Atypical teratoid/rhabdoid tumour - Revision history

Jensflorian: /* Microscopic */ DDx

2020-01-21T11:00:42Z

Microscopic: DDx

← Older revision		Revision as of 11:00, 21 January 2020
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	*[[Embryonal carcinoma]].		*[[Embryonal carcinoma]].
	*[[Rhabdoid meningioma]].		*[[Rhabdoid meningioma]].
			*Intracranial [[Desmoplastic small round cell tumour]].

	===Images===		===Images===

Michael at 16:40, 29 September 2017

2017-09-29T16:40:54Z

← Older revision		Revision as of 16:40, 29 September 2017
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	\| Micro = cellular tumour with small round cells usu. with a prominent nucleolus, rhabdoid cells (eosinophilic granular cytoplasm + eccentric nucleus), mitoses. +/-necrosis (common)		\| Micro = cellular tumour with small round cells usu. with a prominent nucleolus, rhabdoid cells (eosinophilic granular cytoplasm + eccentric nucleus), mitoses. +/-necrosis (common)
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[primitive neuroectodermal tumour]] (PNET), [[medulloblastoma]], [[diffuse astrocytoma]], [[choroid plexus carcinoma]],[[embryonal carcinoma]]		\| LMDDx = [[primitive neuroectodermal tumour]] (PNET), [[medulloblastoma]], [[diffuse astrocytoma]], [[choroid plexus carcinoma]], [[embryonal carcinoma]]
	\| Stains =		\| Stains =
	\| IHC = INI1 -ve, S-100 +ve, EMA +ve, SMA +ve		\| IHC = INI1 -ve, S-100 +ve, EMA +ve, SMA +ve

Michael: /* Molecular */

2017-09-29T16:40:40Z

Molecular

← Older revision		Revision as of 16:40, 29 September 2017
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	*Single cases with SMARCA4 mutation.<ref>{{Cite journal \| last1 = Hasselblatt \| first1 = M. \| last2 = Gesk \| first2 = S. \| last3 = Oyen \| first3 = F. \| last4 = Rossi \| first4 = S. \| last5 = Viscardi \| first5 = E. \| last6 = Giangaspero \| first6 = F. \| last7 = Giannini \| first7 = C. \| last8 = Judkins \| first8 = AR. \| last9 = Frühwald \| first9 = MC. \| title = Nonsense mutation and inactivation of SMARCA4 (BRG1) in an atypical teratoid/rhabdoid tumor showing retained SMARCB1 (INI1) expression. \| journal = Am J Surg Pathol \| volume = 35 \| issue = 6 \| pages = 933-5 \| month = Jun \| year = 2011 \| doi = 10.1097/PAS.0b013e3182196a39 \| PMID = 21566516 }}</ref>		*Single cases with SMARCA4 mutation.<ref>{{Cite journal \| last1 = Hasselblatt \| first1 = M. \| last2 = Gesk \| first2 = S. \| last3 = Oyen \| first3 = F. \| last4 = Rossi \| first4 = S. \| last5 = Viscardi \| first5 = E. \| last6 = Giangaspero \| first6 = F. \| last7 = Giannini \| first7 = C. \| last8 = Judkins \| first8 = AR. \| last9 = Frühwald \| first9 = MC. \| title = Nonsense mutation and inactivation of SMARCA4 (BRG1) in an atypical teratoid/rhabdoid tumor showing retained SMARCB1 (INI1) expression. \| journal = Am J Surg Pathol \| volume = 35 \| issue = 6 \| pages = 933-5 \| month = Jun \| year = 2011 \| doi = 10.1097/PAS.0b013e3182196a39 \| PMID = 21566516 }}</ref>
	* Two molecular subgroups:<ref>{{Cite journal \| last1 = Torchia \| first1 = J. \| last2 = Picard \| first2 = D. \| last3 = Lafay-Cousin \| first3 = L. \| last4 = Hawkins \| first4 = CE. \| last5 = Kim \| first5 = SK. \| last6 = Letourneau \| first6 = L. \| last7 = Ra \| first7 = YS. \| last8 = Ho \| first8 = KC. \| last9 = Chan \| first9 = TS. \| title = Molecular subgroups of atypical teratoid rhabdoid tumours in children: an integrated genomic and clinicopathological analysis. \| journal = Lancet Oncol \| volume = 16 \| issue = 5 \| pages = 569-82 \| month = May \| year = 2015 \| doi = 10.1016/S1470-2045(15)70114-2 \| PMID = 25882982 }}</ref>		* Two molecular subgroups:<ref>{{Cite journal \| last1 = Torchia \| first1 = J. \| last2 = Picard \| first2 = D. \| last3 = Lafay-Cousin \| first3 = L. \| last4 = Hawkins \| first4 = CE. \| last5 = Kim \| first5 = SK. \| last6 = Letourneau \| first6 = L. \| last7 = Ra \| first7 = YS. \| last8 = Ho \| first8 = KC. \| last9 = Chan \| first9 = TS. \| title = Molecular subgroups of atypical teratoid rhabdoid tumours in children: an integrated genomic and clinicopathological analysis. \| journal = Lancet Oncol \| volume = 16 \| issue = 5 \| pages = 569-82 \| month = May \| year = 2015 \| doi = 10.1016/S1470-2045(15)70114-2 \| PMID = 25882982 }}</ref>
	** Group 1: usu. supratentorial, ASCL1-positive: high-risk		** Group 1: usu. supratentorial, ASCL1-positive: high-risk.
	** Group 2: usu. infratentorial, BMP-signalling: very high risk		** Group 2: usu. infratentorial, BMP-signalling: very high risk.

