B cell small lymphocytic lymphoma/chronic lymphocytic leukemia - Revision history

Michael: /* IHC */

2015-08-13T15:16:59Z

IHC

← Older revision		Revision as of 15:16, 13 August 2015
Line 77:		Line 77:
	**CD38 -ve suggests a good prognosis.<ref name=pmid12676780>{{cite journal \|author=Guarini A, Gaidano G, Mauro FR, ''et al.'' \|title=Chronic lymphocytic leukemia patients with highly stable and indolent disease show distinctive phenotypic and genotypic features \|journal=Blood \|volume=102 \|issue=3 \|pages=1035–41 \|year=2003 \|month=August \|pmid=12676780 \|doi=10.1182/blood-2002-12-3639 \|url=}}</ref>		**CD38 -ve suggests a good prognosis.<ref name=pmid12676780>{{cite journal \|author=Guarini A, Gaidano G, Mauro FR, ''et al.'' \|title=Chronic lymphocytic leukemia patients with highly stable and indolent disease show distinctive phenotypic and genotypic features \|journal=Blood \|volume=102 \|issue=3 \|pages=1035–41 \|year=2003 \|month=August \|pmid=12676780 \|doi=10.1182/blood-2002-12-3639 \|url=}}</ref>

			===Panel===
	A basic panel - based on ''Rizzo and Nassiri'':<ref name=lymphoma>{{Cite journal \| last1 = Rizzo \| first1 = K. \| last2 = Nassiri\| first2 = M. \| title = Diagnostic Workup of Small B Cell Lymphomas: A Laboratory Perspective. \| journal = Lymphoma \| volume = \| issue = \| pages = \| month = \| year = 2012 \| doi =doi:10.1155/2012/346084\| PMID = }}</ref>		A basic panel - based on ''Rizzo and Nassiri'':<ref name=lymphoma>{{Cite journal \| last1 = Rizzo \| first1 = K. \| last2 = Nassiri\| first2 = M. \| title = Diagnostic Workup of Small B Cell Lymphomas: A Laboratory Perspective. \| journal = Lymphoma \| volume = \| issue = \| pages = \| month = \| year = 2012 \| doi =doi:10.1155/2012/346084\| PMID = }}</ref>
	*CD5, CD10, BCL6, CD23, cyclin D1.		*CD5, CD10, BCL6, CD23, cyclin D1.
	Additional IHC:		Additional IHC:
	*CD20, CD3, CD43.		*CD20, CD3, CD43, BCL2.

	==Molecular==		==Molecular==

Michael: /* IHC */

2015-08-13T15:15:18Z

IHC

← Older revision		Revision as of 15:15, 13 August 2015
Line 77:		Line 77:
	**CD38 -ve suggests a good prognosis.<ref name=pmid12676780>{{cite journal \|author=Guarini A, Gaidano G, Mauro FR, ''et al.'' \|title=Chronic lymphocytic leukemia patients with highly stable and indolent disease show distinctive phenotypic and genotypic features \|journal=Blood \|volume=102 \|issue=3 \|pages=1035–41 \|year=2003 \|month=August \|pmid=12676780 \|doi=10.1182/blood-2002-12-3639 \|url=}}</ref>		**CD38 -ve suggests a good prognosis.<ref name=pmid12676780>{{cite journal \|author=Guarini A, Gaidano G, Mauro FR, ''et al.'' \|title=Chronic lymphocytic leukemia patients with highly stable and indolent disease show distinctive phenotypic and genotypic features \|journal=Blood \|volume=102 \|issue=3 \|pages=1035–41 \|year=2003 \|month=August \|pmid=12676780 \|doi=10.1182/blood-2002-12-3639 \|url=}}</ref>

	A panel - based on ''Rizzo and Nassiri'':<ref name=lymphoma>{{Cite journal \| last1 = Rizzo \| first1 = K. \| last2 = Nassiri\| first2 = M. \| title = Diagnostic Workup of Small B Cell Lymphomas: A Laboratory Perspective. \| journal = Lymphoma \| volume = \| issue = \| pages = \| month = \| year = 2012 \| doi =doi:10.1155/2012/346084\| PMID = }}</ref>		A basic panel - based on ''Rizzo and Nassiri'':<ref name=lymphoma>{{Cite journal \| last1 = Rizzo \| first1 = K. \| last2 = Nassiri\| first2 = M. \| title = Diagnostic Workup of Small B Cell Lymphomas: A Laboratory Perspective. \| journal = Lymphoma \| volume = \| issue = \| pages = \| month = \| year = 2012 \| doi =doi:10.1155/2012/346084\| PMID = }}</ref>
	*~~CD20~~, ~~CD5~~, ~~CD21~~, CD23, CD3, CD43~~, cyclin D1~~.		*CD5, CD10, BCL6, CD23, cyclin D1.
			Additional IHC:
			*CD20, CD3, CD43.

