Basal cell carcinoma - Revision history

Marcia: /* Images */

2022-01-15T18:45:53Z

Images

← Older revision		Revision as of 18:45, 15 January 2022
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	Image:SkinTumors-P6040209.JPG \| Fibroepithelioma of Pinkus. (WC)		Image:SkinTumors-P6040209.JPG \| Fibroepithelioma of Pinkus. (WC)
	Fiboepithelioma of Pinkus 10x 4.tif \| Fiboepithelioma of Pinkus 10x 4.tif (MLA)		Fiboepithelioma of Pinkus 10x 4.tif \| Fiboepithelioma of Pinkus 10x 4.tif (MLA)
			Fiboepithelioma of Pinkus 10x 3.tif \| Fiboepithelioma of Pinkus 10x 3.tif (MLA)
			Fiboepithelioma of Pinkus 10x 2.tif \| Fiboepithelioma of Pinkus 10x 2.tif (MLA)
			Fiboepithelioma of Pinkus 10x.tif \| Fiboepithelioma of Pinkus 10x.tif (MLA)
			Fibro of pinkus.tif \| Fiboepithelioma of Pinkus 4x.tif (MLA)
	</gallery>		</gallery>

Marcia: /* Images */

2022-01-15T18:40:29Z

Images

← Older revision		Revision as of 18:40, 15 January 2022
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	Image:Basal_cell_carcinoma_fibroepitheliomatous_pattern_-_very_low_mag.jpg \| Fibroepithelioma of Pinkus. (WC/Nephron)		Image:Basal_cell_carcinoma_fibroepitheliomatous_pattern_-_very_low_mag.jpg \| Fibroepithelioma of Pinkus. (WC/Nephron)
	Image:SkinTumors-P6040209.JPG \| Fibroepithelioma of Pinkus. (WC)		Image:SkinTumors-P6040209.JPG \| Fibroepithelioma of Pinkus. (WC)
	Fiboepithelioma of Pinkus 10x 4.tif		Fiboepithelioma of Pinkus 10x 4.tif \| Fiboepithelioma of Pinkus 10x 4.tif (MLA)
	</gallery>		</gallery>

Marcia: /* Images */

2022-01-15T18:39:42Z

Images

← Older revision		Revision as of 18:39, 15 January 2022
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	Image:Basal_cell_carcinoma_fibroepitheliomatous_pattern_-_very_low_mag.jpg \| Fibroepithelioma of Pinkus. (WC/Nephron)		Image:Basal_cell_carcinoma_fibroepitheliomatous_pattern_-_very_low_mag.jpg \| Fibroepithelioma of Pinkus. (WC/Nephron)
	Image:SkinTumors-P6040209.JPG \| Fibroepithelioma of Pinkus. (WC)		Image:SkinTumors-P6040209.JPG \| Fibroepithelioma of Pinkus. (WC)
			Fiboepithelioma of Pinkus 10x 4.tif
	</gallery>		</gallery>

