Cardiomyopathy - Revision history

Michael: +BHS

2024-08-26T17:11:02Z

+BHS

← Older revision		Revision as of 17:11, 26 August 2024
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	*Prominent "mesh-like" [[trabeculae]] carnae.		*Prominent "mesh-like" [[trabeculae]] carnae.
	**Enlarged intertrabecular recesses.<ref name=pmid2372897>{{cite journal \|author=Chin TK, Perloff JK, Williams RG, Jue K, Mohrmann R \|title=Isolated noncompaction of left ventricular myocardium. A study of eight cases \|journal=Circulation \|volume=82 \|issue=2 \|pages=507–13 \|year=1990 \|month=August \|pmid=2372897 \|doi= \|url=}}</ref>		**Enlarged intertrabecular recesses.<ref name=pmid2372897>{{cite journal \|author=Chin TK, Perloff JK, Williams RG, Jue K, Mohrmann R \|title=Isolated noncompaction of left ventricular myocardium. A study of eight cases \|journal=Circulation \|volume=82 \|issue=2 \|pages=507–13 \|year=1990 \|month=August \|pmid=2372897 \|doi= \|url=}}</ref>

			==Takotsubo cardiomyopathy==
			{{Main\|Takotsubo cardiomyopathy}}
			*Also known as ''broken heart syndrome''.

	==See also==		==See also==

Michael: /* Microscopic */

2017-02-08T18:10:52Z

Microscopic

← Older revision		Revision as of 18:10, 8 February 2017
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	*Myocytes have "bubbly" appearance with loss of myofibres and cross-striations.		*Myocytes have "bubbly" appearance with loss of myofibres and cross-striations.

	Images:		====Images====
	*[http:~~//en~~.~~wikipedia~~.~~org/wiki/Arrhythmogenic_right_ventricular_dysplasia ARVC micrograph~~ (WP)].		<gallery>
			Image: Arrhythmogenic right ventricular cardiomyopathy - histology.jpg \| ARVC. (WC)
			</gallery>
			=====www=====
	*[http://path.upmc.edu/cases/case223.html ARVC - several images (upmc.edu)].		*[http://path.upmc.edu/cases/case223.html ARVC - several images (upmc.edu)].

Michael: /* Arrhythmogenic right ventricular cardiomyopathy */

2014-07-21T01:29:31Z

Arrhythmogenic right ventricular cardiomyopathy

← Older revision		Revision as of 01:29, 21 July 2014
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	===Gross===		===Gross===
	Features:<ref name=emedicine1612324>URL: [http://emedicine.medscape.com/article/1612324-overview http://emedicine.medscape.com/article/1612324-overview].</ref>		Features:<ref name=emedicine1612324>URL: [http://emedicine.medscape.com/article/1612324-overview http://emedicine.medscape.com/article/1612324-overview].</ref>
	*RV wall thinning/replacement with fat.		*Right ventricular wall thinning/replacement with fat. †
	**Especially fat where fat is ''not'' usually seen - posterior RV wall, RVOT.		**Especially fat where fat is ''not'' usually seen - posterior RV wall, RVOT.
	*Septum usually has relative sparing		*Septum usually has relative sparing
	**Thus, endomyocardial biopsy is ''not'' reliable.		**Thus, endomyocardial biopsy is ''not'' reliable.
	*+/-Aneurysms/dilation.		*+/-Aneurysms/dilation.

			Note:
			*† May involve the left ventricle.<ref name=pmid23761986>{{cite journal \|author=Romero J, Mejia-Lopez E, Manrique C, Lucariello R \|title=Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC/D): A Systematic Literature Review \|journal=Clin Med Insights Cardiol \|volume=7 \|issue= \|pages=97–114 \|year=2013 \|pmid=23761986 \|pmc=3667685 \|doi=10.4137/CMC.S10940 \|url=}}</ref>

