image =		\| Image = Consistent with cholesteatoma -- low mag.jpg
	\| Width =		\| Width =
	\| Caption =		\| Caption = Keratinaceous debris consistent with cholesteatoma. [[H&E stain]]. (WC/Nephron)
	\| Synonyms =		\| Synonyms =
	\| Micro = keratinaceous debris (key feature), +/-squamous epithelium, +/-macrophages and giant cells giant cell, +/-chronic inflammation (lymphocytes)		\| Micro = keratinaceous debris (key feature), +/-squamous epithelium, +/-macrophages and giant cells giant cell, +/-chronic inflammation (lymphocytes)
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	*[[Epidermal inclusion cyst]] - history different.{{fact}}		*[[Epidermal inclusion cyst]] - history different.{{fact}}

			===Images===
			<gallery>
			Image: Consistent with cholesteatoma -- very low mag.jpg \| Cholesteatoma --very low mag.
			Image: Consistent with cholesteatoma -- low mag.jpg \| Cholesteatoma -- low mag.
			Image: Consistent with cholesteatoma -- intermed mag.jpg \| Cholesteatoma -- intermed. mag.
			Image: Consistent with cholesteatoma - alt -- intermed mag.jpg \| Cholesteatoma -- intermed. mag.
			Image: Consistent with cholesteatoma -- high mag.jpg \| Cholesteatoma -- high mag.
			</gallery>
	==Sign out==		==Sign out==
	<pre>		<pre>

Michael: tweak

2017-02-19T03:22:37Z

tweak

← Older revision		Revision as of 03:22, 19 February 2017
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	C'''~~holesteatoma~~''' is a [[head and neck pathology]] [[ditzel]].		{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image =
			\| Width =
			\| Caption =
			\| Synonyms =
			\| Micro = keratinaceous debris (key feature), +/-squamous epithelium, +/-macrophages and giant cells giant cell, +/-chronic inflammation (lymphocytes)
			\| Subtypes =
			\| LMDDx = cholesterol granuloma, [[squamous cell carcinoma]], [[epidermal inclusion cyst]] - history different
			\| Stains =
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Staging =
			\| Site = middle ear - see ''[[head and neck pathology]]''
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx = +/-family history, +/-history of trauma
			\| Signs = whitish mass in the middle ear
			\| Symptoms =
			\| Prevalence =
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = benign
			\| Other =
			\| ClinDDx =
			\| Tx =
			}}
			'''Cholesteatoma''' is a [[head and neck pathology]] [[ditzel]].

	==General==		==General==
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	*Whitish mass in the middle ear.<ref name=pmid23217274>{{Cite journal \| last1 = Al Balushi \| first1 = T. \| last2 = Naik \| first2 = JZ. \| last3 = Al Khabori \| first3 = M. \| title = Congenital cholesteatoma in identical twins. \| journal = J Laryngol Otol \| volume = 127 \| issue = 1 \| pages = 67-9 \| month = Jan \| year = 2013 \| doi = 10.1017/S0022215112002757 \| PMID = 23217274 }}</ref>		*Whitish mass in the middle ear.<ref name=pmid23217274>{{Cite journal \| last1 = Al Balushi \| first1 = T. \| last2 = Naik \| first2 = JZ. \| last3 = Al Khabori \| first3 = M. \| title = Congenital cholesteatoma in identical twins. \| journal = J Laryngol Otol \| volume = 127 \| issue = 1 \| pages = 67-9 \| month = Jan \| year = 2013 \| doi = 10.1017/S0022215112002757 \| PMID = 23217274 }}</ref>

	Image:		===Image===
	<gallery>		<gallery>
	Image:Cholesteatom_kuppelraum_1a.jpg \| Cholesteatoma. (WC)		Image:Cholesteatom_kuppelraum_1a.jpg \| Cholesteatoma. (WC)

Michael: /* Sign out */

2016-12-29T13:39:50Z

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← Older revision		Revision as of 13:39, 29 December 2016
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	- KERATINACEOUS DEBRIS AND GIANT CELLS, COMPATIBLE WITH CHOLESTEATOMA.		- KERATINACEOUS DEBRIS AND GIANT CELLS, COMPATIBLE WITH CHOLESTEATOMA.
	</pre>		</pre>

			===Micro===
			The section shows keratinaceous debris and benign squamous epithelium with a granular layer. There is no significant cellular atypia and giant cells are not present.

	==See also==		==See also==

Michael: /* Sign out */

2016-12-29T13:08:46Z

Sign out

← Older revision		Revision as of 13:08, 29 December 2016
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	==Sign out==		==Sign out==
	<pre>		<pre>
	Submitted as "~~Right~~ Mastoid Cholesteatoma", Excision:		Submitted as "Left Mastoid Cholesteatoma", Excision:
	- Keratinaceous debris and benign squamous epithelium, consistent with cholesteatoma.		- Keratinaceous debris and benign squamous epithelium, consistent with cholesteatoma.