	==See also==		==See also==

Jensflorian: /* IHC */ wikify

2015-09-21T20:28:08Z

IHC: wikify

← Older revision		Revision as of 20:28, 21 September 2015
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	==IHC==		==IHC==
	* INI1-ve ([[AKA]] ''BAF-47'', [[AKA]] ''SMARCB1'' - the HGNC symbol<ref name=omim601607>{{OMIM\|601607}}</ref>) - virtually diagnostic (4/4 cases<ref name=pmid19212771/>).		* [[INI1]]-ve ([[AKA]] ''BAF-47'', [[AKA]] ''SMARCB1'' - the HGNC symbol<ref name=omim601607>{{OMIM\|601607}}</ref>) - virtually diagnostic (4/4 cases<ref name=pmid19212771/>).
	**Endothelial cells +ve control.		**Endothelial cells +ve control.
	*S-100 +ve (4/4 cases<ref name=pmid19212771>{{Cite journal \| last1 = Ertan \| first1 = Y. \| last2 = Sezak \| first2 = M. \| last3 = Turhan \| first3 = T. \| last4 = Kantar \| first4 = M. \| last5 = Erşahin \| first5 = Y. \| last6 = Mutluer \| first6 = S. \| last7 = Vergin \| first7 = C. \| last8 = Oniz \| first8 = H. \| last9 = Akalin \| first9 = T. \| title = Atypical teratoid/rhabdoid tumor of the central nervous system: clinicopathologic and immunohistochemical features of four cases. \| journal = Childs Nerv Syst \| volume = 25 \| issue = 6 \| pages = 707-11 \| month = Jun \| year = 2009 \| doi = 10.1007/s00381-009-0811-0 \| PMID = 19212771 }}</ref>).		*S-100 +ve (4/4 cases<ref name=pmid19212771>{{Cite journal \| last1 = Ertan \| first1 = Y. \| last2 = Sezak \| first2 = M. \| last3 = Turhan \| first3 = T. \| last4 = Kantar \| first4 = M. \| last5 = Erşahin \| first5 = Y. \| last6 = Mutluer \| first6 = S. \| last7 = Vergin \| first7 = C. \| last8 = Oniz \| first8 = H. \| last9 = Akalin \| first9 = T. \| title = Atypical teratoid/rhabdoid tumor of the central nervous system: clinicopathologic and immunohistochemical features of four cases. \| journal = Childs Nerv Syst \| volume = 25 \| issue = 6 \| pages = 707-11 \| month = Jun \| year = 2009 \| doi = 10.1007/s00381-009-0811-0 \| PMID = 19212771 }}</ref>).