	===Microscopic===		===Microscopic===

Michael: /* General */ w

2013-04-17T03:44:03Z

General: w

← Older revision		Revision as of 03:44, 17 April 2013
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	*Myocarditis - leading cause, usually viral.<ref name=pmid19017683>{{cite journal \|author=Luk A, Ahn E, Soor GS, Butany J \|title=Dilated cardiomyopathy: a review \|journal=J. Clin. Pathol. \|volume=62 \|issue=3 \|pages=219–25 \|year=2009 \|month=March \|pmid=19017683 \|doi=10.1136/jcp.2008.060731 \|url=}}</ref>		*Myocarditis - leading cause, usually viral.<ref name=pmid19017683>{{cite journal \|author=Luk A, Ahn E, Soor GS, Butany J \|title=Dilated cardiomyopathy: a review \|journal=J. Clin. Pathol. \|volume=62 \|issue=3 \|pages=219–25 \|year=2009 \|month=March \|pmid=19017683 \|doi=10.1136/jcp.2008.060731 \|url=}}</ref>
	*Familial ~ 30% - can be AD with variable penetrance, AR, X-linked.		*Familial ~ 30% - can be AD with variable penetrance, AR, X-linked.
	*In the [[forensic pathology\|forensic]] context, usually caused by alcoholism.<ref name=Ref_HoFP43>{{Ref HoFP\|43}}</ref>		*In the [[forensic pathology\|forensic]] context, usually caused by [[alcoholism]].<ref name=Ref_HoFP43>{{Ref HoFP\|43}}</ref>

	===Microscopic===		===Microscopic===

Michael: /* Dilated cardiomyopathy */ +abbrev.

2013-03-06T18:36:50Z

Dilated cardiomyopathy: +abbrev.

← Older revision		Revision as of 18:36, 6 March 2013
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	==Dilated cardiomyopathy==		==Dilated cardiomyopathy==
			*Abbreviated ''DCM''.
	===General===		===General===
	*Most common of the cardiomyopathies.		*Most common of the cardiomyopathies.

Michael: /* Restrictive cardiomyopathy */

2013-02-08T20:37:14Z

Restrictive cardiomyopathy

← Older revision		Revision as of 20:37, 8 February 2013
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	*[[amyloidosis#Cardiac_amyloidosis\|Amyloidosis]].		*[[amyloidosis#Cardiac_amyloidosis\|Amyloidosis]].
	**Classically described as "stiff" or "rubbery".		**Classically described as "stiff" or "rubbery".
	*[[Sarcoidosis]].		*[[Cardiac sarcoidosis\|Sarcoidosis]].
	*Storage diseases (e.g. [[Pompe disease]]).		*Storage diseases (e.g. [[Pompe disease]]).
	*Eosinophilic endocarditis (Loeffler Endocarditis).		*Eosinophilic endocarditis (Loeffler Endocarditis).

Michael: /* Etiology */

2012-05-01T19:52:47Z

Etiology

← Older revision		Revision as of 19:52, 1 May 2012
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	Multiple causes - an incomplete list:<ref name=Ref_HoFP44-5>{{Ref HoFP\|44-5}}</ref>		Multiple causes - an incomplete list:<ref name=Ref_HoFP44-5>{{Ref HoFP\|44-5}}</ref>
	*[[Hemochromatosis]] - rare.<ref name=pmid7446557>{{Cite journal \| last1 = Cutler \| first1 = DJ. \| last2 = Isner \| first2 = JM. \| last3 = Bracey \| first3 = AW. \| last4 = Hufnagel \| first4 = CA. \| last5 = Conrad \| first5 = PW. \| last6 = Roberts \| first6 = WC. \| last7 = Kerwin \| first7 = DM. \| last8 = Weintraub \| first8 = AM. \| title = Hemochromatosis heart disease: an unemphasized cause of potentially reversible restrictive cardiomyopathy. \| journal = Am J Med \| volume = 69 \| issue = 6 \| pages = 923-8 \| month = Dec \| year = 1980 \| doi = \| PMID = 7446557 }}</ref>		*[[Hemochromatosis]] - rare.<ref name=pmid7446557>{{Cite journal \| last1 = Cutler \| first1 = DJ. \| last2 = Isner \| first2 = JM. \| last3 = Bracey \| first3 = AW. \| last4 = Hufnagel \| first4 = CA. \| last5 = Conrad \| first5 = PW. \| last6 = Roberts \| first6 = WC. \| last7 = Kerwin \| first7 = DM. \| last8 = Weintraub \| first8 = AM. \| title = Hemochromatosis heart disease: an unemphasized cause of potentially reversible restrictive cardiomyopathy. \| journal = Am J Med \| volume = 69 \| issue = 6 \| pages = 923-8 \| month = Dec \| year = 1980 \| doi = \| PMID = 7446557 }}</ref>
			**Hemochromatosis more commonly causes a [[DCM]].
	*[[amyloidosis#Cardiac_amyloidosis\|Amyloidosis]].		*[[amyloidosis#Cardiac_amyloidosis\|Amyloidosis]].
	**Classically described as "stiff" or "rubbery".		**Classically described as "stiff" or "rubbery".