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	<pre>		<pre>
	Soft tissue, left ear ("left ear keratosis"), excision:		Soft tissue, left ear ("left ear keratosis"), excision:
	- Keratinaceous debris, squamous epithelium and bone (consistent with cholesteatoma).		- Keratinaceous debris, squamous epithelium and bone (consistent with cholesteatoma).
	</pre>		</pre>
	===Block letters===		===Block letters===

Michael at 13:08, 29 December 2016

2016-12-29T13:08:10Z

← Older revision		Revision as of 13:08, 29 December 2016
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	*Cholesterol granuloma.<ref>URL: [http://path.upmc.edu/cases/case273/dx.html http://path.upmc.edu/cases/case273/dx.html]. Accessed on: 14 January 2012.</ref>		*Cholesterol granuloma.<ref>URL: [http://path.upmc.edu/cases/case273/dx.html http://path.upmc.edu/cases/case273/dx.html]. Accessed on: 14 January 2012.</ref>
	*[[Squamous cell carcinoma]].<ref name=pmid19563937/>		*[[Squamous cell carcinoma]].<ref name=pmid19563937/>
			*[[Epidermal inclusion cyst]] - history different.{{fact}}

	==Sign out==		==Sign out==
	<pre>		<pre>
	~~SOFT TISSUE (CHOLESTEATOMA)~~, ~~SITE NOT FURTHER SPECIFIED, REMOVAL~~:		Submitted as "Right Mastoid Cholesteatoma", Excision:
	- ~~KERATINACEOUS DEBRIS~~, ~~COMPATIBLE WITH CHOLESTEATOMA~~.		- Keratinaceous debris and benign squamous epithelium, consistent with cholesteatoma.

	</pre>		</pre>

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	Soft tissue, left ear ("left ear keratosis"), excision:		Soft tissue, left ear ("left ear keratosis"), excision:
	- Keratinaceous debris, squamous epithelium and bone (consistent with cholesteatoma).		- Keratinaceous debris, squamous epithelium and bone (consistent with cholesteatoma).
			</pre>
			===Block letters===
			<pre>
			SOFT TISSUE (CHOLESTEATOMA), SITE NOT FURTHER SPECIFIED, REMOVAL:
			- KERATINACEOUS DEBRIS, COMPATIBLE WITH CHOLESTEATOMA.
	</pre>		</pre>

	<pre>		<pre>
	TISSUE ("CHOLESTEATOMA"), LEFT, REMOVAL:		TISSUE ("CHOLESTEATOMA"), LEFT, REMOVAL:
	- KERATINACEOUS DEBRIS AND GIANT CELLS, COMPATIBLE WITH CHOLESTEATOMA.		- KERATINACEOUS DEBRIS AND GIANT CELLS, COMPATIBLE WITH CHOLESTEATOMA.
	</pre>		</pre>

Michael: split out

2016-10-14T21:06:21Z

split out

← Older revision		Revision as of 21:06, 14 October 2016
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	~~#redirect~~ [[Ditzels~~#Cholesteatoma~~]]		C'''holesteatoma''' is a [[head and neck pathology]] [[ditzel]].

