Castleman disease - Revision history

Michael: vauthors -> authors

2021-03-25T17:22:53Z

vauthors -> authors

← Older revision		Revision as of 17:22, 25 March 2021
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	==Microscopic==		==Microscopic==
	===Hyaline-vascular variant===		===Hyaline-vascular variant===
	Features:<ref>URL: [http://www.ispub.com/journal/the_internet_journal_of_otorhinolaryngology/volume_9_number_2_11/article/a_rare_case_of_castleman_s_disease_presenting_as_cervical_neck_mass.html http://www.ispub.com/journal/the_internet_journal_of_otorhinolaryngology/volume_9_number_2_11/article/a_rare_case_of_castleman_s_disease_presenting_as_cervical_neck_mass.html]. Accessed on: 15 June 2010.</ref><ref name=Ref_ILNP236>{{Ref ILNP\|236}}</ref><ref name=pmid28100459>{{cite journal \|~~vauthors~~=Yu L, Tu M, Cortes J, Xu-Monette ZY, Miranda RN, Zhang J, Orlowski RZ, Neelapu S, Boddu PC, Akosile MA, Uldrick TS, Yarchoan R, Medeiros LJ, Li Y, Fajgenbaum DC, Young KH \|title=Clinical and pathological characteristics of HIV- and HHV-8-negative Castleman disease \|journal=Blood \|volume=129 \|issue=12 \|pages=1658–1668 \|date=March 2017 \|pmid=28100459 \|pmc=5364343 \|doi=10.1182/blood-2016-11-748855 \|url=}}</ref>		Features:<ref>URL: [http://www.ispub.com/journal/the_internet_journal_of_otorhinolaryngology/volume_9_number_2_11/article/a_rare_case_of_castleman_s_disease_presenting_as_cervical_neck_mass.html http://www.ispub.com/journal/the_internet_journal_of_otorhinolaryngology/volume_9_number_2_11/article/a_rare_case_of_castleman_s_disease_presenting_as_cervical_neck_mass.html]. Accessed on: 15 June 2010.</ref><ref name=Ref_ILNP236>{{Ref ILNP\|236}}</ref><ref name=pmid28100459>{{cite journal \|authors=Yu L, Tu M, Cortes J, Xu-Monette ZY, Miranda RN, Zhang J, Orlowski RZ, Neelapu S, Boddu PC, Akosile MA, Uldrick TS, Yarchoan R, Medeiros LJ, Li Y, Fajgenbaum DC, Young KH \|title=Clinical and pathological characteristics of HIV- and HHV-8-negative Castleman disease \|journal=Blood \|volume=129 \|issue=12 \|pages=1658–1668 \|date=March 2017 \|pmid=28100459 \|pmc=5364343 \|doi=10.1182/blood-2016-11-748855 \|url=}}</ref>