Michael: /* IHC */

2021-11-16T19:34:00Z

IHC

← Older revision		Revision as of 19:34, 16 November 2021
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	*[[Ber-EP4]] +ve -- typically weak and focal staining.		*[[Ber-EP4]] +ve -- typically weak and focal staining.
	**[[Microcystic adnexal carcinoma]] negative.<ref name=pmid23398472 >{{Cite journal \| last1 = Sellheyer \| first1 = K. \| last2 = Nelson \| first2 = P. \| last3 = Kutzner \| first3 = H. \| last4 = Patel \| first4 = RM. \| title = The immunohistochemical differential diagnosis of microcystic adnexal carcinoma, desmoplastic trichoepithelioma and morpheaform basal cell carcinoma using BerEP4 and stem cell markers. \| journal = J Cutan Pathol \| volume = 40 \| issue = 4 \| pages = 363-70 \| month = Apr \| year = 2013 \| doi = 10.1111/cup.12085 \| PMID = 23398472 }}</ref>		**[[Microcystic adnexal carcinoma]] negative.<ref name=pmid23398472 >{{Cite journal \| last1 = Sellheyer \| first1 = K. \| last2 = Nelson \| first2 = P. \| last3 = Kutzner \| first3 = H. \| last4 = Patel \| first4 = RM. \| title = The immunohistochemical differential diagnosis of microcystic adnexal carcinoma, desmoplastic trichoepithelioma and morpheaform basal cell carcinoma using BerEP4 and stem cell markers. \| journal = J Cutan Pathol \| volume = 40 \| issue = 4 \| pages = 363-70 \| month = Apr \| year = 2013 \| doi = 10.1111/cup.12085 \| PMID = 23398472 }}</ref>
	*CK5/6 +ve.		*CK5/6 +ve (52 of 52<ref name=pmid18496426/>).
	**Useful to assess [[margins]]... if very close.		**Useful to assess [[margins]]... if very close.
			*CK7 +ve (30 +ve of 52 cases<ref name=pmid18496426>{{cite journal \|authors=Alessi E, Venegoni L, Fanoni D, Berti E \|title=Cytokeratin profile in basal cell carcinoma \|journal=Am J Dermatopathol \|volume=30 \|issue=3 \|pages=249–55 \|date=June 2008 \|pmid=18496426 \|doi=10.1097/DAD.0b013e31816c828a \|url=}}</ref>).
			*CK19 -ve/+ve (14 +ve 52<ref name=pmid18496426/>).
	*CD10 +ve.		*CD10 +ve.
	*Actin +ve.		*Actin +ve.

Michael: /* Block letters */ add site

2021-09-05T16:02:20Z

Block letters: add site

← Older revision		Revision as of 16:02, 5 September 2021
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	====Block letters====		====Block letters====
	<pre>		<pre>
	SKIN LESION, SHAVE BIOPSY WITH ELECTRODESICCATION AND CURETTAGE (EDC):		SKIN LESION, LEFT FOREARM, SHAVE BIOPSY WITH ELECTRODESICCATION AND CURETTAGE (EDC):
	- BASAL CELL CARCINOMA, MARGIN STATUS ASSESSED CLINICALLY DURING EDC.		- BASAL CELL CARCINOMA, MARGIN STATUS ASSESSED CLINICALLY DURING EDC.
	- EXTENSIVE SOLAR ELASTOSIS.		- EXTENSIVE SOLAR ELASTOSIS.

Michael: /* Electrodesiccation and curettage */

2018-03-02T14:41:32Z

Electrodesiccation and curettage

← Older revision		Revision as of 14:41, 2 March 2018
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	===Electrodesiccation and curettage===		===Electrodesiccation and curettage===
			<pre>
			Skin, Left Brow, Biopsy with Electrodesiccation and Curettage (EDC):
			- BASAL CELL CARCINOMA, margin status assessed clinically during EDC.
			</pre>

			====Block letters====
	<pre>		<pre>
	SKIN LESION, SHAVE BIOPSY WITH ELECTRODESICCATION AND CURETTAGE (EDC):		SKIN LESION, SHAVE BIOPSY WITH ELECTRODESICCATION AND CURETTAGE (EDC):

Mitchell: /* Images */ added a case

2016-12-22T01:55:22Z

Images: added a case

← Older revision		Revision as of 01:55, 22 December 2016
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	Image:SkinTumors-P6040209.JPG \| Fibroepithelioma of Pinkus. (WC)		Image:SkinTumors-P6040209.JPG \| Fibroepithelioma of Pinkus. (WC)
	</gallery>		</gallery>

			[[File: 5 41110532329262 sl 1.png\|Basal cell carcinoma with mucin production]]
			[[File: 5 41110532329262 sl 2.png\|Basal cell carcinoma with mucin production]]
			[[File: 5 41110532329262 sl 3.png\|Basal cell carcinoma with mucin production]]

