Celiac sprue - Revision history

Michael: /* TTG result not available */ tweak a bit + add obesity

2019-06-13T12:50:45Z

TTG result not available: tweak a bit + add obesity

← Older revision		Revision as of 12:50, 13 June 2019
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	Focally, there are approximately 50 lymphocytes/100 enterocytes. Increased intraepithelial		Focally, there are approximately 50 lymphocytes/100 enterocytes. Increased intraepithelial
	lymphocytes is a nonspecific finding that may be seen in a number of conditions, including		lymphocytes is a nonspecific finding that may be seen in a number of conditions, including
	infections (e.g. Helicobacter gastritis), and autoimmune disorders (e.g. Crohn's disease).		infections (e.g. Helicobacter gastritis), obesity, and autoimmune disorders (e.g. Crohn's
	It is seen in celiac disease; correlation with ~~TTG~~ serology is suggested, if not done.		disease). It is seen in celiac disease; correlation with serology is suggested, if not done.
	</pre>		</pre>

Michael: /* DDx */

2018-05-15T17:57:45Z

DDx

← Older revision		Revision as of 17:57, 15 May 2018
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	**Super duper rare.		**Super duper rare.
	*Drugs - e.g. olmesartan.<ref name=pmid24852741>{{Cite journal \| last1 = Fiorucci \| first1 = G. \| last2 = Puxeddu \| first2 = E. \| last3 = Colella \| first3 = R. \| last4 = Paolo Reboldi \| first4 = G. \| last5 = Villanacci \| first5 = V. \| last6 = Bassotti \| first6 = G. \| title = Severe spruelike enteropathy due to olmesartan. \| journal = Rev Esp Enferm Dig \| volume = 106 \| issue = 2 \| pages = 142-4 \| month = Feb \| year = 2014 \| doi = \| PMID = 24852741 }}</ref>		*Drugs - e.g. olmesartan.<ref name=pmid24852741>{{Cite journal \| last1 = Fiorucci \| first1 = G. \| last2 = Puxeddu \| first2 = E. \| last3 = Colella \| first3 = R. \| last4 = Paolo Reboldi \| first4 = G. \| last5 = Villanacci \| first5 = V. \| last6 = Bassotti \| first6 = G. \| title = Severe spruelike enteropathy due to olmesartan. \| journal = Rev Esp Enferm Dig \| volume = 106 \| issue = 2 \| pages = 142-4 \| month = Feb \| year = 2014 \| doi = \| PMID = 24852741 }}</ref>
			*[[obesity\|Morbid obesity]].<ref name=pmid17516730>{{Cite journal \| last1 = Harpaz \| first1 = N. \| last2 = Levi \| first2 = GS. \| last3 = Yurovitsky \| first3 = A. \| last4 = Kini \| first4 = S. \| title = Intraepithelial lymphocytosis in architecturally normal small intestinal mucosa: association with morbid obesity. \| journal = Arch Pathol Lab Med \| volume = 131 \| issue = 3 \| pages = 344; author reply 344 \| month = Mar \| year = 2007 \| doi = 10.1043/1543-2165(2007)131[344b:IR]2.0.CO;2 \| PMID = 17516730 }}</ref>

	===Image===		===Image===

Michael: /* Microscopic */

2016-05-25T14:28:34Z

Microscopic

← Older revision		Revision as of 14:28, 25 May 2016
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	==Microscopic==		==Microscopic==
	Features:<ref name=Ref_PBoD843>{{Ref PBoD\|843}}</ref>		Features:<ref name=Ref_PBoD843>{{Ref PBoD\|843}}</ref>
	*Intraepithelial lymphocytes (IELs) - '''key feature'''.		*[[Intraepithelial lymphocytes]] (IELs) - '''key feature'''.
	**Should be more pronounced at tips of villi.<ref name=pmid15280404>{{cite journal \|author=Biagi F, Luinetti O, Campanella J, ''et al.'' \|title=Intraepithelial lymphocytes in the villous tip: do they indicate potential coeliac disease? \|journal=J. Clin. Pathol. \|volume=57 \|issue=8 \|pages=835–9 \|year=2004 \|month=August \|pmid=15280404 \|pmc=1770380 \|doi=10.1136/jcp.2003.013607 \|url=}}</ref>		**Should be more pronounced at tips of villi.<ref name=pmid15280404>{{cite journal \|author=Biagi F, Luinetti O, Campanella J, ''et al.'' \|title=Intraepithelial lymphocytes in the villous tip: do they indicate potential coeliac disease? \|journal=J. Clin. Pathol. \|volume=57 \|issue=8 \|pages=835–9 \|year=2004 \|month=August \|pmid=15280404 \|pmc=1770380 \|doi=10.1136/jcp.2003.013607 \|url=}}</ref>
	**Criteria for number varies:		**Criteria for number varies:

Michael: /* TTG result not available */

2016-05-19T19:12:01Z

TTG result not available

← Older revision		Revision as of 19:12, 19 May 2016
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	==Sign out==		==Sign out==
	===TTG result not available===		===TTG result not available===
			<pre>
			Duodenum, Biopsy:
			- Small bowel mucosa with increased intraepithelial lymphocytes, villous
			architecture and crypt architecture within normal limits, see comment.
			- Brunner's glands present.
			- NEGATIVE for acute duodenitis.
			- NEGATIVE for dysplasia.