Jensflorian: case 102 added

2015-09-21T20:03:57Z

case 102 added

← Older revision		Revision as of 20:03, 21 September 2015
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	Image:Rhabdoid cells ATRT1.jpg \| Rhabdoid cells in a AT/RT (WC/jensflorian)		Image:Rhabdoid cells ATRT1.jpg \| Rhabdoid cells in a AT/RT (WC/jensflorian)
	Image:ATRT-MRI.jpg \| AT/RT may be found anywhere in the brain or spinal cord (WC/marvin101)		Image:ATRT-MRI.jpg \| AT/RT may be found anywhere in the brain or spinal cord (WC/marvin101)
			Image:Neuropathology_case_IV_01.jpg \| AT/RT low mag.(WC/jensflorian)
			Image:Neuropathology_case_IV_02.jpg \| AT/RT intermed. mag.(WC/jensflorian)
			Image:Neuropathology_case_IV_03.jpg \| AT/RT high mag.(WC/jensflorian)
			Image:Neuropathology_case_IV_04.jpg \| INI1 loss in a AT/RT. (WC/jensflorian)
	</gallery>		</gallery>
	www:		www:
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	==IHC==		==IHC==
	*~~BAF-47~~ -ve ([[AKA]] ''~~INI1~~'', [[AKA]] ''SMARCB1'' - the HGNC symbol<ref name=omim601607>{{OMIM\|601607}}</ref>) - virtually diagnostic (4/4 cases<ref name=pmid19212771/>).		* INI1-ve ([[AKA]] ''BAF-47'', [[AKA]] ''SMARCB1'' - the HGNC symbol<ref name=omim601607>{{OMIM\|601607}}</ref>) - virtually diagnostic (4/4 cases<ref name=pmid19212771/>).
	**Endothelial cells +ve control.		**Endothelial cells +ve control.
	*S-100 +ve (4/4 cases<ref name=pmid19212771>{{Cite journal \| last1 = Ertan \| first1 = Y. \| last2 = Sezak \| first2 = M. \| last3 = Turhan \| first3 = T. \| last4 = Kantar \| first4 = M. \| last5 = Erşahin \| first5 = Y. \| last6 = Mutluer \| first6 = S. \| last7 = Vergin \| first7 = C. \| last8 = Oniz \| first8 = H. \| last9 = Akalin \| first9 = T. \| title = Atypical teratoid/rhabdoid tumor of the central nervous system: clinicopathologic and immunohistochemical features of four cases. \| journal = Childs Nerv Syst \| volume = 25 \| issue = 6 \| pages = 707-11 \| month = Jun \| year = 2009 \| doi = 10.1007/s00381-009-0811-0 \| PMID = 19212771 }}</ref>).		*S-100 +ve (4/4 cases<ref name=pmid19212771>{{Cite journal \| last1 = Ertan \| first1 = Y. \| last2 = Sezak \| first2 = M. \| last3 = Turhan \| first3 = T. \| last4 = Kantar \| first4 = M. \| last5 = Erşahin \| first5 = Y. \| last6 = Mutluer \| first6 = S. \| last7 = Vergin \| first7 = C. \| last8 = Oniz \| first8 = H. \| last9 = Akalin \| first9 = T. \| title = Atypical teratoid/rhabdoid tumor of the central nervous system: clinicopathologic and immunohistochemical features of four cases. \| journal = Childs Nerv Syst \| volume = 25 \| issue = 6 \| pages = 707-11 \| month = Jun \| year = 2009 \| doi = 10.1007/s00381-009-0811-0 \| PMID = 19212771 }}</ref>).
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	*[[Renal malignant rhabdoid tumour]].		*[[Renal malignant rhabdoid tumour]].
	*[[Miscellaneous ovarian tumours\|Ovarian small cell carcinoma of the hypercalcemic type]]		*[[Miscellaneous ovarian tumours\|Ovarian small cell carcinoma of the hypercalcemic type]]