			Basal cell carcinoma with mucin production in the left nasal bridge of a 59 year old man, presenting as a presumptive lacrimal cyst. Because of the location, immunohistochemical stains were needed to exclude eccrine tumors and salivary gland type tumors. A. A spheroidal, well circumscribed mass shows intertwining nests (green arrow), isles with cribriforming (yellow arrows), and large acini (cyan arrows), with good circumscription. B. Round to ovoid nuclei show > 4:1 nuclear size variation in some adjacent pairs (black arrows) and occasional pyknotic nuclei (green arrows). Lumens show mucinous material with vacuoles (yellow arrows); the color argues against adenoid cystic carcinoma, but certainty in that respect could not be maintained without immunostains. Note lining up of nuclei suggestive of palisades (blue arrows). C. Nuclei are P63 positive, not shown are the negative stains for SOX10, CK7, and CD117.



	www:		www:
	*[http://missinglink.ucsf.edu/lm/DermatologyGlossary/img/Dermatology%20Glossary/Glossary%20Histo%20Images/basal_cell_carcinoma_high_power.jpg BCC (ucsf.edu)].<ref>URL: [http://missinglink.ucsf.edu/lm/DermatologyGlossary/basal_cell_carcinoma.html http://missinglink.ucsf.edu/lm/DermatologyGlossary/basal_cell_carcinoma.html]. Accessed on: 4 September 2011.</ref>		*[http://missinglink.ucsf.edu/lm/DermatologyGlossary/img/Dermatology%20Glossary/Glossary%20Histo%20Images/basal_cell_carcinoma_high_power.jpg BCC (ucsf.edu)].<ref>URL: [http://missinglink.ucsf.edu/lm/DermatologyGlossary/basal_cell_carcinoma.html http://missinglink.ucsf.edu/lm/DermatologyGlossary/basal_cell_carcinoma.html]. Accessed on: 4 September 2011.</ref>

Michael: /* IHC */

2016-05-15T16:23:28Z

IHC

← Older revision		Revision as of 16:23, 15 May 2016
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	==IHC==		==IHC==
	*Ber-EP4 +ve -- typically weak and focal staining.		*[[Ber-EP4]] +ve -- typically weak and focal staining.
	**[[Microcystic adnexal carcinoma]] negative.<ref name=pmid23398472 >{{Cite journal \| last1 = Sellheyer \| first1 = K. \| last2 = Nelson \| first2 = P. \| last3 = Kutzner \| first3 = H. \| last4 = Patel \| first4 = RM. \| title = The immunohistochemical differential diagnosis of microcystic adnexal carcinoma, desmoplastic trichoepithelioma and morpheaform basal cell carcinoma using BerEP4 and stem cell markers. \| journal = J Cutan Pathol \| volume = 40 \| issue = 4 \| pages = 363-70 \| month = Apr \| year = 2013 \| doi = 10.1111/cup.12085 \| PMID = 23398472 }}</ref>		**[[Microcystic adnexal carcinoma]] negative.<ref name=pmid23398472 >{{Cite journal \| last1 = Sellheyer \| first1 = K. \| last2 = Nelson \| first2 = P. \| last3 = Kutzner \| first3 = H. \| last4 = Patel \| first4 = RM. \| title = The immunohistochemical differential diagnosis of microcystic adnexal carcinoma, desmoplastic trichoepithelioma and morpheaform basal cell carcinoma using BerEP4 and stem cell markers. \| journal = J Cutan Pathol \| volume = 40 \| issue = 4 \| pages = 363-70 \| month = Apr \| year = 2013 \| doi = 10.1111/cup.12085 \| PMID = 23398472 }}</ref>
	*CK5/6 +ve.		*CK5/6 +ve.

Michael: /* IHC */

2015-12-15T22:14:17Z

IHC

← Older revision		Revision as of 22:14, 15 December 2015
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	*SMA +ve.<ref>URL: [http://www.ihcworld.com/_newsletter/2004/2004-12_basal_cell_vs_squamous_v1.pdf http://www.ihcworld.com/_newsletter/2004/2004-12_basal_cell_vs_squamous_v1.pdf]. Accessed on: 19 December 2012.</ref>		*SMA +ve.<ref>URL: [http://www.ihcworld.com/_newsletter/2004/2004-12_basal_cell_vs_squamous_v1.pdf http://www.ihcworld.com/_newsletter/2004/2004-12_basal_cell_vs_squamous_v1.pdf]. Accessed on: 19 December 2012.</ref>
	**SCC usually negative.		**SCC usually negative.

