Biphenotypic sinonasal sarcoma - Revision history

Michael: /* Images */

2018-11-19T14:20:42Z

Images

← Older revision		Revision as of 14:20, 19 November 2018
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	===Images===		===Images===
	<gallery>		<gallery>
	Image: Biphenotypic Sinonasal Sarcoma LDRT 12255.tif \| BSS. (WC)		Image: Biphenotypic Sinonasal Sarcoma LDRT 12255.tif \| BSS. (WC/LESTERTHEINVESTOR)
	Image: Biphenotypic Sinonasal Sarcoma LDRT 12256.tif \| BSS. (WC)		Image: Biphenotypic Sinonasal Sarcoma LDRT 12256.tif \| BSS. (WC/LESTERTHEINVESTOR)
	</gallery>		</gallery>

	==IHC==		==IHC==
	Features:		Features:

Michael: /* IHC */

2018-11-19T14:20:28Z

IHC

← Older revision		Revision as of 14:20, 19 November 2018
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	*[[AE1/AE3]] -ve.		*[[AE1/AE3]] -ve.
	*Vimentin +ve.		*Vimentin +ve.

			===Images===
			<gallery>
			Image: Biphenotypic Sinonasal Sarcoma LDRT 12255 S100.tif \| BSS S-100. (WC/LESTERTHEINVESTOR)
			Image: Biphenotypic Sinonasal Sarcoma LDRT 12255 SMA.tif \| BSS - SMA. (WC/LESTERTHEINVESTOR)
			</gallery>

	==Molecular==		==Molecular==

Michael: +images

2018-11-19T14:18:17Z

+images

← Older revision		Revision as of 14:18, 19 November 2018
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image =		\| Image = Biphenotypic Sinonasal Sarcoma LDRT 12255.tif
	\| Width =		\| Width =
	\| Caption =		\| Caption = [[Micrograph]] showing a biphenotypic sinonasal sarcoma. [[H&E stain]]. (WC/LESTERTHEINVESTOR)
	\| Synonyms = low-grade sinonasal sarcoma with neural and myogenic features		\| Synonyms = low-grade sinonasal sarcoma with neural and myogenic features
	\| Micro = bland hypercellular stroma typically without many mitoses, invaginating glandular epithelium		\| Micro = bland hypercellular stroma typically without many mitoses, invaginating glandular epithelium
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	\| Signs =		\| Signs =
	\| Symptoms =		\| Symptoms =
	\| Prevalence = very rare ~ large series 28 ~~individual~~ as of 2012		\| Prevalence = very rare ~ large series 28 individuals as of 2012
	\| Bloodwork =		\| Bloodwork =
	\| Rads =		\| Rads =
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	*Benign [[nasal polyp]].		*Benign [[nasal polyp]].

			===Images===
			<gallery>
			Image: Biphenotypic Sinonasal Sarcoma LDRT 12255.tif \| BSS. (WC)
			Image: Biphenotypic Sinonasal Sarcoma LDRT 12256.tif \| BSS. (WC)
			</gallery>
	==IHC==		==IHC==
	Features:		Features:

Michael: /* See also */ +multiphenotypic carcioma

2018-02-21T20:55:57Z

Michael: /* IHC */

2016-07-31T19:34:04Z

IHC

← Older revision		Revision as of 19:34, 31 July 2016
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	Others:<ref name=pmid25488011/>		Others:<ref name=pmid25488011/>
	*Desmin -ve.		*Desmin -ve.
	*AE1/AE3 -ve.		*[[AE1/AE3]] -ve.
	*Vimentin +ve.		*Vimentin +ve.