	==Molecular==		==Molecular==

Michael: /* IHC */ fix

2015-08-13T15:12:48Z

IHC: fix

← Older revision		Revision as of 15:12, 13 August 2015
Line 77:		Line 77:
	**CD38 -ve suggests a good prognosis.<ref name=pmid12676780>{{cite journal \|author=Guarini A, Gaidano G, Mauro FR, ''et al.'' \|title=Chronic lymphocytic leukemia patients with highly stable and indolent disease show distinctive phenotypic and genotypic features \|journal=Blood \|volume=102 \|issue=3 \|pages=1035–41 \|year=2003 \|month=August \|pmid=12676780 \|doi=10.1182/blood-2002-12-3639 \|url=}}</ref>		**CD38 -ve suggests a good prognosis.<ref name=pmid12676780>{{cite journal \|author=Guarini A, Gaidano G, Mauro FR, ''et al.'' \|title=Chronic lymphocytic leukemia patients with highly stable and indolent disease show distinctive phenotypic and genotypic features \|journal=Blood \|volume=102 \|issue=3 \|pages=1035–41 \|year=2003 \|month=August \|pmid=12676780 \|doi=10.1182/blood-2002-12-3639 \|url=}}</ref>

	A panel - based on ''Rizzo and Nassiri'':~~<ref>~~<ref name=lymphoma>{{Cite journal \| last1 = Rizzo \| first1 = K. \| last2 = Nassiri\| first2 = M. \| title = Diagnostic Workup of Small B Cell Lymphomas: A Laboratory Perspective. \| journal = Lymphoma \| volume = \| issue = \| pages = \| month = \| year = 2012 \| doi =doi:10.1155/2012/346084\| PMID = }}</ref>		A panel - based on ''Rizzo and Nassiri'':<ref name=lymphoma>{{Cite journal \| last1 = Rizzo \| first1 = K. \| last2 = Nassiri\| first2 = M. \| title = Diagnostic Workup of Small B Cell Lymphomas: A Laboratory Perspective. \| journal = Lymphoma \| volume = \| issue = \| pages = \| month = \| year = 2012 \| doi =doi:10.1155/2012/346084\| PMID = }}</ref>
	*CD20, CD5, CD21, CD23, CD3, CD43, cyclin D1.		*CD20, CD5, CD21, CD23, CD3, CD43, cyclin D1.

Michael: /* IHC */

2015-08-13T15:12:35Z

IHC

← Older revision		Revision as of 15:12, 13 August 2015
Line 76:		Line 76:
	*CD38 -ve/+ve.		*CD38 -ve/+ve.
	**CD38 -ve suggests a good prognosis.<ref name=pmid12676780>{{cite journal \|author=Guarini A, Gaidano G, Mauro FR, ''et al.'' \|title=Chronic lymphocytic leukemia patients with highly stable and indolent disease show distinctive phenotypic and genotypic features \|journal=Blood \|volume=102 \|issue=3 \|pages=1035–41 \|year=2003 \|month=August \|pmid=12676780 \|doi=10.1182/blood-2002-12-3639 \|url=}}</ref>		**CD38 -ve suggests a good prognosis.<ref name=pmid12676780>{{cite journal \|author=Guarini A, Gaidano G, Mauro FR, ''et al.'' \|title=Chronic lymphocytic leukemia patients with highly stable and indolent disease show distinctive phenotypic and genotypic features \|journal=Blood \|volume=102 \|issue=3 \|pages=1035–41 \|year=2003 \|month=August \|pmid=12676780 \|doi=10.1182/blood-2002-12-3639 \|url=}}</ref>

			A panel - based on ''Rizzo and Nassiri'':<ref><ref name=lymphoma>{{Cite journal \| last1 = Rizzo \| first1 = K. \| last2 = Nassiri\| first2 = M. \| title = Diagnostic Workup of Small B Cell Lymphomas: A Laboratory Perspective. \| journal = Lymphoma \| volume = \| issue = \| pages = \| month = \| year = 2012 \| doi =doi:10.1155/2012/346084\| PMID = }}</ref>
			*CD20, CD5, CD21, CD23, CD3, CD43, cyclin D1.