	==References==		==References==
	{{Reflist\|2}}		{{Reflist\|2}}

Jensflorian: update molecular

2015-06-03T14:19:48Z

update molecular

← Older revision		Revision as of 14:19, 3 June 2015
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	*Individuals usually <3 years old, uncommon in adults.<ref name=pmid24477665>{{Cite journal \| last1 = Kanoto \| first1 = M. \| last2 = Toyoguchi \| first2 = Y. \| last3 = Hosoya \| first3 = T. \| last4 = Kuchiki \| first4 = M. \| last5 = Sugai \| first5 = Y. \| title = Radiological Image Features of the Atypical Teratoid/Rhabdoid Tumor in Adults: A Systematic Review. \| journal = Clin Neuroradiol \| volume = \| issue = \| pages = \| month = Jan \| year = 2014 \| doi = 10.1007/s00062-013-0282-2 \| PMID = 24477665 }}</ref>		*Individuals usually <3 years old, uncommon in adults.<ref name=pmid24477665>{{Cite journal \| last1 = Kanoto \| first1 = M. \| last2 = Toyoguchi \| first2 = Y. \| last3 = Hosoya \| first3 = T. \| last4 = Kuchiki \| first4 = M. \| last5 = Sugai \| first5 = Y. \| title = Radiological Image Features of the Atypical Teratoid/Rhabdoid Tumor in Adults: A Systematic Review. \| journal = Clin Neuroradiol \| volume = \| issue = \| pages = \| month = Jan \| year = 2014 \| doi = 10.1007/s00062-013-0282-2 \| PMID = 24477665 }}</ref>
	*Prognosis very poor, but long-term survivors reported.<ref>{{Cite journal \| last1 = von Hoff \| first1 = K. \| last2 = Hinkes \| first2 = B. \| last3 = Dannenmann-Stern \| first3 = E. \| last4 = von Bueren \| first4 = AO. \| last5 = Warmuth-Metz \| first5 = M. \| last6 = Soerensen \| first6 = N. \| last7 = Emser \| first7 = A. \| last8 = Zwiener \| first8 = I. \| last9 = Schlegel \| first9 = PG. \| title = Frequency, risk-factors and survival of children with atypical teratoid rhabdoid tumors (AT/RT) of the CNS diagnosed between 1988 and 2004, and registered to the German HIT database. \| journal = Pediatr Blood Cancer \| volume = 57 \| issue = 6 \| pages = 978-85 \| month = Dec \| year = 2011 \| doi = 10.1002/pbc.23236 \| PMID = 21796761 }}</ref>		*Prognosis very poor, but long-term survivors reported.<ref>{{Cite journal \| last1 = von Hoff \| first1 = K. \| last2 = Hinkes \| first2 = B. \| last3 = Dannenmann-Stern \| first3 = E. \| last4 = von Bueren \| first4 = AO. \| last5 = Warmuth-Metz \| first5 = M. \| last6 = Soerensen \| first6 = N. \| last7 = Emser \| first7 = A. \| last8 = Zwiener \| first8 = I. \| last9 = Schlegel \| first9 = PG. \| title = Frequency, risk-factors and survival of children with atypical teratoid rhabdoid tumors (AT/RT) of the CNS diagnosed between 1988 and 2004, and registered to the German HIT database. \| journal = Pediatr Blood Cancer \| volume = 57 \| issue = 6 \| pages = 978-85 \| month = Dec \| year = 2011 \| doi = 10.1002/pbc.23236 \| PMID = 21796761 }}</ref>
	*Almost all cases associated with SMARCB1 abberations.<ref>{{Cite journal \| last1 = Hasselblatt \| first1 = M. \| last2 = Isken \| first2 = S. \| last3 = Linge \| first3 = A. \| last4 = Eikmeier \| first4 = K. \| last5 = Jeibmann \| first5 = A. \| last6 = Oyen \| first6 = F. \| last7 = Nagel \| first7 = I. \| last8 = Richter \| first8 = J. \| last9 = Bartelheim \| first9 = K. \| title = High-resolution genomic analysis suggests the absence of recurrent genomic alterations other than SMARCB1 aberrations in atypical teratoid/rhabdoid tumors. \| journal = Genes Chromosomes Cancer \| volume = 52 \| issue = 2 \| pages = 185-90 \| month = Feb \| year = 2013 \| doi = 10.1002/gcc.22018 \| PMID = 23074045 }}</ref>
	*Single cases with SMARCA4 mutation.<ref>{{Cite journal \| last1 = Hasselblatt \| first1 = M. \| last2 = Gesk \| first2 = S. \| last3 = Oyen \| first3 = F. \| last4 = Rossi \| first4 = S. \| last5 = Viscardi \| first5 = E. \| last6 = Giangaspero \| first6 = F. \| last7 = Giannini \| first7 = C. \| last8 = Judkins \| first8 = AR. \| last9 = Frühwald \| first9 = MC. \| title = Nonsense mutation and inactivation of SMARCA4 (BRG1) in an atypical teratoid/rhabdoid tumor showing retained SMARCB1 (INI1) expression. \| journal = Am J Surg Pathol \| volume = 35 \| issue = 6 \| pages = 933-5 \| month = Jun \| year = 2011 \| doi = 10.1097/PAS.0b013e3182196a39 \| PMID = 21566516 }}</ref>

