Brenner tumour - Revision history

Michael at 18:21, 31 October 2024

2024-10-31T18:21:12Z

← Older revision		Revision as of 18:21, 31 October 2024
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	*Main DDx of Coffee bean nucleus = [[granulosa cell tumour]].		*Main DDx of Coffee bean nucleus = [[granulosa cell tumour]].
	*Stromal component may be predominant.		*Stromal component may be predominant.

			Subclassification:
			*Benign.
			*Borderline.
			*Malignant <5% of tumour.<ref>{{cite journal \|authors=Zhang Y, Staley SA, Tucker K, Clark LH \|title=Malignant Brenner tumor of the ovary: Case series and review of treatment strategies \|journal=Gynecol Oncol Rep \|volume=28 \|issue= \|pages=29–32 \|date=May 2019 \|pmid=30815527 \|pmc=6378317 \|doi=10.1016/j.gore.2019.02.003 \|url=}}</ref>

	DDx:<ref name=Ref_GP437>{{Ref GP\|437}}</ref>		DDx:<ref name=Ref_GP437>{{Ref GP\|437}}</ref>

Michael: /* Microscopic */

2016-03-08T05:57:48Z

Microscopic

← Older revision		Revision as of 05:57, 8 March 2016
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	**Serous carcinoma.		**Serous carcinoma.
	**Metastatic urothelial carcinoma.		**Metastatic urothelial carcinoma.
	*[[Walthard cell rest]] - typically one nest of cells, ~~lack~~ the surrounding fibromatous stroma.		*[[Walthard cell rest]] - typically one nest of cells, lacks the surrounding fibromatous stroma.

	===Images===		===Images===

Michael at 18:41, 7 March 2016

2016-03-07T18:41:35Z

← Older revision		Revision as of 18:41, 7 March 2016
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	\| Micro = nests cells that have a "[[coffee bean nucleus]]" (nucleus = elliptical shape, nuclear groove along long axis), distinct nucleoli, moderate-to-abundant gray/pale cytoplasm, dense fibrous stroma around nests		\| Micro = nests cells that have a "[[coffee bean nucleus]]" (nucleus = elliptical shape, nuclear groove along long axis), distinct nucleoli, moderate-to-abundant gray/pale cytoplasm, dense fibrous stroma around nests
	\| Subtypes = benign (most common), borderline, malignant		\| Subtypes = benign (most common), borderline, malignant
	\| LMDDx = [[granulosa cell tumour]], [[ovarian fibroma]], [[thecoma]]		\| LMDDx = [[granulosa cell tumour]], [[ovarian fibroma]], [[thecoma]], [[Walthard cell rest]]
	\| Stains =		\| Stains =
	\| IHC = AR +ve, calretinin -ve		\| IHC = AR +ve, calretinin -ve

Michael: /* Microscopic */

2016-03-07T18:36:22Z

Microscopic

← Older revision		Revision as of 18:36, 7 March 2016
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	**Serous carcinoma.		**Serous carcinoma.
	**Metastatic urothelial carcinoma.		**Metastatic urothelial carcinoma.
			*[[Walthard cell rest]] - typically one nest of cells, lack the surrounding fibromatous stroma.

	===Images===		===Images===

Michael: /* IHC */

2016-02-10T01:05:11Z

IHC

← Older revision		Revision as of 01:05, 10 February 2016
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	==IHC==		==IHC==
	Features:<ref name=pmid24012099>{{Cite journal \| last1 = Kuhn \| first1 = E. \| last2 = Ayhan \| first2 = A. \| last3 = Shih \| first3 = IeM. \| last4 = Seidman \| first4 = JD. \| last5 = Kurman \| first5 = RJ. \| title = Ovarian Brenner tumour: a morphologic and immunohistochemical analysis suggesting an origin from fallopian tube epithelium. \| journal = Eur J Cancer \| volume = 49 \| issue = 18 \| pages = 3839-49 \| month = Dec \| year = 2013 \| doi = 10.1016/j.ejca.2013.08.011 \| PMID = 24012099 }}</ref>		Features:<ref name=pmid24012099>{{Cite journal \| last1 = Kuhn \| first1 = E. \| last2 = Ayhan \| first2 = A. \| last3 = Shih \| first3 = IeM. \| last4 = Seidman \| first4 = JD. \| last5 = Kurman \| first5 = RJ. \| title = Ovarian Brenner tumour: a morphologic and immunohistochemical analysis suggesting an origin from fallopian tube epithelium. \| journal = Eur J Cancer \| volume = 49 \| issue = 18 \| pages = 3839-49 \| month = Dec \| year = 2013 \| doi = 10.1016/j.ejca.2013.08.011 \| PMID = 24012099 }}</ref>
	*AR +ve.		*[[Androgen receptor\|AR]] +ve.
	*Calretinin -ve.		*Calretinin -ve.
	**Surrounding stroma +ve.		**Surrounding stroma +ve.