Michael at 18:05, 1 May 2016

2016-05-01T18:05:37Z

← Older revision		Revision as of 18:05, 1 May 2016
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image =
			\| Width =
			\| Caption =
			\| Synonyms = low-grade sinonasal sarcoma with neural and myogenic features
			\| Micro = bland hypercellular stroma typically without many mitoses, invaginating glandular epithelium
			\| Subtypes =
			\| LMDDx = [[solitary fibrous tumour]], [[schwannoma]], [[sinonasal-type hemangiopericytoma]], benign [[nasal polyp]]
			\| Stains =
			\| IHC = S-100 +ve, actin +ve, beta-catenin +ve (nuclear)
			\| EM =
			\| Molecular = PAX3-MAML3 fusion - t(2;4)(q35;q31.1)
			\| IF =
			\| Gross =
			\| Grossing =
			\| Staging =
			\| Site = [[head and neck pathology\|head and neck]] - ethmoid sinus and/or nasal cavity
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx = female predominant (3:1)
			\| Signs =
			\| Symptoms =
			\| Prevalence = very rare ~ large series 28 individual as of 2012
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis =
			\| Other =
			\| ClinDDx =
			\| Tx =
			}}
	'''Biphenotypic sinonasal sarcoma''', abbreviated '''SNS''',<ref name=pmid24859338/> is a rare bland appearing [[cancer\|malignant]] tumour of the [[head and neck pathology\|head and neck]].		'''Biphenotypic sinonasal sarcoma''', abbreviated '''SNS''',<ref name=pmid24859338/> is a rare bland appearing [[cancer\|malignant]] tumour of the [[head and neck pathology\|head and neck]].

	It is also known as '''low grade sinonasal sarcoma with neural and myogenic features'''.<ref>{{Cite journal \| last1 = Powers \| first1 = KA. \| last2 = Han \| first2 = LM. \| last3 = Chiu \| first3 = AG. \| last4 = Aly \| first4 = FZ. \| title = Low-grade sinonasal sarcoma with neural and myogenic features--diagnostic challenge and pathogenic insight. \| journal = Oral Surg Oral Med Oral Pathol Oral Radiol \| volume = 119 \| issue = 5 \| pages = e265-9 \| month = May \| year = 2015 \| doi = 10.1016/j.oooo.2014.10.007 \| PMID = 25488011 }}</ref>		It is also known as '''low-grade sinonasal sarcoma with neural and myogenic features'''.<ref name=pmid25488011>{{Cite journal \| last1 = Powers \| first1 = KA. \| last2 = Han \| first2 = LM. \| last3 = Chiu \| first3 = AG. \| last4 = Aly \| first4 = FZ. \| title = Low-grade sinonasal sarcoma with neural and myogenic features--diagnostic challenge and pathogenic insight. \| journal = Oral Surg Oral Med Oral Pathol Oral Radiol \| volume = 119 \| issue = 5 \| pages = e265-9 \| month = May \| year = 2015 \| doi = 10.1016/j.oooo.2014.10.007 \| PMID = 25488011 }}</ref>

	==General==		==General==

Michael: /* IHC */

2016-05-01T17:50:30Z

IHC

← Older revision		Revision as of 17:50, 1 May 2016
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	*Actin +ve (27 +ve of 28 cases<ref name=pmid22301502/>).		*Actin +ve (27 +ve of 28 cases<ref name=pmid22301502/>).
	*Beta-catenin - nuclear +ve.<ref>http://dx.doi.org/10.1016/j.humpath.2016.04.009		*Beta-catenin - nuclear +ve.<ref>http://dx.doi.org/10.1016/j.humpath.2016.04.009
	</ref><~~reF~~>{{Cite journal \| last1 = Powers \| first1 = KA. \| last2 = Han \| first2 = LM. \| last3 = Chiu \| first3 = AG. \| last4 = Aly \| first4 = FZ. \| title = Low-grade sinonasal sarcoma with neural and myogenic features--diagnostic challenge and pathogenic insight. \| journal = Oral Surg Oral Med Oral Pathol Oral Radiol \| volume = 119 \| issue = 5 \| pages = e265-9 \| month = May \| year = 2015 \| doi = 10.1016/j.oooo.2014.10.007 \| PMID = 25488011 }}</ref>		</ref><ref name=pmid25488011>{{Cite journal \| last1 = Powers \| first1 = KA. \| last2 = Han \| first2 = LM. \| last3 = Chiu \| first3 = AG. \| last4 = Aly \| first4 = FZ. \| title = Low-grade sinonasal sarcoma with neural and myogenic features--diagnostic challenge and pathogenic insight. \| journal = Oral Surg Oral Med Oral Pathol Oral Radiol \| volume = 119 \| issue = 5 \| pages = e265-9 \| month = May \| year = 2015 \| doi = 10.1016/j.oooo.2014.10.007 \| PMID = 25488011 }}</ref>

			Others:<ref name=pmid25488011/>
			*Desmin -ve.
			*AE1/AE3 -ve.
			*Vimentin +ve.

