Barrett's esophagus - Revision history

Michael: /* Gross */

2022-09-15T14:23:05Z

Gross

← Older revision		Revision as of 14:23, 15 September 2022
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	*Red/light brown esophageal mucosa.		*Red/light brown esophageal mucosa.
	**Normal mucosa = light pink.		**Normal mucosa = light pink.

	~~<gallery>~~
	~~Image:Barretts_esophagus.jpg \| Endoscopic image of BE. (WC)~~
	~~</gallery>~~


	===Prague Classification Barrett's Esophagus===		===Prague Classification Barrett's Esophagus===
	*Commonly used in by endoscopists.		*Commonly used in by endoscopists.
			*Quantifies the extent of Barrett's esophagus.

	Meaning:<ref name=pmid22248595>{{cite journal \|vauthors=Vahabzadeh B, Seetharam AB, Cook MB, Wani S, Rastogi A, Bansal A, Early DS, Sharma P \|title=Validation of the Prague C & M criteria for the endoscopic grading of Barrett's esophagus by gastroenterology trainees: a multicenter study \|journal=Gastrointest Endosc \|volume=75 \|issue=2 \|pages=236–41 \|date=February 2012 \|pmid=22248595 \|pmc=4547779 \|doi=10.1016/j.gie.2011.09.017 \|url=}}</ref>		Meaning:<ref name=pmid22248595>{{cite journal \|vauthors=Vahabzadeh B, Seetharam AB, Cook MB, Wani S, Rastogi A, Bansal A, Early DS, Sharma P \|title=Validation of the Prague C & M criteria for the endoscopic grading of Barrett's esophagus by gastroenterology trainees: a multicenter study \|journal=Gastrointest Endosc \|volume=75 \|issue=2 \|pages=236–41 \|date=February 2012 \|pmid=22248595 \|pmc=4547779 \|doi=10.1016/j.gie.2011.09.017 \|url=}}</ref>
	*C = circumferential length.		*C = circumferential length.
	*M = maximal length.		*M = maximal length.

			===Images===
			<gallery>
			Image:Barretts_esophagus.jpg \| Endoscopic image of BE. (WC)
			</gallery>

	==Microscopic==		==Microscopic==

Michael: /* Gross */

2022-09-15T14:22:08Z

Gross

← Older revision		Revision as of 14:22, 15 September 2022
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	Image:Barretts_esophagus.jpg \| Endoscopic image of BE. (WC)		Image:Barretts_esophagus.jpg \| Endoscopic image of BE. (WC)
	</gallery>		</gallery>


			===Prague Classification Barrett's Esophagus===
			*Commonly used in by endoscopists.

			Meaning:<ref name=pmid22248595>{{cite journal \|vauthors=Vahabzadeh B, Seetharam AB, Cook MB, Wani S, Rastogi A, Bansal A, Early DS, Sharma P \|title=Validation of the Prague C & M criteria for the endoscopic grading of Barrett's esophagus by gastroenterology trainees: a multicenter study \|journal=Gastrointest Endosc \|volume=75 \|issue=2 \|pages=236–41 \|date=February 2012 \|pmid=22248595 \|pmc=4547779 \|doi=10.1016/j.gie.2011.09.017 \|url=}}</ref>
			*C = circumferential length.
			*M = maximal length.

	==Microscopic==		==Microscopic==
	Features:		Features:

Michael: tweak

2020-01-28T19:05:31Z

tweak

← Older revision		Revision as of 19:05, 28 January 2020
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	*Diagnosis is made by '''clinicans ''not'' pathologists'''.		*Diagnosis is made by '''clinicans ''not'' pathologists'''.
	**A common histologic correlate is metaplastic transformation of stratified squamous epithelium to simple columnar epithelium with goblet cells.		**A common histologic correlate is metaplastic transformation of stratified squamous epithelium to simple columnar epithelium with goblet cells.
	***There is disagreement whether goblet cells are required for the diagnosis.<ref name=pmid19623166>{{Cite journal \| last1 = Riddell \| first1 = RH. \| last2 = Odze \| first2 = RD. \| title = Definition of Barrett's esophagus: time for a rethink--is intestinal metaplasia dead? \| journal = Am J Gastroenterol \| volume = 104 \| issue = 10 \| pages = 2588-94 \| month = Oct \| year = 2009 \| doi = 10.1038/ajg.2009.390 \| PMID = 19623166 }}</ref> In the United States and Canada goblet cells are required for the diagnosis.<ref name=pmid29998421>{{cite journal \|~~vauthors~~=Odze R \|title=Histology of Barrett's Metaplasia: Do Goblet Cells Matter? \|journal=Dig. Dis. Sci. \|volume=63 \|issue=8 \|pages=2042–2051 \|date=August 2018 \|pmid=29998421 \|doi=10.1007/s10620-018-5151-z \|url=}}</ref> In the UK, goblet cells are not required.		***There is disagreement whether goblet cells are required for the diagnosis.<ref name=pmid19623166>{{Cite journal \| last1 = Riddell \| first1 = RH. \| last2 = Odze \| first2 = RD. \| title = Definition of Barrett's esophagus: time for a rethink--is intestinal metaplasia dead? \| journal = Am J Gastroenterol \| volume = 104 \| issue = 10 \| pages = 2588-94 \| month = Oct \| year = 2009 \| doi = 10.1038/ajg.2009.390 \| PMID = 19623166 }}</ref> In the United States and Canada goblet cells are required for the diagnosis.<ref name=pmid29998421>{{cite journal \|authors=Odze R \|title=Histology of Barrett's Metaplasia: Do Goblet Cells Matter? \|journal=Dig. Dis. Sci. \|volume=63 \|issue=8 \|pages=2042–2051 \|date=August 2018 \|pmid=29998421 \|doi=10.1007/s10620-018-5151-z \|url=}}</ref> In the UK, goblet cells are not required.
	****One large study suggests that goblets cells are only absent due to undersampling.<ref name=pmid21959311>{{Cite journal \| last1 = Chandrasoma \| first1 = P. \| last2 = Wijetunge \| first2 = S. \| last3 = DeMeester \| first3 = S. \| last4 = Ma \| first4 = Y. \| last5 = Hagen \| first5 = J. \| last6 = Zamis \| first6 = L. \| last7 = DeMeester \| first7 = T. \| title = Columnar-lined esophagus without intestinal metaplasia has no proven risk of adenocarcinoma. \| journal = Am J Surg Pathol \| volume = 36 \| issue = 1 \| pages = 1-7 \| month = Jan \| year = 2012 \| doi = 10.1097/PAS.0b013e31822a5a2c \| PMID = 21959311 }}</ref>		****One large study suggests that goblets cells are only absent due to undersampling.<ref name=pmid21959311>{{Cite journal \| last1 = Chandrasoma \| first1 = P. \| last2 = Wijetunge \| first2 = S. \| last3 = DeMeester \| first3 = S. \| last4 = Ma \| first4 = Y. \| last5 = Hagen \| first5 = J. \| last6 = Zamis \| first6 = L. \| last7 = DeMeester \| first7 = T. \| title = Columnar-lined esophagus without intestinal metaplasia has no proven risk of adenocarcinoma. \| journal = Am J Surg Pathol \| volume = 36 \| issue = 1 \| pages = 1-7 \| month = Jan \| year = 2012 \| doi = 10.1097/PAS.0b013e31822a5a2c \| PMID = 21959311 }}</ref>
	*Associated with [[gastroesophageal reflux disease]] (GERD).		*Associated with [[gastroesophageal reflux disease]] (GERD).