	*Pale concentric (expanded) mantle zone lymphocytes - '''key feature'''.		*Pale concentric (expanded) mantle zone lymphocytes - '''key feature'''.
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	*Sinus preserved.		*Sinus preserved.
	*In HHV8-negative cases, several other conditions can give a Castleman-like appearance, listed comprehensively in the consensus criteria for HHV8-negative CD:		*In HHV8-negative cases, several other conditions can give a Castleman-like appearance, listed comprehensively in the consensus criteria for HHV8-negative CD:
	<ref name=pmid28087540>{{cite journal \|~~vauthors~~=Fajgenbaum DC, Uldrick TS, Bagg A, Frank D, Wu D, Srkalovic G, Simpson D, Liu AY, Menke D, Chandrakasan S, Lechowicz MJ, Wong RS, Pierson S, Paessler M, Rossi JF, Ide M, Ruth J, Croglio M, Suarez A, Krymskaya V, Chadburn A, Colleoni G, Nasta S, Jayanthan R, Nabel CS, Casper C, Dispenzieri A, Fosså A, Kelleher D, Kurzrock R, Voorhees P, Dogan A, Yoshizaki K, van Rhee F, Oksenhendler E, Jaffe ES, Elenitoba-Johnson KS, Lim MS \|title=International, evidence-based consensus diagnostic criteria for HHV-8-negative/idiopathic multicentric Castleman disease \|journal=Blood \|volume=129 \|issue=12 \|pages=1646–1657 \|date=March 2017 \|pmid=28087540 \|pmc=5364342 \|doi=10.1182/blood-2016-10-746933 \|url=}}</ref>		<ref name=pmid28087540>{{cite journal \|authors=Fajgenbaum DC, Uldrick TS, Bagg A, Frank D, Wu D, Srkalovic G, Simpson D, Liu AY, Menke D, Chandrakasan S, Lechowicz MJ, Wong RS, Pierson S, Paessler M, Rossi JF, Ide M, Ruth J, Croglio M, Suarez A, Krymskaya V, Chadburn A, Colleoni G, Nasta S, Jayanthan R, Nabel CS, Casper C, Dispenzieri A, Fosså A, Kelleher D, Kurzrock R, Voorhees P, Dogan A, Yoshizaki K, van Rhee F, Oksenhendler E, Jaffe ES, Elenitoba-Johnson KS, Lim MS \|title=International, evidence-based consensus diagnostic criteria for HHV-8-negative/idiopathic multicentric Castleman disease \|journal=Blood \|volume=129 \|issue=12 \|pages=1646–1657 \|date=March 2017 \|pmid=28087540 \|pmc=5364342 \|doi=10.1182/blood-2016-10-746933 \|url=}}</ref>
	**Autoimmune diseases		**Autoimmune diseases
	**Infections		**Infections

Mark: some references

2020-07-26T14:02:02Z

some references

← Older revision		Revision as of 14:02, 26 July 2020
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	===Classification===		===Classification===
			By site of involvement:
			*Unicentric (one lymph node or a cluster of nodes at one site)
			**~75% hyaline vascular variant
			**~25% Plasma cell variant
			*Multicentric often associated with splenomegaly (75%) and hepatomegaly (50%)
			**>90% plasma cell variant
			**<10% hyaline vascular variant

	CD is grouped by histologic appearance:<ref name=Ref_ILNP228>{{Ref ILNP\|228}}</ref>		CD is grouped by histologic appearance:<ref name=Ref_ILNP228>{{Ref ILNP\|228}}</ref>
	#Hyaline vascular (HV) variant (described by Castleman).		#Hyaline vascular (HV) variant (described by Castleman).
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	#*Usually multicentric, may be unicentric.		#*Usually multicentric, may be unicentric.
	#*Abundant plasma cells.		#*Abundant plasma cells.
	#*~~Associated~~ with [[HHV-8]] infection (the same virus implicated in ''Kaposi's sarcoma'').		#*50-60% associated with [[HHV-8]] infection (the same virus implicated in ''Kaposi's sarcoma''). The virus produces an IL-6 analogue which drives many of the systemic features.

			Some divide the multicentric pattern into
			#[[POEMS]]-associated CD
			#HHV8+ CD
			#*HIV+
			#*HIV-
			#HHV8- CD, further sub-divided into
			#*TAFRO syndrome associated
			#Others

