Carcinoma ex pleomorphic adenoma - Revision history

Michael: touch

2014-12-26T01:42:15Z

touch

← Older revision		Revision as of 01:42, 26 December 2014
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image = Carcinoma ex pleomorphic adenoma -- low mag.jpg		\| Image = Carcinoma ex pleomorphic adenoma -- low mag.jpg
	\| Width =		\| Width =
	\| Caption = Carcinoma ex pleomorphic adenoma. [[H&E stain]].		\| Caption = Carcinoma ex pleomorphic adenoma. [[H&E stain]].

Michael at 01:36, 9 March 2014

2014-03-09T01:36:08Z

← Older revision		Revision as of 01:36, 9 March 2014
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image = Carcinoma ex pleomorphic adenoma -- ~~intermed~~ mag.jpg		\| Image = Carcinoma ex pleomorphic adenoma -- low mag.jpg
	\| Width =		\| Width =
	\| Caption = Carcinoma ex pleomorphic adenoma. [[H&E stain]].		\| Caption = Carcinoma ex pleomorphic adenoma. [[H&E stain]].
	\| Micro = epithelial or myoepithelial cells with cytologic features of malignancy, pleomorphic adenoma (required if no hx)		\| Micro = epithelial or myoepithelial cells with cytologic features of malignancy, pleomorphic adenoma (required if no history)
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[salivary duct carcinoma]], [[mucoepidermoid carcinoma]], [[adenoid cystic carcinoma]], [[pleomorphic adenoma]]		\| LMDDx = [[salivary duct carcinoma]], [[mucoepidermoid carcinoma]], [[adenoid cystic carcinoma]], [[pleomorphic adenoma]]

Michael: +images

2014-03-09T00:48:12Z

+images

← Older revision		Revision as of 00:48, 9 March 2014
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image =		\| Image = Carcinoma ex pleomorphic adenoma -- intermed mag.jpg
	\| Width =		\| Width =
	\| Caption =		\| Caption = Carcinoma ex pleomorphic adenoma. [[H&E stain]].
	\| Micro = epithelial or myoepithelial cells with cytologic features of malignancy, pleomorphic adenoma (required if no hx)		\| Micro = epithelial or myoepithelial cells with cytologic features of malignancy, pleomorphic adenoma (required if no hx)
	\| Subtypes =		\| Subtypes =
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	===Images===		===Images===
			<gallery>
			Image: Carcinoma ex pleomorphic adenoma -- very low mag.jpg \| Ca ex PA - very low mag.
			Image: Carcinoma ex pleomorphic adenoma -- low mag.jpg \| Ca ex PA - low mag.
			Image: Carcinoma ex pleomorphic adenoma - a1 -- low mag.jpg \| Ca ex PA - low mag.
			Image: Carcinoma ex pleomorphic adenoma - a2 -- low mag.jpg \| Ca ex PA - low mag.
			Image: Carcinoma ex pleomorphic adenoma -- intermed mag.jpg \| Ca ex PA - intermed. mag.
			Image: Carcinoma ex pleomorphic adenoma - a1 -- intermed mag.jpg \| Ca ex PA - intermed. mag.
			Image: Carcinoma ex pleomorphic adenoma -- high mag.jpg \| Ca ex PA - high mag.
			Image: Carcinoma ex pleomorphic adenoma -- very high mag.jpg \| Ca ex PA - very high mag.
			</gallery>
			www:
	*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311945/figure/Fig1/ Ca ex PA - showing ca and PA areas (nih.gov)].<ref name=pmid21744105/>		*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311945/figure/Fig1/ Ca ex PA - showing ca and PA areas (nih.gov)].<ref name=pmid21744105/>
	*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311945/figure/Fig2/ Ca ex PA - showing capsule invasion (nih.gov)].		*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311945/figure/Fig2/ Ca ex PA - showing capsule invasion (nih.gov)].

Michael: +SO

2013-12-02T16:10:45Z

+SO

← Older revision		Revision as of 16:10, 2 December 2013
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	*CK7 +ve.		*CK7 +ve.
	*AE1/AE3 +ve.		*AE1/AE3 +ve.

			==Sign out==
			<pre>
			PAROTID GLAND (MASS), LEFT, EXCISION:
			- CARCINOMA EX PLEOMORPHIC ADENOMA, LOW-GRADE, INTRACAPSULAR.
			-- MARGINS NEGATIVE.
			-- SEE TUMOUR SUMMARY AND COMMENTS.
			- THREE BENIGN LYMPH NODES.
			</pre>

			===Micro===
			The sections show a lesion with spindled (myoepithelial) cells and an epithelial component,
			on a background of a chondromyxoid stroma. The lesion is encapsulated by a thin layer of
			fibrous tissue.

			Focally, within the lesion, nuclear atypia and mitotic activity are identified, including an atypical mitotic figure. The atypical region stains with p53. Approximately 45% of the atypical cells stain with Ki-67. There is no appreciable HER2 staining.

			Unremarkable parotid gland and lymph nodes are present.