			Comment:
			Focally, there are approximately 50 lymphocytes/100 enterocytes. Increased intraepithelial
			lymphocytes is a nonspecific finding that may be seen in a number of conditions, including
			infections (e.g. Helicobacter gastritis), and autoimmune disorders (e.g. Crohn's disease).
			It is seen in celiac disease; correlation with TTG serology is suggested, if not done.
			</pre>

			====Block letters====
	<pre>		<pre>
	SMALL BOWEL (DUODENUM), BIOPSY:		SMALL BOWEL (DUODENUM), BIOPSY:
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	</pre>		</pre>

	====Alternate====		=====Alternate=====
	<pre>		<pre>
	DUODENUM, BIOPSY:		DUODENUM, BIOPSY:

Michael: /* General */

2016-04-13T16:11:45Z

General

← Older revision		Revision as of 16:11, 13 April 2016
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	==General==		==General==
	*Considered an autoimmune disease.		*Considered an autoimmune disease.
			*The typical individual with celiac disease has a normal weight or is underweight.
			**[[Obese]] and overweight individuals can have celiac disease.<ref name=pmid26892766>{{Cite journal \| last1 = Singh \| first1 = I. \| last2 = Agnihotri \| first2 = A. \| last3 = Sharma \| first3 = A. \| last4 = Verma \| first4 = AK. \| last5 = Das \| first5 = P. \| last6 = Thakur \| first6 = B. \| last7 = Sreenivas \| first7 = V. \| last8 = Gupta \| first8 = SD. \| last9 = Ahuja \| first9 = V. \| title = Patients with celiac disease may have normal weight or may even be overweight. \| journal = Indian J Gastroenterol \| volume = \| issue = \| pages = \| month = Feb \| year = 2016 \| doi = 10.1007/s12664-016-0620-9 \| PMID = 26892766 }}</ref>

	===Epidemiology===		===Epidemiology===

Michael: /* Epidemiology */

2016-03-21T03:20:56Z

Epidemiology

← Older revision		Revision as of 03:20, 21 March 2016
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	*Small bowel adenocarcinoma - increased risk.<ref name=pmid1060711>{{Cite journal \| last1 = West \| first1 = RA. \| last2 = McNeill \| first2 = RW. \| title = Maxillary alveolar hyperplasia, diagnosis and treatment planning. \| journal = J Maxillofac Surg \| volume = 3 \| issue = 4 \| pages = 239-50 \| month = Dec \| year = 1975 \| doi = \| PMID = 1060711 }}</ref><ref name=pmid12940435>{{Cite journal \| last1 = Rampertab \| first1 = SD. \| last2 = Fleischauer \| first2 = A. \| last3 = Neugut \| first3 = AI. \| last4 = Green \| first4 = PH. \| title = Risk of duodenal adenoma in celiac disease. \| journal = Scand J Gastroenterol \| volume = 38 \| issue = 8 \| pages = 831-3 \| month = Aug \| year = 2003 \| doi = \| PMID = 12940435 }}</ref>		*Small bowel adenocarcinoma - increased risk.<ref name=pmid1060711>{{Cite journal \| last1 = West \| first1 = RA. \| last2 = McNeill \| first2 = RW. \| title = Maxillary alveolar hyperplasia, diagnosis and treatment planning. \| journal = J Maxillofac Surg \| volume = 3 \| issue = 4 \| pages = 239-50 \| month = Dec \| year = 1975 \| doi = \| PMID = 1060711 }}</ref><ref name=pmid12940435>{{Cite journal \| last1 = Rampertab \| first1 = SD. \| last2 = Fleischauer \| first2 = A. \| last3 = Neugut \| first3 = AI. \| last4 = Green \| first4 = PH. \| title = Risk of duodenal adenoma in celiac disease. \| journal = Scand J Gastroenterol \| volume = 38 \| issue = 8 \| pages = 831-3 \| month = Aug \| year = 2003 \| doi = \| PMID = 12940435 }}</ref>
	*Thought to be related to the very rare [[collagenous sprue]] - controversial.<ref name=pmid21631278>{{Cite journal \| last1 = Zhao \| first1 = X. \| last2 = Johnson \| first2 = RL. \| title = Collagenous sprue: a rare, severe small-bowel malabsorptive disorder. \| journal = Arch Pathol Lab Med \| volume = 135 \| issue = 6 \| pages = 803-9 \| month = Jun \| year = 2011 \| doi = 10.1043/2010-0028-RS.1 \| PMID = 21631278 }}</ref><ref name=pmid23735026>{{Cite journal \| last1 = Busto-Bea \| first1 = V. \| last2 = Crespo-Pérez \| first2 = L. \| last3 = García-Miralles \| first3 = N. \| last4 = Ruiz-Del-Árbol-Olmos \| first4 = L. \| last5 = Cano-Ruiz \| first5 = A. \| title = Collagenous sprue: Don´t forget connective tissue in chronic diarrhea evaluation. \| journal = Rev Esp Enferm Dig \| volume = 105 \| issue = 3 \| pages = 171-174 \| month = May \| year = 2013 \| doi = \| PMID = 23735026 }}</ref>		*Thought to be related to the very rare [[collagenous sprue]] - controversial.<ref name=pmid21631278>{{Cite journal \| last1 = Zhao \| first1 = X. \| last2 = Johnson \| first2 = RL. \| title = Collagenous sprue: a rare, severe small-bowel malabsorptive disorder. \| journal = Arch Pathol Lab Med \| volume = 135 \| issue = 6 \| pages = 803-9 \| month = Jun \| year = 2011 \| doi = 10.1043/2010-0028-RS.1 \| PMID = 21631278 }}</ref><ref name=pmid23735026>{{Cite journal \| last1 = Busto-Bea \| first1 = V. \| last2 = Crespo-Pérez \| first2 = L. \| last3 = García-Miralles \| first3 = N. \| last4 = Ruiz-Del-Árbol-Olmos \| first4 = L. \| last5 = Cano-Ruiz \| first5 = A. \| title = Collagenous sprue: Don´t forget connective tissue in chronic diarrhea evaluation. \| journal = Rev Esp Enferm Dig \| volume = 105 \| issue = 3 \| pages = 171-174 \| month = May \| year = 2013 \| doi = \| PMID = 23735026 }}</ref>
			*[[Lymphocytic gastritis]] - seen in ~10% of individuals with celiac disease.<ref name=pmid9659261>{{Cite journal \| last1 = Feeley \| first1 = KM. \| last2 = Heneghan \| first2 = MA. \| last3 = Stevens \| first3 = FM. \| last4 = McCarthy \| first4 = CF. \| title = Lymphocytic gastritis and coeliac disease: evidence of a positive association. \| journal = J Clin Pathol \| volume = 51 \| issue = 3 \| pages = 207-10 \| month = Mar \| year = 1998 \| doi = \| PMID = 9659261 }}</ref>