Michael: /* General */ ref for goblet cells required

2020-01-28T19:03:33Z

General: ref for goblet cells required

← Older revision		Revision as of 19:03, 28 January 2020
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	*Diagnosis is made by '''clinicans ''not'' pathologists'''.		*Diagnosis is made by '''clinicans ''not'' pathologists'''.
	**A common histologic correlate is metaplastic transformation of stratified squamous epithelium to simple columnar epithelium with goblet cells.		**A common histologic correlate is metaplastic transformation of stratified squamous epithelium to simple columnar epithelium with goblet cells.
	***There is disagreement whether goblet cells are required for the diagnosis.<ref name=pmid19623166>{{Cite journal \| last1 = Riddell \| first1 = RH. \| last2 = Odze \| first2 = RD. \| title = Definition of Barrett's esophagus: time for a rethink--is intestinal metaplasia dead? \| journal = Am J Gastroenterol \| volume = 104 \| issue = 10 \| pages = 2588-94 \| month = Oct \| year = 2009 \| doi = 10.1038/ajg.2009.390 \| PMID = 19623166 }}</ref> In the United States and Canada goblet cells are required for the diagnosis. In the UK, goblet cells are not required.		***There is disagreement whether goblet cells are required for the diagnosis.<ref name=pmid19623166>{{Cite journal \| last1 = Riddell \| first1 = RH. \| last2 = Odze \| first2 = RD. \| title = Definition of Barrett's esophagus: time for a rethink--is intestinal metaplasia dead? \| journal = Am J Gastroenterol \| volume = 104 \| issue = 10 \| pages = 2588-94 \| month = Oct \| year = 2009 \| doi = 10.1038/ajg.2009.390 \| PMID = 19623166 }}</ref> In the United States and Canada goblet cells are required for the diagnosis.<ref name=pmid29998421>{{cite journal \|vauthors=Odze R \|title=Histology of Barrett's Metaplasia: Do Goblet Cells Matter? \|journal=Dig. Dis. Sci. \|volume=63 \|issue=8 \|pages=2042–2051 \|date=August 2018 \|pmid=29998421 \|doi=10.1007/s10620-018-5151-z \|url=}}</ref> In the UK, goblet cells are not required.
	****One large study suggests that goblets cells are only absent due to undersampling.<ref name=pmid21959311>{{Cite journal \| last1 = Chandrasoma \| first1 = P. \| last2 = Wijetunge \| first2 = S. \| last3 = DeMeester \| first3 = S. \| last4 = Ma \| first4 = Y. \| last5 = Hagen \| first5 = J. \| last6 = Zamis \| first6 = L. \| last7 = DeMeester \| first7 = T. \| title = Columnar-lined esophagus without intestinal metaplasia has no proven risk of adenocarcinoma. \| journal = Am J Surg Pathol \| volume = 36 \| issue = 1 \| pages = 1-7 \| month = Jan \| year = 2012 \| doi = 10.1097/PAS.0b013e31822a5a2c \| PMID = 21959311 }}</ref>		****One large study suggests that goblets cells are only absent due to undersampling.<ref name=pmid21959311>{{Cite journal \| last1 = Chandrasoma \| first1 = P. \| last2 = Wijetunge \| first2 = S. \| last3 = DeMeester \| first3 = S. \| last4 = Ma \| first4 = Y. \| last5 = Hagen \| first5 = J. \| last6 = Zamis \| first6 = L. \| last7 = DeMeester \| first7 = T. \| title = Columnar-lined esophagus without intestinal metaplasia has no proven risk of adenocarcinoma. \| journal = Am J Surg Pathol \| volume = 36 \| issue = 1 \| pages = 1-7 \| month = Jan \| year = 2012 \| doi = 10.1097/PAS.0b013e31822a5a2c \| PMID = 21959311 }}</ref>
	*Associated with [[gastroesophageal reflux disease]] (GERD).		*Associated with [[gastroesophageal reflux disease]] (GERD).