	==Microscopic==		==Microscopic==
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	*Cytokeratin +ve.<ref>{{Cite journal \| last1 = Lee \| first1 = MC. \| last2 = Park \| first2 = SK. \| last3 = Lim \| first3 = JS. \| last4 = Jung \| first4 = S. \| last5 = Kim \| first5 = JH. \| last6 = Woo \| first6 = YJ. \| last7 = Lee \| first7 = JS. \| last8 = Kim \| first8 = HI. \| last9 = Jeong \| first9 = MJ. \| title = Atypical teratoid/rhabdoid tumor of the central nervous system: clinico-pathological study. \| journal = Neuropathology \| volume = 22 \| issue = 4 \| pages = 252-60 \| month = Dec \| year = 2002 \| doi = \| PMID = 12564764 }}</ref>		*Cytokeratin +ve.<ref>{{Cite journal \| last1 = Lee \| first1 = MC. \| last2 = Park \| first2 = SK. \| last3 = Lim \| first3 = JS. \| last4 = Jung \| first4 = S. \| last5 = Kim \| first5 = JH. \| last6 = Woo \| first6 = YJ. \| last7 = Lee \| first7 = JS. \| last8 = Kim \| first8 = HI. \| last9 = Jeong \| first9 = MJ. \| title = Atypical teratoid/rhabdoid tumor of the central nervous system: clinico-pathological study. \| journal = Neuropathology \| volume = 22 \| issue = 4 \| pages = 252-60 \| month = Dec \| year = 2002 \| doi = \| PMID = 12564764 }}</ref>
	*Kir 7.1 occasionally +ve<ref>{{Cite journal \| last1 = Schittenhelm \| first1 = J. \| last2 = Nagel \| first2 = C. \| last3 = Meyermann \| first3 = R. \| last4 = Beschorner \| first4 = R. \| title = Atypical teratoid/rhabdoid tumors may show morphological and immunohistochemical features seen in choroid plexus tumors. \| journal = Neuropathology \| volume = 31 \| issue = 5 \| pages = 461-7 \| month = Oct \| year = 2011 \| doi = 10.1111/j.1440-1789.2010.01189.x \| PMID = 21276081 }}</ref>		*Kir 7.1 occasionally +ve<ref>{{Cite journal \| last1 = Schittenhelm \| first1 = J. \| last2 = Nagel \| first2 = C. \| last3 = Meyermann \| first3 = R. \| last4 = Beschorner \| first4 = R. \| title = Atypical teratoid/rhabdoid tumors may show morphological and immunohistochemical features seen in choroid plexus tumors. \| journal = Neuropathology \| volume = 31 \| issue = 5 \| pages = 461-7 \| month = Oct \| year = 2011 \| doi = 10.1111/j.1440-1789.2010.01189.x \| PMID = 21276081 }}</ref>

			==Molecular==
			*Almost all cases associated with SMARCB1 abberations.<ref>{{Cite journal \| last1 = Hasselblatt \| first1 = M. \| last2 = Isken \| first2 = S. \| last3 = Linge \| first3 = A. \| last4 = Eikmeier \| first4 = K. \| last5 = Jeibmann \| first5 = A. \| last6 = Oyen \| first6 = F. \| last7 = Nagel \| first7 = I. \| last8 = Richter \| first8 = J. \| last9 = Bartelheim \| first9 = K. \| title = High-resolution genomic analysis suggests the absence of recurrent genomic alterations other than SMARCB1 aberrations in atypical teratoid/rhabdoid tumors. \| journal = Genes Chromosomes Cancer \| volume = 52 \| issue = 2 \| pages = 185-90 \| month = Feb \| year = 2013 \| doi = 10.1002/gcc.22018 \| PMID = 23074045 }}</ref>
			*Single cases with SMARCA4 mutation.<ref>{{Cite journal \| last1 = Hasselblatt \| first1 = M. \| last2 = Gesk \| first2 = S. \| last3 = Oyen \| first3 = F. \| last4 = Rossi \| first4 = S. \| last5 = Viscardi \| first5 = E. \| last6 = Giangaspero \| first6 = F. \| last7 = Giannini \| first7 = C. \| last8 = Judkins \| first8 = AR. \| last9 = Frühwald \| first9 = MC. \| title = Nonsense mutation and inactivation of SMARCA4 (BRG1) in an atypical teratoid/rhabdoid tumor showing retained SMARCB1 (INI1) expression. \| journal = Am J Surg Pathol \| volume = 35 \| issue = 6 \| pages = 933-5 \| month = Jun \| year = 2011 \| doi = 10.1097/PAS.0b013e3182196a39 \| PMID = 21566516 }}</ref>
			* Two molecular subgroups:<ref>{{Cite journal \| last1 = Torchia \| first1 = J. \| last2 = Picard \| first2 = D. \| last3 = Lafay-Cousin \| first3 = L. \| last4 = Hawkins \| first4 = CE. \| last5 = Kim \| first5 = SK. \| last6 = Letourneau \| first6 = L. \| last7 = Ra \| first7 = YS. \| last8 = Ho \| first8 = KC. \| last9 = Chan \| first9 = TS. \| title = Molecular subgroups of atypical teratoid rhabdoid tumours in children: an integrated genomic and clinicopathological analysis. \| journal = Lancet Oncol \| volume = 16 \| issue = 5 \| pages = 569-82 \| month = May \| year = 2015 \| doi = 10.1016/S1470-2045(15)70114-2 \| PMID = 25882982 }}</ref>
			** Group 1: usu. supratentorial, ASCL1-positive: high-risk
			** Group 2: usu. infratentorial, BMP-signalling: very high risk