			Other:
			*p63 +ve.<ref name=pmid16630179>{{Cite journal \| last1 = Bircan \| first1 = S. \| last2 = Candir \| first2 = O. \| last3 = Kapucoglu \| first3 = N. \| last4 = Baspinar \| first4 = S. \| title = The expression of p63 in basal cell carcinomas and association with histological differentiation. \| journal = J Cutan Pathol \| volume = 33 \| issue = 4 \| pages = 293-8 \| month = Apr \| year = 2006 \| doi = 10.1111/j.0303-6987.2006.00436.x \| PMID = 16630179 }}</ref>

	==Sign-out==		==Sign-out==

Michael: /* Microscopic */

2015-11-02T16:46:05Z

Microscopic

← Older revision		Revision as of 16:46, 2 November 2015
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	*[http://dermatlas.med.jhmi.edu/derm/indexDisplay.cfm?ImageID=930934558 BCC with fibroepitheliomatous pattern (dermatlas.med.jhmi.edu)].		*[http://dermatlas.med.jhmi.edu/derm/indexDisplay.cfm?ImageID=930934558 BCC with fibroepitheliomatous pattern (dermatlas.med.jhmi.edu)].
	*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157603/figure/Fig2/ BCC in vitiligo (nih.gov)].<ref name=pmid20623309>{{Cite journal \| last1 = Rustemeyer \| first1 = J. \| last2 = Günther \| first2 = L. \| last3 = Deichert \| first3 = L. \| title = A rare association: basal cell carcinoma in a vitiliginous macula. \| journal = Oral Maxillofac Surg \| volume = 15 \| issue = 3 \| pages = 175-7 \| month = Sep \| year = 2011 \| doi = 10.1007/s10006-010-0240-y \| PMID = 20623309 }}</ref>		*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157603/figure/Fig2/ BCC in vitiligo (nih.gov)].<ref name=pmid20623309>{{Cite journal \| last1 = Rustemeyer \| first1 = J. \| last2 = Günther \| first2 = L. \| last3 = Deichert \| first3 = L. \| title = A rare association: basal cell carcinoma in a vitiliginous macula. \| journal = Oral Maxillofac Surg \| volume = 15 \| issue = 3 \| pages = 175-7 \| month = Sep \| year = 2011 \| doi = 10.1007/s10006-010-0240-y \| PMID = 20623309 }}</ref>
			*[https://dermpath.wordpress.com/category/malignant-cutaneous-neoplasms/basal-cell-carcinoma/ Clear cell BCC (dermpath.wordpress.com)].

	===Basal cell carcinoma subtypes/unique features===		===Basal cell carcinoma subtypes/unique features===

← Older revision		Revision as of 18:45, 15 January 2022
Line 94:		Line 94:
	Image:SkinTumors-P6040209.JPG \| Fibroepithelioma of Pinkus. (WC)		Image:SkinTumors-P6040209.JPG \| Fibroepithelioma of Pinkus. (WC)
	Fiboepithelioma of Pinkus 10x 4.tif \| Fiboepithelioma of Pinkus 10x 4.tif (MLA)		Fiboepithelioma of Pinkus 10x 4.tif \| Fiboepithelioma of Pinkus 10x 4.tif (MLA)
			Fiboepithelioma of Pinkus 10x 3.tif \| Fiboepithelioma of Pinkus 10x 3.tif (MLA)
			Fiboepithelioma of Pinkus 10x 2.tif \| Fiboepithelioma of Pinkus 10x 2.tif (MLA)
			Fiboepithelioma of Pinkus 10x.tif \| Fiboepithelioma of Pinkus 10x.tif (MLA)
			Fibro of pinkus.tif \| Fiboepithelioma of Pinkus 4x.tif (MLA)
	</gallery>		</gallery>