Michael: /* General */

2016-07-10T15:11:50Z

General

← Older revision		Revision as of 15:11, 10 July 2016
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	*Diagnosis is made by '''clinicans ''not'' pathologists'''.		*Diagnosis is made by '''clinicans ''not'' pathologists'''.
	**A common histologic correlate is metaplastic transformation of stratified squamous epithelium to simple columnar epithelium with goblet cells.		**A common histologic correlate is metaplastic transformation of stratified squamous epithelium to simple columnar epithelium with goblet cells.
	***There is disagreement whether goblet cells are required for the diagnosis;<ref name=pmid19623166>{{Cite journal \| last1 = Riddell \| first1 = RH. \| last2 = Odze \| first2 = RD. \| title = Definition of Barrett's esophagus: time for a rethink--is intestinal metaplasia dead? \| journal = Am J Gastroenterol \| volume = 104 \| issue = 10 \| pages = 2588-94 \| month = Oct \| year = 2009 \| doi = 10.1038/ajg.2009.390 \| PMID = 19623166 }}</ref> in the ~~US/~~Canada goblet cells are required. In the UK, goblet cells are not required.		***There is disagreement whether goblet cells are required for the diagnosis.<ref name=pmid19623166>{{Cite journal \| last1 = Riddell \| first1 = RH. \| last2 = Odze \| first2 = RD. \| title = Definition of Barrett's esophagus: time for a rethink--is intestinal metaplasia dead? \| journal = Am J Gastroenterol \| volume = 104 \| issue = 10 \| pages = 2588-94 \| month = Oct \| year = 2009 \| doi = 10.1038/ajg.2009.390 \| PMID = 19623166 }}</ref> In the United States and Canada goblet cells are required for the diagnosis. In the UK, goblet cells are not required.
	****One large study suggests that goblets cells are only absent due to undersampling.<ref name=pmid21959311>{{Cite journal \| last1 = Chandrasoma \| first1 = P. \| last2 = Wijetunge \| first2 = S. \| last3 = DeMeester \| first3 = S. \| last4 = Ma \| first4 = Y. \| last5 = Hagen \| first5 = J. \| last6 = Zamis \| first6 = L. \| last7 = DeMeester \| first7 = T. \| title = Columnar-lined esophagus without intestinal metaplasia has no proven risk of adenocarcinoma. \| journal = Am J Surg Pathol \| volume = 36 \| issue = 1 \| pages = 1-7 \| month = Jan \| year = 2012 \| doi = 10.1097/PAS.0b013e31822a5a2c \| PMID = 21959311 }}</ref>		****One large study suggests that goblets cells are only absent due to undersampling.<ref name=pmid21959311>{{Cite journal \| last1 = Chandrasoma \| first1 = P. \| last2 = Wijetunge \| first2 = S. \| last3 = DeMeester \| first3 = S. \| last4 = Ma \| first4 = Y. \| last5 = Hagen \| first5 = J. \| last6 = Zamis \| first6 = L. \| last7 = DeMeester \| first7 = T. \| title = Columnar-lined esophagus without intestinal metaplasia has no proven risk of adenocarcinoma. \| journal = Am J Surg Pathol \| volume = 36 \| issue = 1 \| pages = 1-7 \| month = Jan \| year = 2012 \| doi = 10.1097/PAS.0b013e31822a5a2c \| PMID = 21959311 }}</ref>
	*Associated with [[gastroesophageal reflux disease]] (GERD).		*Associated with [[gastroesophageal reflux disease]] (GERD).