	Notes:		Notes:
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	==Microscopic==		==Microscopic==
	===Hyaline-vascular variant===		===Hyaline-vascular variant===
	Features:<ref>URL: [http://www.ispub.com/journal/the_internet_journal_of_otorhinolaryngology/volume_9_number_2_11/article/a_rare_case_of_castleman_s_disease_presenting_as_cervical_neck_mass.html http://www.ispub.com/journal/the_internet_journal_of_otorhinolaryngology/volume_9_number_2_11/article/a_rare_case_of_castleman_s_disease_presenting_as_cervical_neck_mass.html]. Accessed on: 15 June 2010.</ref><ref name=Ref_ILNP236>{{Ref ILNP\|236}}</ref>		Features:<ref>URL: [http://www.ispub.com/journal/the_internet_journal_of_otorhinolaryngology/volume_9_number_2_11/article/a_rare_case_of_castleman_s_disease_presenting_as_cervical_neck_mass.html http://www.ispub.com/journal/the_internet_journal_of_otorhinolaryngology/volume_9_number_2_11/article/a_rare_case_of_castleman_s_disease_presenting_as_cervical_neck_mass.html]. Accessed on: 15 June 2010.</ref><ref name=Ref_ILNP236>{{Ref ILNP\|236}}</ref><ref name=pmid28100459>{{cite journal \|vauthors=Yu L, Tu M, Cortes J, Xu-Monette ZY, Miranda RN, Zhang J, Orlowski RZ, Neelapu S, Boddu PC, Akosile MA, Uldrick TS, Yarchoan R, Medeiros LJ, Li Y, Fajgenbaum DC, Young KH \|title=Clinical and pathological characteristics of HIV- and HHV-8-negative Castleman disease \|journal=Blood \|volume=129 \|issue=12 \|pages=1658–1668 \|date=March 2017 \|pmid=28100459 \|pmc=5364343 \|doi=10.1182/blood-2016-11-748855 \|url=}}</ref>

	*Pale concentric (expanded) mantle zone lymphocytes - '''key feature'''.		*Pale concentric (expanded) mantle zone lymphocytes - '''key feature'''.
	**"Regressed follicles" - germinal center (pale area) is small.		**"Regressed follicles" - germinal center (pale area) is small.
	*"Lollipops":		*"Lollipops":
	**Germinal centers fed by prominent (radially penetrating sclerotic) vessels; lollipop-like appearance.		**Germinal centers fed by prominent (radially penetrating sclerotic) vessels; lollipop-like appearance.
	*Two germinal centers in one follicle.		*Two germinal centers in one follicle, so called "twinning".
	*Hyaline material (pink acellular stuff on H&E) in germinal center.		*Hyaline material (pink acellular stuff on H&E) in germinal center.
	*Sinuses effaced (lost).		*Sinuses effaced (lost).
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	*Interfollicular sheets of plasma cells - '''key feature'''.		*Interfollicular sheets of plasma cells - '''key feature'''.
	*Active germinal centers - mitoses present.		*Active germinal centers - mitoses present.
	*Sinus ~~perserved~~.		*Sinus preserved.
			*In HHV8-negative cases, several other conditions can give a Castleman-like appearance, listed comprehensively in the consensus criteria for HHV8-negative CD:
			<ref name=pmid28087540>{{cite journal \|vauthors=Fajgenbaum DC, Uldrick TS, Bagg A, Frank D, Wu D, Srkalovic G, Simpson D, Liu AY, Menke D, Chandrakasan S, Lechowicz MJ, Wong RS, Pierson S, Paessler M, Rossi JF, Ide M, Ruth J, Croglio M, Suarez A, Krymskaya V, Chadburn A, Colleoni G, Nasta S, Jayanthan R, Nabel CS, Casper C, Dispenzieri A, Fosså A, Kelleher D, Kurzrock R, Voorhees P, Dogan A, Yoshizaki K, van Rhee F, Oksenhendler E, Jaffe ES, Elenitoba-Johnson KS, Lim MS \|title=International, evidence-based consensus diagnostic criteria for HHV-8-negative/idiopathic multicentric Castleman disease \|journal=Blood \|volume=129 \|issue=12 \|pages=1646–1657 \|date=March 2017 \|pmid=28087540 \|pmc=5364342 \|doi=10.1182/blood-2016-10-746933 \|url=}}</ref>
			**Autoimmune diseases
			**Infections
			**Malignancies