	==Molecular==		==Molecular==

Michael at 12:55, 10 June 2014

2014-06-10T12:55:34Z

← Older revision		Revision as of 12:55, 10 June 2014
Line 15:		Line 15:
	\| Gross =		\| Gross =
	\| Grossing =		\| Grossing =
	\| Site = [[bone marrow]]/[[lymph nodes]]		\| Site = blood + [[bone marrow]]/[[lymph nodes]]
	\| Assdx =		\| Assdx =
	\| Syndromes =		\| Syndromes =
Line 22:		Line 22:
	\| Symptoms =		\| Symptoms =
	\| Prevalence = common		\| Prevalence = common
	\| Bloodwork =		\| Bloodwork = elevated WBC (≥5 × 10<sup>9</sup>/L)
	\| Rads =		\| Rads =
	\| Endoscopy =		\| Endoscopy =
Line 28:		Line 28:
	\| Other =		\| Other =
	\| ClinDDx =		\| ClinDDx =
	\| Tx =		\| Tx = often followup
	}}		}}
	'''B cell small lymphocytic lymphoma/chronic lymphocytic leukemia''', often referred to as '''chronic lymphocytic leukemia''' (abbreviated '''CLL''') or '''small lymphocytic lymphoma''' (abbreviated '''SLL'''), is a common low-grade hematologic [[malignancy]]. It typically afflicts older individuals.		'''B cell small lymphocytic lymphoma/chronic lymphocytic leukemia''', often referred to as '''chronic lymphocytic leukemia''' (abbreviated '''CLL''') or '''small lymphocytic lymphoma''' (abbreviated '''SLL'''), is a common low-grade hematologic [[malignancy]]. It typically afflicts older individuals.
Line 37:		Line 37:
	**May transform to an aggressive lymphoma - see below.		**May transform to an aggressive lymphoma - see below.
	*Older individuals.		*Older individuals.
	*Elevated WBC.		*Elevated WBC ≥5 × 10<sup>9</sup>/L - required for diagnosis (clinically).<ref>{{cite journal \|author=Call TG, Norman AD, Hanson CA, ''et al.'' \|title=Incidence of chronic lymphocytic leukemia and high-count monoclonal B-cell lymphocytosis using the 2008 guidelines \|journal=Cancer \|volume= \|issue= \|pages= \|year=2014 \|month=April \|pmid=24711224 \|doi=10.1002/cncr.28690 \|url=}}</ref>

	===Richter's transformation===		===Richter's transformation===

Michael at 12:49, 10 June 2014

2014-06-10T12:49:16Z

← Older revision		Revision as of 12:49, 10 June 2014
Line 30:		Line 30:
	\| Tx =		\| Tx =
	}}		}}
	'''B cell small lymphocytic lymphoma/chronic lymphocytic leukemia''', often referred to as '''chronic lymphocytic leukemia''' (abbreviated '''CLL''') or '''small lymphocytic lymphoma''' (abbreviated '''SLL'''), is a common low-grade hematologic [[malignancy]]. ~~That~~ typically afflicts older individuals.		'''B cell small lymphocytic lymphoma/chronic lymphocytic leukemia''', often referred to as '''chronic lymphocytic leukemia''' (abbreviated '''CLL''') or '''small lymphocytic lymphoma''' (abbreviated '''SLL'''), is a common low-grade hematologic [[malignancy]]. It typically afflicts older individuals.

	==General==		==General==
	*Very common.		*Very common.
	*Good prognosis.		*Good prognosis - treatment may be simply followup.<ref name=pmid12676780>{{cite journal \|author=Guarini A, Gaidano G, Mauro FR, ''et al.'' \|title=Chronic lymphocytic leukemia patients with highly stable and indolent disease show distinctive phenotypic and genotypic features \|journal=Blood \|volume=102 \|issue=3 \|pages=1035–41 \|year=2003 \|month=August \|pmid=12676780 \|doi=10.1182/blood-2002-12-3639 \|url=}}</ref>
			**May transform to an aggressive lymphoma - see below.
			*Older individuals.
			*Elevated WBC.

	===Richter's transformation===		===Richter's transformation===
Line 71:		Line 74:
	Others:		Others:
	*Cyclin D1 -ve.		*Cyclin D1 -ve.
			*CD38 -ve/+ve.
			**CD38 -ve suggests a good prognosis.<ref name=pmid12676780>{{cite journal \|author=Guarini A, Gaidano G, Mauro FR, ''et al.'' \|title=Chronic lymphocytic leukemia patients with highly stable and indolent disease show distinctive phenotypic and genotypic features \|journal=Blood \|volume=102 \|issue=3 \|pages=1035–41 \|year=2003 \|month=August \|pmid=12676780 \|doi=10.1182/blood-2002-12-3639 \|url=}}</ref>