	==Variants of celiac sprue==		==Variants of celiac sprue==

Michael: /* Epidemiology */

2016-03-21T03:17:40Z

Epidemiology

← Older revision		Revision as of 03:17, 21 March 2016
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	*Considered an autoimmune disease.		*Considered an autoimmune disease.

	==Epidemiology==		===Epidemiology===
	Associated with:		Associated with:
	*[[Dermatitis herpetiformis]] - skin condition.<ref name=Ref_TN2007_D22>{{Ref TN2007\| D22}}</ref>		*[[Dermatitis herpetiformis]] - skin condition.<ref name=Ref_TN2007_D22>{{Ref TN2007\| D22}}</ref>

Michael at 16:00, 13 February 2016

2016-02-13T16:00:23Z

← Older revision		Revision as of 16:00, 13 February 2016
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	\| Tx = gluten free diet		\| Tx = gluten free diet
	}}		}}
	'''Celiac sprue''', also '''celiac disease''', is a common pathology that affects the [[duodenum]].		'''Celiac sprue''', also '''celiac disease''' (abbreviated '''CD'''), is a common pathology that affects the [[duodenum]].

	It should not be confused with ''tropical sprue''.		It should not be confused with ''tropical sprue''.

Michael: /* DDx */

2014-09-04T19:44:31Z

DDx

← Older revision		Revision as of 19:44, 4 September 2014
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	*[[Autoimmune enteropathy]] - pediatric population.		*[[Autoimmune enteropathy]] - pediatric population.
	**Super duper rare.		**Super duper rare.
			*Drugs - e.g. olmesartan.<ref name=pmid24852741>{{Cite journal \| last1 = Fiorucci \| first1 = G. \| last2 = Puxeddu \| first2 = E. \| last3 = Colella \| first3 = R. \| last4 = Paolo Reboldi \| first4 = G. \| last5 = Villanacci \| first5 = V. \| last6 = Bassotti \| first6 = G. \| title = Severe spruelike enteropathy due to olmesartan. \| journal = Rev Esp Enferm Dig \| volume = 106 \| issue = 2 \| pages = 142-4 \| month = Feb \| year = 2014 \| doi = \| PMID = 24852741 }}</ref>

	===Image===		===Image===

Michael: /* External links */ +cat

2013-12-24T03:58:33Z

External links: +cat

← Older revision		Revision as of 03:58, 24 December 2013
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	[[Category:Gastrointestinal pathology]]		[[Category:Gastrointestinal pathology]]
	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Duodenum]]