Case 107 - Revision history

Michael: /* Other cases */

2015-09-24T04:27:36Z

Other cases

← Older revision		Revision as of 04:27, 24 September 2015
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	[[Category:Cases]]		[[Category:Cases]]

	~~<!-- SELECT A CATEGORY~~
	[[Category:Cases in ~~gynecological~~ pathology]]		[[Category:Cases in gynecologic pathology]]
	-->		[[Category:Cases in gynecologic pathology - senior]]

	[[Category:Cases difficulty 4]] <!-- difficulty 1-7 -- should roughly correspond to the PGY level -->		[[Category:Cases difficulty 4]] <!-- difficulty 1-7 -- should roughly correspond to the PGY level -->

Vinita at 17:32, 23 September 2015

2015-09-23T17:32:05Z

← Older revision		Revision as of 17:32, 23 September 2015
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	<!-- SELECT A CATEGORY		<!-- SELECT A CATEGORY
	[[Category:Cases in ~~genitourinary~~ pathology]]		[[Category:Cases in gynecological pathology]]
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	[[Category:Cases difficulty 4]] <!-- difficulty 1-7 -- should roughly correspond to the PGY level -->		[[Category:Cases difficulty 4]] <!-- difficulty 1-7 -- should roughly correspond to the PGY level -->

Vinita: /* Diagnosis */

2015-09-23T17:28:54Z

Diagnosis

← Older revision		Revision as of 17:28, 23 September 2015
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	===Diagnosis===		===Diagnosis===
	{{hidden\|Diagnosis\|<center>CLEAR CELL CARCINOMA OF THE OVARY. This is the most commonly missed pattern of clear cells carcinoma in the ovary ~~(as~~ is the papillary pattern which resembles a borderline serous tumor). Most often the luminal contents are watery, but can ~~have a thicker quality to it~~. The tumor ~~may be~~ difficult to recognize because the atypia is not pronounced. ~~However,~~ hobnailed cells ~~are a clue and~~ clear cells ~~are often more commonly identified in the smaller cysts~~. Tumor cells are characteristically WT1, ER, PR negative which distinguishes it from a serous tumor. However, this immunoprofile is also true of mucinous tumors of the ovary, although that is uncommonly in the differential. Tumor cells are positive for Napsin, HNF1beta and Arid IA, which distinguishes it from its mimics. </center>}}		{{hidden\|Diagnosis\|<center>CLEAR CELL CARCINOMA OF THE OVARY. This is the most commonly missed pattern of clear cells carcinoma in the ovary. Another pattern that is commonly missed is the papillary pattern which resembles a borderline serous tumor. Most often the luminal contents are watery, but can be thick and tenacious. The tumor is difficult to recognize because the atypia is not pronounced. Closer examination will reveal hobnailed cells (image 2). Smaller cysts often reveal the diagnostic clear cells. Tumor cells are characteristically WT1, ER, PR negative which distinguishes it from a serous tumor. However, this immunoprofile is also true of mucinous tumors of the ovary, although that is uncommonly in the differential. Tumor cells are positive for Napsin, HNF1beta and Arid IA, which distinguishes it from its mimics. </center>}}
	<br>		<br>

	===Other cases===		===Other cases===
	{{Cases navigation}}		{{Cases navigation}}

Vinita: Created page with "===Provided clinical history=== 53 year old woman with a 11 cm cystic mass with focal small solid area on ultrasound, thought to be a cystadenoma or cystadenofibroma preoperat..."

2015-09-23T17:25:50Z

Created page with "===Provided clinical history=== 53 year old woman with a 11 cm cystic mass with focal small solid area on ultrasound, thought to be a cystadenoma or cystadenofibroma preoperat..."

New page

===Provided clinical history===
53 year old woman with a 11 cm cystic mass with focal small solid area on ultrasound, thought to be a cystadenoma or cystadenofibroma preoperatively

===Site===
Ovary- epithelial

===Primary image===
[[Image: Tubulocystic clear cell carcinoma of the ovary.jpg |500px|link=|center|]]
<center>Low magnification. [[H&E stain]].</center>

{{hidden|Intermediate magnification|[[Image: High magnification of tubulocystic clear cell carcinoma of ovary.jpg|500px|link=|center|]]
<center>Intermediate magnification. [[H&E stain]].</center>}}

{{hidden|High magnification|[[Image: High magnification of tubulocystic clear cell carcinoma of the ovary.jpg|500px|link=|center|]]
<center>High magnification. [[H&E stain]].</center>}}

===Differential diagnosis===
{{hidden|Differential diagnosis|<center>THE DDx GOES HERE</center>}}

===Additional tests===
====More history====
{{hidden|More history|<center>MORE HISTORY HERE</center>}}

====Ask a colleague====
{{hidden|Ask a colleague|<center>COLLEAGUE'S ADVICE HERE</center>}}