	==See also==		==See also==

Jensflorian: +cat

2015-04-30T18:02:48Z

+cat

← Older revision		Revision as of 18:02, 30 April 2015
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	[[Category:Diagnosis]]		[[Category:Diagnosis]]
	[[Category:Neuropathology tumours]]		[[Category:Neuropathology tumours]]
			[[Category:Small round blue cell tumours]]

Michael: /* Microscopic */ wikify

2015-04-02T22:29:43Z

Microscopic: wikify

← Older revision		Revision as of 22:29, 2 April 2015
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	*[[Primitive neuroectodermal tumour]] (PNET).		*[[Primitive neuroectodermal tumour]] (PNET).
	*[[Medulloblastoma]].		*[[Medulloblastoma]].
	*Small cell carcinoma metastasis.		*[[Small cell carcinoma]] metastasis.
	*[[Choroid plexus carcinoma]].		*[[Choroid plexus carcinoma]].
	*[[Embryonal carcinoma]].		*[[Embryonal carcinoma]].
	*Rhabdoid meningioma.		*[[Rhabdoid meningioma]].

	===Images===		===Images===

Jensflorian: +genetics, +references

2015-04-01T10:27:24Z

+genetics, +references

← Older revision		Revision as of 10:27, 1 April 2015
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	*Usually supratentorial, occasionally in posterior fossa, case reports of spinal cord.		*Usually supratentorial, occasionally in posterior fossa, case reports of spinal cord.
	*Individuals usually <3 years old, uncommon in adults.<ref name=pmid24477665>{{Cite journal \| last1 = Kanoto \| first1 = M. \| last2 = Toyoguchi \| first2 = Y. \| last3 = Hosoya \| first3 = T. \| last4 = Kuchiki \| first4 = M. \| last5 = Sugai \| first5 = Y. \| title = Radiological Image Features of the Atypical Teratoid/Rhabdoid Tumor in Adults: A Systematic Review. \| journal = Clin Neuroradiol \| volume = \| issue = \| pages = \| month = Jan \| year = 2014 \| doi = 10.1007/s00062-013-0282-2 \| PMID = 24477665 }}</ref>		*Individuals usually <3 years old, uncommon in adults.<ref name=pmid24477665>{{Cite journal \| last1 = Kanoto \| first1 = M. \| last2 = Toyoguchi \| first2 = Y. \| last3 = Hosoya \| first3 = T. \| last4 = Kuchiki \| first4 = M. \| last5 = Sugai \| first5 = Y. \| title = Radiological Image Features of the Atypical Teratoid/Rhabdoid Tumor in Adults: A Systematic Review. \| journal = Clin Neuroradiol \| volume = \| issue = \| pages = \| month = Jan \| year = 2014 \| doi = 10.1007/s00062-013-0282-2 \| PMID = 24477665 }}</ref>
	*Prognosis very poor.<ref ~~name~~=~~pmid24477665~~/>		*Prognosis very poor, but long-term survivors reported.<ref>{{Cite journal \| last1 = von Hoff \| first1 = K. \| last2 = Hinkes \| first2 = B. \| last3 = Dannenmann-Stern \| first3 = E. \| last4 = von Bueren \| first4 = AO. \| last5 = Warmuth-Metz \| first5 = M. \| last6 = Soerensen \| first6 = N. \| last7 = Emser \| first7 = A. \| last8 = Zwiener \| first8 = I. \| last9 = Schlegel \| first9 = PG. \| title = Frequency, risk-factors and survival of children with atypical teratoid rhabdoid tumors (AT/RT) of the CNS diagnosed between 1988 and 2004, and registered to the German HIT database. \| journal = Pediatr Blood Cancer \| volume = 57 \| issue = 6 \| pages = 978-85 \| month = Dec \| year = 2011 \| doi = 10.1002/pbc.23236 \| PMID = 21796761 }}</ref>
			*Almost all cases associated with SMARCB1 abberations.<ref>{{Cite journal \| last1 = Hasselblatt \| first1 = M. \| last2 = Isken \| first2 = S. \| last3 = Linge \| first3 = A. \| last4 = Eikmeier \| first4 = K. \| last5 = Jeibmann \| first5 = A. \| last6 = Oyen \| first6 = F. \| last7 = Nagel \| first7 = I. \| last8 = Richter \| first8 = J. \| last9 = Bartelheim \| first9 = K. \| title = High-resolution genomic analysis suggests the absence of recurrent genomic alterations other than SMARCB1 aberrations in atypical teratoid/rhabdoid tumors. \| journal = Genes Chromosomes Cancer \| volume = 52 \| issue = 2 \| pages = 185-90 \| month = Feb \| year = 2013 \| doi = 10.1002/gcc.22018 \| PMID = 23074045 }}</ref>
			*Single cases with SMARCA4 mutation.<ref>{{Cite journal \| last1 = Hasselblatt \| first1 = M. \| last2 = Gesk \| first2 = S. \| last3 = Oyen \| first3 = F. \| last4 = Rossi \| first4 = S. \| last5 = Viscardi \| first5 = E. \| last6 = Giangaspero \| first6 = F. \| last7 = Giannini \| first7 = C. \| last8 = Judkins \| first8 = AR. \| last9 = Frühwald \| first9 = MC. \| title = Nonsense mutation and inactivation of SMARCA4 (BRG1) in an atypical teratoid/rhabdoid tumor showing retained SMARCB1 (INI1) expression. \| journal = Am J Surg Pathol \| volume = 35 \| issue = 6 \| pages = 933-5 \| month = Jun \| year = 2011 \| doi = 10.1097/PAS.0b013e3182196a39 \| PMID = 21566516 }}</ref>

