Cardiac myxoma - Revision history

Michael: /* Images */

2016-07-23T16:11:00Z

Images

← Older revision		Revision as of 16:11, 23 July 2016
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	===Images===		===Images===
	<gallery>		<gallery>
	Image:~~Atrial_myxoma_high_mag~~.jpg \| Atrial myxoma - ~~high~~ mag. ~~(WC)~~		Image:Atrial myxoma low mag.jpg\| AM - low mag.
	Image:~~Atrial_myxoma_edge_high_mag~~.jpg \| ~~Atrial myxoma - endothelial covering~~ - high mag. ~~(WC)~~		Image:Atrial myxoma intermed mag.jpg\| AM - intermed. mag.
	Image:~~Atrial_myxoma_edge_low_mag~~.jpg \| Atrial myxoma - ~~sharp border - low~~ mag. ~~(WC)~~		Image:Atrial myxoma high mag.jpg\| AM - high mag.

			Image:Atrial myxoma edge low mag.jpg\| AM with interface to muscular wall - low mag.
			Image:Atrial myxoma edge high mag.jpg\| AM with endothelium - high mag.
	</gallery>		</gallery>
	www:		====www====
	*[http://radiographics.rsna.org/content/22/3/673/F3.expansion.html Atrial myxoma (rsna.org)].<ref name=pmid12006696/>		*[http://radiographics.rsna.org/content/22/3/673/F3.expansion.html Atrial myxoma (rsna.org)].<ref name=pmid12006696/>
	*[http://radiographics.rsna.org/content/22/3/673/F4.expansion.html Gamna bodies (rsna.org)].<ref name=pmid12006696/>		*[http://radiographics.rsna.org/content/22/3/673/F4.expansion.html Gamna bodies (rsna.org)].<ref name=pmid12006696/>

Michael: fix ref

2016-06-06T18:41:59Z

fix ref

← Older revision		Revision as of 18:41, 6 June 2016
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	Location:<ref name=pmid3188128/>		Location:<ref name=pmid3188128/>
	*Usually atrial.		*Usually atrial.
	*Usually left side ~60%.<ref name=pmid12006696>{{Cite journal \| last1 = Grebenc \| first1 = ML. \| last2 = Rosado-de-Christenson \| first2 = ML. \| last3 = Green \| first3 = CE. \| last4 = Burke \| first4 = AP. \| last5 = Galvin \| first5 = JR. \| title = Cardiac myxoma: imaging features in 83 patients. \| journal = Radiographics \| volume = 22 \| issue = 3 \| pages = 673-89 \| month = \| year = \| doi = \| PMID = 12006696 }}</~~ref~~>		*Usually left side ~60%.<ref name=pmid12006696/>

	Features:<ref name=pmid12006696>{{cite journal \|author=Grebenc ML, Rosado-de-Christenson ML, Green CE, Burke AP, Galvin JR \|title=Cardiac myxoma: imaging features in 83 patients \|journal=Radiographics \|volume=22 \|issue=3 \|pages=673-89 \|year=2002 \|pmid=12006696 \|doi= \|url=http://radiographics.rsna.org/content/22/3/673.long}}</ref>		Features:<ref name=pmid12006696>{{cite journal \|author=Grebenc ML, Rosado-de-Christenson ML, Green CE, Burke AP, Galvin JR \|title=Cardiac myxoma: imaging features in 83 patients \|journal=Radiographics \|volume=22 \|issue=3 \|pages=673-89 \|year=2002 \|pmid=12006696 \|doi= \|url=http://radiographics.rsna.org/content/22/3/673.long}}</ref>

Michael: /* Image */

2016-06-06T18:40:31Z

Image

← Older revision		Revision as of 18:40, 6 June 2016
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	===Image===		===Image===
	<gallery>		<gallery>
	Image:Myxoma.jpg \|Cardiac myxoma. (WC/~~PIER~~)		Image:Myxoma.jpg \|Cardiac myxoma. (WC/AFIP)
	</gallery>		</gallery>

Michael: /* Gross */

2016-06-06T18:40:12Z

Gross

← Older revision		Revision as of 18:40, 6 June 2016
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	*Lobular surface.		*Lobular surface.
	*Smooth surface.		*Smooth surface.