	==Molecular==		==Molecular==

Michael at 11:24, 10 June 2014

2014-06-10T11:24:32Z

← Older revision		Revision as of 11:24, 10 June 2014
Line 1:		Line 1:
			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Chronic lymphocytic leukemia - low mag.jpg
			\| Width =
			\| Caption = Small lymphocytic lymphoma. [[H&E stain]].
			\| Synonyms =
			\| Micro = mixed population of lymphoid cells with "proliferation centers": (1) nodular collections of larger cells (~ 1.5x the size of resting lymphocyte ~ 12-15 micrometers) with nucleoli) - surrounded by (2) small dark cells (~ size of resting lymphocyte ~ 8-10 micrometers) - predominant population, lack nucleolus
			\| Subtypes =
			\| LMDDx = other [[small cell lymphomas]] esp. [[mantle cell lymphoma]] (IHC similar)
			\| Stains =
			\| IHC = CD20 +ve, CD23 +ve, CD5 +ve, cyclin D1 -ve, CD43 +ve
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[bone marrow]]/[[lymph nodes]]
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms =
			\| Prevalence = common
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = good
			\| Other =
			\| ClinDDx =
			\| Tx =
			}}
	'''B cell small lymphocytic lymphoma/chronic lymphocytic leukemia''', often referred to as '''chronic lymphocytic leukemia''' (abbreviated '''CLL''') or '''small lymphocytic lymphoma''' (abbreviated '''SLL'''), is a common low-grade hematologic [[malignancy]]. That typically afflicts older individuals.		'''B cell small lymphocytic lymphoma/chronic lymphocytic leukemia''', often referred to as '''chronic lymphocytic leukemia''' (abbreviated '''CLL''') or '''small lymphocytic lymphoma''' (abbreviated '''SLL'''), is a common low-grade hematologic [[malignancy]]. That typically afflicts older individuals.

Michael: split out

2014-06-10T11:15:18Z

split out

New page

'''B cell small lymphocytic lymphoma/chronic lymphocytic leukemia''', often referred to as '''chronic lymphocytic leukemia''' (abbreviated '''CLL''') or '''small lymphocytic lymphoma''' (abbreviated '''SLL'''), is a common low-grade hematologic [[malignancy]]. That typically afflicts older individuals.

==General==
*Very common.
*Good prognosis.

===Richter's transformation===
*CLL/SLL may under go a ''Richter's transformation'' into a high-grade non-Hodgkin's lymphoma (NHL), e.g. [[DLBCL]]:<ref name=pmid16616072>{{cite journal |author=Tsimberidou AM, Keating MJ |title=Richter's transformation in chronic lymphocytic leukemia |journal=Semin. Oncol. |volume=33 |issue=2 |pages=250–6 |year=2006 |month=April |pmid=16616072 |doi=10.1053/j.seminoncol.2006.01.016 |url=}}</ref>
**Incidence of transformation <5%.
**Prognosis < 1 year.

==Microscopic==
Features in a lymph node:<ref>DG. 17 August 2010.</ref>
*Mixed population of lymphoid cells with "proliferation centers" - '''key feature''':
*#Larger cells (~ 1.5x the size of resting lymphocyte ~ 12-15 micrometers):
*#*Nucleoli.
*#*Form (nodular) collections.
*#Small dark cells (~ size of resting lymphocyte ~ 8-10 micrometers):
*#*Predominant population.
*#*Lack nucleolus.

===Images===
<gallery>
Image:Chronic lymphocytic leukemia - low mag.jpg | CLL - low mag. (WC)
Image:Chronic lymphocytic leukemia - intermed mag.jpg | CLL - intermed. mag. (WC)
Image:Chronic lymphocytic leukemia - high mag.jpg | CLL - high mag. (WC)
Image:Chronic lymphocytic leukemia - very high mag.jpg | CLL - very high mag. (WC)
</gallery>
www:
*[http://www.pathologyatlas.ro/chronic-lymphoid-leukemia-liver.php CLL in the liver (pathologyatlas.ro)].
*[http://path.upmc.edu/cases/case296.html SLL in the parotid - several images (upmc.edu)].
*[http://path.upmc.edu/cases/case446.html CLL with Richter transformation - several images (upmc.edu)].

==IHC==
*CD20 +ve.
*CD5 +ve.
*[[CD23]] +ve -- occasionally negative.<ref>URL: [http://path.upmc.edu/cases/case296/dx.html http://path.upmc.edu/cases/case296/dx.html]. Accessed on: 14 January 2012.</ref>
*CD43 +ve.

Others:
*Cyclin D1 -ve.

==Molecular==
*Lacks t(11;14) seen in [[mantle cell lymphoma]].

==See also==
*[[Small cell lymphomas]].

==References==
{{Reflist|2}}

[[Category:Diagnosis]]
[[Category:Small cell lymphomas]]