https://librepathology.org/w/index.php?action=history&feed=atom&title=Case_119 Case 119 - Revision history 2026-04-09T23:34:22Z Revision history for this page on the wiki MediaWiki 1.36.3 https://librepathology.org/w/index.php?title=Case_119&diff=40359&oldid=prev Jensflorian: case 119 2015-10-05T09:49:39Z <p>case 119</p> <p><b>New page</b></p><div>===Provided clinical history===<br /> 37 year old female with muscular pain and atrophy of the proximal muscles.<br /> <br /> ===Site===<br /> Left quadiceps muscle<br /> <br /> ===Primary image===<br /> [[Image:Neuropathology case XII 01.jpg |500px|link=|center|]]<br /> &lt;center&gt;Intermediate magnification. [[H&amp;E stain]].&lt;/center&gt;<br /> <br /> {{hidden|High magnification|[[Image:Neuropathology case XII 02.jpg |500px|link=|center|]]<br /> &lt;center&gt;Intermediate magnification. [[H&amp;E stain]].&lt;/center&gt;}}<br /> <br /> ===Differential diagnosis===<br /> {{hidden|Differential diagnosis|&lt;center&gt;Polymyositis, Dermatomyositis, Inclusion body myositis, paraneoplastic myostis, Granulomatous myositis&lt;/center&gt;}}<br /> <br /> ===Additional tests===<br /> ====More history====<br /> {{hidden|More history|&lt;center&gt;Creatinkinase 1085 U/l&lt;/center&gt;}}<br /> <br /> ====Ask a colleague====<br /> {{hidden|Ask a colleague|&lt;center&gt;Do the inflammtory infiltrate invade non-necrotic fibers?&lt;/center&gt;}}<br /> <br /> ====Stains====<br /> {{Case Stains<br /> | blank=Dr White would ask why!<br /> | alcpas= <br /> | alc1= <br /> | alc25= <br /> | aur= <br /> | biel= <br /> | bili= <br /> | iron= <br /> | congored= <br /> | cresylv= <br /> | dieterle= <br /> | diffquik= <br /> | fontana= <br /> | gallyas= <br /> | giemsa= <br /> | gms= <br /> | gomori= <br /> | gram= <br /> | gremelius= <br /> | jms= <br /> | jones= <br /> | kinyoun= <br /> | luxol= <br /> | masson= <br /> | mmas= <br /> | movat= <br /> | mucicar= <br /> | oilredo= <br /> | orecein= <br /> | pas= '''NEGATIVE'''<br /> | pasd= <br /> | pasf= <br /> | ptah= <br /> | prussian= <br /> | reticulin= <br /> | sudanblackb= <br /> | toluidine= <br /> | verhoeff= <br /> | vonkossa= <br /> | warthinstarry= <br /> | zn= <br /> }}<br /> ====IHC====<br /> {{Case IHC<br /> | blank=Dr White would ask why!<br /> | a1at= <br /> | acth= <br /> | ae1ae3= <br /> | afp= <br /> | alk1= <br /> | amacr= <br /> | ar=<br /> | atrx= <br /> | b2microglobulin= <br /> | b72_3= <br /> | bcatenin= <br /> | bcl2= <br /> | bcl6= <br /> | bclxl= <br /> | c3= <br /> | ca9= <br /> | calcitonin= <br /> | calponin= <br /> | calretinin= <br /> | cam5p2= <br /> | cathepsink= <br /> | cd10= <br /> | cd117= <br /> | cd138= <br /> | cd15= <br /> | cd1a= <br /> | cd20= <br /> | cd21= <br /> | cd23= <br /> | cd3= <br /> | cd30= '''NEGATIVE'''<br /> | cd31= '''NEGATIVE'''<br /> | cd34= '''NEGATIVE'''<br /> | cd35= <br /> | cd4= <br /> | cd43= <br /> | cd45= [[Image:Neuropathology case XII 03.jpg |500px|link=|center|]]<br /> | cd5= <br /> | cd56= <br /> | cd57= <br /> | cd68= <br /> | cd7= <br /> | cd79a= <br /> | cd8= <br /> | cd99= <br /> | cdx2= <br /> | cea= <br /> | chromo= <br /> | ck17= <br /> | ck19= <br /> | ck20= <br /> | ck34be12= <br /> | ck5_6= <br /> | ck7= <br /> | cmv= <br /> | cmyc= <br /> | cyclin_d1= <br /> | d2_40= <br /> | desmin= <br /> | dog1= <br /> | ebv= <br /> | ema= <br /> | erpr= <br /> | f_viii= <br /> | f_xiiia= <br /> | fascin= <br /> | fh=<br /> | fsh= <br /> | gastrin= <br /> | gata3= <br /> | gcdfp= <br /> | gfap= '''NEGATIVE'''<br /> | gh= <br /> | glucagon= <br /> | glypican3= '''NEGATIVE'''<br /> | hbme1= <br /> | hbv_core= <br /> | hbv_surf= <br /> | hcaldesmon= <br /> | hcg= <br /> | helicobacter= <br /> | hepatocyte= <br /> | her2= <br /> | hhv8= <br /> | hmb45= <br /> | hnf1beta= <br /> | hpv= <br /> | hsv1= <br /> | hsv2= <br /> | Idh-1= <br /> | inhibin= <br /> | ini1= <br /> | insulin= <br /> | kappa= <br /> | ki67= '''8%'''<br /> | lambda= <br /> | leu7= <br /> | lga= <br /> | lgg= <br /> | lgm= <br /> | lh= <br /> | lysozyme= <br /> | mammogl=<br /> | map2= <br /> | mcv= <br /> | melanin_a= '''NEGATIVE'''<br /> | mhcI=[[Image:Neuropathology case XII 04.jpg |500px|link=|center|]]<br /> | mitf= <br /> | mum1= <br /> | myleoperox= <br /> | myo_d1= <br /> | myog= <br /> | nf= <br /> | nkx3_1= <br /> | nse= <br /> | oct3_4=<br /> | p16= <br /> | p501s= <br /> | p53= <br /> | p57= <br /> | p63= <br /> | panker= <br /> | pax2= <br /> | pax5= <br /> | pax8= <br /> | pcna= <br /> | pdgfr= <br /> | plap= <br /> | pnl-2c= <br /> | prolactin= <br /> | psa= <br /> | psap= <br /> | rcc= <br /> | s100= <br /> | sma= <br /> | somatsatin= <br /> | stat6= <br /> | synapto= <br /> | tdt= <br /> | tfe3= <br /> | tfeb= <br /> | thyrogl= <br /> | toxopl= <br /> | tsh= <br /> | ttf1= <br /> | ubiquitin= <br /> | uchl1= <br /> | ulex_europe= <br /> | vim= <br /> | vip= <br /> | vzv= <br /> | wt1= <br /> }}<br /> <br /> ====Molecular testing====<br /> =====Chromosomal translocations=====<br /> {{Case Translocations<br /> | blank=Dr White would ask why!<br /> | t1_13= <br /> | t2_13= <br /> | t8_14= <br /> | t9_22bcr_abl= <br /> | t9_22chn_ews= <br /> | t11_14= <br /> | t11_22dsrct= <br /> | t11_22ews= <br /> | t12_15= <br /> | t12_16afh= <br /> | t12_16liposar= <br /> | t12_22= <br /> | t14_18= <br /> | t15_17= <br /> | t16_21= <br /> | t17_22= <br /> | t21_22= <br /> | tx_1= <br /> | tx_17= <br /> | tx_18= <br /> }}<br /> =====Other molecular tests=====<br /> {{Case Molecular<br /> | blank=Dr White would ask why!<br /> | alk = <br /> | b_cell_clone = <br /> | bcl2 = <br /> | braf = <br /> | EBV_pcr = <br /> | egrf = <br /> | h3f3a = <br /> | hhv8_pcr = <br /> | identity_test = <br /> | idh1_2 = <br /> | jak2_v617f = <br /> | kit = <br /> | loh_1p19q = <br /> | t_cell_clone = <br /> }}<br /> <br /> ===Diagnosis===<br /> {{hidden|Diagnosis|&lt;center&gt;Polymyositis&lt;/center&gt;<br /> &lt;br&gt;<br /> Comment: Polymyositis (diagnosed by MHC class I upregulation and CD45-positive cells invading myofibers) has an associated increased risk of malignancy. Therefore patients should undergo screening to exclude a paraneoplastic condition.}}<br /> <br /> ===Other cases===<br /> {{Cases navigation}}<br /> <br /> __NOTOC__<br /> <br /> [[Category:Cases]]<br /> <br /> [[Category:Cases in neuropathology]]<br /> [[Category:Cases in neuropathology - senior]]<br /> <br /> [[Category:Cases difficulty 4]] &lt;!-- difficulty 1-7 -- should roughly correspond to the PGY level --&gt;</div> Jensflorian