	==See also==		==See also==

Michael: x sop

2013-11-25T03:52:29Z

x sop

← Older revision		Revision as of 03:52, 25 November 2013
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	==Gross==		==Gross==
	*Usually mass lesion - typically ~~partoid~~ gland.<ref name=pmid21744105/>		*Usually mass lesion - typically parotid gland.<ref name=pmid21744105/>

	==Microscopic==		==Microscopic==

Michael: twak

2013-11-24T22:10:21Z

twak

← Older revision		Revision as of 22:10, 24 November 2013
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	\| Width =		\| Width =
	\| Caption =		\| Caption =
	\| Micro = cells with cytologic features of malignancy, pleomorphic adenoma (required if no hx)		\| Micro = epithelial or myoepithelial cells with cytologic features of malignancy, pleomorphic adenoma (required if no hx)
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[salivary duct carcinoma]], [[mucoepidermoid carcinoma]], [[adenoid cystic carcinoma]], [[pleomorphic adenoma]]		\| LMDDx = [[salivary duct carcinoma]], [[mucoepidermoid carcinoma]], [[adenoid cystic carcinoma]], [[pleomorphic adenoma]]
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	==Microscopic==		==Microscopic==
	Features:		Features:
	*Cells with cytologic features of malignancy - '''key feature'''.		*Cells (epithelial or myoepithelial) with cytologic features of malignancy - '''key feature'''.
	*Architecture (any of the following):		*Architecture (any of the following):
	**Glands.		**Glands.

Michael: more

2013-11-24T22:07:29Z

← Older revision		Revision as of 22:07, 24 November 2013
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	\| Width =		\| Width =
	\| Caption =		\| Caption =
	\| Micro =		\| Micro = cells with cytologic features of malignancy, pleomorphic adenoma (required if no hx)
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[salivary duct carcinoma]], [[mucoepidermoid carcinoma]], [[adenoid cystic carcinoma]], [[pleomorphic adenoma]]		\| LMDDx = [[salivary duct carcinoma]], [[mucoepidermoid carcinoma]], [[adenoid cystic carcinoma]], [[pleomorphic adenoma]]
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	\| Assdx =		\| Assdx =
	\| Syndromes =		\| Syndromes =
	\| Clinicalhx =		\| Clinicalhx = pleomorphic adenoma (required if not present in assoc. with carcinoma)
	\| Signs = usu. mass lesion, firm		\| Signs = usu. mass lesion, firm
	\| Symptoms =		\| Symptoms =

Michael: weak

2013-11-24T22:02:15Z

weak

← Older revision		Revision as of 22:02, 24 November 2013
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	\| Syndromes =		\| Syndromes =
	\| Clinicalhx =		\| Clinicalhx =
	\| Signs = usu. ~~parotid~~ mass, firm		\| Signs = usu. mass lesion, firm
	\| Symptoms =		\| Symptoms =
	\| Prevalence = uncommon		\| Prevalence = uncommon
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	\| ClinDDx =		\| ClinDDx =
	}}		}}
	'''Carcinoma ex pleomorphic adenoma''', abbreviated '''ca ex PA''', is a rare malignant [[salivary gland]] tumour that ~~arise~~ from a [[pleomorphic adenoma]].		'''Carcinoma ex pleomorphic adenoma''', abbreviated '''ca ex PA''', is a rare malignant [[salivary gland]] tumour that arises from a [[pleomorphic adenoma]].

	==General==		==General==

Michael: /* IHC */

2013-11-24T14:47:32Z

IHC

← Older revision		Revision as of 14:47, 24 November 2013
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	==IHC==		==IHC==
	Features - ca ex PA versus PA:<ref name=pmid23821206>{{Cite journal \| last1 = Di Palma \| first1 = S. \| title = Carcinoma ex pleomorphic adenoma, with particular emphasis on early lesions. \| journal = Head Neck Pathol \| volume = 7 Suppl 1 \| issue = \| pages = S68-76 \| month = Jul \| year = 2013 \| doi = 10.1007/s12105-013-0454-z \| PMID = 23821206 }}</ref>		Features - ca ex PA versus PA:<ref name=pmid23821206>{{Cite journal \| last1 = Di Palma \| first1 = S. \| title = Carcinoma ex pleomorphic adenoma, with particular emphasis on early lesions. \| journal = Head Neck Pathol \| volume = 7 Suppl 1 \| issue = \| pages = S68-76 \| month = Jul \| year = 2013 \| doi = 10.1007/s12105-013-0454-z \| PMID = 23821206 }}</ref>
	*Ki-67 ~~elevated~~.		*Ki-67 >35% of cells.
	*HER2 +ve		*HER2 +ve membrane staining (3+ for high-grade, 2+ or less for low-grade).
	*p53 +ve.		*p53 +ve.
			*AR +ve.

			Others:<ref name=pmid23821206/>
			*CK7 +ve.
			*AE1/AE3 +ve.

	==See also==		==See also==

Michael: /* Microscopic */

2013-11-24T14:29:09Z

Microscopic

← Older revision		Revision as of 14:29, 24 November 2013
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	**Single cells (may be subtle).		**Single cells (may be subtle).

	~~Architectural~~ patterns:		Subtyping/patterns:
	*Epithelial carcinoma (~75% of cases<ref name=pmid21744105/>):		*Epithelial carcinoma (~75% of cases<ref name=pmid21744105/>):
	**[[Ductal carcinoma]] NOS (arising from ductal cells) - most common pattern for Ca ex PA.		**[[Ductal carcinoma]] NOS (arising from ductal cells) - most common pattern for ca ex PA.
	**"Named carcinoma":		**"Named carcinoma":
	***[[Salivary duct carcinoma]] - second most common pattern for Ca ex PA.		***[[Salivary duct carcinoma]] - second most common pattern for Ca ex PA.
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	*Myoepithelial carcinoma NOS (arising from myoepithelial cells).		*Myoepithelial carcinoma NOS (arising from myoepithelial cells).

	~~Note~~:		Notes:
	*Often adenocarcinoma-like.
	*Myoepithelial cells may be clear cells.		*Myoepithelial cells may be clear cells.