====Stains====
{{Case Stains
| blank=Dr Torres would ask why!
| alcpas=
| alc1=
| alc25=
| aur=
| biel=
| bili=
| iron=
| congored=
| cresylv=
| dieterle=
| diffquik=
| fontana=
| gallyas=
| giemsa=
| gms=
| gomori=
| gram=
| gremelius=
| jms=
| jones=
| kinyoun=
| luxol=
| masson=
| mmas=
| movat=
| mucicar=
| oilredo=
| orecein=
| pas=
| pasd=
| pasf=
| ptah=
| prussian=
| reticulin=
| sudanblackb=
| toluidine=
| verhoeff=
| vonkossa=
| warthinstarry=
| zn=
}}
====IHC====
{{Case IHC
| blank=Dr Torres would ask why!
| a1at=
| acth=
| ae1ae3=
| afp=
| alk1=
| amacr=
| ar=
| atrx=
| b2microglobulin=
| b72_3=
| bcatenin=
| bcl2=
| bcl6=
| bclxl=
| c3=
| ca9=
| calcitonin=
| calponin=
| calretinin=
| cam5p2=
| cathepsink=
| cd10=
| cd117=
| cd138=
| cd15=
| cd1a=
| cd20=
| cd21=
| cd23=
| cd3=
| cd30=
| cd31=
| cd34=
| cd35=
| cd4=
| cd43=
| cd45=
| cd5=
| cd56=
| cd57=
| cd68=
| cd7=
| cd79a=
| cd8=
| cd99=
| cdx2=
| cea=
| chromo=
| ck17=
| ck19=
| ck20=
| ck34be12=
| ck5_6=
| ck7=
| cmv=
| cmyc=
| cyclin_d1=
| d2_40=
| desmin=
| dog1=
| ebv=
| ema=
| erpr= NEGATIVE
| f_viii=
| f_xiiia=
| fascin=
| fh=
| fsh=
| gastrin=
| gata3=
| gcdfp=
| gfap=
| gh=
| glucagon=
| glypican3=
| hbme1=
| hbv_core=
| hbv_surf=
| hcaldesmon=
| hcg=
| helicobacter=
| hepatocyte=
| her2=
| hhv8=
| hmb45=
| hnf1beta= POSITIVE
| hpv=
| hsv1=
| hsv2=
| Idh-1=
| inhibin=
| ini1=
| insulin=
| kappa=
| ki67=
| lambda=
| leu7=
| lga=
| lgg=
| lgm=
| lh=
| lysozyme=
| mammogl=
| map2=
| mcv=
| melanin_a=
| mitf=
| mum1=
| myleoperox=
| myo_d1=
| myog=
| nf=
| nkx3_1=
| nse=
| oct3_4=
| p16=
| p501s=
| p53=
| p57=
| p63=
| panker=
| pax2=
| pax5=
| pax8=
| pcna=
| pdgfr=
| plap=
| pnl-2c=
| prolactin=
| psa=
| psap=
| rcc=
| s100=
| sma=
| somatsatin=
| synapto=
| tdt=
| tfe3=
| tfeb=
| thyrogl=
| toxopl=
| tsh=
| ttf1=
| ubiquitin=
| uchl1=
| ulex_europe=
| vim=
| vip=
| vzv=
| wt1= NEGATIVE
}}

====Molecular testing====
=====Chromosomal translocations=====
{{Case Translocations
| blank=Dr Torres would ask why!
| t1_13=
| t2_13=
| t8_14=
| t9_22bcr_abl=
| t9_22chn_ews=
| t11_14=
| t11_22dsrct=
| t11_22ews=
| t12_15=
| t12_16afh=
| t12_16liposar=
| t12_22=
| t14_18=
| t15_17=
| t16_21=
| t17_22=
| t21_22=
| tx_1=
| tx_17=
| tx_18=
}}
=====Other molecular tests=====
{{Case Molecular
| blank=Dr Torres would ask why!
| alk =
| b_cell_clone =
| bcl2 =
| braf =
| EBV_pcr =
| egrf =
| h3f3a =
| hhv8_pcr =
| identity_test =
| idh1_2 =
| jak2_v617f =
| kit =
| loh_1p19q =
| t_cell_clone =
}}

===Diagnosis===
{{hidden|Diagnosis|<center>CLEAR CELL CARCINOMA OF THE OVARY. This is the most commonly missed pattern of clear cells carcinoma in the ovary (as is the papillary pattern which resembles a borderline serous tumor). Most often the luminal contents are watery, but can have a thicker quality to it. The tumor may be difficult to recognize because the atypia is not pronounced. However, hobnailed cells are a clue and clear cells are often more commonly identified in the smaller cysts. Tumor cells are characteristically WT1, ER, PR negative which distinguishes it from a serous tumor. However, this immunoprofile is also true of mucinous tumors of the ovary, although that is uncommonly in the differential. Tumor cells are positive for Napsin, HNF1beta and Arid IA, which distinguishes it from its mimics. </center>}}
<br>
===Other cases===
{{Cases navigation}}

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