Michael: fix refs

2016-02-10T01:04:50Z

fix refs

← Older revision		Revision as of 01:04, 10 February 2016
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	==IHC==		==IHC==
	Features:<ref>{{Cite journal \| last1 = Kuhn \| first1 = E. \| last2 = Ayhan \| first2 = A. \| last3 = Shih \| first3 = IeM. \| last4 = Seidman \| first4 = JD. \| last5 = Kurman \| first5 = RJ. \| title = Ovarian Brenner tumour: a morphologic and immunohistochemical analysis suggesting an origin from fallopian tube epithelium. \| journal = Eur J Cancer \| volume = 49 \| issue = 18 \| pages = 3839-49 \| month = Dec \| year = 2013 \| doi = 10.1016/j.ejca.2013.08.011 \| PMID = 24012099 }}</ref>		Features:<ref name=pmid24012099>{{Cite journal \| last1 = Kuhn \| first1 = E. \| last2 = Ayhan \| first2 = A. \| last3 = Shih \| first3 = IeM. \| last4 = Seidman \| first4 = JD. \| last5 = Kurman \| first5 = RJ. \| title = Ovarian Brenner tumour: a morphologic and immunohistochemical analysis suggesting an origin from fallopian tube epithelium. \| journal = Eur J Cancer \| volume = 49 \| issue = 18 \| pages = 3839-49 \| month = Dec \| year = 2013 \| doi = 10.1016/j.ejca.2013.08.011 \| PMID = 24012099 }}</ref>
	*AR +ve.		*AR +ve.
	*Calretinin -ve.		*Calretinin -ve.
	**Surrounding stroma +ve.		**Surrounding stroma +ve.
	*Inhibin +ve.<ref name=pmid24012099>{{~~cite~~ journal \|~~author~~=Kuhn E, Ayhan A, Shih IeM, Seidman JD, Kurman RJ \|title=Ovarian Brenner tumour: a morphologic and immunohistochemical analysis suggesting an origin from fallopian tube epithelium \|journal=Eur. J. Cancer \|volume=49 \|issue=18 \|pages=~~3839–49 \|year=2013~~ \|month=~~December~~ \|~~pmid~~=~~24012099~~ \|doi=10.1016/j.ejca.2013.08.011 \|~~url~~=}}</ref>		*Inhibin +ve.<ref name=pmid24012099>{{Cite journal \| last1 = Kuhn \| first1 = E. \| last2 = Ayhan \| first2 = A. \| last3 = Shih \| first3 = IeM. \| last4 = Seidman \| first4 = JD. \| last5 = Kurman \| first5 = RJ. \| title = Ovarian Brenner tumour: a morphologic and immunohistochemical analysis suggesting an origin from fallopian tube epithelium. \| journal = Eur J Cancer \| volume = 49 \| issue = 18 \| pages = 3839-49 \| month = Dec \| year = 2013 \| doi = 10.1016/j.ejca.2013.08.011 \| PMID = 24012099 }}</ref>

	==See also==		==See also==

Michael: /* Microscopic */

2016-01-08T19:00:33Z

Microscopic

← Older revision		Revision as of 19:00, 8 January 2016
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	*Stromal component may be predominant.		*Stromal component may be predominant.

	DDx:		DDx:<ref name=Ref_GP437>{{Ref GP\|437}}</ref>
	*Benign:		*Benign:
			**Endometrioid adenofibroma.
	**[[Ovarian fibroma]].		**[[Ovarian fibroma]].
	**[[Thecoma]].
	*Borderline:		*Borderline:
	**Benign Brenner tumour.		**Benign Brenner tumour.
	**Malignant Brenner tumour.		**Malignant Brenner tumour.
	**Metastatic papillary urothelial carcinoma.		**Metastatic papillary urothelial carcinoma.
	*Malignant:~~<ref name=Ref_GP437>{{Ref GP\|437}}</ref>~~		*Malignant:
	**Undifferentiated carcinoma - no Brenner tumour component.		**Undifferentiated carcinoma - no Brenner tumour component.
	**Granulosa cell tumour.		**Granulosa cell tumour.

Michael at 18:57, 8 January 2016

2016-01-08T18:57:27Z

← Older revision		Revision as of 18:57, 8 January 2016
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	===Epidemiology===		===Epidemiology===
	*Mostly benign clinical course.		*Mostly benign clinical course - 99% of Brenner tumours benign.<ref name=Ref_GP437>{{Ref GP\|437}}</ref>
	*Thought to arise from [[Walthard cell rest]].		*Thought to arise from [[Walthard cell rest]].
	*Frequently an incidental finding, i.e. oophorectomy was done for another reason.		*Frequently an incidental finding, i.e. oophorectomy was done for another reason.

Michael at 18:55, 8 January 2016

2016-01-08T18:55:11Z

← Older revision		Revision as of 18:55, 8 January 2016
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	\| Synonyms =		\| Synonyms =
	\| Micro = nests cells that have a "[[coffee bean nucleus]]" (nucleus = elliptical shape, nuclear groove along long axis), distinct nucleoli, moderate-to-abundant gray/pale cytoplasm, dense fibrous stroma around nests		\| Micro = nests cells that have a "[[coffee bean nucleus]]" (nucleus = elliptical shape, nuclear groove along long axis), distinct nucleoli, moderate-to-abundant gray/pale cytoplasm, dense fibrous stroma around nests
	\| Subtypes =		\| Subtypes = benign (most common), borderline, malignant
	\| LMDDx = [[granulosa cell tumour]], [[ovarian fibroma]], [[thecoma]]		\| LMDDx = [[granulosa cell tumour]], [[ovarian fibroma]], [[thecoma]]
	\| Stains =		\| Stains =

Michael: /* Microscopic */

2016-01-08T18:54:46Z

Microscopic

← Older revision		Revision as of 18:54, 8 January 2016
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	DDx:		DDx:
	*[[Ovarian fibroma]].		*Benign:
	*[[Thecoma]].		**[[Ovarian fibroma]].
			**[[Thecoma]].
			*Borderline:
			**Benign Brenner tumour.
			**Malignant Brenner tumour.
			**Metastatic papillary urothelial carcinoma.
			*Malignant:<ref name=Ref_GP437>{{Ref GP\|437}}</ref>
			**Undifferentiated carcinoma - no Brenner tumour component.
			**Granulosa cell tumour.
			**Serous carcinoma.
			**Metastatic urothelial carcinoma.

	===Images===		===Images===