Michael: /* Arrhythmogenic right ventricular cardiomyopathy */ re-order

2012-04-03T17:44:04Z

Arrhythmogenic right ventricular cardiomyopathy: re-order

← Older revision		Revision as of 17:44, 3 April 2012
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	==Arrhythmogenic right ventricular cardiomyopathy==		==Arrhythmogenic right ventricular cardiomyopathy==
	*Abbreviated ''ARVC''.		*Abbreviated ''ARVC''.
			*Previously known as ''arrhythmogenic right ventricular dysplasia'', abbreviated ''ARVD''.
	===General===		===General===
	*Previously known as "arrhythmogenic right ventricular dysplasia" (abbreviated ''ARVD'').
	*Associated with sudden cardiac death in "young people".<ref>Sudden cardiac death due to hypertrophic cardiomyopathy can be reduced by pre-participation cardiovascular screening in young athletes. URL: [http://eurheartj.oxfordjournals.org/cgi/content/full/27/18/2152 http://eurheartj.oxfordjournals.org/cgi/content/full/27/18/2152]. Accessed on: 16 December 2009.</ref>		*Associated with sudden cardiac death in "young people".<ref>Sudden cardiac death due to hypertrophic cardiomyopathy can be reduced by pre-participation cardiovascular screening in young athletes. URL: [http://eurheartj.oxfordjournals.org/cgi/content/full/27/18/2152 http://eurheartj.oxfordjournals.org/cgi/content/full/27/18/2152]. Accessed on: 16 December 2009.</ref>
	*Male > female.		*Male > female.

	~~====~~Etiology~~====~~		Etiology:
	*Genetic - mutations in:		*Genetic - mutations in:
	**Desmosomal proteins, especially plakoglobin and desmoplakin.		**Desmosomal proteins, especially plakoglobin and desmoplakin.
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	*Autosomal recessive variant: Naxos syndrome.<ref>[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601214 http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601214]</ref>		*Autosomal recessive variant: Naxos syndrome.<ref>[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601214 http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601214]</ref>
	**Clinical: wooly hair, palmar & plantar keratoses.		**Clinical: wooly hair, palmar & plantar keratoses.

			===Gross===
			Features:<ref name=emedicine1612324>URL: [http://emedicine.medscape.com/article/1612324-overview http://emedicine.medscape.com/article/1612324-overview].</ref>
			*RV wall thinning/replacement with fat.
			**Especially fat where fat is ''not'' usually seen - posterior RV wall, RVOT.
			*Septum usually has relative sparing
			**Thus, endomyocardial biopsy is ''not'' reliable.
			*+/-Aneurysms/dilation.

	===Microscopic===		===Microscopic===
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	*[http://en.wikipedia.org/wiki/Arrhythmogenic_right_ventricular_dysplasia ARVC micrograph (WP)].		*[http://en.wikipedia.org/wiki/Arrhythmogenic_right_ventricular_dysplasia ARVC micrograph (WP)].
	*[http://path.upmc.edu/cases/case223.html ARVC - several images (upmc.edu)].		*[http://path.upmc.edu/cases/case223.html ARVC - several images (upmc.edu)].

	~~===Gross features===~~
	~~Gross:<ref name=emedicine1612324>URL: [http://emedicine.medscape.com/article/1612324-overview http://emedicine.medscape.com/article/1612324-overview].</ref>~~
	*RV wall thinning/replacement with fat.
	**Especially fat where fat is ''not'' usually seen - posterior RV wall, RVOT.
	*Septum usually has relative sparing
	**Thus, endomyocardial biopsy is ''not'' reliable.
	*+/-Aneurysms/dilation.

	==Noncompaction cardiomyopathy==		==Noncompaction cardiomyopathy==

Michael: /* Restrictive cardiomyopathy */

2012-03-16T00:13:41Z

Restrictive cardiomyopathy

← Older revision		Revision as of 00:13, 16 March 2012
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	**Classically described as "stiff" or "rubbery".		**Classically described as "stiff" or "rubbery".
	*[[Sarcoidosis]].		*[[Sarcoidosis]].
	*Storage diseases ([[Pompe disease]]).		*Storage diseases (e.g. [[Pompe disease]]).
	*Eosinophilic endocarditis (Loeffler Endocarditis).		*Eosinophilic endocarditis (Loeffler Endocarditis).

Michael: /* Microscopic */ w

2012-03-01T04:59:59Z

Microscopic: w

← Older revision		Revision as of 04:59, 1 March 2012
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	DDx:		DDx:
	*Mitochondrial myopathy.		*[[Mitochondrial myopathy]].
	**Perinuclear clearing on light microscopy due to abundant mitochondria.		**Perinuclear clearing on light microscopy due to abundant mitochondria.
	**Atypical mitochondria on [[electron microscopy]].		**Atypical mitochondria on [[electron microscopy]].
	*Muscular dystrophy.		*[[Muscular dystrophy]].
	*[[Storage disease]].		*[[Storage disease]].