Jensflorian: +molecular

2015-09-21T08:37:55Z

+molecular

← Older revision		Revision as of 08:37, 21 September 2015
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	\| vip=		\| vip=
	\| vzv=		\| vzv=
			}}

			=====Other molecular tests=====
			{{Case Molecular
			\| blank=Dr Torres would ask why!
			\| alk =
			\| b_cell_clone =
			\| bcl2 =
			\| braf =
			\| EBV_pcr =
			\| egrf =
			\| h3f3a = '''NEGATIVE'''
			\| hhv8_pcr =
			\| identity_test =
			\| idh1_2 = '''IDH1 R132H mutation'''
			\| jak2_v617f =
			\| kit =
			\| loh_1p19q = '''NEGATIVE'''
			\| t_cell_clone =
	}}		}}

Jensflorian: Created page with "===Clinical history=== 45 year old woman with a lesion in the left temporal lobe. ===Primary image=== center| Supr..."

2015-09-18T14:24:33Z

Created page with "===Clinical history=== 45 year old woman with a lesion in the left temporal lobe. ===Primary image=== 500px|link=|center| <center>Supr..."

New page

===Clinical history===
45 year old woman with a lesion in the left temporal lobe.

===Primary image===
[[Image:Neuropathology_case_II_01.jpg|500px|link=|center|]]
<center>Supratentorial lesion. [[H&E stain]].</center>

{{hidden|Intermediate magnification|[[Image:Neuropathology_case_II_02.jpg|500px|link=|center|]]
<center>Intermediate magnification. [[H&E stain]].</center>}}

{{hidden|High magnification|[[Image:Neuropathology_case_II_03.jpg|500px|link=|center|]]
<center>High magnification. [[H&E stain]].</center>}}

===Differential diagnosis===
{{hidden|Differential diagnosis|<center>Astrocytoma, Oligodendroglioma, pilomyxoid astrocytoma, dysembryoplastic neuroepithelial tumor</center>}}

===Additional tests===
====More history====
{{hidden|More history|<center> The lesion shows no enhancement after CM application.</center>}}

====Ask a friend====
{{hidden|Ask a friend|<center>Extensive microcyst formations and mucoid degeneration is indicative of a protoplasmic glial brain tumor.</center>}}

====Stains====
{{Case Stains
| blank=I'm sorry but this is of no help.
| alcpas=
| alc1=
| alc25=
| aur=
| biel=
| bili=
| iron=
| congored=
| cresylv=
| diffquik=
| fontana=
| gallyas=
| giemsa=
| gms=
| gomori=
| gram=
| gremelius=
| jms=
| jones=
| kinyoun=
| luxol=
| masson=
| mmas=
| mucicar=
| oilredo=
| orecein=
| pas=
| pasd=
| pasf=
| ptah=
| prussian=
| reticulin= This stain highlights the capillaries within the tumor
| sudanblackb=
| toluidine=
| verhoeff=
| vonkossa=
| warthinstarry=
}}

====IHC====
{{Case IHC
| blank=I'm sorry but this is of no help.
| ae1ae3= '''NEGATIVE'''
| a1at=
| acth=
| afp=
| alk1=
| amacr=
| atrx = [[Image:Neuropathology_case_II_ATRX_immunohistochemistry.jpg|500px|link=|center|]]
| b2microgl=
| b723=
| bcl2=
| bcl6=
| bclxl=
| c3=
| calcit=
| calponin=
| calretinin=
| cd10=
| cd117=
| cd15=
| cd1a=
| cd20=
| cd21=
| cd23=
| cd3=
| cd30=
| cd31=
| cd34= '''NEGATIVE'''
| cd35=
| cd4=
| cd43=
| cd45= '''NEGATIVE'''
| cd5=
| cd56=
| cd68=
| cd7=
| cd79a=
| cd8=
| cd99=
| cea=
| chromo=
| ck19=
| ck20=
| ck34be12=
| ck7=
| cmv=
| cmyc=
| cyclind1=
| desmin=
| ebv=
| ema= '''NEGATIVE'''
| erpr=
| fascin=
| fsh=
| fviii=
| fxiiia=
| gastrin=
| gcdfp=
| gfap = [[Image:Neuropathology_case_II_06.jpg|500px|link=|center|]]
| gh=
| glucag=
| hbme1=
| hbvc=
| hbvs=
| hcg=
| hepatocyte=
| her2=
| hmb45=
| hpv=
| hsv1=
| hsv2=
| Idh-1=[[Image:Neuropathology_case_II_05.jpg|500px|link=|center|]]
| inhibin=
| insulin=
| kappa=
| ki67= [[Image:Neuropathology_case_II_04.jpg|500px|link=|center|]]
| lambda=
| lca= '''NEGATIVE'''
| leu7=
| lga=
| lgg=
| lgm=
| lh=
| lysozyme=
| melanina=
| map2= [[Image:Neuropathology_case_II_07.jpg|500px|link=|center|]]
| myleoperox=
| myod1=
| myog=
| myog=
| nse= '''NEGATIVE'''
| nf= '''NEGATIVE'''
| p53=
| p63=
| panker= '''NEGATIVE'''
| pcna=
| plap=
| pnl2c=
| prolac=
| psa=
| s100= '''POSITIVE'''
| sma=
| somatsat=
| synapto=
| tdt=
| thyrogl=
| toxopl=
| tsh=
| ttf1=
| ubiquitin=
| uchl1=
| ulexeurope=
| vim=
| vip=
| vzv=
}}

===Diagnosis===
{{hidden|Diagnosis|<center>Diffuse [[Astrocytoma]], WHO grade II.</center><br>Comment:<br>This protoplasmic variant has scant GFAP expression and thus is often misdiagnosed as oligodendroglioma, but nuclear ATRX loss and absence of deletions in chromosomal arms 1p/19q confirm the diagnosis.}}
<br>
===Other cases===
{{Cases navigation|state=collapsed}}

__NOTOC__

[[Category:Cases]]
[[Category:Cases in neuropathology]]

[[Category:Cases difficulty 4]]
[[Category:Cases in neuropathology - senior]]

Case 83 - Revision history

Jensflorian: +molecular

Jensflorian: Created page with "===Clinical history=== 45 year old woman with a lesion in the left temporal lobe. ===Primary image=== center| Supr..."