			==General==
			*Squamous epithelium in the middle ear - leading to accumulation of keratinaceous debris.<ref>URL: [http://www.harrisonspractice.com/practice/ub/view/Harrisons%20Practice/141015/all/otitis_media_and_mastoiditis http://www.harrisonspractice.com/practice/ub/view/Harrisons%20Practice/141015/all/otitis_media_and_mastoiditis]. Accessed on: 16 March 2011.</ref>
			**''Keratosis obturans'' - accumulation in the external ear canal - is considered to be a different process;<ref>{{cite journal \|author=Piepergerdes MC, Kramer BM, Behnke EE \|title=Keratosis obturans and external auditory canal cholesteatoma \|journal=Laryngoscope \|volume=90 \|issue=3 \|pages=383–91 \|year=1980 \|month=March \|pmid=7359960 \|doi= \|url=}}</ref> though some consider it a synonym.<ref>{{cite journal \|author=Shire JR, Donegan JO \|title=Cholesteatoma of the external auditory canal and keratosis obturans \|journal=Am J Otol \|volume=7 \|issue=5 \|pages=361–4 \|year=1986 \|month=September \|pmid=3538893 \|doi= \|url=}}</ref>
			*The etiology is ''not'' well understood.<ref name=pmid20860924>{{Cite journal \| last1 = Nevoux \| first1 = J. \| last2 = Lenoir \| first2 = M. \| last3 = Roger \| first3 = G. \| last4 = Denoyelle \| first4 = F. \| last5 = Ducou Le Pointe \| first5 = H. \| last6 = Garabédian \| first6 = EN. \| title = Childhood cholesteatoma. \| journal = Eur Ann Otorhinolaryngol Head Neck Dis \| volume = 127 \| issue = 4 \| pages = 143-50 \| month = Sep \| year = 2010 \| doi = 10.1016/j.anorl.2010.07.001 \| PMID = 20860924 }}</ref><ref name=pmid20156369>{{Cite journal \| last1 = Louw \| first1 = L. \| title = Acquired cholesteatoma pathogenesis: stepwise explanations. \| journal = J Laryngol Otol \| volume = 124 \| issue = 6 \| pages = 587-93 \| month = Jun \| year = 2010 \| doi = 10.1017/S0022215109992763 \| PMID = 20156369 }}</ref>
			**Theories include migration/hyperplasia, and metaplasia.<ref name=pmid20156369/>
			*Rarely transforms into [[squamous cell carcinoma]].<ref name=pmid19563937>{{Cite journal \| last1 = Rothschild \| first1 = S. \| last2 = Ciernik \| first2 = IF. \| last3 = Hartmann \| first3 = M. \| last4 = Schuknecht \| first4 = B. \| last5 = Lütolf \| first5 = UM. \| last6 = Huber \| first6 = AM. \| title = Cholesteatoma triggering squamous cell carcinoma: case report and literature review of a rare tumor. \| journal = Am J Otolaryngol \| volume = 30 \| issue = 4 \| pages = 256-60 \| month = \| year = \| doi = 10.1016/j.amjoto.2008.06.011 \| PMID = 19563937 }}</ref><ref name=pmid15699729>{{Cite journal \| last1 = Takahashi \| first1 = K. \| last2 = Yamamoto \| first2 = Y. \| last3 = Sato \| first3 = K. \| last4 = Sato \| first4 = Y. \| last5 = Takahashi \| first5 = S. \| title = Middle ear carcinoma originating from a primary acquired cholesteatoma: a case report. \| journal = Otol Neurotol \| volume = 26 \| issue = 1 \| pages = 105-8 \| month = Jan \| year = 2005 \| doi = \| PMID = 15699729 }}</ref>

			===Classification===
			May be subdivided into:<ref name=pmid20860924/>
			*Acquired - due to trauma, surgery or infection.
			*Congenital.

			==Gross==
			*Whitish mass in the middle ear.<ref name=pmid23217274>{{Cite journal \| last1 = Al Balushi \| first1 = T. \| last2 = Naik \| first2 = JZ. \| last3 = Al Khabori \| first3 = M. \| title = Congenital cholesteatoma in identical twins. \| journal = J Laryngol Otol \| volume = 127 \| issue = 1 \| pages = 67-9 \| month = Jan \| year = 2013 \| doi = 10.1017/S0022215112002757 \| PMID = 23217274 }}</ref>

			Image:
			<gallery>
			Image:Cholesteatom_kuppelraum_1a.jpg \| Cholesteatoma. (WC)
			</gallery>

			==Microscopic==
			Features:<ref name=pmid1694387>{{cite journal \|author=Iino Y, Toriyama M, Ohmi S, Kanegasaki S \|title=Activation of peritoneal macrophages with human cholesteatoma debris and alpha-keratin \|journal=Acta Otolaryngol. \|volume=109 \|issue=5-6 \|pages=444–9 \|year=1990 \|pmid=1694387 \|doi= \|url=}}</ref>
			*Keratinaceous debris - '''key feature'''.
			*Squamous epithelium.
			*Macrophages +/- giant cell (containing keratinceous debris).
			*Chronic inflammation (lymphocytes).

			DDx:
			*Cholesterol granuloma.<ref>URL: [http://path.upmc.edu/cases/case273/dx.html http://path.upmc.edu/cases/case273/dx.html]. Accessed on: 14 January 2012.</ref>
			*[[Squamous cell carcinoma]].<ref name=pmid19563937/>

			==Sign out==
			<pre>
			SOFT TISSUE (CHOLESTEATOMA), SITE NOT FURTHER SPECIFIED, REMOVAL:
			- KERATINACEOUS DEBRIS, COMPATIBLE WITH CHOLESTEATOMA.
			</pre>

			<pre>
			Soft tissue, left ear ("left ear keratosis"), excision:
			- Keratinaceous debris, squamous epithelium and bone (consistent with cholesteatoma).
			</pre>

			<pre>
			TISSUE ("CHOLESTEATOMA"), LEFT, REMOVAL:
			- KERATINACEOUS DEBRIS AND GIANT CELLS, COMPATIBLE WITH CHOLESTEATOMA.
			</pre>

			==See also==
			*[[Ditzels]].

			==References==
			{{Reflist\|1}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Ditzels]]

Michael: +cat.

2011-12-10T06:24:47Z

+cat.

← Older revision		Revision as of 06:24, 10 December 2011
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	#redirect [[Ditzels#Cholesteatoma]]		#redirect [[Ditzels#Cholesteatoma]]

			[[Category:Diagnosis]]

Michael: redirect

2011-03-16T12:35:38Z

redirect

New page

#redirect [[Ditzels#Cholesteatoma]]