	==Microscopic==		==Microscopic==
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	*[[Primitive neuroectodermal tumour]] (PNET).		*[[Primitive neuroectodermal tumour]] (PNET).
	*[[Medulloblastoma]].		*[[Medulloblastoma]].
	*~~[[Diffuse astrocytoma]]~~.		*Small cell carcinoma metastasis.
	*[[Choroid plexus carcinoma]].		*[[Choroid plexus carcinoma]].
	*[[Embryonal carcinoma]].		*[[Embryonal carcinoma]].
			*Rhabdoid meningioma.

	===Images===		===Images===
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	Image:ATRT-INI1.jpg \| AT/RT -ve for INI1. (WC/marvin101)		Image:ATRT-INI1.jpg \| AT/RT -ve for INI1. (WC/marvin101)
	Image:Rhabdoid cells ATRT1.jpg \| Rhabdoid cells in a AT/RT (WC/jensflorian)		Image:Rhabdoid cells ATRT1.jpg \| Rhabdoid cells in a AT/RT (WC/jensflorian)
	Image:ATRT-MRI.jpg \| ~~Although many of them are infratentorial,~~ AT/RT may be found anywhere in the brain or spinal cord (WC/marvin101)		Image:ATRT-MRI.jpg \| AT/RT may be found anywhere in the brain or spinal cord (WC/marvin101)
	</gallery>		</gallery>
	www:		www:
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	**Few other brain tumours express it.		**Few other brain tumours express it.
	*Vimentin +ve - perinuclear condensation (4/4 cases<ref name=pmid19212771/>).		*Vimentin +ve - perinuclear condensation (4/4 cases<ref name=pmid19212771/>).
			*LIN28 focally +ve <ref>{{Cite journal \| last1 = Korshunov \| first1 = A. \| last2 = Ryzhova \| first2 = M. \| last3 = Jones \| first3 = DT. \| last4 = Northcott \| first4 = PA. \| last5 = van Sluis \| first5 = P. \| last6 = Volckmann \| first6 = R. \| last7 = Koster \| first7 = J. \| last8 = Versteeg \| first8 = R. \| last9 = Cowdrey \| first9 = C. \| title = LIN28A immunoreactivity is a potent diagnostic marker of embryonal tumor with multilayered rosettes (ETMR). \| journal = Acta Neuropathol \| volume = 124 \| issue = 6 \| pages = 875-81 \| month = Dec \| year = 2012 \| doi = 10.1007/s00401-012-1068-3 \| PMID = 23161096 }}</ref>