			===Image===
			<gallery>
			Image:Myxoma.jpg \|Cardiac myxoma. (WC/PIER)
			</gallery>

	==Microscopic==		==Microscopic==

Michael at 14:51, 3 July 2014

2014-07-03T14:51:22Z

← Older revision		Revision as of 14:51, 3 July 2014
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	Most common presentations:<ref name=pmid3188128/>		Most common presentations:<ref name=pmid3188128/>
	*Dyspnea - 45%.		*[[Dyspnea]] - 45%.
	*Neurologic symptoms 36%.		*Neurologic symptoms 36%.

Michael at 08:10, 8 May 2014

2014-05-08T08:10:52Z

← Older revision		Revision as of 08:10, 8 May 2014
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	\| Other =		\| Other =
	\| ClinDDx = other heart tumours		\| ClinDDx = other heart tumours
			}}
			{{ Infobox external links
			\| Name = {{PAGENAME}}
			\| EHVSC =
			\| EHVSC_mult =
			\| pathprotocols =
			\| wikipedia = atrial myxoma
			\| pathoutlines =
			\| rosaicollection = 1267
	}}		}}
	'''Cardiac myxoma''' is the most common [[Cardiac tumours\|tumour of the heart]]. They are typical in the atrium; thus, a synonym is '''atrial myxoma'''.		'''Cardiac myxoma''' is the most common [[Cardiac tumours\|tumour of the heart]]. They are typical in the atrium; thus, a synonym is '''atrial myxoma'''.

Michael at 16:14, 1 April 2014

2014-04-01T16:14:38Z

← Older revision		Revision as of 16:14, 1 April 2014
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	\| Molecular =		\| Molecular =
	\| IF =		\| IF =
	\| Gross = usu. atrium, usu. left side		\| Gross = usu. atrium, usu. left side, classically projects into the lumen
	\| Grossing =		\| Grossing =
	\| Site = [[heart]]		\| Site = [[heart]]

Michael: split-out +infobox

2013-10-03T06:39:40Z

split-out +infobox

← Older revision		Revision as of 06:39, 3 October 2013
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	~~#redirect~~ [[Cardiac tumours#Cardiac myxoma]]		{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Atrial_myxoma_edge_high_mag.jpg
			\| Width =
			\| Caption = Atrial myxoma. [[H&E stain]].
			\| Micro = myxoid material (extra cellular), myxoma cells (stellate, polygonal or spindled morphology; +/-multinucleated, inconspicuous [[nucleoli]]; abundant cytoplasm), calcified elastic fibers (''gamna bodies''), +/-hemorrhage, +/-endothelial covering, +/-ossification, +/-fibrosis
			\| Subtypes =
			\| LMDDx = [[myxofibrosarcoma]], [[myxoid liposarcoma]], [[papillary fibroelastoma]]
			\| Stains =
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross = usu. atrium, usu. left side
			\| Grossing =
			\| Site = [[heart]]
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms = +/-dyspnea, +/-neurologic symptoms
			\| Prevalence = most common heart tumour, generally uncommon
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis =
			\| Other =
			\| ClinDDx = other heart tumours
			}}
			'''Cardiac myxoma''' is the most common [[Cardiac tumours\|tumour of the heart]]. They are typical in the atrium; thus, a synonym is '''atrial myxoma'''.

			==General==
			*Uncommon.
			*Clinical: may lead to cerebral infarction.<ref name=pmid3188128>{{cite journal \|author=Knepper LE, Biller J, Adams HP, Bruno A \|title=Neurologic manifestations of atrial myxoma. A 12-year experience and review \|journal=Stroke \|volume=19 \|issue=11 \|pages=1435-40 \|year=1988 \|month=November \|pmid=3188128 \|doi= \|url=http://stroke.ahajournals.org/cgi/reprint/19/11/1435}}</ref>
			*Diagnosed by imaging.
			*May be familial, i.e. [[Carney complex]] ([[AKA]] NAME syndrome, [[AKA]] LAMB syndrome).<ref>{{Ref WMSP\|135}}</ref>
			**NAME = Nevi, Atrial myxoma, Myxoid neurofibroma, and Ephelides (freckles<ref>URL: [http://emedicine.medscape.com/article/1119293-overview http://emedicine.medscape.com/article/1119293-overview]. Accessed on: 7 January 2011.</ref>).
			**LAMB = Lentigines, Atrial myxomas, Mucocutaneous myxomas, Blue nevi.

			Most common presentations:<ref name=pmid3188128/>
			*Dyspnea - 45%.
			*Neurologic symptoms 36%.

			==Gross==
			Location:<ref name=pmid3188128/>
			*Usually atrial.
			*Usually left side ~60%.<ref name=pmid12006696>{{Cite journal \| last1 = Grebenc \| first1 = ML. \| last2 = Rosado-de-Christenson \| first2 = ML. \| last3 = Green \| first3 = CE. \| last4 = Burke \| first4 = AP. \| last5 = Galvin \| first5 = JR. \| title = Cardiac myxoma: imaging features in 83 patients. \| journal = Radiographics \| volume = 22 \| issue = 3 \| pages = 673-89 \| month = \| year = \| doi = \| PMID = 12006696 }}</ref>

			Features:<ref name=pmid12006696>{{cite journal \|author=Grebenc ML, Rosado-de-Christenson ML, Green CE, Burke AP, Galvin JR \|title=Cardiac myxoma: imaging features in 83 patients \|journal=Radiographics \|volume=22 \|issue=3 \|pages=673-89 \|year=2002 \|pmid=12006696 \|doi= \|url=http://radiographics.rsna.org/content/22/3/673.long}}</ref>
			*Lobular surface.
			*Smooth surface.

			==Microscopic==
			Features:<ref name=pmid12006696/>
			*[[myxoid stroma\|Myxoid]] material - extra cellular - '''key feature'''.
			*Myxoma cells:<ref name=pmid16508920>{{Cite journal \| last1 = Orlandi \| first1 = A. \| last2 = Ciucci \| first2 = A. \| last3 = Ferlosio \| first3 = A. \| last4 = Genta \| first4 = R. \| last5 = Spagnoli \| first5 = LG. \| last6 = Gabbiani \| first6 = G. \| title = Cardiac myxoma cells exhibit embryonic endocardial stem cell features. \| journal = J Pathol \| volume = 209 \| issue = 2 \| pages = 231-9 \| month = Jun \| year = 2006 \| doi = 10.1002/path.1959 \| PMID = 16508920 }}</ref>
			**Stellate, polygonal or spindled morphology.
			**+/-Multinucleated.
			**Inconspicuous [[nucleoli]].
			**Abundant cytoplasm.
			*Calcified elastic fibers - ''gamna bodies''.
			*Hemorrhage common.
			*Often covered by endothelium.
			*+/-Ossification.
			*+/-Fibrosis.

			DDx:<ref>{{Ref DCHH\|79}}</ref>
			*[[Papillary fibroelastoma]] - not really in the histomorphologic [[differential diagnosis]].
			*[[Myxofibrosarcoma]] - nuclear pleomorphism.
			*[[Myxoid liposarcoma]] - chickenwire vasculature.

			===Images===
			<gallery>
			Image:Atrial_myxoma_high_mag.jpg \| Atrial myxoma - high mag. (WC)
			Image:Atrial_myxoma_edge_high_mag.jpg \| Atrial myxoma - endothelial covering - high mag. (WC)
			Image:Atrial_myxoma_edge_low_mag.jpg \| Atrial myxoma - sharp border - low mag. (WC)
			</gallery>
			www:
			*[http://radiographics.rsna.org/content/22/3/673/F3.expansion.html Atrial myxoma (rsna.org)].<ref name=pmid12006696/>
			*[http://radiographics.rsna.org/content/22/3/673/F4.expansion.html Gamna bodies (rsna.org)].<ref name=pmid12006696/>

			==Sign out==
			<pre>
			MASS, LEFT ATRIUM, EXCISION:
			- MYXOMA.
			</pre>

			===Micro===
			The sections show paucicellular myxoid material containing polygonal and spindled cells with eosinophilic myxoid cytoplasm, bland nuclei, inconspicuous nucleoli and focal multinucleation (myxoma cells). Hemosiderin-laden macrophages, calcified elastic fibres (gamna bodies) and scattered inflammatory cells are also present. There is no nuclear atypia. Mitotic activity is not evident. Several sections show fresh hemorrhage. The edge has a fibrotic rim and appears to be covered by endothelium. No cardiac muscle is identified.

			==See also==
			*[[Cardiac tumours]].
			*[[Myxoid lesions]].

			==References==
			{{Reflist\|2}}

			[[Category:Cardiovascular pathology]]
			[[Category:Cardiac tumours]]

Michael: redirect

2011-10-23T02:00:14Z

redirect

New page

#redirect [[Cardiac tumours#Cardiac myxoma]]