	==IHC==		==IHC==

Michael at 01:43, 26 December 2013

2013-12-26T01:43:58Z

← Older revision		Revision as of 01:43, 26 December 2013
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Castleman_disease_-_high_mag.jpg
			\| Width =
			\| Caption = Castleman disease (hyaline-vascular variant). [[H&E stain]].
			\| Synonyms =
			\| Micro =
			\| Subtypes = hyaline-vascular variant (HVV), plasma cell variant (PCV)
			\| LMDDx = HVV: [[mantle cell lymphoma]]
			\| Stains =
			\| IHC = HVV: cyclin D1 -ve, other stains to exclude lymphoma; PCV: HHV-8 +ve
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[lymph node]] - see ''[[lymph node pathology]]''
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms =
			\| Prevalence = rare
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis =
			\| Other =
			\| ClinDDx =
			\| Tx =
			}}
	'''Castleman disease''', abbreviated '''CD''', is a rare [[Lymph node pathology\|pathology of the lymph node]].		'''Castleman disease''', abbreviated '''CD''', is a rare [[Lymph node pathology\|pathology of the lymph node]].

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	==General==		==General==
	*Benign.		*Benign.
	*Hyaline vascular variant - a pathology of the follicular dendritic cells.<ref>{{Cite journal \| last1 = Cokelaere \| first1 = K. \| last2 = Debiec-Rychter \| first2 = M. \| last3 = De Wolf-Peeters \| first3 = C. \| last4 = Hagemeijer \| first4 = A. \| last5 = Sciot \| first5 = R. \| title = Hyaline vascular Castleman's disease with HMGIC rearrangement in follicular dendritic cells: molecular evidence of mesenchymal tumorigenesis. \| journal = Am J Surg Pathol \| volume = 26 \| issue = 5 \| pages = 662-9 \| month = May \| year = 2002 \| doi = \| PMID = 11979097 }}</ref>		*Hyaline vascular variant (classic Castleman disease) - a pathology of the follicular dendritic cells.<ref>{{Cite journal \| last1 = Cokelaere \| first1 = K. \| last2 = Debiec-Rychter \| first2 = M. \| last3 = De Wolf-Peeters \| first3 = C. \| last4 = Hagemeijer \| first4 = A. \| last5 = Sciot \| first5 = R. \| title = Hyaline vascular Castleman's disease with HMGIC rearrangement in follicular dendritic cells: molecular evidence of mesenchymal tumorigenesis. \| journal = Am J Surg Pathol \| volume = 26 \| issue = 5 \| pages = 662-9 \| month = May \| year = 2002 \| doi = \| PMID = 11979097 }}</ref>

	===Classification===		===Classification===

Michael: split out

2013-12-26T01:36:21Z

split out

← Older revision		Revision as of 01:36, 26 December 2013
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	~~#redirect~~ [[Lymph node pathology#Castleman disease]]		'''Castleman disease''', abbreviated '''CD''', is a rare [[Lymph node pathology\|pathology of the lymph node]].

			It is also known as '''angiofollicular lymph node hyperplasia''' and '''giant lymph node hyperplasia'''.<ref>URL: [http://www.mayoclinic.com/health/castleman-disease/DS01000 http://www.mayoclinic.com/health/castleman-disease/DS01000]. Accessed on: 17 June 2010.</ref>

			==General==
			*Benign.
			*Hyaline vascular variant - a pathology of the follicular dendritic cells.<ref>{{Cite journal \| last1 = Cokelaere \| first1 = K. \| last2 = Debiec-Rychter \| first2 = M. \| last3 = De Wolf-Peeters \| first3 = C. \| last4 = Hagemeijer \| first4 = A. \| last5 = Sciot \| first5 = R. \| title = Hyaline vascular Castleman's disease with HMGIC rearrangement in follicular dendritic cells: molecular evidence of mesenchymal tumorigenesis. \| journal = Am J Surg Pathol \| volume = 26 \| issue = 5 \| pages = 662-9 \| month = May \| year = 2002 \| doi = \| PMID = 11979097 }}</ref>