Michael: /* General */

2016-07-10T15:10:55Z

General

← Older revision		Revision as of 15:10, 10 July 2016
Line 35:		Line 35:
	*Diagnosis is made by '''clinicans ''not'' pathologists'''.		*Diagnosis is made by '''clinicans ''not'' pathologists'''.
	**A common histologic correlate is metaplastic transformation of stratified squamous epithelium to simple columnar epithelium with goblet cells.		**A common histologic correlate is metaplastic transformation of stratified squamous epithelium to simple columnar epithelium with goblet cells.
	***There is disagreement whether goblet cells are required for the diagnosis.<ref name=pmid19623166>{{Cite journal \| last1 = Riddell \| first1 = RH. \| last2 = Odze \| first2 = RD. \| title = Definition of Barrett's esophagus: time for a rethink--is intestinal metaplasia dead? \| journal = Am J Gastroenterol \| volume = 104 \| issue = 10 \| pages = 2588-94 \| month = Oct \| year = 2009 \| doi = 10.1038/ajg.2009.390 \| PMID = 19623166 }}</ref>		***There is disagreement whether goblet cells are required for the diagnosis;<ref name=pmid19623166>{{Cite journal \| last1 = Riddell \| first1 = RH. \| last2 = Odze \| first2 = RD. \| title = Definition of Barrett's esophagus: time for a rethink--is intestinal metaplasia dead? \| journal = Am J Gastroenterol \| volume = 104 \| issue = 10 \| pages = 2588-94 \| month = Oct \| year = 2009 \| doi = 10.1038/ajg.2009.390 \| PMID = 19623166 }}</ref> in the US/Canada goblet cells are required. In the UK, goblet cells are not required.
	****One large study suggests that goblets cells are only absent due to undersampling.<ref name=pmid21959311>{{Cite journal \| last1 = Chandrasoma \| first1 = P. \| last2 = Wijetunge \| first2 = S. \| last3 = DeMeester \| first3 = S. \| last4 = Ma \| first4 = Y. \| last5 = Hagen \| first5 = J. \| last6 = Zamis \| first6 = L. \| last7 = DeMeester \| first7 = T. \| title = Columnar-lined esophagus without intestinal metaplasia has no proven risk of adenocarcinoma. \| journal = Am J Surg Pathol \| volume = 36 \| issue = 1 \| pages = 1-7 \| month = Jan \| year = 2012 \| doi = 10.1097/PAS.0b013e31822a5a2c \| PMID = 21959311 }}</ref>		****One large study suggests that goblets cells are only absent due to undersampling.<ref name=pmid21959311>{{Cite journal \| last1 = Chandrasoma \| first1 = P. \| last2 = Wijetunge \| first2 = S. \| last3 = DeMeester \| first3 = S. \| last4 = Ma \| first4 = Y. \| last5 = Hagen \| first5 = J. \| last6 = Zamis \| first6 = L. \| last7 = DeMeester \| first7 = T. \| title = Columnar-lined esophagus without intestinal metaplasia has no proven risk of adenocarcinoma. \| journal = Am J Surg Pathol \| volume = 36 \| issue = 1 \| pages = 1-7 \| month = Jan \| year = 2012 \| doi = 10.1097/PAS.0b013e31822a5a2c \| PMID = 21959311 }}</ref>
	*Associated with [[gastroesophageal reflux disease]] (GERD).		*Associated with [[gastroesophageal reflux disease]] (GERD).

Michael: /* Sign-out */

2015-10-23T14:10:28Z

Sign-out

← Older revision		Revision as of 14:10, 23 October 2015
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	==Sign-out==		==Sign-out==
			<pre>
			Esophagus, Distal, Biopsy:
			- Columnar epithelium with intestinal metaplasia, see comment.
			- Reactive squamous epithelium.
			- NEGATIVE for dysplasia and NEGATIVE for malignancy.

			Comment:
			The findings are consistent with Barrett's esophagus in the appropriate endoscopic setting.
			</pre>

			===Block letters===
	<pre>		<pre>
	ESOPHAGUS, DISTAL, BIOPSY:		ESOPHAGUS, DISTAL, BIOPSY:

Michael at 03:27, 31 December 2013

2013-12-31T03:27:31Z

← Older revision		Revision as of 03:27, 31 December 2013
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	\| Other =		\| Other =
	\| ClinDDx =		\| ClinDDx =
			\| Tx = on-going surveillance for [[columnar dysplasia of the esophagus\|columnar dysplasia]]
	}}		}}
	:''Intestinal metaplasia of the esophagus'' redirects here.		:''Intestinal metaplasia of the esophagus'' redirects here.

Michael: +'s

2013-12-31T03:25:59Z

+'s

← Older revision		Revision as of 03:25, 31 December 2013
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	}}		}}
	:''Intestinal metaplasia of the esophagus'' redirects here.		:''Intestinal metaplasia of the esophagus'' redirects here.
	'''Barrett esophagus''', abbreviated '''BE''', is a relatively common pathology of the [[esophagus]], that is associated with an increased risk of [[esophageal adenocarcinoma]].		'''Barrett's esophagus''', abbreviated '''BE''', is a relatively common pathology of the [[esophagus]], that is associated with an increased risk of [[esophageal adenocarcinoma]].

	==General==		==General==

Michael: Michael moved page Barrett esophagus to Barrett's esophagus: more commonly used

2013-12-31T03:25:41Z

Michael moved page Barrett esophagus to Barrett's esophagus: more commonly used

← Older revision	Revision as of 03:25, 31 December 2013
(No difference)