	==Molecular==		==Molecular==

Michael: /* IHC */

2016-05-01T17:49:45Z

IHC

← Older revision		Revision as of 17:49, 1 May 2016
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	*S-100 +ve - strong (28 +ve of 28 cases<ref name=pmid22301502/>).		*S-100 +ve - strong (28 +ve of 28 cases<ref name=pmid22301502/>).
	*Actin +ve (27 +ve of 28 cases<ref name=pmid22301502/>).		*Actin +ve (27 +ve of 28 cases<ref name=pmid22301502/>).
			*Beta-catenin - nuclear +ve.<ref>http://dx.doi.org/10.1016/j.humpath.2016.04.009
			</ref><reF>{{Cite journal \| last1 = Powers \| first1 = KA. \| last2 = Han \| first2 = LM. \| last3 = Chiu \| first3 = AG. \| last4 = Aly \| first4 = FZ. \| title = Low-grade sinonasal sarcoma with neural and myogenic features--diagnostic challenge and pathogenic insight. \| journal = Oral Surg Oral Med Oral Pathol Oral Radiol \| volume = 119 \| issue = 5 \| pages = e265-9 \| month = May \| year = 2015 \| doi = 10.1016/j.oooo.2014.10.007 \| PMID = 25488011 }}</ref>

	==Molecular==		==Molecular==

Michael: /* General */

2016-03-22T04:43:02Z

General

← Older revision		Revision as of 04:43, 22 March 2016
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	Prognosis:		Prognosis:
	*No (far away) [[metastasis]] of death in a series of 28 patients.<ref name=pmid22301502/>		*No (far away) [[metastasis]] or death in a series of 28 patients.<ref name=pmid22301502/>

	==Gross==		==Gross==

Michael: /* Microscopic */

2016-03-13T16:33:54Z

Microscopic

← Older revision		Revision as of 16:33, 13 March 2016
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	Note:		Note:
	*May have rhabdomyoblastic differentiation.<ref name=pmid26371783>{{Cite journal \| last1 = Huang \| first1 = SC. \| last2 = Ghossein \| first2 = RA. \| last3 = Bishop \| first3 = JA. \| last4 = Zhang \| first4 = L. \| last5 = Chen \| first5 = TC. \| last6 = Huang \| first6 = HY. \| last7 = Antonescu \| first7 = CR. \| title = Novel PAX3-NCOA1 Fusions in Biphenotypic Sinonasal Sarcoma With Focal Rhabdomyoblastic Differentiation. \| journal = Am J Surg Pathol \| volume = 40 \| issue = 1 \| pages = 51-9 \| month = Jan \| year = 2016 \| doi = 10.1097/PAS.0000000000000492 \| PMID = 26371783 }}</ref>		*May have rhabdomyoblastic differentiation - case report.<ref name=pmid26371783>{{Cite journal \| last1 = Huang \| first1 = SC. \| last2 = Ghossein \| first2 = RA. \| last3 = Bishop \| first3 = JA. \| last4 = Zhang \| first4 = L. \| last5 = Chen \| first5 = TC. \| last6 = Huang \| first6 = HY. \| last7 = Antonescu \| first7 = CR. \| title = Novel PAX3-NCOA1 Fusions in Biphenotypic Sinonasal Sarcoma With Focal Rhabdomyoblastic Differentiation. \| journal = Am J Surg Pathol \| volume = 40 \| issue = 1 \| pages = 51-9 \| month = Jan \| year = 2016 \| doi = 10.1097/PAS.0000000000000492 \| PMID = 26371783 }}</ref>

	DDx:		DDx:

← Older revision		Revision as of 20:55, 21 February 2018
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	==See also==		==See also==
	*[[Head and neck pathology]].		*[[Head and neck pathology]].
			*[[HPV-related multiphenotypic sinonasal carcinoma]].

	==References==		==References==