			===Classification===
			CD is grouped by histologic appearance:<ref name=Ref_ILNP228>{{Ref ILNP\|228}}</ref>
			#Hyaline vascular (HV) variant (described by Castleman).
			#*Usually unicentric.
			#*Typically mediastinal or axial.
			#*More common than plasma cell variant; represents 80-90% of CD cases.
			#*May be associated with [[follicular dendritic cell neoplasia]].<ref name=Ref_WMSP_596>{{Ref WMSP\|596}}</ref>
			#Plasma cell (PC) variant.
			#*Usually multicentric, may be unicentric.
			#*Abundant plasma cells.
			#*Associated with [[HHV-8]] infection (the same virus implicated in ''Kaposi's sarcoma'').

			Notes:
			*The subclassification of CD is in some flux. Some authors advocate splitting-out ''HHV-8'' and ''multicentric'' as separate subtypes.<ref name=pmid19546611>{{Cite journal \| last1 = Cronin \| first1 = DM. \| last2 = Warnke \| first2 = RA. \| title = Castleman disease: an update on classification and the spectrum of associated lesions. \| journal = Adv Anat Pathol \| volume = 16 \| issue = 4 \| pages = 236-46 \| month = Jul \| year = 2009 \| doi = 10.1097/PAP.0b013e3181a9d4d3 \| PMID = 19546611 }}</ref>

			==Microscopic==
			===Hyaline-vascular variant===
			Features:<ref>URL: [http://www.ispub.com/journal/the_internet_journal_of_otorhinolaryngology/volume_9_number_2_11/article/a_rare_case_of_castleman_s_disease_presenting_as_cervical_neck_mass.html http://www.ispub.com/journal/the_internet_journal_of_otorhinolaryngology/volume_9_number_2_11/article/a_rare_case_of_castleman_s_disease_presenting_as_cervical_neck_mass.html]. Accessed on: 15 June 2010.</ref><ref name=Ref_ILNP236>{{Ref ILNP\|236}}</ref>
			*Pale concentric (expanded) mantle zone lymphocytes - '''key feature'''.
			**"Regressed follicles" - germinal center (pale area) is small.
			*"Lollipops":
			**Germinal centers fed by prominent (radially penetrating sclerotic) vessels; lollipop-like appearance.
			*Two germinal centers in one follicle.
			*Hyaline material (pink acellular stuff on H&E) in germinal center.
			*Sinuses effaced (lost).
			*Mitoses absent.

			====Images====
			<gallery>
			Image:Castleman_disease_-_high_mag.jpg \| CD HVV - "lollipop" sign - high mag. (WC)
			Image:Castleman_disease_-_intermed_mag.jpg \| CD HVV - showing expanded mantle zone - intermed. mag. (WC)
			</gallery>
			www:
			*[http://path.upmc.edu/cases/case115.html CD HVV - case 1 - several images (upmc.edu)].
			*[http://path.upmc.edu/cases/case301.html CD HVV - case 2 - several images (upmc.edu)].

			===Plasma cell variant===
			Features:<ref name=Ref_ILNP236>{{Ref ILNP\|236}}</ref>
			*Interfollicular sheets of plasma cells - '''key feature'''.
			*Active germinal centers - mitoses present.
			*Sinus perserved.

			==IHC==
			Hyaline-vascular variant:
			*Stains to exclude [[mantle cell lymphoma]]:
			**Cyclin D1.

			Plasma cell variant:
			*HHV-8 +ve.

			==See also==
			*[[Lymph node pathology]].

			==References==
			{{Reflist\|2}}

			[[Category:Diagnosis]]
			[[Category:Lymph node pathology]]

Michael: redirect

2011-11-15T05:55:25Z

redirect

New page

#redirect [[Lymph node pathology#Castleman disease]]