Michael: fix dx

2015-09-27T02:36:27Z

fix dx

← Older revision		Revision as of 02:36, 27 September 2015
Line 274:		Line 274:
	<br>		<br>
	Comment: Glioblastoma (GBM) is the most common malignant brain tumour. Primary GBM usually do not harbor any IDH1/2 and ATRX alterations, while secondary GBM that develop from lower-grade precursor lesions usaually show nuclear [[ATRX]] loss and positive [[IDH-1]] immunostaining.		Comment: Glioblastoma (GBM) is the most common malignant brain tumour. Primary GBM usually do not harbor any IDH1/2 and ATRX alterations, while secondary GBM that develop from lower-grade precursor lesions usaually show nuclear [[ATRX]] loss and positive [[IDH-1]] immunostaining.
			}}

	===Other cases===		===Other cases===

Jensflorian: Case 114

2015-09-25T15:29:02Z

Case 114

New page

===Provided clinical history===
64 year old male with weakness in the left arm.

===Site===
Right fronto-parietal lobes.

===Primary image===
[[Image:Neuropathology case IX 01.jpg|500px|link=|center|]]
<center>Low magnification. [[H&E stain]].</center>

{{hidden|Intermediate magnification|[[Image:Neuropathology case IX 02.jpg |500px|link=|center|]]
<center>Intermediate magnification. [[H&E stain]].</center>}}

{{hidden|High magnification|[[Image:Neuropathology case IX 03.jpg |500px|link=|center|]]
<center>High magnification. [[H&E stain]].</center>}}

===Differential diagnosis===
{{hidden|Differential diagnosis|<center>Gemistocytic [[astrocytoma]], [[Glioblastoma]], [[Pleomorphic xanthoastrocytoma]] </center>}}

===Additional tests===
====More history====
{{hidden|More history|<center>The clinical history is very short.</center>}}

====Ask a colleague====
{{hidden|Ask a colleague|<center>Not too hard. Gemistocytic tumor cells, necrosis and endothelial proliferations. </center>}}

====Stains====
{{Case Stains
| blank=Dr Torres would ask why!
| alcpas=
| alc1=
| alc25=
| aur=
| biel=
| bili=
| iron=
| congored=
| cresylv=
| dieterle=
| diffquik=
| fontana=
| gallyas=
| giemsa=
| gms=
| gomori=
| gram=
| gremelius=
| jms=
| jones=
| kinyoun=
| luxol=
| masson=
| mmas=
| movat=
| mucicar=
| oilredo=
| orecein=
| pas=
| pasd=
| pasf=
| ptah=
| prussian=
| reticulin=
| sudanblackb=
| toluidine=
| verhoeff=
| vonkossa=
| warthinstarry=
| zn=
}}
====IHC====
{{Case IHC
| blank=Dr Torres would ask why!
| a1at=
| acth=
| ae1ae3= '''NEGATIVE'''
| afp=
| alk1=
| amacr=
| ar=
| atrx= '''NO LOSS'''
| b2microglobulin=
| b72_3=
| bcatenin=
| bcl2=
| bcl6=
| bclxl=
| c3=
| ca9=
| calcitonin=
| calponin=
| calretinin=
| cam5p2= '''NEGATIVE'''
| cathepsink=
| cd10=
| cd117=
| cd138=
| cd15=
| cd1a=
| cd20=
| cd21=
| cd23=
| cd3=
| cd30=
| cd31=
| cd34=
| cd35=
| cd4=
| cd43=
| cd45= '''NEGATIVE'''
| cd5=
| cd56=
| cd57=
| cd68=
| cd7=
| cd79a=
| cd8=
| cd99=
| cdx2=
| cea=
| chromo=
| ck17=
| ck19=
| ck20=
| ck34be12=
| ck5_6=
| ck7=
| cmv=
| cmyc=
| cyclin_d1=
| d2_40=
| desmin=
| dog1=
| ebv=
| ema=
| erpr=
| f_viii=
| f_xiiia=
| fascin=
| fh=
| fsh=
| gastrin=
| gata3=
| gcdfp=
| gfap= [[Image:Neuropathology case IX 04.jpg |500px|link=|center|]]
| gh=
| glucagon=
| glypican3=
| hbme1=
| hbv_core=
| hbv_surf=
| hcaldesmon=
| hcg=
| helicobacter=
| hepatocyte=
| her2=
| hhv8=
| hmb45=
| hnf1beta=
| hpv=
| hsv1=
| hsv2=
| Idh-1= '''NEGATIVE'''
| inhibin=
| ini1=
| insulin=
| kappa=
| ki67= [[Image:Neuropathology case IX 06.jpg |500px|link=|center|]]
| lambda=
| leu7=
| lga=
| lgg=
| lgm=
| lh=
| lysozyme=
| mammogl=
| map2= [[Image:Neuropathology case IX 05.jpg |500px|link=|center|]]
| mcv=
| melanin_a=
| mitf=
| mum1=
| myleoperox=
| myo_d1=
| myog=
| napsin=
| nf= '''NEGATIVE'''
| nkx3_1=
| nse=
| oct3_4=
| p16=
| p501s=
| p53=
| p57=
| p63=
| panker=
| pax2=
| pax5=
| pax8=
| pcna=
| pdgfr=
| plap=
| pnl-2c=
| prolactin=
| psa=
| psap=
| rcc=
| s100=
| sma=
| somatsatin=
| synapto= '''NEGATIVE'''
| tdt=
| tfe3=
| tfeb=
| thyrogl=
| toxopl=
| tsh=
| ttf1=
| ubiquitin=
| uchl1=
| ulex_europe=
| vim= '''POSITIVE'''
| vip=
| vzv=
| wt1= [[Image:Wilms tumor protein wt1 immunohistocehmistry glioblastoma.JPG |500px|link=|center|]]
}}

====Molecular testing====
=====Chromosomal translocations=====
{{Case Translocations
| blank=Dr Torres would ask why!
| t1_13=
| t2_13=
| t8_14=
| t9_22bcr_abl=
| t9_22chn_ews=
| t11_14=
| t11_22dsrct=
| t11_22ews=
| t12_15=
| t12_16afh=
| t12_16liposar=
| t12_22=
| t14_18=
| t15_17=
| t16_21=
| t17_22=
| t21_22=
| tx_1=
| tx_17=
| tx_18=
}}
=====Other molecular tests=====
{{Case Molecular
| blank=Dr Torres would ask why!
| alk =
| b_cell_clone =
| bcl2 =
| braf =
| EBV_pcr =
| egrf =
| h3f3a = '''WILDTYPE'''
| hhv8_pcr =
| identity_test =
| idh1_2 = '''WILDTYPE'''
| jak2_v617f =
| kit =
| loh_1p19q = '''NO LOH 1p/19q'''
| t_cell_clone =
}}

===Diagnosis===

{{hidden|Diagnosis|<center>[[Glioblastoma]], WHO grade IV</center>
<br>
Comment: Glioblastoma (GBM) is the most common malignant brain tumour. Primary GBM usually do not harbor any IDH1/2 and ATRX alterations, while secondary GBM that develop from lower-grade precursor lesions usaually show nuclear [[ATRX]] loss and positive [[IDH-1]] immunostaining.

===Other cases===
{{Cases navigation}}

__NOTOC__

[[Category:Cases]]
[[Category:Cases in neuropathology]]
[[Category:Cases in neuropathology - junior]]

[[Category:Cases difficulty 1]]

Case 114 - Revision history

Michael: fix dx

Jensflorian: Case 114