	Others:		Others:
	*GFAP +ve (focal - in tumour cells).		*GFAP +ve (focal - in tumour cells).
	*EMA +ve - patchy cytoplasmic (4/4 cases<ref name=pmid19212771/>).		*EMA +ve - patchy cytoplasmic (4/4 cases<ref name=pmid19212771/>).
	*Smooth muscle actin +ve.(4/4 cases<ref name=pmid19212771/>).		*Smooth muscle actin +ve.(4/4 cases<ref name=pmid19212771/>). <ref>{{Cite journal \| last1 = Lee \| first1 = MC. \| last2 = Park \| first2 = SK. \| last3 = Lim \| first3 = JS. \| last4 = Jung \| first4 = S. \| last5 = Kim \| first5 = JH. \| last6 = Woo \| first6 = YJ. \| last7 = Lee \| first7 = JS. \| last8 = Kim \| first8 = HI. \| last9 = Jeong \| first9 = MJ. \| title = Atypical teratoid/rhabdoid tumor of the central nervous system: clinico-pathological study. \| journal = Neuropathology \| volume = 22 \| issue = 4 \| pages = 252-60 \| month = Dec \| year = 2002 \| doi = \| PMID = 12564764 }}</ref>
	*Cytokeratin +ve.{{~~fact~~}}		*Cytokeratin +ve.<ref>{{Cite journal \| last1 = Lee \| first1 = MC. \| last2 = Park \| first2 = SK. \| last3 = Lim \| first3 = JS. \| last4 = Jung \| first4 = S. \| last5 = Kim \| first5 = JH. \| last6 = Woo \| first6 = YJ. \| last7 = Lee \| first7 = JS. \| last8 = Kim \| first8 = HI. \| last9 = Jeong \| first9 = MJ. \| title = Atypical teratoid/rhabdoid tumor of the central nervous system: clinico-pathological study. \| journal = Neuropathology \| volume = 22 \| issue = 4 \| pages = 252-60 \| month = Dec \| year = 2002 \| doi = \| PMID = 12564764 }}</ref>
			*Kir 7.1 occasionally +ve<ref>{{Cite journal \| last1 = Schittenhelm \| first1 = J. \| last2 = Nagel \| first2 = C. \| last3 = Meyermann \| first3 = R. \| last4 = Beschorner \| first4 = R. \| title = Atypical teratoid/rhabdoid tumors may show morphological and immunohistochemical features seen in choroid plexus tumors. \| journal = Neuropathology \| volume = 31 \| issue = 5 \| pages = 461-7 \| month = Oct \| year = 2011 \| doi = 10.1111/j.1440-1789.2010.01189.x \| PMID = 21276081 }}</ref>

	==See also==		==See also==
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	*[[Extrarenal malignant rhabdoid tumour]].		*[[Extrarenal malignant rhabdoid tumour]].
	*[[Renal malignant rhabdoid tumour]].		*[[Renal malignant rhabdoid tumour]].
			*[[Miscellaneous ovarian tumours\|Ovarian small cell carcinoma of the hypercalcemic type]]
	==References==		==References==
	{{Reflist\|2}}		{{Reflist\|2}}

Jensflorian: /* Images */ +pictures added

2015-04-01T09:55:45Z

Images: +pictures added

← Older revision		Revision as of 09:55, 1 April 2015
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	===Images===		===Images===
	<gallery>		<gallery>
	Image:Rhabdoidtumourcell.jpg \| Rhabdoid tumour cell. (WC)		Image:Rhabdoidtumourcell.jpg \| Rhabdoid tumour cell. (WC/marvin101)
	Image:ATRT-HE-Overview.jpg \| AT/RT. (WC)		Image:ATRT-HE-Overview.jpg \| AT/RT. (WC/marvin101)
	Image:ATRT-INI1.jpg \| AT/RT -ve for INI1. (WC)		Image:ATRT-INI1.jpg \| AT/RT -ve for INI1. (WC/marvin101)
			Image:Rhabdoid cells ATRT1.jpg \| Rhabdoid cells in a AT/RT (WC/jensflorian)
			Image:ATRT-MRI.jpg \| Although many of them are infratentorial, AT/RT may be found anywhere in the brain or spinal cord (WC/marvin101)
	</gallery>		</gallery>
	www:		www: